Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus
ABSTRACT Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid D...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rosane Kupfer [verfasserIn] Manuella Rangel Larrúbia [verfasserIn] Isabela Bussade [verfasserIn] Joana Rodrigues Dantas Pereira [verfasserIn] Giovanna A. Balarini Lima [verfasserIn] Marcio Antonio Epifanio [verfasserIn] Claudio Domenico Sahione Schettino [verfasserIn] Denise Prado Momesso [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Übergeordnetes Werk: |
In: Archives of Endocrinology and Metabolism - Brazilian Society of Endocrinology and Metabolism, 2017, 61(2017), 2, Seite 115-121 |
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| Übergeordnetes Werk: |
volume:61 ; year:2017 ; number:2 ; pages:115-121 |
| Links: |
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| DOI / URN: |
10.1590/2359-3997000000255 |
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| Katalog-ID: |
DOAJ074983342 |
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| 520 | |a ABSTRACT Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. Conclusion Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. | ||
| 650 | 4 | |a Type 1 diabetes | |
| 650 | 4 | |a central obesity | |
| 650 | 4 | |a subclinical atherosclerosis | |
| 650 | 4 | |a carotid intima-media thickness | |
| 650 | 4 | |a insulin resistance | |
| 653 | 0 | |a Medicine | |
| 653 | 0 | |a R | |
| 653 | 0 | |a Diseases of the endocrine glands. Clinical endocrinology | |
| 700 | 0 | |a Manuella Rangel Larrúbia |e verfasserin |4 aut | |
| 700 | 0 | |a Isabela Bussade |e verfasserin |4 aut | |
| 700 | 0 | |a Joana Rodrigues Dantas Pereira |e verfasserin |4 aut | |
| 700 | 0 | |a Giovanna A. Balarini Lima |e verfasserin |4 aut | |
| 700 | 0 | |a Marcio Antonio Epifanio |e verfasserin |4 aut | |
| 700 | 0 | |a Claudio Domenico Sahione Schettino |e verfasserin |4 aut | |
| 700 | 0 | |a Denise Prado Momesso |e verfasserin |4 aut | |
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10.1590/2359-3997000000255 doi (DE-627)DOAJ074983342 (DE-599)DOAJd3fc6a35685642e881573a6acb8ab499 DE-627 ger DE-627 rakwb eng RC648-665 Rosane Kupfer verfasserin aut Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. Conclusion Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Type 1 diabetes central obesity subclinical atherosclerosis carotid intima-media thickness insulin resistance Medicine R Diseases of the endocrine glands. Clinical endocrinology Manuella Rangel Larrúbia verfasserin aut Isabela Bussade verfasserin aut Joana Rodrigues Dantas Pereira verfasserin aut Giovanna A. Balarini Lima verfasserin aut Marcio Antonio Epifanio verfasserin aut Claudio Domenico Sahione Schettino verfasserin aut Denise Prado Momesso verfasserin aut In Archives of Endocrinology and Metabolism Brazilian Society of Endocrinology and Metabolism, 2017 61(2017), 2, Seite 115-121 (DE-627)1760589977 23594292 nnns volume:61 year:2017 number:2 pages:115-121 https://doi.org/10.1590/2359-3997000000255 kostenfrei https://doaj.org/article/d3fc6a35685642e881573a6acb8ab499 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200115&lng=en&tlng=en kostenfrei https://doaj.org/toc/2359-4292 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 61 2017 2 115-121 |
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10.1590/2359-3997000000255 doi (DE-627)DOAJ074983342 (DE-599)DOAJd3fc6a35685642e881573a6acb8ab499 DE-627 ger DE-627 rakwb eng RC648-665 Rosane Kupfer verfasserin aut Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. Conclusion Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Type 1 diabetes central obesity subclinical atherosclerosis carotid intima-media thickness insulin resistance Medicine R Diseases of the endocrine glands. Clinical endocrinology Manuella Rangel Larrúbia verfasserin aut Isabela Bussade verfasserin aut Joana Rodrigues Dantas Pereira verfasserin aut Giovanna A. Balarini Lima verfasserin aut Marcio Antonio Epifanio verfasserin aut Claudio Domenico Sahione Schettino verfasserin aut Denise Prado Momesso verfasserin aut In Archives of Endocrinology and Metabolism Brazilian Society of Endocrinology and Metabolism, 2017 61(2017), 2, Seite 115-121 (DE-627)1760589977 23594292 nnns volume:61 year:2017 number:2 pages:115-121 https://doi.org/10.1590/2359-3997000000255 kostenfrei https://doaj.org/article/d3fc6a35685642e881573a6acb8ab499 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200115&lng=en&tlng=en kostenfrei https://doaj.org/toc/2359-4292 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 61 2017 2 115-121 |
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10.1590/2359-3997000000255 doi (DE-627)DOAJ074983342 (DE-599)DOAJd3fc6a35685642e881573a6acb8ab499 DE-627 ger DE-627 rakwb eng RC648-665 Rosane Kupfer verfasserin aut Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. Conclusion Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Type 1 diabetes central obesity subclinical atherosclerosis carotid intima-media thickness insulin resistance Medicine R Diseases of the endocrine glands. Clinical endocrinology Manuella Rangel Larrúbia verfasserin aut Isabela Bussade verfasserin aut Joana Rodrigues Dantas Pereira verfasserin aut Giovanna A. Balarini Lima verfasserin aut Marcio Antonio Epifanio verfasserin aut Claudio Domenico Sahione Schettino verfasserin aut Denise Prado Momesso verfasserin aut In Archives of Endocrinology and Metabolism Brazilian Society of Endocrinology and Metabolism, 2017 61(2017), 2, Seite 115-121 (DE-627)1760589977 23594292 nnns volume:61 year:2017 number:2 pages:115-121 https://doi.org/10.1590/2359-3997000000255 kostenfrei https://doaj.org/article/d3fc6a35685642e881573a6acb8ab499 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200115&lng=en&tlng=en kostenfrei https://doaj.org/toc/2359-4292 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 61 2017 2 115-121 |
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10.1590/2359-3997000000255 doi (DE-627)DOAJ074983342 (DE-599)DOAJd3fc6a35685642e881573a6acb8ab499 DE-627 ger DE-627 rakwb eng RC648-665 Rosane Kupfer verfasserin aut Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. Conclusion Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Type 1 diabetes central obesity subclinical atherosclerosis carotid intima-media thickness insulin resistance Medicine R Diseases of the endocrine glands. Clinical endocrinology Manuella Rangel Larrúbia verfasserin aut Isabela Bussade verfasserin aut Joana Rodrigues Dantas Pereira verfasserin aut Giovanna A. Balarini Lima verfasserin aut Marcio Antonio Epifanio verfasserin aut Claudio Domenico Sahione Schettino verfasserin aut Denise Prado Momesso verfasserin aut In Archives of Endocrinology and Metabolism Brazilian Society of Endocrinology and Metabolism, 2017 61(2017), 2, Seite 115-121 (DE-627)1760589977 23594292 nnns volume:61 year:2017 number:2 pages:115-121 https://doi.org/10.1590/2359-3997000000255 kostenfrei https://doaj.org/article/d3fc6a35685642e881573a6acb8ab499 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200115&lng=en&tlng=en kostenfrei https://doaj.org/toc/2359-4292 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 61 2017 2 115-121 |
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10.1590/2359-3997000000255 doi (DE-627)DOAJ074983342 (DE-599)DOAJd3fc6a35685642e881573a6acb8ab499 DE-627 ger DE-627 rakwb eng RC648-665 Rosane Kupfer verfasserin aut Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. Conclusion Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Type 1 diabetes central obesity subclinical atherosclerosis carotid intima-media thickness insulin resistance Medicine R Diseases of the endocrine glands. Clinical endocrinology Manuella Rangel Larrúbia verfasserin aut Isabela Bussade verfasserin aut Joana Rodrigues Dantas Pereira verfasserin aut Giovanna A. Balarini Lima verfasserin aut Marcio Antonio Epifanio verfasserin aut Claudio Domenico Sahione Schettino verfasserin aut Denise Prado Momesso verfasserin aut In Archives of Endocrinology and Metabolism Brazilian Society of Endocrinology and Metabolism, 2017 61(2017), 2, Seite 115-121 (DE-627)1760589977 23594292 nnns volume:61 year:2017 number:2 pages:115-121 https://doi.org/10.1590/2359-3997000000255 kostenfrei https://doaj.org/article/d3fc6a35685642e881573a6acb8ab499 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200115&lng=en&tlng=en kostenfrei https://doaj.org/toc/2359-4292 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 61 2017 2 115-121 |
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Rosane Kupfer @@aut@@ Manuella Rangel Larrúbia @@aut@@ Isabela Bussade @@aut@@ Joana Rodrigues Dantas Pereira @@aut@@ Giovanna A. Balarini Lima @@aut@@ Marcio Antonio Epifanio @@aut@@ Claudio Domenico Sahione Schettino @@aut@@ Denise Prado Momesso @@aut@@ |
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Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. 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Rosane Kupfer misc RC648-665 misc Type 1 diabetes misc central obesity misc subclinical atherosclerosis misc carotid intima-media thickness misc insulin resistance misc Medicine misc R misc Diseases of the endocrine glands. Clinical endocrinology Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus |
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RC648-665 Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus Type 1 diabetes central obesity subclinical atherosclerosis carotid intima-media thickness insulin resistance |
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Rosane Kupfer Manuella Rangel Larrúbia Isabela Bussade Joana Rodrigues Dantas Pereira Giovanna A. Balarini Lima Marcio Antonio Epifanio Claudio Domenico Sahione Schettino Denise Prado Momesso |
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predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus |
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Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus |
| abstract |
ABSTRACT Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. Conclusion Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. |
| abstractGer |
ABSTRACT Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. Conclusion Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. |
| abstract_unstemmed |
ABSTRACT Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. Conclusion Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. |
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Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus |
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Manuella Rangel Larrúbia Isabela Bussade Joana Rodrigues Dantas Pereira Giovanna A. Balarini Lima Marcio Antonio Epifanio Claudio Domenico Sahione Schettino Denise Prado Momesso |
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Manuella Rangel Larrúbia Isabela Bussade Joana Rodrigues Dantas Pereira Giovanna A. Balarini Lima Marcio Antonio Epifanio Claudio Domenico Sahione Schettino Denise Prado Momesso |
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