Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3

Abstract We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous fi...
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Autor*in:	Soren Alexandersen [verfasserIn] Tiffanie M. Nelson [verfasserIn] Jason Hodge [verfasserIn] Julian Druce [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Scientific Reports - Nature Portfolio, 2011, 7(2017), 1, Seite 12
Übergeordnetes Werk:	volume:7 ; year:2017 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41598-017-04145-2

Katalog-ID:	DOAJ07468535X

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author	Soren Alexandersen
spellingShingle	Soren Alexandersen misc Medicine misc R misc Science misc Q Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
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topic_title	Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
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title	Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
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title_full	Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
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title_sort	evolutionary and network analysis of virus sequences from infants infected with an australian recombinant strain of human parechovirus type 3
title_auth	Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
abstract	Abstract We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level. The phylogenetic and network analyses performed support a temporal evolution from the first Australian recombinant virus sequence from November 2013 to March/April 2014, onto the 2015 outbreak. The 2015 outbreak samples fall into two separate clusters with a possible common ancestor between March/April 2014 and September 2015, with each cluster further evolving in the period from September to November/December 2015.
abstractGer	Abstract We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level. The phylogenetic and network analyses performed support a temporal evolution from the first Australian recombinant virus sequence from November 2013 to March/April 2014, onto the 2015 outbreak. The 2015 outbreak samples fall into two separate clusters with a possible common ancestor between March/April 2014 and September 2015, with each cluster further evolving in the period from September to November/December 2015.
abstract_unstemmed	Abstract We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level. The phylogenetic and network analyses performed support a temporal evolution from the first Australian recombinant virus sequence from November 2013 to March/April 2014, onto the 2015 outbreak. The 2015 outbreak samples fall into two separate clusters with a possible common ancestor between March/April 2014 and September 2015, with each cluster further evolving in the period from September to November/December 2015.
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title_short	Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
url	https://doi.org/10.1038/s41598-017-04145-2 https://doaj.org/article/92a1136b8df64992b009fa8896f1031d https://doaj.org/toc/2045-2322
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Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3

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