An ex vivo organ culture screening model revealed that low temperature conditions prevent side effects of anticancer drugs
Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex vivo screening model and described a method for s...
Ausführliche Beschreibung
Autor*in: |
Tian Tian [verfasserIn] Kanako Miyazaki [verfasserIn] Yuta Chiba [verfasserIn] Keita Funada [verfasserIn] Tomomi Yuta [verfasserIn] Kanji Mizuta [verfasserIn] Yao Fu [verfasserIn] Jumpei Kawahara [verfasserIn] Xue Han [verfasserIn] Yuna Ando [verfasserIn] Ami Funada [verfasserIn] Aya Yamada [verfasserIn] Tsutomu Iwamoto [verfasserIn] Seiji Nakamura [verfasserIn] Ichiro Takahashi [verfasserIn] Satoshi Fukumoto [verfasserIn] Keigo Yoshizaki [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: Scientific Reports - Nature Portfolio, 2011, 12(2022), 1, Seite 16 |
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Übergeordnetes Werk: |
volume:12 ; year:2022 ; number:1 ; pages:16 |
Links: |
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DOI / URN: |
10.1038/s41598-022-06945-7 |
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Katalog-ID: |
DOAJ074888730 |
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10.1038/s41598-022-06945-7 doi (DE-627)DOAJ074888730 (DE-599)DOAJ5ee8772b55b244938fbece62a21f02ff DE-627 ger DE-627 rakwb eng Tian Tian verfasserin aut An ex vivo organ culture screening model revealed that low temperature conditions prevent side effects of anticancer drugs 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex vivo screening model and described a method for suppressing side effects. Cyclophosphamide (CPA) is a commonly used anticancer drug and causes severe side effects in developing organs with intensive proliferation, including the teeth and hair. Using the organ culture model, we found that treatment with CPA disturbed the growth of tooth germs by inducing DNA damage, apoptosis and suppressing cellular proliferation and differentiation. Furthermore, low temperature suppressed CPA-mediated inhibition of organ development. Our ex vivo and in vitro analysis revealed that low temperature impeded Rb phosphorylation and caused cell cycle arrest at the G1 phase during CPA treatment. This can prevent the CPA-mediated cell damage of DNA replication caused by the cross-linking reaction of CPA. Our findings suggest that the side effects of anticancer drugs on organ development can be avoided by maintaining the internal environment under low temperature. Medicine R Science Q Kanako Miyazaki verfasserin aut Yuta Chiba verfasserin aut Keita Funada verfasserin aut Tomomi Yuta verfasserin aut Kanji Mizuta verfasserin aut Yao Fu verfasserin aut Jumpei Kawahara verfasserin aut Xue Han verfasserin aut Yuna Ando verfasserin aut Ami Funada verfasserin aut Aya Yamada verfasserin aut Tsutomu Iwamoto verfasserin aut Seiji Nakamura verfasserin aut Ichiro Takahashi verfasserin aut Satoshi Fukumoto verfasserin aut Keigo Yoshizaki verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 16 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:16 https://doi.org/10.1038/s41598-022-06945-7 kostenfrei https://doaj.org/article/5ee8772b55b244938fbece62a21f02ff kostenfrei https://doi.org/10.1038/s41598-022-06945-7 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 16 |
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10.1038/s41598-022-06945-7 doi (DE-627)DOAJ074888730 (DE-599)DOAJ5ee8772b55b244938fbece62a21f02ff DE-627 ger DE-627 rakwb eng Tian Tian verfasserin aut An ex vivo organ culture screening model revealed that low temperature conditions prevent side effects of anticancer drugs 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex vivo screening model and described a method for suppressing side effects. Cyclophosphamide (CPA) is a commonly used anticancer drug and causes severe side effects in developing organs with intensive proliferation, including the teeth and hair. Using the organ culture model, we found that treatment with CPA disturbed the growth of tooth germs by inducing DNA damage, apoptosis and suppressing cellular proliferation and differentiation. Furthermore, low temperature suppressed CPA-mediated inhibition of organ development. Our ex vivo and in vitro analysis revealed that low temperature impeded Rb phosphorylation and caused cell cycle arrest at the G1 phase during CPA treatment. This can prevent the CPA-mediated cell damage of DNA replication caused by the cross-linking reaction of CPA. Our findings suggest that the side effects of anticancer drugs on organ development can be avoided by maintaining the internal environment under low temperature. Medicine R Science Q Kanako Miyazaki verfasserin aut Yuta Chiba verfasserin aut Keita Funada verfasserin aut Tomomi Yuta verfasserin aut Kanji Mizuta verfasserin aut Yao Fu verfasserin aut Jumpei Kawahara verfasserin aut Xue Han verfasserin aut Yuna Ando verfasserin aut Ami Funada verfasserin aut Aya Yamada verfasserin aut Tsutomu Iwamoto verfasserin aut Seiji Nakamura verfasserin aut Ichiro Takahashi verfasserin aut Satoshi Fukumoto verfasserin aut Keigo Yoshizaki verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 16 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:16 https://doi.org/10.1038/s41598-022-06945-7 kostenfrei https://doaj.org/article/5ee8772b55b244938fbece62a21f02ff kostenfrei https://doi.org/10.1038/s41598-022-06945-7 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 16 |
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10.1038/s41598-022-06945-7 doi (DE-627)DOAJ074888730 (DE-599)DOAJ5ee8772b55b244938fbece62a21f02ff DE-627 ger DE-627 rakwb eng Tian Tian verfasserin aut An ex vivo organ culture screening model revealed that low temperature conditions prevent side effects of anticancer drugs 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex vivo screening model and described a method for suppressing side effects. Cyclophosphamide (CPA) is a commonly used anticancer drug and causes severe side effects in developing organs with intensive proliferation, including the teeth and hair. Using the organ culture model, we found that treatment with CPA disturbed the growth of tooth germs by inducing DNA damage, apoptosis and suppressing cellular proliferation and differentiation. Furthermore, low temperature suppressed CPA-mediated inhibition of organ development. Our ex vivo and in vitro analysis revealed that low temperature impeded Rb phosphorylation and caused cell cycle arrest at the G1 phase during CPA treatment. This can prevent the CPA-mediated cell damage of DNA replication caused by the cross-linking reaction of CPA. Our findings suggest that the side effects of anticancer drugs on organ development can be avoided by maintaining the internal environment under low temperature. Medicine R Science Q Kanako Miyazaki verfasserin aut Yuta Chiba verfasserin aut Keita Funada verfasserin aut Tomomi Yuta verfasserin aut Kanji Mizuta verfasserin aut Yao Fu verfasserin aut Jumpei Kawahara verfasserin aut Xue Han verfasserin aut Yuna Ando verfasserin aut Ami Funada verfasserin aut Aya Yamada verfasserin aut Tsutomu Iwamoto verfasserin aut Seiji Nakamura verfasserin aut Ichiro Takahashi verfasserin aut Satoshi Fukumoto verfasserin aut Keigo Yoshizaki verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 16 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:16 https://doi.org/10.1038/s41598-022-06945-7 kostenfrei https://doaj.org/article/5ee8772b55b244938fbece62a21f02ff kostenfrei https://doi.org/10.1038/s41598-022-06945-7 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 16 |
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10.1038/s41598-022-06945-7 doi (DE-627)DOAJ074888730 (DE-599)DOAJ5ee8772b55b244938fbece62a21f02ff DE-627 ger DE-627 rakwb eng Tian Tian verfasserin aut An ex vivo organ culture screening model revealed that low temperature conditions prevent side effects of anticancer drugs 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex vivo screening model and described a method for suppressing side effects. Cyclophosphamide (CPA) is a commonly used anticancer drug and causes severe side effects in developing organs with intensive proliferation, including the teeth and hair. Using the organ culture model, we found that treatment with CPA disturbed the growth of tooth germs by inducing DNA damage, apoptosis and suppressing cellular proliferation and differentiation. Furthermore, low temperature suppressed CPA-mediated inhibition of organ development. Our ex vivo and in vitro analysis revealed that low temperature impeded Rb phosphorylation and caused cell cycle arrest at the G1 phase during CPA treatment. This can prevent the CPA-mediated cell damage of DNA replication caused by the cross-linking reaction of CPA. Our findings suggest that the side effects of anticancer drugs on organ development can be avoided by maintaining the internal environment under low temperature. Medicine R Science Q Kanako Miyazaki verfasserin aut Yuta Chiba verfasserin aut Keita Funada verfasserin aut Tomomi Yuta verfasserin aut Kanji Mizuta verfasserin aut Yao Fu verfasserin aut Jumpei Kawahara verfasserin aut Xue Han verfasserin aut Yuna Ando verfasserin aut Ami Funada verfasserin aut Aya Yamada verfasserin aut Tsutomu Iwamoto verfasserin aut Seiji Nakamura verfasserin aut Ichiro Takahashi verfasserin aut Satoshi Fukumoto verfasserin aut Keigo Yoshizaki verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 16 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:16 https://doi.org/10.1038/s41598-022-06945-7 kostenfrei https://doaj.org/article/5ee8772b55b244938fbece62a21f02ff kostenfrei https://doi.org/10.1038/s41598-022-06945-7 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 16 |
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10.1038/s41598-022-06945-7 doi (DE-627)DOAJ074888730 (DE-599)DOAJ5ee8772b55b244938fbece62a21f02ff DE-627 ger DE-627 rakwb eng Tian Tian verfasserin aut An ex vivo organ culture screening model revealed that low temperature conditions prevent side effects of anticancer drugs 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex vivo screening model and described a method for suppressing side effects. Cyclophosphamide (CPA) is a commonly used anticancer drug and causes severe side effects in developing organs with intensive proliferation, including the teeth and hair. Using the organ culture model, we found that treatment with CPA disturbed the growth of tooth germs by inducing DNA damage, apoptosis and suppressing cellular proliferation and differentiation. Furthermore, low temperature suppressed CPA-mediated inhibition of organ development. Our ex vivo and in vitro analysis revealed that low temperature impeded Rb phosphorylation and caused cell cycle arrest at the G1 phase during CPA treatment. This can prevent the CPA-mediated cell damage of DNA replication caused by the cross-linking reaction of CPA. Our findings suggest that the side effects of anticancer drugs on organ development can be avoided by maintaining the internal environment under low temperature. Medicine R Science Q Kanako Miyazaki verfasserin aut Yuta Chiba verfasserin aut Keita Funada verfasserin aut Tomomi Yuta verfasserin aut Kanji Mizuta verfasserin aut Yao Fu verfasserin aut Jumpei Kawahara verfasserin aut Xue Han verfasserin aut Yuna Ando verfasserin aut Ami Funada verfasserin aut Aya Yamada verfasserin aut Tsutomu Iwamoto verfasserin aut Seiji Nakamura verfasserin aut Ichiro Takahashi verfasserin aut Satoshi Fukumoto verfasserin aut Keigo Yoshizaki verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 16 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:16 https://doi.org/10.1038/s41598-022-06945-7 kostenfrei https://doaj.org/article/5ee8772b55b244938fbece62a21f02ff kostenfrei https://doi.org/10.1038/s41598-022-06945-7 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 16 |
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Tian Tian @@aut@@ Kanako Miyazaki @@aut@@ Yuta Chiba @@aut@@ Keita Funada @@aut@@ Tomomi Yuta @@aut@@ Kanji Mizuta @@aut@@ Yao Fu @@aut@@ Jumpei Kawahara @@aut@@ Xue Han @@aut@@ Yuna Ando @@aut@@ Ami Funada @@aut@@ Aya Yamada @@aut@@ Tsutomu Iwamoto @@aut@@ Seiji Nakamura @@aut@@ Ichiro Takahashi @@aut@@ Satoshi Fukumoto @@aut@@ Keigo Yoshizaki @@aut@@ |
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Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex vivo screening model and described a method for suppressing side effects. Cyclophosphamide (CPA) is a commonly used anticancer drug and causes severe side effects in developing organs with intensive proliferation, including the teeth and hair. Using the organ culture model, we found that treatment with CPA disturbed the growth of tooth germs by inducing DNA damage, apoptosis and suppressing cellular proliferation and differentiation. Furthermore, low temperature suppressed CPA-mediated inhibition of organ development. Our ex vivo and in vitro analysis revealed that low temperature impeded Rb phosphorylation and caused cell cycle arrest at the G1 phase during CPA treatment. This can prevent the CPA-mediated cell damage of DNA replication caused by the cross-linking reaction of CPA. Our findings suggest that the side effects of anticancer drugs on organ development can be avoided by maintaining the internal environment under low temperature. |
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Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex vivo screening model and described a method for suppressing side effects. Cyclophosphamide (CPA) is a commonly used anticancer drug and causes severe side effects in developing organs with intensive proliferation, including the teeth and hair. Using the organ culture model, we found that treatment with CPA disturbed the growth of tooth germs by inducing DNA damage, apoptosis and suppressing cellular proliferation and differentiation. Furthermore, low temperature suppressed CPA-mediated inhibition of organ development. Our ex vivo and in vitro analysis revealed that low temperature impeded Rb phosphorylation and caused cell cycle arrest at the G1 phase during CPA treatment. This can prevent the CPA-mediated cell damage of DNA replication caused by the cross-linking reaction of CPA. Our findings suggest that the side effects of anticancer drugs on organ development can be avoided by maintaining the internal environment under low temperature. |
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Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex vivo screening model and described a method for suppressing side effects. Cyclophosphamide (CPA) is a commonly used anticancer drug and causes severe side effects in developing organs with intensive proliferation, including the teeth and hair. Using the organ culture model, we found that treatment with CPA disturbed the growth of tooth germs by inducing DNA damage, apoptosis and suppressing cellular proliferation and differentiation. Furthermore, low temperature suppressed CPA-mediated inhibition of organ development. Our ex vivo and in vitro analysis revealed that low temperature impeded Rb phosphorylation and caused cell cycle arrest at the G1 phase during CPA treatment. This can prevent the CPA-mediated cell damage of DNA replication caused by the cross-linking reaction of CPA. Our findings suggest that the side effects of anticancer drugs on organ development can be avoided by maintaining the internal environment under low temperature. |
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An ex vivo organ culture screening model revealed that low temperature conditions prevent side effects of anticancer drugs |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ074888730</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309130934.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1038/s41598-022-06945-7</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ074888730</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ5ee8772b55b244938fbece62a21f02ff</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Tian Tian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="3"><subfield code="a">An ex vivo organ culture screening model revealed that low temperature conditions prevent side effects of anticancer drugs</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. 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Our findings suggest that the side effects of anticancer drugs on organ development can be avoided by maintaining the internal environment under low temperature.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Science</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Q</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kanako Miyazaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yuta Chiba</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Keita Funada</subfield><subfield code="e">verfasserin</subfield><subfield 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