ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB

Transcription-coupled homologous recombination (TC-HR) is activated by reactive oxygen species-induced DNA damage to maintain transcribed genome stability. The authors demonstrate that R loops are induced by ROS at the transcribed genome, triggering a CSB-RAD52- dependent but BRCA1/2-independent RAD...
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Autor*in:	Yaqun Teng [verfasserIn] Tribhuwan Yadav [verfasserIn] Meihan Duan [verfasserIn] Jun Tan [verfasserIn] Yufei Xiang [verfasserIn] Boya Gao [verfasserIn] Jianquan Xu [verfasserIn] Zhuobin Liang [verfasserIn] Yang Liu [verfasserIn] Satoshi Nakajima [verfasserIn] Yi Shi [verfasserIn] Arthur S. Levine [verfasserIn] Lee Zou [verfasserIn] Li Lan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 12
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-018-06586-3

Katalog-ID:	DOAJ074720643

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author	Yaqun Teng
spellingShingle	Yaqun Teng misc Science misc Q ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
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topic_title	ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
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format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
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title	ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
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title_full	ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
author_sort	Yaqun Teng
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author_browse	Yaqun Teng Tribhuwan Yadav Meihan Duan Jun Tan Yufei Xiang Boya Gao Jianquan Xu Zhuobin Liang Yang Liu Satoshi Nakajima Yi Shi Arthur S. Levine Lee Zou Li Lan
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title_sort	ros-induced r loops trigger a transcription-coupled but brca1/2-independent homologous recombination pathway through csb
title_auth	ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
abstract	Transcription-coupled homologous recombination (TC-HR) is activated by reactive oxygen species-induced DNA damage to maintain transcribed genome stability. The authors demonstrate that R loops are induced by ROS at the transcribed genome, triggering a CSB-RAD52- dependent but BRCA1/2-independent RAD51 loading for repair.
abstractGer	Transcription-coupled homologous recombination (TC-HR) is activated by reactive oxygen species-induced DNA damage to maintain transcribed genome stability. The authors demonstrate that R loops are induced by ROS at the transcribed genome, triggering a CSB-RAD52- dependent but BRCA1/2-independent RAD51 loading for repair.
abstract_unstemmed	Transcription-coupled homologous recombination (TC-HR) is activated by reactive oxygen species-induced DNA damage to maintain transcribed genome stability. The authors demonstrate that R loops are induced by ROS at the transcribed genome, triggering a CSB-RAD52- dependent but BRCA1/2-independent RAD51 loading for repair.
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title_short	ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
url	https://doi.org/10.1038/s41467-018-06586-3 https://doaj.org/article/6df57d01d9cd4272a9ddbb25bd5cd4fe https://doaj.org/toc/2041-1723
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author2	Tribhuwan Yadav Meihan Duan Jun Tan Yufei Xiang Boya Gao Jianquan Xu Zhuobin Liang Yang Liu Satoshi Nakajima Yi Shi Arthur S. Levine Lee Zou Li Lan
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up_date	2024-07-04T00:19:08.911Z
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