Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo

To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of pa...
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Autor*in:	Caiqing Wu [verfasserIn] Ping Wai Or [verfasserIn] Jones Iok Tong Chong [verfasserIn] Isuru K. K. Pathirage Don [verfasserIn] Ching Hymn Christopher Lee [verfasserIn] Kaili Wu [verfasserIn] Minbin Yu [verfasserIn] David C. C. Lam [verfasserIn] Yangfan Yang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	glaucoma soft contact lens pirfenidone sustained delivery of drug

Übergeordnetes Werk:	In: Drug Delivery - Taylor & Francis Group, 2017, 28(2021), 1, Seite 634-641
Übergeordnetes Werk:	volume:28 ; year:2021 ; number:1 ; pages:634-641

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/10717544.2021.1895911

Katalog-ID:	DOAJ075106760

Internformat


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520			\|a To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of parameters of SCLs and external environment on drug release in vitro were evaluated by ultraviolet–visible spectrophotometer at 312 nm. Safety of SCLs was evaluated in vitro by transformed human corneal epithelial cell. Safety in vivo was determined by optical coherence tomography and histology of anterior segment of rabbits. Drug release study in tear fluid and aqueous humor were measured by ultra-performance liquid chromatography. SCLs had smooth surface and were fit for experimental rabbits. Amount of PFD in PVA film and SCLs were 153.515 μg ± 12.508 and 127.438 μg ± 19.674, respectively, PFD in PVA film was significantly higher than SCLs (p=.006) and closed to 150 μg (targeting amount of PFD to be loaded). Thickness of SCLs, molecular weight of PVA, and amount of PVA used in SCLs affected drug release in vitro significantly. Thickness of PVA film and amount of drug in SCLs had no effect on drug release rate in vitro. SCLs were safe in vitro and in vivo, PFD released from SCLs could be detected around 12 hours in tears and aqueous humor, and the concentration of drug was higher than eye drop at all detected time points while amount of PFD in SCLs was lower than eye drop. Drug loaded PVA film embedded SCLs may be a promising ocular drug delivery system.
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700	0		\|a Yangfan Yang \|e verfasserin \|4 aut
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allfields	10.1080/10717544.2021.1895911 doi (DE-627)DOAJ075106760 (DE-599)DOAJc5436c71fcb3442fbe431fe301f3125c DE-627 ger DE-627 rakwb eng RM1-950 Caiqing Wu verfasserin aut Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of parameters of SCLs and external environment on drug release in vitro were evaluated by ultraviolet–visible spectrophotometer at 312 nm. Safety of SCLs was evaluated in vitro by transformed human corneal epithelial cell. Safety in vivo was determined by optical coherence tomography and histology of anterior segment of rabbits. Drug release study in tear fluid and aqueous humor were measured by ultra-performance liquid chromatography. SCLs had smooth surface and were fit for experimental rabbits. Amount of PFD in PVA film and SCLs were 153.515 μg ± 12.508 and 127.438 μg ± 19.674, respectively, PFD in PVA film was significantly higher than SCLs (p=.006) and closed to 150 μg (targeting amount of PFD to be loaded). Thickness of SCLs, molecular weight of PVA, and amount of PVA used in SCLs affected drug release in vitro significantly. Thickness of PVA film and amount of drug in SCLs had no effect on drug release rate in vitro. SCLs were safe in vitro and in vivo, PFD released from SCLs could be detected around 12 hours in tears and aqueous humor, and the concentration of drug was higher than eye drop at all detected time points while amount of PFD in SCLs was lower than eye drop. Drug loaded PVA film embedded SCLs may be a promising ocular drug delivery system. glaucoma soft contact lens pirfenidone sustained delivery of drug Therapeutics. Pharmacology Ping Wai Or verfasserin aut Jones Iok Tong Chong verfasserin aut Isuru K. K. Pathirage Don verfasserin aut Ching Hymn Christopher Lee verfasserin aut Kaili Wu verfasserin aut Minbin Yu verfasserin aut David C. C. Lam verfasserin aut Yangfan Yang verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 28(2021), 1, Seite 634-641 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:28 year:2021 number:1 pages:634-641 https://doi.org/10.1080/10717544.2021.1895911 kostenfrei https://doaj.org/article/c5436c71fcb3442fbe431fe301f3125c kostenfrei http://dx.doi.org/10.1080/10717544.2021.1895911 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2021 1 634-641
spelling	10.1080/10717544.2021.1895911 doi (DE-627)DOAJ075106760 (DE-599)DOAJc5436c71fcb3442fbe431fe301f3125c DE-627 ger DE-627 rakwb eng RM1-950 Caiqing Wu verfasserin aut Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of parameters of SCLs and external environment on drug release in vitro were evaluated by ultraviolet–visible spectrophotometer at 312 nm. Safety of SCLs was evaluated in vitro by transformed human corneal epithelial cell. Safety in vivo was determined by optical coherence tomography and histology of anterior segment of rabbits. Drug release study in tear fluid and aqueous humor were measured by ultra-performance liquid chromatography. SCLs had smooth surface and were fit for experimental rabbits. Amount of PFD in PVA film and SCLs were 153.515 μg ± 12.508 and 127.438 μg ± 19.674, respectively, PFD in PVA film was significantly higher than SCLs (p=.006) and closed to 150 μg (targeting amount of PFD to be loaded). Thickness of SCLs, molecular weight of PVA, and amount of PVA used in SCLs affected drug release in vitro significantly. Thickness of PVA film and amount of drug in SCLs had no effect on drug release rate in vitro. SCLs were safe in vitro and in vivo, PFD released from SCLs could be detected around 12 hours in tears and aqueous humor, and the concentration of drug was higher than eye drop at all detected time points while amount of PFD in SCLs was lower than eye drop. Drug loaded PVA film embedded SCLs may be a promising ocular drug delivery system. glaucoma soft contact lens pirfenidone sustained delivery of drug Therapeutics. Pharmacology Ping Wai Or verfasserin aut Jones Iok Tong Chong verfasserin aut Isuru K. K. Pathirage Don verfasserin aut Ching Hymn Christopher Lee verfasserin aut Kaili Wu verfasserin aut Minbin Yu verfasserin aut David C. C. Lam verfasserin aut Yangfan Yang verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 28(2021), 1, Seite 634-641 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:28 year:2021 number:1 pages:634-641 https://doi.org/10.1080/10717544.2021.1895911 kostenfrei https://doaj.org/article/c5436c71fcb3442fbe431fe301f3125c kostenfrei http://dx.doi.org/10.1080/10717544.2021.1895911 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2021 1 634-641
allfields_unstemmed	10.1080/10717544.2021.1895911 doi (DE-627)DOAJ075106760 (DE-599)DOAJc5436c71fcb3442fbe431fe301f3125c DE-627 ger DE-627 rakwb eng RM1-950 Caiqing Wu verfasserin aut Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of parameters of SCLs and external environment on drug release in vitro were evaluated by ultraviolet–visible spectrophotometer at 312 nm. Safety of SCLs was evaluated in vitro by transformed human corneal epithelial cell. Safety in vivo was determined by optical coherence tomography and histology of anterior segment of rabbits. Drug release study in tear fluid and aqueous humor were measured by ultra-performance liquid chromatography. SCLs had smooth surface and were fit for experimental rabbits. Amount of PFD in PVA film and SCLs were 153.515 μg ± 12.508 and 127.438 μg ± 19.674, respectively, PFD in PVA film was significantly higher than SCLs (p=.006) and closed to 150 μg (targeting amount of PFD to be loaded). Thickness of SCLs, molecular weight of PVA, and amount of PVA used in SCLs affected drug release in vitro significantly. Thickness of PVA film and amount of drug in SCLs had no effect on drug release rate in vitro. SCLs were safe in vitro and in vivo, PFD released from SCLs could be detected around 12 hours in tears and aqueous humor, and the concentration of drug was higher than eye drop at all detected time points while amount of PFD in SCLs was lower than eye drop. Drug loaded PVA film embedded SCLs may be a promising ocular drug delivery system. glaucoma soft contact lens pirfenidone sustained delivery of drug Therapeutics. Pharmacology Ping Wai Or verfasserin aut Jones Iok Tong Chong verfasserin aut Isuru K. K. Pathirage Don verfasserin aut Ching Hymn Christopher Lee verfasserin aut Kaili Wu verfasserin aut Minbin Yu verfasserin aut David C. C. Lam verfasserin aut Yangfan Yang verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 28(2021), 1, Seite 634-641 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:28 year:2021 number:1 pages:634-641 https://doi.org/10.1080/10717544.2021.1895911 kostenfrei https://doaj.org/article/c5436c71fcb3442fbe431fe301f3125c kostenfrei http://dx.doi.org/10.1080/10717544.2021.1895911 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2021 1 634-641
allfieldsGer	10.1080/10717544.2021.1895911 doi (DE-627)DOAJ075106760 (DE-599)DOAJc5436c71fcb3442fbe431fe301f3125c DE-627 ger DE-627 rakwb eng RM1-950 Caiqing Wu verfasserin aut Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of parameters of SCLs and external environment on drug release in vitro were evaluated by ultraviolet–visible spectrophotometer at 312 nm. Safety of SCLs was evaluated in vitro by transformed human corneal epithelial cell. Safety in vivo was determined by optical coherence tomography and histology of anterior segment of rabbits. Drug release study in tear fluid and aqueous humor were measured by ultra-performance liquid chromatography. SCLs had smooth surface and were fit for experimental rabbits. Amount of PFD in PVA film and SCLs were 153.515 μg ± 12.508 and 127.438 μg ± 19.674, respectively, PFD in PVA film was significantly higher than SCLs (p=.006) and closed to 150 μg (targeting amount of PFD to be loaded). Thickness of SCLs, molecular weight of PVA, and amount of PVA used in SCLs affected drug release in vitro significantly. Thickness of PVA film and amount of drug in SCLs had no effect on drug release rate in vitro. SCLs were safe in vitro and in vivo, PFD released from SCLs could be detected around 12 hours in tears and aqueous humor, and the concentration of drug was higher than eye drop at all detected time points while amount of PFD in SCLs was lower than eye drop. Drug loaded PVA film embedded SCLs may be a promising ocular drug delivery system. glaucoma soft contact lens pirfenidone sustained delivery of drug Therapeutics. Pharmacology Ping Wai Or verfasserin aut Jones Iok Tong Chong verfasserin aut Isuru K. K. Pathirage Don verfasserin aut Ching Hymn Christopher Lee verfasserin aut Kaili Wu verfasserin aut Minbin Yu verfasserin aut David C. C. Lam verfasserin aut Yangfan Yang verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 28(2021), 1, Seite 634-641 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:28 year:2021 number:1 pages:634-641 https://doi.org/10.1080/10717544.2021.1895911 kostenfrei https://doaj.org/article/c5436c71fcb3442fbe431fe301f3125c kostenfrei http://dx.doi.org/10.1080/10717544.2021.1895911 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2021 1 634-641
allfieldsSound	10.1080/10717544.2021.1895911 doi (DE-627)DOAJ075106760 (DE-599)DOAJc5436c71fcb3442fbe431fe301f3125c DE-627 ger DE-627 rakwb eng RM1-950 Caiqing Wu verfasserin aut Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of parameters of SCLs and external environment on drug release in vitro were evaluated by ultraviolet–visible spectrophotometer at 312 nm. Safety of SCLs was evaluated in vitro by transformed human corneal epithelial cell. Safety in vivo was determined by optical coherence tomography and histology of anterior segment of rabbits. Drug release study in tear fluid and aqueous humor were measured by ultra-performance liquid chromatography. SCLs had smooth surface and were fit for experimental rabbits. Amount of PFD in PVA film and SCLs were 153.515 μg ± 12.508 and 127.438 μg ± 19.674, respectively, PFD in PVA film was significantly higher than SCLs (p=.006) and closed to 150 μg (targeting amount of PFD to be loaded). Thickness of SCLs, molecular weight of PVA, and amount of PVA used in SCLs affected drug release in vitro significantly. Thickness of PVA film and amount of drug in SCLs had no effect on drug release rate in vitro. SCLs were safe in vitro and in vivo, PFD released from SCLs could be detected around 12 hours in tears and aqueous humor, and the concentration of drug was higher than eye drop at all detected time points while amount of PFD in SCLs was lower than eye drop. Drug loaded PVA film embedded SCLs may be a promising ocular drug delivery system. glaucoma soft contact lens pirfenidone sustained delivery of drug Therapeutics. Pharmacology Ping Wai Or verfasserin aut Jones Iok Tong Chong verfasserin aut Isuru K. K. Pathirage Don verfasserin aut Ching Hymn Christopher Lee verfasserin aut Kaili Wu verfasserin aut Minbin Yu verfasserin aut David C. C. Lam verfasserin aut Yangfan Yang verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 28(2021), 1, Seite 634-641 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:28 year:2021 number:1 pages:634-641 https://doi.org/10.1080/10717544.2021.1895911 kostenfrei https://doaj.org/article/c5436c71fcb3442fbe431fe301f3125c kostenfrei http://dx.doi.org/10.1080/10717544.2021.1895911 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2021 1 634-641
language	English
source	In Drug Delivery 28(2021), 1, Seite 634-641 volume:28 year:2021 number:1 pages:634-641
sourceStr	In Drug Delivery 28(2021), 1, Seite 634-641 volume:28 year:2021 number:1 pages:634-641
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	glaucoma soft contact lens pirfenidone sustained delivery of drug Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Drug Delivery
authorswithroles_txt_mv	Caiqing Wu @@aut@@ Ping Wai Or @@aut@@ Jones Iok Tong Chong @@aut@@ Isuru K. K. Pathirage Don @@aut@@ Ching Hymn Christopher Lee @@aut@@ Kaili Wu @@aut@@ Minbin Yu @@aut@@ David C. C. Lam @@aut@@ Yangfan Yang @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	320604675
id	DOAJ075106760
language_de	englisch
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callnumber-first	R - Medicine
author	Caiqing Wu
spellingShingle	Caiqing Wu misc RM1-950 misc glaucoma misc soft contact lens misc pirfenidone misc sustained delivery of drug misc Therapeutics. Pharmacology Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo
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topic_title	RM1-950 Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo glaucoma soft contact lens pirfenidone sustained delivery of drug
topic	misc RM1-950 misc glaucoma misc soft contact lens misc pirfenidone misc sustained delivery of drug misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc glaucoma misc soft contact lens misc pirfenidone misc sustained delivery of drug misc Therapeutics. Pharmacology
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title	Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo
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title_full	Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo
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author_browse	Caiqing Wu Ping Wai Or Jones Iok Tong Chong Isuru K. K. Pathirage Don Ching Hymn Christopher Lee Kaili Wu Minbin Yu David C. C. Lam Yangfan Yang
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title_sort	controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo
callnumber	RM1-950
title_auth	Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo
abstract	To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of parameters of SCLs and external environment on drug release in vitro were evaluated by ultraviolet–visible spectrophotometer at 312 nm. Safety of SCLs was evaluated in vitro by transformed human corneal epithelial cell. Safety in vivo was determined by optical coherence tomography and histology of anterior segment of rabbits. Drug release study in tear fluid and aqueous humor were measured by ultra-performance liquid chromatography. SCLs had smooth surface and were fit for experimental rabbits. Amount of PFD in PVA film and SCLs were 153.515 μg ± 12.508 and 127.438 μg ± 19.674, respectively, PFD in PVA film was significantly higher than SCLs (p=.006) and closed to 150 μg (targeting amount of PFD to be loaded). Thickness of SCLs, molecular weight of PVA, and amount of PVA used in SCLs affected drug release in vitro significantly. Thickness of PVA film and amount of drug in SCLs had no effect on drug release rate in vitro. SCLs were safe in vitro and in vivo, PFD released from SCLs could be detected around 12 hours in tears and aqueous humor, and the concentration of drug was higher than eye drop at all detected time points while amount of PFD in SCLs was lower than eye drop. Drug loaded PVA film embedded SCLs may be a promising ocular drug delivery system.
abstractGer	To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of parameters of SCLs and external environment on drug release in vitro were evaluated by ultraviolet–visible spectrophotometer at 312 nm. Safety of SCLs was evaluated in vitro by transformed human corneal epithelial cell. Safety in vivo was determined by optical coherence tomography and histology of anterior segment of rabbits. Drug release study in tear fluid and aqueous humor were measured by ultra-performance liquid chromatography. SCLs had smooth surface and were fit for experimental rabbits. Amount of PFD in PVA film and SCLs were 153.515 μg ± 12.508 and 127.438 μg ± 19.674, respectively, PFD in PVA film was significantly higher than SCLs (p=.006) and closed to 150 μg (targeting amount of PFD to be loaded). Thickness of SCLs, molecular weight of PVA, and amount of PVA used in SCLs affected drug release in vitro significantly. Thickness of PVA film and amount of drug in SCLs had no effect on drug release rate in vitro. SCLs were safe in vitro and in vivo, PFD released from SCLs could be detected around 12 hours in tears and aqueous humor, and the concentration of drug was higher than eye drop at all detected time points while amount of PFD in SCLs was lower than eye drop. Drug loaded PVA film embedded SCLs may be a promising ocular drug delivery system.
abstract_unstemmed	To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of parameters of SCLs and external environment on drug release in vitro were evaluated by ultraviolet–visible spectrophotometer at 312 nm. Safety of SCLs was evaluated in vitro by transformed human corneal epithelial cell. Safety in vivo was determined by optical coherence tomography and histology of anterior segment of rabbits. Drug release study in tear fluid and aqueous humor were measured by ultra-performance liquid chromatography. SCLs had smooth surface and were fit for experimental rabbits. Amount of PFD in PVA film and SCLs were 153.515 μg ± 12.508 and 127.438 μg ± 19.674, respectively, PFD in PVA film was significantly higher than SCLs (p=.006) and closed to 150 μg (targeting amount of PFD to be loaded). Thickness of SCLs, molecular weight of PVA, and amount of PVA used in SCLs affected drug release in vitro significantly. Thickness of PVA film and amount of drug in SCLs had no effect on drug release rate in vitro. SCLs were safe in vitro and in vivo, PFD released from SCLs could be detected around 12 hours in tears and aqueous humor, and the concentration of drug was higher than eye drop at all detected time points while amount of PFD in SCLs was lower than eye drop. Drug loaded PVA film embedded SCLs may be a promising ocular drug delivery system.
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container_issue	1
title_short	Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo
url	https://doi.org/10.1080/10717544.2021.1895911 https://doaj.org/article/c5436c71fcb3442fbe431fe301f3125c http://dx.doi.org/10.1080/10717544.2021.1895911 https://doaj.org/toc/1071-7544 https://doaj.org/toc/1521-0464
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author2	Ping Wai Or Jones Iok Tong Chong Isuru K. K. Pathirage Don Ching Hymn Christopher Lee Kaili Wu Minbin Yu David C. C. Lam Yangfan Yang
author2Str	Ping Wai Or Jones Iok Tong Chong Isuru K. K. Pathirage Don Ching Hymn Christopher Lee Kaili Wu Minbin Yu David C. C. Lam Yangfan Yang
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Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo

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