Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2

Abstract The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic...
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Autor*in:	Yi‐Hao Chan [verfasserIn] Siew‐Wai Fong [verfasserIn] Chek‐Meng Poh [verfasserIn] Guillaume Carissimo [verfasserIn] Nicholas Kim‐Wah Yeo [verfasserIn] Siti Naqiah Amrun [verfasserIn] Yun Shan Goh [verfasserIn] Jackwee Lim [verfasserIn] Weili Xu [verfasserIn] Rhonda Sin‐Ling Chee [verfasserIn] Anthony Torres‐Ruesta [verfasserIn] Cheryl Yi‐Pin Lee [verfasserIn] Matthew Zirui Tay [verfasserIn] Zi Wei Chang [verfasserIn] Wen‐Hsin Lee [verfasserIn] Bei Wang [verfasserIn] Seow‐Yen Tan [verfasserIn] Shirin Kalimuddin [verfasserIn] Barnaby Edward Young [verfasserIn] Yee‐Sin Leo [verfasserIn] Cheng‐I Wang [verfasserIn] Bernett Lee [verfasserIn] Olaf Rötzschke [verfasserIn] David Chien Lye [verfasserIn] Laurent Renia [verfasserIn] Lisa F P Ng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	asymptomatic COVID‐19 disease tolerance SARS‐CoV‐2

Übergeordnetes Werk:	In: EMBO Molecular Medicine - Wiley, 2012, 13(2021), 6, Seite n/a-n/a
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:6 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.15252/emmm.202114045

Katalog-ID:	DOAJ074483110

Internformat


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520			\|a Abstract The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS‐CoV‐2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro‐inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro‐inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus‐specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS‐CoV‐2 was observed in asymptomatic patients. In addition, asymptomatic COVID‐19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro‐inflammatory and more protective immune responses against SARS‐CoV‐2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID‐19.
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700	0		\|a Zi Wei Chang \|e verfasserin \|4 aut
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700	0		\|a David Chien Lye \|e verfasserin \|4 aut
700	0		\|a Laurent Renia \|e verfasserin \|4 aut
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allfields	10.15252/emmm.202114045 doi (DE-627)DOAJ074483110 (DE-599)DOAJ3b73e26cedcc4068b8a198daa09cbea2 DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Yi‐Hao Chan verfasserin aut Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS‐CoV‐2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro‐inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro‐inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus‐specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS‐CoV‐2 was observed in asymptomatic patients. In addition, asymptomatic COVID‐19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro‐inflammatory and more protective immune responses against SARS‐CoV‐2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID‐19. asymptomatic COVID‐19 disease tolerance SARS‐CoV‐2 Medicine (General) Genetics Siew‐Wai Fong verfasserin aut Chek‐Meng Poh verfasserin aut Guillaume Carissimo verfasserin aut Nicholas Kim‐Wah Yeo verfasserin aut Siti Naqiah Amrun verfasserin aut Yun Shan Goh verfasserin aut Jackwee Lim verfasserin aut Weili Xu verfasserin aut Rhonda Sin‐Ling Chee verfasserin aut Anthony Torres‐Ruesta verfasserin aut Cheryl Yi‐Pin Lee verfasserin aut Matthew Zirui Tay verfasserin aut Zi Wei Chang verfasserin aut Wen‐Hsin Lee verfasserin aut Bei Wang verfasserin aut Seow‐Yen Tan verfasserin aut Shirin Kalimuddin verfasserin aut Barnaby Edward Young verfasserin aut Yee‐Sin Leo verfasserin aut Cheng‐I Wang verfasserin aut Bernett Lee verfasserin aut Olaf Rötzschke verfasserin aut David Chien Lye verfasserin aut Laurent Renia verfasserin aut Lisa F P Ng verfasserin aut In EMBO Molecular Medicine Wiley, 2012 13(2021), 6, Seite n/a-n/a (DE-627)594772761 (DE-600)2485479-7 17574684 nnns volume:13 year:2021 number:6 pages:n/a-n/a https://doi.org/10.15252/emmm.202114045 kostenfrei https://doaj.org/article/3b73e26cedcc4068b8a198daa09cbea2 kostenfrei https://doi.org/10.15252/emmm.202114045 kostenfrei https://doaj.org/toc/1757-4676 Journal toc kostenfrei https://doaj.org/toc/1757-4684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6 n/a-n/a
spelling	10.15252/emmm.202114045 doi (DE-627)DOAJ074483110 (DE-599)DOAJ3b73e26cedcc4068b8a198daa09cbea2 DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Yi‐Hao Chan verfasserin aut Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS‐CoV‐2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro‐inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro‐inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus‐specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS‐CoV‐2 was observed in asymptomatic patients. In addition, asymptomatic COVID‐19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro‐inflammatory and more protective immune responses against SARS‐CoV‐2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID‐19. asymptomatic COVID‐19 disease tolerance SARS‐CoV‐2 Medicine (General) Genetics Siew‐Wai Fong verfasserin aut Chek‐Meng Poh verfasserin aut Guillaume Carissimo verfasserin aut Nicholas Kim‐Wah Yeo verfasserin aut Siti Naqiah Amrun verfasserin aut Yun Shan Goh verfasserin aut Jackwee Lim verfasserin aut Weili Xu verfasserin aut Rhonda Sin‐Ling Chee verfasserin aut Anthony Torres‐Ruesta verfasserin aut Cheryl Yi‐Pin Lee verfasserin aut Matthew Zirui Tay verfasserin aut Zi Wei Chang verfasserin aut Wen‐Hsin Lee verfasserin aut Bei Wang verfasserin aut Seow‐Yen Tan verfasserin aut Shirin Kalimuddin verfasserin aut Barnaby Edward Young verfasserin aut Yee‐Sin Leo verfasserin aut Cheng‐I Wang verfasserin aut Bernett Lee verfasserin aut Olaf Rötzschke verfasserin aut David Chien Lye verfasserin aut Laurent Renia verfasserin aut Lisa F P Ng verfasserin aut In EMBO Molecular Medicine Wiley, 2012 13(2021), 6, Seite n/a-n/a (DE-627)594772761 (DE-600)2485479-7 17574684 nnns volume:13 year:2021 number:6 pages:n/a-n/a https://doi.org/10.15252/emmm.202114045 kostenfrei https://doaj.org/article/3b73e26cedcc4068b8a198daa09cbea2 kostenfrei https://doi.org/10.15252/emmm.202114045 kostenfrei https://doaj.org/toc/1757-4676 Journal toc kostenfrei https://doaj.org/toc/1757-4684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6 n/a-n/a
allfields_unstemmed	10.15252/emmm.202114045 doi (DE-627)DOAJ074483110 (DE-599)DOAJ3b73e26cedcc4068b8a198daa09cbea2 DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Yi‐Hao Chan verfasserin aut Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS‐CoV‐2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro‐inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro‐inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus‐specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS‐CoV‐2 was observed in asymptomatic patients. In addition, asymptomatic COVID‐19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro‐inflammatory and more protective immune responses against SARS‐CoV‐2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID‐19. asymptomatic COVID‐19 disease tolerance SARS‐CoV‐2 Medicine (General) Genetics Siew‐Wai Fong verfasserin aut Chek‐Meng Poh verfasserin aut Guillaume Carissimo verfasserin aut Nicholas Kim‐Wah Yeo verfasserin aut Siti Naqiah Amrun verfasserin aut Yun Shan Goh verfasserin aut Jackwee Lim verfasserin aut Weili Xu verfasserin aut Rhonda Sin‐Ling Chee verfasserin aut Anthony Torres‐Ruesta verfasserin aut Cheryl Yi‐Pin Lee verfasserin aut Matthew Zirui Tay verfasserin aut Zi Wei Chang verfasserin aut Wen‐Hsin Lee verfasserin aut Bei Wang verfasserin aut Seow‐Yen Tan verfasserin aut Shirin Kalimuddin verfasserin aut Barnaby Edward Young verfasserin aut Yee‐Sin Leo verfasserin aut Cheng‐I Wang verfasserin aut Bernett Lee verfasserin aut Olaf Rötzschke verfasserin aut David Chien Lye verfasserin aut Laurent Renia verfasserin aut Lisa F P Ng verfasserin aut In EMBO Molecular Medicine Wiley, 2012 13(2021), 6, Seite n/a-n/a (DE-627)594772761 (DE-600)2485479-7 17574684 nnns volume:13 year:2021 number:6 pages:n/a-n/a https://doi.org/10.15252/emmm.202114045 kostenfrei https://doaj.org/article/3b73e26cedcc4068b8a198daa09cbea2 kostenfrei https://doi.org/10.15252/emmm.202114045 kostenfrei https://doaj.org/toc/1757-4676 Journal toc kostenfrei https://doaj.org/toc/1757-4684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6 n/a-n/a
allfieldsGer	10.15252/emmm.202114045 doi (DE-627)DOAJ074483110 (DE-599)DOAJ3b73e26cedcc4068b8a198daa09cbea2 DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Yi‐Hao Chan verfasserin aut Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS‐CoV‐2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro‐inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro‐inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus‐specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS‐CoV‐2 was observed in asymptomatic patients. In addition, asymptomatic COVID‐19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro‐inflammatory and more protective immune responses against SARS‐CoV‐2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID‐19. asymptomatic COVID‐19 disease tolerance SARS‐CoV‐2 Medicine (General) Genetics Siew‐Wai Fong verfasserin aut Chek‐Meng Poh verfasserin aut Guillaume Carissimo verfasserin aut Nicholas Kim‐Wah Yeo verfasserin aut Siti Naqiah Amrun verfasserin aut Yun Shan Goh verfasserin aut Jackwee Lim verfasserin aut Weili Xu verfasserin aut Rhonda Sin‐Ling Chee verfasserin aut Anthony Torres‐Ruesta verfasserin aut Cheryl Yi‐Pin Lee verfasserin aut Matthew Zirui Tay verfasserin aut Zi Wei Chang verfasserin aut Wen‐Hsin Lee verfasserin aut Bei Wang verfasserin aut Seow‐Yen Tan verfasserin aut Shirin Kalimuddin verfasserin aut Barnaby Edward Young verfasserin aut Yee‐Sin Leo verfasserin aut Cheng‐I Wang verfasserin aut Bernett Lee verfasserin aut Olaf Rötzschke verfasserin aut David Chien Lye verfasserin aut Laurent Renia verfasserin aut Lisa F P Ng verfasserin aut In EMBO Molecular Medicine Wiley, 2012 13(2021), 6, Seite n/a-n/a (DE-627)594772761 (DE-600)2485479-7 17574684 nnns volume:13 year:2021 number:6 pages:n/a-n/a https://doi.org/10.15252/emmm.202114045 kostenfrei https://doaj.org/article/3b73e26cedcc4068b8a198daa09cbea2 kostenfrei https://doi.org/10.15252/emmm.202114045 kostenfrei https://doaj.org/toc/1757-4676 Journal toc kostenfrei https://doaj.org/toc/1757-4684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6 n/a-n/a
allfieldsSound	10.15252/emmm.202114045 doi (DE-627)DOAJ074483110 (DE-599)DOAJ3b73e26cedcc4068b8a198daa09cbea2 DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Yi‐Hao Chan verfasserin aut Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS‐CoV‐2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro‐inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro‐inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus‐specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS‐CoV‐2 was observed in asymptomatic patients. In addition, asymptomatic COVID‐19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro‐inflammatory and more protective immune responses against SARS‐CoV‐2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID‐19. asymptomatic COVID‐19 disease tolerance SARS‐CoV‐2 Medicine (General) Genetics Siew‐Wai Fong verfasserin aut Chek‐Meng Poh verfasserin aut Guillaume Carissimo verfasserin aut Nicholas Kim‐Wah Yeo verfasserin aut Siti Naqiah Amrun verfasserin aut Yun Shan Goh verfasserin aut Jackwee Lim verfasserin aut Weili Xu verfasserin aut Rhonda Sin‐Ling Chee verfasserin aut Anthony Torres‐Ruesta verfasserin aut Cheryl Yi‐Pin Lee verfasserin aut Matthew Zirui Tay verfasserin aut Zi Wei Chang verfasserin aut Wen‐Hsin Lee verfasserin aut Bei Wang verfasserin aut Seow‐Yen Tan verfasserin aut Shirin Kalimuddin verfasserin aut Barnaby Edward Young verfasserin aut Yee‐Sin Leo verfasserin aut Cheng‐I Wang verfasserin aut Bernett Lee verfasserin aut Olaf Rötzschke verfasserin aut David Chien Lye verfasserin aut Laurent Renia verfasserin aut Lisa F P Ng verfasserin aut In EMBO Molecular Medicine Wiley, 2012 13(2021), 6, Seite n/a-n/a (DE-627)594772761 (DE-600)2485479-7 17574684 nnns volume:13 year:2021 number:6 pages:n/a-n/a https://doi.org/10.15252/emmm.202114045 kostenfrei https://doaj.org/article/3b73e26cedcc4068b8a198daa09cbea2 kostenfrei https://doi.org/10.15252/emmm.202114045 kostenfrei https://doaj.org/toc/1757-4676 Journal toc kostenfrei https://doaj.org/toc/1757-4684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6 n/a-n/a
language	English
source	In EMBO Molecular Medicine 13(2021), 6, Seite n/a-n/a volume:13 year:2021 number:6 pages:n/a-n/a
sourceStr	In EMBO Molecular Medicine 13(2021), 6, Seite n/a-n/a volume:13 year:2021 number:6 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	asymptomatic COVID‐19 disease tolerance SARS‐CoV‐2 Medicine (General) Genetics
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container_title	EMBO Molecular Medicine
authorswithroles_txt_mv	Yi‐Hao Chan @@aut@@ Siew‐Wai Fong @@aut@@ Chek‐Meng Poh @@aut@@ Guillaume Carissimo @@aut@@ Nicholas Kim‐Wah Yeo @@aut@@ Siti Naqiah Amrun @@aut@@ Yun Shan Goh @@aut@@ Jackwee Lim @@aut@@ Weili Xu @@aut@@ Rhonda Sin‐Ling Chee @@aut@@ Anthony Torres‐Ruesta @@aut@@ Cheryl Yi‐Pin Lee @@aut@@ Matthew Zirui Tay @@aut@@ Zi Wei Chang @@aut@@ Wen‐Hsin Lee @@aut@@ Bei Wang @@aut@@ Seow‐Yen Tan @@aut@@ Shirin Kalimuddin @@aut@@ Barnaby Edward Young @@aut@@ Yee‐Sin Leo @@aut@@ Cheng‐I Wang @@aut@@ Bernett Lee @@aut@@ Olaf Rötzschke @@aut@@ David Chien Lye @@aut@@ Laurent Renia @@aut@@ Lisa F P Ng @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	594772761
id	DOAJ074483110
language_de	englisch
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callnumber-first	R - Medicine
author	Yi‐Hao Chan
spellingShingle	Yi‐Hao Chan misc R5-920 misc QH426-470 misc asymptomatic misc COVID‐19 misc disease tolerance misc SARS‐CoV‐2 misc Medicine (General) misc Genetics Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2
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topic_title	R5-920 QH426-470 Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2 asymptomatic COVID‐19 disease tolerance SARS‐CoV‐2
topic	misc R5-920 misc QH426-470 misc asymptomatic misc COVID‐19 misc disease tolerance misc SARS‐CoV‐2 misc Medicine (General) misc Genetics
topic_unstemmed	misc R5-920 misc QH426-470 misc asymptomatic misc COVID‐19 misc disease tolerance misc SARS‐CoV‐2 misc Medicine (General) misc Genetics
topic_browse	misc R5-920 misc QH426-470 misc asymptomatic misc COVID‐19 misc disease tolerance misc SARS‐CoV‐2 misc Medicine (General) misc Genetics
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title_sort	asymptomatic covid‐19: disease tolerance with efficient anti‐viral immunity against sars‐cov‐2
callnumber	R5-920
title_auth	Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2
abstract	Abstract The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS‐CoV‐2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro‐inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro‐inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus‐specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS‐CoV‐2 was observed in asymptomatic patients. In addition, asymptomatic COVID‐19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro‐inflammatory and more protective immune responses against SARS‐CoV‐2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID‐19.
abstractGer	Abstract The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS‐CoV‐2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro‐inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro‐inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus‐specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS‐CoV‐2 was observed in asymptomatic patients. In addition, asymptomatic COVID‐19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro‐inflammatory and more protective immune responses against SARS‐CoV‐2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID‐19.
abstract_unstemmed	Abstract The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS‐CoV‐2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro‐inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro‐inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus‐specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS‐CoV‐2 was observed in asymptomatic patients. In addition, asymptomatic COVID‐19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro‐inflammatory and more protective immune responses against SARS‐CoV‐2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID‐19.
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container_issue	6
title_short	Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2
url	https://doi.org/10.15252/emmm.202114045 https://doaj.org/article/3b73e26cedcc4068b8a198daa09cbea2 https://doaj.org/toc/1757-4676 https://doaj.org/toc/1757-4684
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author2	Siew‐Wai Fong Chek‐Meng Poh Guillaume Carissimo Nicholas Kim‐Wah Yeo Siti Naqiah Amrun Yun Shan Goh Jackwee Lim Weili Xu Rhonda Sin‐Ling Chee Anthony Torres‐Ruesta Cheryl Yi‐Pin Lee Matthew Zirui Tay Zi Wei Chang Wen‐Hsin Lee Bei Wang Seow‐Yen Tan Shirin Kalimuddin Barnaby Edward Young Yee‐Sin Leo Cheng‐I Wang Bernett Lee Olaf Rötzschke David Chien Lye Laurent Renia Lisa F P Ng
author2Str	Siew‐Wai Fong Chek‐Meng Poh Guillaume Carissimo Nicholas Kim‐Wah Yeo Siti Naqiah Amrun Yun Shan Goh Jackwee Lim Weili Xu Rhonda Sin‐Ling Chee Anthony Torres‐Ruesta Cheryl Yi‐Pin Lee Matthew Zirui Tay Zi Wei Chang Wen‐Hsin Lee Bei Wang Seow‐Yen Tan Shirin Kalimuddin Barnaby Edward Young Yee‐Sin Leo Cheng‐I Wang Bernett Lee Olaf Rötzschke David Chien Lye Laurent Renia Lisa F P Ng
ppnlink	594772761
callnumber-subject	R - General Medicine
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isOA_txt	true
hochschulschrift_bool	false
doi_str	10.15252/emmm.202114045
callnumber-a	R5-920
up_date	2024-07-03T23:19:42.072Z
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