Reirradiation for Nasal Cavity or Paranasal Sinus Tumor—A Multi-Institutional Study

We evaluated the efficacy and toxicity of reirradiation of nasal cavity or paranasal sinus tumors. We collected and analyzed multi-institutional data of reirradiation cases. Seventy-eight patients with nasal or paranasal sinus tumors underwent reirradiation. The median survival time was 20 months wi...
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Autor*in:	Hideya Yamazaki [verfasserIn] Gen Suzuki [verfasserIn] Norihiro Aibe [verfasserIn] Makoto Yasuda [verfasserIn] Hiroya Shiomi [verfasserIn] Ryoong-Jin Oh [verfasserIn] Ken Yoshida [verfasserIn] Satoaki Nakamura [verfasserIn] Koji Konishi [verfasserIn] Mikio Ogita [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	nasal cavity and paranasal sinus reirradiation optic pathway

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 24, p 6315
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:24, p 6315

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13246315

Katalog-ID:	DOAJ074407295

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authorswithroles_txt_mv	Hideya Yamazaki @@aut@@ Gen Suzuki @@aut@@ Norihiro Aibe @@aut@@ Makoto Yasuda @@aut@@ Hiroya Shiomi @@aut@@ Ryoong-Jin Oh @@aut@@ Ken Yoshida @@aut@@ Satoaki Nakamura @@aut@@ Koji Konishi @@aut@@ Mikio Ogita @@aut@@
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callnumber-first	R - Medicine
author	Hideya Yamazaki
spellingShingle	Hideya Yamazaki misc RC254-282 misc nasal cavity and paranasal sinus misc reirradiation misc optic pathway misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Reirradiation for Nasal Cavity or Paranasal Sinus Tumor—A Multi-Institutional Study
authorStr	Hideya Yamazaki
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topic_title	RC254-282 Reirradiation for Nasal Cavity or Paranasal Sinus Tumor—A Multi-Institutional Study nasal cavity and paranasal sinus reirradiation optic pathway
topic	misc RC254-282 misc nasal cavity and paranasal sinus misc reirradiation misc optic pathway misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc nasal cavity and paranasal sinus misc reirradiation misc optic pathway misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc nasal cavity and paranasal sinus misc reirradiation misc optic pathway misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Reirradiation for Nasal Cavity or Paranasal Sinus Tumor—A Multi-Institutional Study
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title_full	Reirradiation for Nasal Cavity or Paranasal Sinus Tumor—A Multi-Institutional Study
author_sort	Hideya Yamazaki
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author_browse	Hideya Yamazaki Gen Suzuki Norihiro Aibe Makoto Yasuda Hiroya Shiomi Ryoong-Jin Oh Ken Yoshida Satoaki Nakamura Koji Konishi Mikio Ogita
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title_sort	reirradiation for nasal cavity or paranasal sinus tumor—a multi-institutional study
callnumber	RC254-282
title_auth	Reirradiation for Nasal Cavity or Paranasal Sinus Tumor—A Multi-Institutional Study
abstract	We evaluated the efficacy and toxicity of reirradiation of nasal cavity or paranasal sinus tumors. We collected and analyzed multi-institutional data of reirradiation cases. Seventy-eight patients with nasal or paranasal sinus tumors underwent reirradiation. The median survival time was 20 months with a medial follow-up of 10.7 months. The 2-year local control and overall survival rates were 43% and 44%, respectively. Tumor volume (≤25 cm<sup<3</sup<), duration between previous radiotherapy and reirradiation (≤12 months), histology (squamous cell carcinoma), male sex, and lymph node involvement were predisposing factors for poor survival. Distant metastasis was observed in 20 patients (25.6%). Grade ≥ 3 adverse events were observed in 22% of the patients, including five grade 4 (8.6%) cases and one grade 5 (1.2%) case. Tumor location adjacent to the optic pathway was a significant predisposing factor for grade ≥3 visual toxicity. Reirradiation of nasal and paranasal sinus tumors is feasible and effective. However, adverse events, including disease-related toxicities, were significant. Prognostic factors emerge from this study to guide multidisciplinary approaches and clinical trial designs.
abstractGer	We evaluated the efficacy and toxicity of reirradiation of nasal cavity or paranasal sinus tumors. We collected and analyzed multi-institutional data of reirradiation cases. Seventy-eight patients with nasal or paranasal sinus tumors underwent reirradiation. The median survival time was 20 months with a medial follow-up of 10.7 months. The 2-year local control and overall survival rates were 43% and 44%, respectively. Tumor volume (≤25 cm<sup<3</sup<), duration between previous radiotherapy and reirradiation (≤12 months), histology (squamous cell carcinoma), male sex, and lymph node involvement were predisposing factors for poor survival. Distant metastasis was observed in 20 patients (25.6%). Grade ≥ 3 adverse events were observed in 22% of the patients, including five grade 4 (8.6%) cases and one grade 5 (1.2%) case. Tumor location adjacent to the optic pathway was a significant predisposing factor for grade ≥3 visual toxicity. Reirradiation of nasal and paranasal sinus tumors is feasible and effective. However, adverse events, including disease-related toxicities, were significant. Prognostic factors emerge from this study to guide multidisciplinary approaches and clinical trial designs.
abstract_unstemmed	We evaluated the efficacy and toxicity of reirradiation of nasal cavity or paranasal sinus tumors. We collected and analyzed multi-institutional data of reirradiation cases. Seventy-eight patients with nasal or paranasal sinus tumors underwent reirradiation. The median survival time was 20 months with a medial follow-up of 10.7 months. The 2-year local control and overall survival rates were 43% and 44%, respectively. Tumor volume (≤25 cm<sup<3</sup<), duration between previous radiotherapy and reirradiation (≤12 months), histology (squamous cell carcinoma), male sex, and lymph node involvement were predisposing factors for poor survival. Distant metastasis was observed in 20 patients (25.6%). Grade ≥ 3 adverse events were observed in 22% of the patients, including five grade 4 (8.6%) cases and one grade 5 (1.2%) case. Tumor location adjacent to the optic pathway was a significant predisposing factor for grade ≥3 visual toxicity. Reirradiation of nasal and paranasal sinus tumors is feasible and effective. However, adverse events, including disease-related toxicities, were significant. Prognostic factors emerge from this study to guide multidisciplinary approaches and clinical trial designs.
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container_issue	24, p 6315
title_short	Reirradiation for Nasal Cavity or Paranasal Sinus Tumor—A Multi-Institutional Study
url	https://doi.org/10.3390/cancers13246315 https://doaj.org/article/094c34626aa24aadab5a3dc49db51859 https://www.mdpi.com/2072-6694/13/24/6315 https://doaj.org/toc/2072-6694
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author2	Gen Suzuki Norihiro Aibe Makoto Yasuda Hiroya Shiomi Ryoong-Jin Oh Ken Yoshida Satoaki Nakamura Koji Konishi Mikio Ogita
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up_date	2024-07-03T22:57:44.852Z
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Reirradiation for Nasal Cavity or Paranasal Sinus Tumor—A Multi-Institutional Study

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