Breakdown of Symbiosis in Radiation-Induced Oral Mucositis

Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fu...
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Autor*in:	Gianluca Ingrosso [verfasserIn] Simonetta Saldi [verfasserIn] Simona Marani [verfasserIn] Alicia Y. W. Wong [verfasserIn] Matteo Bertelli [verfasserIn] Cynthia Aristei [verfasserIn] Teresa Zelante [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	oral mucositis microbiota fungal infections lactobacilli radiation therapy

Übergeordnetes Werk:	In: Journal of Fungi - MDPI AG, 2015, 7(2021), 4, p 290
Übergeordnetes Werk:	volume:7 ; year:2021 ; number:4, p 290

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jof7040290

Katalog-ID:	DOAJ074364022

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520			\|a Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as <i<Candida albicans</i<, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy.
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spelling	10.3390/jof7040290 doi (DE-627)DOAJ074364022 (DE-599)DOAJb14f655f266948a4b167131c2bba2084 DE-627 ger DE-627 rakwb eng QH301-705.5 Gianluca Ingrosso verfasserin aut Breakdown of Symbiosis in Radiation-Induced Oral Mucositis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as <i<Candida albicans</i<, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy. oral mucositis <i<Candida albicans</i< microbiota fungal infections lactobacilli radiation therapy Biology (General) Simonetta Saldi verfasserin aut Simona Marani verfasserin aut Alicia Y. W. Wong verfasserin aut Matteo Bertelli verfasserin aut Cynthia Aristei verfasserin aut Teresa Zelante verfasserin aut In Journal of Fungi MDPI AG, 2015 7(2021), 4, p 290 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:7 year:2021 number:4, p 290 https://doi.org/10.3390/jof7040290 kostenfrei https://doaj.org/article/b14f655f266948a4b167131c2bba2084 kostenfrei https://www.mdpi.com/2309-608X/7/4/290 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 4, p 290
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allfieldsGer	10.3390/jof7040290 doi (DE-627)DOAJ074364022 (DE-599)DOAJb14f655f266948a4b167131c2bba2084 DE-627 ger DE-627 rakwb eng QH301-705.5 Gianluca Ingrosso verfasserin aut Breakdown of Symbiosis in Radiation-Induced Oral Mucositis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as <i<Candida albicans</i<, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy. oral mucositis <i<Candida albicans</i< microbiota fungal infections lactobacilli radiation therapy Biology (General) Simonetta Saldi verfasserin aut Simona Marani verfasserin aut Alicia Y. W. Wong verfasserin aut Matteo Bertelli verfasserin aut Cynthia Aristei verfasserin aut Teresa Zelante verfasserin aut In Journal of Fungi MDPI AG, 2015 7(2021), 4, p 290 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:7 year:2021 number:4, p 290 https://doi.org/10.3390/jof7040290 kostenfrei https://doaj.org/article/b14f655f266948a4b167131c2bba2084 kostenfrei https://www.mdpi.com/2309-608X/7/4/290 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 4, p 290
allfieldsSound	10.3390/jof7040290 doi (DE-627)DOAJ074364022 (DE-599)DOAJb14f655f266948a4b167131c2bba2084 DE-627 ger DE-627 rakwb eng QH301-705.5 Gianluca Ingrosso verfasserin aut Breakdown of Symbiosis in Radiation-Induced Oral Mucositis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as <i<Candida albicans</i<, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy. oral mucositis <i<Candida albicans</i< microbiota fungal infections lactobacilli radiation therapy Biology (General) Simonetta Saldi verfasserin aut Simona Marani verfasserin aut Alicia Y. W. Wong verfasserin aut Matteo Bertelli verfasserin aut Cynthia Aristei verfasserin aut Teresa Zelante verfasserin aut In Journal of Fungi MDPI AG, 2015 7(2021), 4, p 290 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:7 year:2021 number:4, p 290 https://doi.org/10.3390/jof7040290 kostenfrei https://doaj.org/article/b14f655f266948a4b167131c2bba2084 kostenfrei https://www.mdpi.com/2309-608X/7/4/290 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 4, p 290
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authorswithroles_txt_mv	Gianluca Ingrosso @@aut@@ Simonetta Saldi @@aut@@ Simona Marani @@aut@@ Alicia Y. W. Wong @@aut@@ Matteo Bertelli @@aut@@ Cynthia Aristei @@aut@@ Teresa Zelante @@aut@@
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callnumber-first	Q - Science
author	Gianluca Ingrosso
spellingShingle	Gianluca Ingrosso misc QH301-705.5 misc oral mucositis misc <i<Candida albicans</i< misc microbiota misc fungal infections misc lactobacilli misc radiation therapy misc Biology (General) Breakdown of Symbiosis in Radiation-Induced Oral Mucositis
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topic_title	QH301-705.5 Breakdown of Symbiosis in Radiation-Induced Oral Mucositis oral mucositis <i<Candida albicans</i< microbiota fungal infections lactobacilli radiation therapy
topic	misc QH301-705.5 misc oral mucositis misc <i<Candida albicans</i< misc microbiota misc fungal infections misc lactobacilli misc radiation therapy misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc oral mucositis misc <i<Candida albicans</i< misc microbiota misc fungal infections misc lactobacilli misc radiation therapy misc Biology (General)
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title	Breakdown of Symbiosis in Radiation-Induced Oral Mucositis
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title_full	Breakdown of Symbiosis in Radiation-Induced Oral Mucositis
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title_sort	breakdown of symbiosis in radiation-induced oral mucositis
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title_auth	Breakdown of Symbiosis in Radiation-Induced Oral Mucositis
abstract	Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as <i<Candida albicans</i<, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy.
abstractGer	Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as <i<Candida albicans</i<, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy.
abstract_unstemmed	Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as <i<Candida albicans</i<, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy.
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title_short	Breakdown of Symbiosis in Radiation-Induced Oral Mucositis
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