Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past

ABSTRACT The influenza pandemic of 1918–1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to reco...
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Autor*in:	Jeffery K. Taubenberger [verfasserIn] David Baltimore [verfasserIn] Peter C. Doherty [verfasserIn] Howard Markel [verfasserIn] David M. Morens [verfasserIn] Robert G. Webster [verfasserIn] Ian A. Wilson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Übergeordnetes Werk:	In: mBio - American Society for Microbiology, 2010, 3(2012), 5
Übergeordnetes Werk:	volume:3 ; year:2012 ; number:5

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1128/mBio.00201-12

Katalog-ID:	DOAJ075096250

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callnumber-first	Q - Science
author	Jeffery K. Taubenberger
spellingShingle	Jeffery K. Taubenberger misc QR1-502 misc Microbiology Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
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topic_title	QR1-502 Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
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title	Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
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title_full	Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
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title_sort	reconstruction of the 1918 influenza virus: unexpected rewards from the past
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title_auth	Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
abstract	ABSTRACT The influenza pandemic of 1918–1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.
abstractGer	ABSTRACT The influenza pandemic of 1918–1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.
abstract_unstemmed	ABSTRACT The influenza pandemic of 1918–1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.
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title_short	Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
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