High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension

Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Risa M. Hoffman [verfasserIn] Florence Chibwana [verfasserIn] Daniel Kahn [verfasserIn] Ben Allan Banda [verfasserIn] Linna Phiri [verfasserIn] Mayamiko Chimombo [verfasserIn] Chiulemu Kussen [verfasserIn] Hitler Sigauke [verfasserIn] Agnes Moses [verfasserIn] Joep J. van Oosterhout [verfasserIn] Sam Phiri [verfasserIn] Jesse W. Currier [verfasserIn] Judith S. Currier [verfasserIn] Corrina Moucheraud [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	hypertension hypertension control hiv antiretroviral therapy adherence noncommunicable diseases

Übergeordnetes Werk:	In: Global Heart - Ubiquity Press, 2020, 16(2021), 1
Übergeordnetes Werk:	volume:16 ; year:2021 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.5334/gh.1081

Katalog-ID:	DOAJ074543431

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520			\|a Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality.
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allfields	10.5334/gh.1081 doi (DE-627)DOAJ074543431 (DE-599)DOAJa1b7e41301cc4be28ffcbb47915eff17 DE-627 ger DE-627 rakwb eng RC666-701 RA1-1270 Risa M. Hoffman verfasserin aut High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality. hypertension hypertension control hiv antiretroviral therapy adherence noncommunicable diseases Diseases of the circulatory (Cardiovascular) system Public aspects of medicine Florence Chibwana verfasserin aut Daniel Kahn verfasserin aut Ben Allan Banda verfasserin aut Linna Phiri verfasserin aut Mayamiko Chimombo verfasserin aut Chiulemu Kussen verfasserin aut Hitler Sigauke verfasserin aut Agnes Moses verfasserin aut Joep J. van Oosterhout verfasserin aut Sam Phiri verfasserin aut Jesse W. Currier verfasserin aut Judith S. Currier verfasserin aut Corrina Moucheraud verfasserin aut In Global Heart Ubiquity Press, 2020 16(2021), 1 (DE-627)669056316 (DE-600)2629633-0 22118179 nnns volume:16 year:2021 number:1 https://doi.org/10.5334/gh.1081 kostenfrei https://doaj.org/article/a1b7e41301cc4be28ffcbb47915eff17 kostenfrei https://globalheartjournal.com/articles/1081 kostenfrei https://doaj.org/toc/2211-8179 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 1
spelling	10.5334/gh.1081 doi (DE-627)DOAJ074543431 (DE-599)DOAJa1b7e41301cc4be28ffcbb47915eff17 DE-627 ger DE-627 rakwb eng RC666-701 RA1-1270 Risa M. Hoffman verfasserin aut High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality. hypertension hypertension control hiv antiretroviral therapy adherence noncommunicable diseases Diseases of the circulatory (Cardiovascular) system Public aspects of medicine Florence Chibwana verfasserin aut Daniel Kahn verfasserin aut Ben Allan Banda verfasserin aut Linna Phiri verfasserin aut Mayamiko Chimombo verfasserin aut Chiulemu Kussen verfasserin aut Hitler Sigauke verfasserin aut Agnes Moses verfasserin aut Joep J. van Oosterhout verfasserin aut Sam Phiri verfasserin aut Jesse W. Currier verfasserin aut Judith S. Currier verfasserin aut Corrina Moucheraud verfasserin aut In Global Heart Ubiquity Press, 2020 16(2021), 1 (DE-627)669056316 (DE-600)2629633-0 22118179 nnns volume:16 year:2021 number:1 https://doi.org/10.5334/gh.1081 kostenfrei https://doaj.org/article/a1b7e41301cc4be28ffcbb47915eff17 kostenfrei https://globalheartjournal.com/articles/1081 kostenfrei https://doaj.org/toc/2211-8179 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 1
allfields_unstemmed	10.5334/gh.1081 doi (DE-627)DOAJ074543431 (DE-599)DOAJa1b7e41301cc4be28ffcbb47915eff17 DE-627 ger DE-627 rakwb eng RC666-701 RA1-1270 Risa M. Hoffman verfasserin aut High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality. hypertension hypertension control hiv antiretroviral therapy adherence noncommunicable diseases Diseases of the circulatory (Cardiovascular) system Public aspects of medicine Florence Chibwana verfasserin aut Daniel Kahn verfasserin aut Ben Allan Banda verfasserin aut Linna Phiri verfasserin aut Mayamiko Chimombo verfasserin aut Chiulemu Kussen verfasserin aut Hitler Sigauke verfasserin aut Agnes Moses verfasserin aut Joep J. van Oosterhout verfasserin aut Sam Phiri verfasserin aut Jesse W. Currier verfasserin aut Judith S. Currier verfasserin aut Corrina Moucheraud verfasserin aut In Global Heart Ubiquity Press, 2020 16(2021), 1 (DE-627)669056316 (DE-600)2629633-0 22118179 nnns volume:16 year:2021 number:1 https://doi.org/10.5334/gh.1081 kostenfrei https://doaj.org/article/a1b7e41301cc4be28ffcbb47915eff17 kostenfrei https://globalheartjournal.com/articles/1081 kostenfrei https://doaj.org/toc/2211-8179 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 1
allfieldsGer	10.5334/gh.1081 doi (DE-627)DOAJ074543431 (DE-599)DOAJa1b7e41301cc4be28ffcbb47915eff17 DE-627 ger DE-627 rakwb eng RC666-701 RA1-1270 Risa M. Hoffman verfasserin aut High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality. hypertension hypertension control hiv antiretroviral therapy adherence noncommunicable diseases Diseases of the circulatory (Cardiovascular) system Public aspects of medicine Florence Chibwana verfasserin aut Daniel Kahn verfasserin aut Ben Allan Banda verfasserin aut Linna Phiri verfasserin aut Mayamiko Chimombo verfasserin aut Chiulemu Kussen verfasserin aut Hitler Sigauke verfasserin aut Agnes Moses verfasserin aut Joep J. van Oosterhout verfasserin aut Sam Phiri verfasserin aut Jesse W. Currier verfasserin aut Judith S. Currier verfasserin aut Corrina Moucheraud verfasserin aut In Global Heart Ubiquity Press, 2020 16(2021), 1 (DE-627)669056316 (DE-600)2629633-0 22118179 nnns volume:16 year:2021 number:1 https://doi.org/10.5334/gh.1081 kostenfrei https://doaj.org/article/a1b7e41301cc4be28ffcbb47915eff17 kostenfrei https://globalheartjournal.com/articles/1081 kostenfrei https://doaj.org/toc/2211-8179 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 1
allfieldsSound	10.5334/gh.1081 doi (DE-627)DOAJ074543431 (DE-599)DOAJa1b7e41301cc4be28ffcbb47915eff17 DE-627 ger DE-627 rakwb eng RC666-701 RA1-1270 Risa M. Hoffman verfasserin aut High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality. hypertension hypertension control hiv antiretroviral therapy adherence noncommunicable diseases Diseases of the circulatory (Cardiovascular) system Public aspects of medicine Florence Chibwana verfasserin aut Daniel Kahn verfasserin aut Ben Allan Banda verfasserin aut Linna Phiri verfasserin aut Mayamiko Chimombo verfasserin aut Chiulemu Kussen verfasserin aut Hitler Sigauke verfasserin aut Agnes Moses verfasserin aut Joep J. van Oosterhout verfasserin aut Sam Phiri verfasserin aut Jesse W. Currier verfasserin aut Judith S. Currier verfasserin aut Corrina Moucheraud verfasserin aut In Global Heart Ubiquity Press, 2020 16(2021), 1 (DE-627)669056316 (DE-600)2629633-0 22118179 nnns volume:16 year:2021 number:1 https://doi.org/10.5334/gh.1081 kostenfrei https://doaj.org/article/a1b7e41301cc4be28ffcbb47915eff17 kostenfrei https://globalheartjournal.com/articles/1081 kostenfrei https://doaj.org/toc/2211-8179 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 1
language	English
source	In Global Heart 16(2021), 1 volume:16 year:2021 number:1
sourceStr	In Global Heart 16(2021), 1 volume:16 year:2021 number:1
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	hypertension hypertension control hiv antiretroviral therapy adherence noncommunicable diseases Diseases of the circulatory (Cardiovascular) system Public aspects of medicine
isfreeaccess_bool	true
container_title	Global Heart
authorswithroles_txt_mv	Risa M. Hoffman @@aut@@ Florence Chibwana @@aut@@ Daniel Kahn @@aut@@ Ben Allan Banda @@aut@@ Linna Phiri @@aut@@ Mayamiko Chimombo @@aut@@ Chiulemu Kussen @@aut@@ Hitler Sigauke @@aut@@ Agnes Moses @@aut@@ Joep J. van Oosterhout @@aut@@ Sam Phiri @@aut@@ Jesse W. Currier @@aut@@ Judith S. Currier @@aut@@ Corrina Moucheraud @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	669056316
id	DOAJ074543431
language_de	englisch
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Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. 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callnumber-first	R - Medicine
author	Risa M. Hoffman
spellingShingle	Risa M. Hoffman misc RC666-701 misc RA1-1270 misc hypertension misc hypertension control misc hiv misc antiretroviral therapy misc adherence misc noncommunicable diseases misc Diseases of the circulatory (Cardiovascular) system misc Public aspects of medicine High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension
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topic_title	RC666-701 RA1-1270 High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension hypertension hypertension control hiv antiretroviral therapy adherence noncommunicable diseases
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title	High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension
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title_full	High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension
author_sort	Risa M. Hoffman
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author_browse	Risa M. Hoffman Florence Chibwana Daniel Kahn Ben Allan Banda Linna Phiri Mayamiko Chimombo Chiulemu Kussen Hitler Sigauke Agnes Moses Joep J. van Oosterhout Sam Phiri Jesse W. Currier Judith S. Currier Corrina Moucheraud
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title_sort	high rates of uncontrolled blood pressure in malawian adults living with hiv and hypertension
callnumber	RC666-701
title_auth	High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension
abstract	Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality.
abstractGer	Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality.
abstract_unstemmed	Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality.
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title_short	High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension
url	https://doi.org/10.5334/gh.1081 https://doaj.org/article/a1b7e41301cc4be28ffcbb47915eff17 https://globalheartjournal.com/articles/1081 https://doaj.org/toc/2211-8179
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author2	Florence Chibwana Daniel Kahn Ben Allan Banda Linna Phiri Mayamiko Chimombo Chiulemu Kussen Hitler Sigauke Agnes Moses Joep J. van Oosterhout Sam Phiri Jesse W. Currier Judith S. Currier Corrina Moucheraud
author2Str	Florence Chibwana Daniel Kahn Ben Allan Banda Linna Phiri Mayamiko Chimombo Chiulemu Kussen Hitler Sigauke Agnes Moses Joep J. van Oosterhout Sam Phiri Jesse W. Currier Judith S. Currier Corrina Moucheraud
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High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension

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