The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation

Abstract Germline variants within BRCA1 or BRCA2 genes account for approximately 25% of familial aggregations of breast-ovarian cancers. Low or no expression of BRCA1 in breast and ovarian cancers is associated with a good clinical response to treatment with platinum therapies and PARP1 inhibitors....
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Agnieszka Strumidło [verfasserIn] Sylwia Skiba [verfasserIn] Rodney J. Scott [verfasserIn] Jan Lubiński [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Breast cancer Ovarian cancer BRCA1 microRNA Treatment

Übergeordnetes Werk:	In: Hereditary Cancer in Clinical Practice - BMC, 2010, 15(2017), 1, Seite 5
Übergeordnetes Werk:	volume:15 ; year:2017 ; number:1 ; pages:5

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13053-017-0076-7

Katalog-ID:	DOAJ074486454

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language	English
source	In Hereditary Cancer in Clinical Practice 15(2017), 1, Seite 5 volume:15 year:2017 number:1 pages:5
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institution	findex.gbv.de
topic_facet	Breast cancer Ovarian cancer BRCA1 microRNA Treatment Neoplasms. Tumors. Oncology. Including cancer and carcinogens Genetics
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container_title	Hereditary Cancer in Clinical Practice
authorswithroles_txt_mv	Agnieszka Strumidło @@aut@@ Sylwia Skiba @@aut@@ Rodney J. Scott @@aut@@ Jan Lubiński @@aut@@
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callnumber-first	R - Medicine
author	Agnieszka Strumidło
spellingShingle	Agnieszka Strumidło misc RC254-282 misc QH426-470 misc Breast cancer misc Ovarian cancer misc BRCA1 misc microRNA misc Treatment misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Genetics The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation
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topic_title	RC254-282 QH426-470 The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation Breast cancer Ovarian cancer BRCA1 microRNA Treatment
topic	misc RC254-282 misc QH426-470 misc Breast cancer misc Ovarian cancer misc BRCA1 misc microRNA misc Treatment misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Genetics
topic_unstemmed	misc RC254-282 misc QH426-470 misc Breast cancer misc Ovarian cancer misc BRCA1 misc microRNA misc Treatment misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Genetics
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title	The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation
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title_full	The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation
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title_sort	potential role of mirnas in therapy of breast and ovarian cancers associated with brca1 mutation
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title_auth	The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation
abstract	Abstract Germline variants within BRCA1 or BRCA2 genes account for approximately 25% of familial aggregations of breast-ovarian cancers. Low or no expression of BRCA1 in breast and ovarian cancers is associated with a good clinical response to treatment with platinum therapies and PARP1 inhibitors. Recent studies demonstrated that microRNAs - small non-coding RNAs, involved in the control of gene expression, can decrease BRCA1 expression by targeting the 3’UTR region of the gene. This article reviews reported relationships between various miRNAs, such as miRNA-9, miRNA-146a, miRNA-182 miRNA-218, miRNA-638 and the response to cytostatic drugs, mainly to platins and PARP1 inhbitors, for the treatment of breast and ovarian cancer associated with BRCA1 mutations.
abstractGer	Abstract Germline variants within BRCA1 or BRCA2 genes account for approximately 25% of familial aggregations of breast-ovarian cancers. Low or no expression of BRCA1 in breast and ovarian cancers is associated with a good clinical response to treatment with platinum therapies and PARP1 inhibitors. Recent studies demonstrated that microRNAs - small non-coding RNAs, involved in the control of gene expression, can decrease BRCA1 expression by targeting the 3’UTR region of the gene. This article reviews reported relationships between various miRNAs, such as miRNA-9, miRNA-146a, miRNA-182 miRNA-218, miRNA-638 and the response to cytostatic drugs, mainly to platins and PARP1 inhbitors, for the treatment of breast and ovarian cancer associated with BRCA1 mutations.
abstract_unstemmed	Abstract Germline variants within BRCA1 or BRCA2 genes account for approximately 25% of familial aggregations of breast-ovarian cancers. Low or no expression of BRCA1 in breast and ovarian cancers is associated with a good clinical response to treatment with platinum therapies and PARP1 inhibitors. Recent studies demonstrated that microRNAs - small non-coding RNAs, involved in the control of gene expression, can decrease BRCA1 expression by targeting the 3’UTR region of the gene. This article reviews reported relationships between various miRNAs, such as miRNA-9, miRNA-146a, miRNA-182 miRNA-218, miRNA-638 and the response to cytostatic drugs, mainly to platins and PARP1 inhbitors, for the treatment of breast and ovarian cancer associated with BRCA1 mutations.
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title_short	The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation
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