Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia

Introduction: This study investigated the association and prognostic values of serum C-reactive protein (CRP), procalcitonin (PCT), soluble urokinase plasminogen activator receptor (suPAR), and neopterin levels in patients with ventilator-associated pneumonia (VAP). Materials and Methods: This prosp...
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Autor*in:	Reyhan ÖZTÜRK [verfasserIn] Hülya BAŞAR [verfasserIn] Vildan FİDANCI [verfasserIn] Salih CESUR [verfasserIn] Ayşe ÖZCAN [verfasserIn] Necla TÜLEK [verfasserIn] Çetin KAYMAK [verfasserIn] Laser ŞANAL [verfasserIn] Ebru AKTEPE [verfasserIn] Ali Pekcan DEMİRÖZ [verfasserIn]

Format:	E-Artikel
Sprache:	Türkisch

Erschienen:	2021

Schlagwörter:	apache prognosis sofa ventilator-associated pneumonia soluble urokinase plasminogen activator receptor (supar)

Übergeordnetes Werk:	In: Mediterranean Journal of Infection, Microbes and Antimicrobials - Galenos Yayinevi, 2017, 10(2021), 1
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4274/mjima.galenos.2021.2021.49

Katalog-ID:	DOAJ074555693

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allfields	10.4274/mjima.galenos.2021.2021.49 doi (DE-627)DOAJ074555693 (DE-599)DOAJd0b647b070f24f4bac037ae3ce863535 DE-627 ger DE-627 rakwb tur RC109-216 Reyhan ÖZTÜRK verfasserin aut Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: This study investigated the association and prognostic values of serum C-reactive protein (CRP), procalcitonin (PCT), soluble urokinase plasminogen activator receptor (suPAR), and neopterin levels in patients with ventilator-associated pneumonia (VAP). Materials and Methods: This prospective observational age-and gender-matched study included 38 adult patients who were diagnosed with VAP and 40 adult patients without VAP. The Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and Clinical Pulmonary Infection Scores were calculated, and the daily positive end-expiratory pressure values of the patients were recorded. The serum levels of CRP, PCT, suPAR, and neopterin were measured once in controls (control group) and on days 0, 3, and 5 and at the end of treatment in the VAP group. Results: The CRP, PCT, neopterin, and suPAR levels were significantly higher in the VAP group than in the control group. APACHE II and SOFA values were higher in the VAP group than in the control group. C-reactive protein value on day 0 of <14.5 ng/ml and PCT level on day five of <1.23 ng/ml were 100% specific for the prediction of mortality in the VAP group. Conclusion: Measuring CRP, PCT, neopterin, and suPAR levels may aid in the early diagnosis of VAP in patients hospitalized in the ICU. High CRP and PCT levels, as well as high APACHE II and SOFA scores, may have prognostic value in the follow-up of patients with VAP. apache prognosis sofa ventilator-associated pneumonia soluble urokinase plasminogen activator receptor (supar) Medicine R Infectious and parasitic diseases Hülya BAŞAR verfasserin aut Vildan FİDANCI verfasserin aut Salih CESUR verfasserin aut Ayşe ÖZCAN verfasserin aut Necla TÜLEK verfasserin aut Çetin KAYMAK verfasserin aut Laser ŞANAL verfasserin aut Ebru AKTEPE verfasserin aut Ali Pekcan DEMİRÖZ verfasserin aut In Mediterranean Journal of Infection, Microbes and Antimicrobials Galenos Yayinevi, 2017 10(2021), 1 (DE-627)1760624780 2147673X nnns volume:10 year:2021 number:1 https://doi.org/10.4274/mjima.galenos.2021.2021.49 kostenfrei https://doaj.org/article/d0b647b070f24f4bac037ae3ce863535 kostenfrei http://mjima.org/abstract.php?id=273 kostenfrei https://doaj.org/toc/2147-673X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1
spelling	10.4274/mjima.galenos.2021.2021.49 doi (DE-627)DOAJ074555693 (DE-599)DOAJd0b647b070f24f4bac037ae3ce863535 DE-627 ger DE-627 rakwb tur RC109-216 Reyhan ÖZTÜRK verfasserin aut Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: This study investigated the association and prognostic values of serum C-reactive protein (CRP), procalcitonin (PCT), soluble urokinase plasminogen activator receptor (suPAR), and neopterin levels in patients with ventilator-associated pneumonia (VAP). Materials and Methods: This prospective observational age-and gender-matched study included 38 adult patients who were diagnosed with VAP and 40 adult patients without VAP. The Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and Clinical Pulmonary Infection Scores were calculated, and the daily positive end-expiratory pressure values of the patients were recorded. The serum levels of CRP, PCT, suPAR, and neopterin were measured once in controls (control group) and on days 0, 3, and 5 and at the end of treatment in the VAP group. Results: The CRP, PCT, neopterin, and suPAR levels were significantly higher in the VAP group than in the control group. APACHE II and SOFA values were higher in the VAP group than in the control group. C-reactive protein value on day 0 of <14.5 ng/ml and PCT level on day five of <1.23 ng/ml were 100% specific for the prediction of mortality in the VAP group. Conclusion: Measuring CRP, PCT, neopterin, and suPAR levels may aid in the early diagnosis of VAP in patients hospitalized in the ICU. High CRP and PCT levels, as well as high APACHE II and SOFA scores, may have prognostic value in the follow-up of patients with VAP. apache prognosis sofa ventilator-associated pneumonia soluble urokinase plasminogen activator receptor (supar) Medicine R Infectious and parasitic diseases Hülya BAŞAR verfasserin aut Vildan FİDANCI verfasserin aut Salih CESUR verfasserin aut Ayşe ÖZCAN verfasserin aut Necla TÜLEK verfasserin aut Çetin KAYMAK verfasserin aut Laser ŞANAL verfasserin aut Ebru AKTEPE verfasserin aut Ali Pekcan DEMİRÖZ verfasserin aut In Mediterranean Journal of Infection, Microbes and Antimicrobials Galenos Yayinevi, 2017 10(2021), 1 (DE-627)1760624780 2147673X nnns volume:10 year:2021 number:1 https://doi.org/10.4274/mjima.galenos.2021.2021.49 kostenfrei https://doaj.org/article/d0b647b070f24f4bac037ae3ce863535 kostenfrei http://mjima.org/abstract.php?id=273 kostenfrei https://doaj.org/toc/2147-673X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1
allfields_unstemmed	10.4274/mjima.galenos.2021.2021.49 doi (DE-627)DOAJ074555693 (DE-599)DOAJd0b647b070f24f4bac037ae3ce863535 DE-627 ger DE-627 rakwb tur RC109-216 Reyhan ÖZTÜRK verfasserin aut Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: This study investigated the association and prognostic values of serum C-reactive protein (CRP), procalcitonin (PCT), soluble urokinase plasminogen activator receptor (suPAR), and neopterin levels in patients with ventilator-associated pneumonia (VAP). Materials and Methods: This prospective observational age-and gender-matched study included 38 adult patients who were diagnosed with VAP and 40 adult patients without VAP. The Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and Clinical Pulmonary Infection Scores were calculated, and the daily positive end-expiratory pressure values of the patients were recorded. The serum levels of CRP, PCT, suPAR, and neopterin were measured once in controls (control group) and on days 0, 3, and 5 and at the end of treatment in the VAP group. Results: The CRP, PCT, neopterin, and suPAR levels were significantly higher in the VAP group than in the control group. APACHE II and SOFA values were higher in the VAP group than in the control group. C-reactive protein value on day 0 of <14.5 ng/ml and PCT level on day five of <1.23 ng/ml were 100% specific for the prediction of mortality in the VAP group. Conclusion: Measuring CRP, PCT, neopterin, and suPAR levels may aid in the early diagnosis of VAP in patients hospitalized in the ICU. High CRP and PCT levels, as well as high APACHE II and SOFA scores, may have prognostic value in the follow-up of patients with VAP. apache prognosis sofa ventilator-associated pneumonia soluble urokinase plasminogen activator receptor (supar) Medicine R Infectious and parasitic diseases Hülya BAŞAR verfasserin aut Vildan FİDANCI verfasserin aut Salih CESUR verfasserin aut Ayşe ÖZCAN verfasserin aut Necla TÜLEK verfasserin aut Çetin KAYMAK verfasserin aut Laser ŞANAL verfasserin aut Ebru AKTEPE verfasserin aut Ali Pekcan DEMİRÖZ verfasserin aut In Mediterranean Journal of Infection, Microbes and Antimicrobials Galenos Yayinevi, 2017 10(2021), 1 (DE-627)1760624780 2147673X nnns volume:10 year:2021 number:1 https://doi.org/10.4274/mjima.galenos.2021.2021.49 kostenfrei https://doaj.org/article/d0b647b070f24f4bac037ae3ce863535 kostenfrei http://mjima.org/abstract.php?id=273 kostenfrei https://doaj.org/toc/2147-673X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1
allfieldsGer	10.4274/mjima.galenos.2021.2021.49 doi (DE-627)DOAJ074555693 (DE-599)DOAJd0b647b070f24f4bac037ae3ce863535 DE-627 ger DE-627 rakwb tur RC109-216 Reyhan ÖZTÜRK verfasserin aut Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: This study investigated the association and prognostic values of serum C-reactive protein (CRP), procalcitonin (PCT), soluble urokinase plasminogen activator receptor (suPAR), and neopterin levels in patients with ventilator-associated pneumonia (VAP). Materials and Methods: This prospective observational age-and gender-matched study included 38 adult patients who were diagnosed with VAP and 40 adult patients without VAP. The Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and Clinical Pulmonary Infection Scores were calculated, and the daily positive end-expiratory pressure values of the patients were recorded. The serum levels of CRP, PCT, suPAR, and neopterin were measured once in controls (control group) and on days 0, 3, and 5 and at the end of treatment in the VAP group. Results: The CRP, PCT, neopterin, and suPAR levels were significantly higher in the VAP group than in the control group. APACHE II and SOFA values were higher in the VAP group than in the control group. C-reactive protein value on day 0 of <14.5 ng/ml and PCT level on day five of <1.23 ng/ml were 100% specific for the prediction of mortality in the VAP group. Conclusion: Measuring CRP, PCT, neopterin, and suPAR levels may aid in the early diagnosis of VAP in patients hospitalized in the ICU. High CRP and PCT levels, as well as high APACHE II and SOFA scores, may have prognostic value in the follow-up of patients with VAP. apache prognosis sofa ventilator-associated pneumonia soluble urokinase plasminogen activator receptor (supar) Medicine R Infectious and parasitic diseases Hülya BAŞAR verfasserin aut Vildan FİDANCI verfasserin aut Salih CESUR verfasserin aut Ayşe ÖZCAN verfasserin aut Necla TÜLEK verfasserin aut Çetin KAYMAK verfasserin aut Laser ŞANAL verfasserin aut Ebru AKTEPE verfasserin aut Ali Pekcan DEMİRÖZ verfasserin aut In Mediterranean Journal of Infection, Microbes and Antimicrobials Galenos Yayinevi, 2017 10(2021), 1 (DE-627)1760624780 2147673X nnns volume:10 year:2021 number:1 https://doi.org/10.4274/mjima.galenos.2021.2021.49 kostenfrei https://doaj.org/article/d0b647b070f24f4bac037ae3ce863535 kostenfrei http://mjima.org/abstract.php?id=273 kostenfrei https://doaj.org/toc/2147-673X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1
allfieldsSound	10.4274/mjima.galenos.2021.2021.49 doi (DE-627)DOAJ074555693 (DE-599)DOAJd0b647b070f24f4bac037ae3ce863535 DE-627 ger DE-627 rakwb tur RC109-216 Reyhan ÖZTÜRK verfasserin aut Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: This study investigated the association and prognostic values of serum C-reactive protein (CRP), procalcitonin (PCT), soluble urokinase plasminogen activator receptor (suPAR), and neopterin levels in patients with ventilator-associated pneumonia (VAP). Materials and Methods: This prospective observational age-and gender-matched study included 38 adult patients who were diagnosed with VAP and 40 adult patients without VAP. The Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and Clinical Pulmonary Infection Scores were calculated, and the daily positive end-expiratory pressure values of the patients were recorded. The serum levels of CRP, PCT, suPAR, and neopterin were measured once in controls (control group) and on days 0, 3, and 5 and at the end of treatment in the VAP group. Results: The CRP, PCT, neopterin, and suPAR levels were significantly higher in the VAP group than in the control group. APACHE II and SOFA values were higher in the VAP group than in the control group. C-reactive protein value on day 0 of <14.5 ng/ml and PCT level on day five of <1.23 ng/ml were 100% specific for the prediction of mortality in the VAP group. Conclusion: Measuring CRP, PCT, neopterin, and suPAR levels may aid in the early diagnosis of VAP in patients hospitalized in the ICU. High CRP and PCT levels, as well as high APACHE II and SOFA scores, may have prognostic value in the follow-up of patients with VAP. apache prognosis sofa ventilator-associated pneumonia soluble urokinase plasminogen activator receptor (supar) Medicine R Infectious and parasitic diseases Hülya BAŞAR verfasserin aut Vildan FİDANCI verfasserin aut Salih CESUR verfasserin aut Ayşe ÖZCAN verfasserin aut Necla TÜLEK verfasserin aut Çetin KAYMAK verfasserin aut Laser ŞANAL verfasserin aut Ebru AKTEPE verfasserin aut Ali Pekcan DEMİRÖZ verfasserin aut In Mediterranean Journal of Infection, Microbes and Antimicrobials Galenos Yayinevi, 2017 10(2021), 1 (DE-627)1760624780 2147673X nnns volume:10 year:2021 number:1 https://doi.org/10.4274/mjima.galenos.2021.2021.49 kostenfrei https://doaj.org/article/d0b647b070f24f4bac037ae3ce863535 kostenfrei http://mjima.org/abstract.php?id=273 kostenfrei https://doaj.org/toc/2147-673X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1
language	Turkish
source	In Mediterranean Journal of Infection, Microbes and Antimicrobials 10(2021), 1 volume:10 year:2021 number:1
sourceStr	In Mediterranean Journal of Infection, Microbes and Antimicrobials 10(2021), 1 volume:10 year:2021 number:1
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	apache prognosis sofa ventilator-associated pneumonia soluble urokinase plasminogen activator receptor (supar) Medicine R Infectious and parasitic diseases
isfreeaccess_bool	true
container_title	Mediterranean Journal of Infection, Microbes and Antimicrobials
authorswithroles_txt_mv	Reyhan ÖZTÜRK @@aut@@ Hülya BAŞAR @@aut@@ Vildan FİDANCI @@aut@@ Salih CESUR @@aut@@ Ayşe ÖZCAN @@aut@@ Necla TÜLEK @@aut@@ Çetin KAYMAK @@aut@@ Laser ŞANAL @@aut@@ Ebru AKTEPE @@aut@@ Ali Pekcan DEMİRÖZ @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	1760624780
id	DOAJ074555693
language_de	türkisch
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Materials and Methods: This prospective observational age-and gender-matched study included 38 adult patients who were diagnosed with VAP and 40 adult patients without VAP. The Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and Clinical Pulmonary Infection Scores were calculated, and the daily positive end-expiratory pressure values of the patients were recorded. The serum levels of CRP, PCT, suPAR, and neopterin were measured once in controls (control group) and on days 0, 3, and 5 and at the end of treatment in the VAP group. Results: The CRP, PCT, neopterin, and suPAR levels were significantly higher in the VAP group than in the control group. APACHE II and SOFA values were higher in the VAP group than in the control group. C-reactive protein value on day 0 of <14.5 ng/ml and PCT level on day five of <1.23 ng/ml were 100% specific for the prediction of mortality in the VAP group. 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callnumber-first	R - Medicine
author	Reyhan ÖZTÜRK
spellingShingle	Reyhan ÖZTÜRK misc RC109-216 misc apache misc prognosis misc sofa misc ventilator-associated pneumonia misc soluble urokinase plasminogen activator receptor (supar) misc Medicine misc R misc Infectious and parasitic diseases Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia
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topic_title	RC109-216 Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia apache prognosis sofa ventilator-associated pneumonia soluble urokinase plasminogen activator receptor (supar)
topic	misc RC109-216 misc apache misc prognosis misc sofa misc ventilator-associated pneumonia misc soluble urokinase plasminogen activator receptor (supar) misc Medicine misc R misc Infectious and parasitic diseases
topic_unstemmed	misc RC109-216 misc apache misc prognosis misc sofa misc ventilator-associated pneumonia misc soluble urokinase plasminogen activator receptor (supar) misc Medicine misc R misc Infectious and parasitic diseases
topic_browse	misc RC109-216 misc apache misc prognosis misc sofa misc ventilator-associated pneumonia misc soluble urokinase plasminogen activator receptor (supar) misc Medicine misc R misc Infectious and parasitic diseases
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title	Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia
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title_full	Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia
author_sort	Reyhan ÖZTÜRK
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author_browse	Reyhan ÖZTÜRK Hülya BAŞAR Vildan FİDANCI Salih CESUR Ayşe ÖZCAN Necla TÜLEK Çetin KAYMAK Laser ŞANAL Ebru AKTEPE Ali Pekcan DEMİRÖZ
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author-letter	Reyhan ÖZTÜRK
doi_str_mv	10.4274/mjima.galenos.2021.2021.49
author2-role	verfasserin
title_sort	diagnostic and prognostic values of serum c-reactive protein, procalcitonin, soluble urokinase plasminogen activator receptor, and neopterin levels in hospitalized patients in the intensive care unit with ventilator-associated pneumonia
callnumber	RC109-216
title_auth	Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia
abstract	Introduction: This study investigated the association and prognostic values of serum C-reactive protein (CRP), procalcitonin (PCT), soluble urokinase plasminogen activator receptor (suPAR), and neopterin levels in patients with ventilator-associated pneumonia (VAP). Materials and Methods: This prospective observational age-and gender-matched study included 38 adult patients who were diagnosed with VAP and 40 adult patients without VAP. The Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and Clinical Pulmonary Infection Scores were calculated, and the daily positive end-expiratory pressure values of the patients were recorded. The serum levels of CRP, PCT, suPAR, and neopterin were measured once in controls (control group) and on days 0, 3, and 5 and at the end of treatment in the VAP group. Results: The CRP, PCT, neopterin, and suPAR levels were significantly higher in the VAP group than in the control group. APACHE II and SOFA values were higher in the VAP group than in the control group. C-reactive protein value on day 0 of <14.5 ng/ml and PCT level on day five of <1.23 ng/ml were 100% specific for the prediction of mortality in the VAP group. Conclusion: Measuring CRP, PCT, neopterin, and suPAR levels may aid in the early diagnosis of VAP in patients hospitalized in the ICU. High CRP and PCT levels, as well as high APACHE II and SOFA scores, may have prognostic value in the follow-up of patients with VAP.
abstractGer	Introduction: This study investigated the association and prognostic values of serum C-reactive protein (CRP), procalcitonin (PCT), soluble urokinase plasminogen activator receptor (suPAR), and neopterin levels in patients with ventilator-associated pneumonia (VAP). Materials and Methods: This prospective observational age-and gender-matched study included 38 adult patients who were diagnosed with VAP and 40 adult patients without VAP. The Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and Clinical Pulmonary Infection Scores were calculated, and the daily positive end-expiratory pressure values of the patients were recorded. The serum levels of CRP, PCT, suPAR, and neopterin were measured once in controls (control group) and on days 0, 3, and 5 and at the end of treatment in the VAP group. Results: The CRP, PCT, neopterin, and suPAR levels were significantly higher in the VAP group than in the control group. APACHE II and SOFA values were higher in the VAP group than in the control group. C-reactive protein value on day 0 of <14.5 ng/ml and PCT level on day five of <1.23 ng/ml were 100% specific for the prediction of mortality in the VAP group. Conclusion: Measuring CRP, PCT, neopterin, and suPAR levels may aid in the early diagnosis of VAP in patients hospitalized in the ICU. High CRP and PCT levels, as well as high APACHE II and SOFA scores, may have prognostic value in the follow-up of patients with VAP.
abstract_unstemmed	Introduction: This study investigated the association and prognostic values of serum C-reactive protein (CRP), procalcitonin (PCT), soluble urokinase plasminogen activator receptor (suPAR), and neopterin levels in patients with ventilator-associated pneumonia (VAP). Materials and Methods: This prospective observational age-and gender-matched study included 38 adult patients who were diagnosed with VAP and 40 adult patients without VAP. The Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and Clinical Pulmonary Infection Scores were calculated, and the daily positive end-expiratory pressure values of the patients were recorded. The serum levels of CRP, PCT, suPAR, and neopterin were measured once in controls (control group) and on days 0, 3, and 5 and at the end of treatment in the VAP group. Results: The CRP, PCT, neopterin, and suPAR levels were significantly higher in the VAP group than in the control group. APACHE II and SOFA values were higher in the VAP group than in the control group. C-reactive protein value on day 0 of <14.5 ng/ml and PCT level on day five of <1.23 ng/ml were 100% specific for the prediction of mortality in the VAP group. Conclusion: Measuring CRP, PCT, neopterin, and suPAR levels may aid in the early diagnosis of VAP in patients hospitalized in the ICU. High CRP and PCT levels, as well as high APACHE II and SOFA scores, may have prognostic value in the follow-up of patients with VAP.
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title_short	Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia
url	https://doi.org/10.4274/mjima.galenos.2021.2021.49 https://doaj.org/article/d0b647b070f24f4bac037ae3ce863535 http://mjima.org/abstract.php?id=273 https://doaj.org/toc/2147-673X
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author2	Hülya BAŞAR Vildan FİDANCI Salih CESUR Ayşe ÖZCAN Necla TÜLEK Çetin KAYMAK Laser ŞANAL Ebru AKTEPE Ali Pekcan DEMİRÖZ
author2Str	Hülya BAŞAR Vildan FİDANCI Salih CESUR Ayşe ÖZCAN Necla TÜLEK Çetin KAYMAK Laser ŞANAL Ebru AKTEPE Ali Pekcan DEMİRÖZ
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Diagnostic and Prognostic Values of Serum C-reactive Protein, Procalcitonin, Soluble Urokinase Plasminogen Activator Receptor, and Neopterin Levels in Hospitalized Patients in the Intensive Care Unit with Ventilator-associated Pneumonia

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