Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party
Measurable residual disease (MRD) quantified by multiparameter flow cytometry (MFC) is a strong and independent prognostic factor in acute myeloid leukemia (AML). However, several technical factors may affect the final read-out of the assay. Experts from the MRD Working Party of the European Leukemi...
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| Autor*in: |
Jesse M. Tettero [verfasserIn] Sylvie Freeman [verfasserIn] Veit Buecklein [verfasserIn] Adriano Venditti [verfasserIn] Luca Maurillo [verfasserIn] Wolfgang Kern [verfasserIn] Roland B. Walter [verfasserIn] Brent L. Wood [verfasserIn] Christophe Roumier [verfasserIn] Jan Philippé [verfasserIn] Barbara Denys [verfasserIn] Jeffrey L. Jorgensen [verfasserIn] Marie C. Bene [verfasserIn] Francis Lacombe [verfasserIn] Adriana Plesa [verfasserIn] Monica L. Guzman [verfasserIn] Agnieszka Wierzbowska [verfasserIn] Anna Czyz [verfasserIn] Lok Lam Ngai [verfasserIn] Adrian Schwarzer [verfasserIn] Costa Bachas [verfasserIn] Jacqueline Cloos [verfasserIn] Marion Subklewe [verfasserIn] Michaela Fuering-Buske [verfasserIn] Francesco Buccisano [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Übergeordnetes Werk: |
In: HemaSphere - Wiley, 2019, 6(2022), 1, p e676 |
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| Übergeordnetes Werk: |
volume:6 ; year:2022 ; number:1, p e676 |
| Links: |
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| DOI / URN: |
10.1097/HS9.0000000000000676 |
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| Katalog-ID: |
DOAJ075134284 |
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| 520 | |a Measurable residual disease (MRD) quantified by multiparameter flow cytometry (MFC) is a strong and independent prognostic factor in acute myeloid leukemia (AML). However, several technical factors may affect the final read-out of the assay. Experts from the MRD Working Party of the European LeukemiaNet evaluated which aspects are crucial for accurate MFC-MRD measurement. Here, we report on the agreement, obtained via a combination of a cross-sectional questionnaire, live discussions, and a Delphi poll. The recommendations consist of several key issues from bone marrow sampling to final laboratory reporting to ensure quality and reproducibility of results. Furthermore, the experiences were tested by comparing two 8-color MRD panels in multiple laboratories. The results presented here underscore the feasibility and the utility of a harmonized theoretical and practical MFC-MRD assessment and are a next step toward further harmonization. | ||
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10.1097/HS9.0000000000000676 doi (DE-627)DOAJ075134284 (DE-599)DOAJ58aecfe07be0436ea3d70c88f7d1c3d5 DE-627 ger DE-627 rakwb eng RC633-647.5 Jesse M. Tettero verfasserin aut Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Measurable residual disease (MRD) quantified by multiparameter flow cytometry (MFC) is a strong and independent prognostic factor in acute myeloid leukemia (AML). However, several technical factors may affect the final read-out of the assay. Experts from the MRD Working Party of the European LeukemiaNet evaluated which aspects are crucial for accurate MFC-MRD measurement. Here, we report on the agreement, obtained via a combination of a cross-sectional questionnaire, live discussions, and a Delphi poll. The recommendations consist of several key issues from bone marrow sampling to final laboratory reporting to ensure quality and reproducibility of results. Furthermore, the experiences were tested by comparing two 8-color MRD panels in multiple laboratories. The results presented here underscore the feasibility and the utility of a harmonized theoretical and practical MFC-MRD assessment and are a next step toward further harmonization. Diseases of the blood and blood-forming organs Sylvie Freeman verfasserin aut Veit Buecklein verfasserin aut Adriano Venditti verfasserin aut Luca Maurillo verfasserin aut Wolfgang Kern verfasserin aut Roland B. Walter verfasserin aut Brent L. Wood verfasserin aut Christophe Roumier verfasserin aut Jan Philippé verfasserin aut Barbara Denys verfasserin aut Jeffrey L. Jorgensen verfasserin aut Marie C. Bene verfasserin aut Francis Lacombe verfasserin aut Adriana Plesa verfasserin aut Monica L. Guzman verfasserin aut Agnieszka Wierzbowska verfasserin aut Anna Czyz verfasserin aut Lok Lam Ngai verfasserin aut Adrian Schwarzer verfasserin aut Costa Bachas verfasserin aut Jacqueline Cloos verfasserin aut Marion Subklewe verfasserin aut Michaela Fuering-Buske verfasserin aut Francesco Buccisano verfasserin aut In HemaSphere Wiley, 2019 6(2022), 1, p e676 (DE-627)1015324924 (DE-600)2922183-3 25729241 nnns volume:6 year:2022 number:1, p e676 https://doi.org/10.1097/HS9.0000000000000676 kostenfrei https://doaj.org/article/58aecfe07be0436ea3d70c88f7d1c3d5 kostenfrei http://journals.lww.com/10.1097/HS9.0000000000000676 kostenfrei https://doaj.org/toc/2572-9241 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2022 1, p e676 |
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10.1097/HS9.0000000000000676 doi (DE-627)DOAJ075134284 (DE-599)DOAJ58aecfe07be0436ea3d70c88f7d1c3d5 DE-627 ger DE-627 rakwb eng RC633-647.5 Jesse M. Tettero verfasserin aut Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Measurable residual disease (MRD) quantified by multiparameter flow cytometry (MFC) is a strong and independent prognostic factor in acute myeloid leukemia (AML). However, several technical factors may affect the final read-out of the assay. Experts from the MRD Working Party of the European LeukemiaNet evaluated which aspects are crucial for accurate MFC-MRD measurement. Here, we report on the agreement, obtained via a combination of a cross-sectional questionnaire, live discussions, and a Delphi poll. The recommendations consist of several key issues from bone marrow sampling to final laboratory reporting to ensure quality and reproducibility of results. Furthermore, the experiences were tested by comparing two 8-color MRD panels in multiple laboratories. The results presented here underscore the feasibility and the utility of a harmonized theoretical and practical MFC-MRD assessment and are a next step toward further harmonization. Diseases of the blood and blood-forming organs Sylvie Freeman verfasserin aut Veit Buecklein verfasserin aut Adriano Venditti verfasserin aut Luca Maurillo verfasserin aut Wolfgang Kern verfasserin aut Roland B. Walter verfasserin aut Brent L. Wood verfasserin aut Christophe Roumier verfasserin aut Jan Philippé verfasserin aut Barbara Denys verfasserin aut Jeffrey L. Jorgensen verfasserin aut Marie C. Bene verfasserin aut Francis Lacombe verfasserin aut Adriana Plesa verfasserin aut Monica L. Guzman verfasserin aut Agnieszka Wierzbowska verfasserin aut Anna Czyz verfasserin aut Lok Lam Ngai verfasserin aut Adrian Schwarzer verfasserin aut Costa Bachas verfasserin aut Jacqueline Cloos verfasserin aut Marion Subklewe verfasserin aut Michaela Fuering-Buske verfasserin aut Francesco Buccisano verfasserin aut In HemaSphere Wiley, 2019 6(2022), 1, p e676 (DE-627)1015324924 (DE-600)2922183-3 25729241 nnns volume:6 year:2022 number:1, p e676 https://doi.org/10.1097/HS9.0000000000000676 kostenfrei https://doaj.org/article/58aecfe07be0436ea3d70c88f7d1c3d5 kostenfrei http://journals.lww.com/10.1097/HS9.0000000000000676 kostenfrei https://doaj.org/toc/2572-9241 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2022 1, p e676 |
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10.1097/HS9.0000000000000676 doi (DE-627)DOAJ075134284 (DE-599)DOAJ58aecfe07be0436ea3d70c88f7d1c3d5 DE-627 ger DE-627 rakwb eng RC633-647.5 Jesse M. Tettero verfasserin aut Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Measurable residual disease (MRD) quantified by multiparameter flow cytometry (MFC) is a strong and independent prognostic factor in acute myeloid leukemia (AML). However, several technical factors may affect the final read-out of the assay. Experts from the MRD Working Party of the European LeukemiaNet evaluated which aspects are crucial for accurate MFC-MRD measurement. Here, we report on the agreement, obtained via a combination of a cross-sectional questionnaire, live discussions, and a Delphi poll. The recommendations consist of several key issues from bone marrow sampling to final laboratory reporting to ensure quality and reproducibility of results. Furthermore, the experiences were tested by comparing two 8-color MRD panels in multiple laboratories. The results presented here underscore the feasibility and the utility of a harmonized theoretical and practical MFC-MRD assessment and are a next step toward further harmonization. Diseases of the blood and blood-forming organs Sylvie Freeman verfasserin aut Veit Buecklein verfasserin aut Adriano Venditti verfasserin aut Luca Maurillo verfasserin aut Wolfgang Kern verfasserin aut Roland B. Walter verfasserin aut Brent L. Wood verfasserin aut Christophe Roumier verfasserin aut Jan Philippé verfasserin aut Barbara Denys verfasserin aut Jeffrey L. Jorgensen verfasserin aut Marie C. Bene verfasserin aut Francis Lacombe verfasserin aut Adriana Plesa verfasserin aut Monica L. Guzman verfasserin aut Agnieszka Wierzbowska verfasserin aut Anna Czyz verfasserin aut Lok Lam Ngai verfasserin aut Adrian Schwarzer verfasserin aut Costa Bachas verfasserin aut Jacqueline Cloos verfasserin aut Marion Subklewe verfasserin aut Michaela Fuering-Buske verfasserin aut Francesco Buccisano verfasserin aut In HemaSphere Wiley, 2019 6(2022), 1, p e676 (DE-627)1015324924 (DE-600)2922183-3 25729241 nnns volume:6 year:2022 number:1, p e676 https://doi.org/10.1097/HS9.0000000000000676 kostenfrei https://doaj.org/article/58aecfe07be0436ea3d70c88f7d1c3d5 kostenfrei http://journals.lww.com/10.1097/HS9.0000000000000676 kostenfrei https://doaj.org/toc/2572-9241 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2022 1, p e676 |
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10.1097/HS9.0000000000000676 doi (DE-627)DOAJ075134284 (DE-599)DOAJ58aecfe07be0436ea3d70c88f7d1c3d5 DE-627 ger DE-627 rakwb eng RC633-647.5 Jesse M. Tettero verfasserin aut Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Measurable residual disease (MRD) quantified by multiparameter flow cytometry (MFC) is a strong and independent prognostic factor in acute myeloid leukemia (AML). However, several technical factors may affect the final read-out of the assay. Experts from the MRD Working Party of the European LeukemiaNet evaluated which aspects are crucial for accurate MFC-MRD measurement. Here, we report on the agreement, obtained via a combination of a cross-sectional questionnaire, live discussions, and a Delphi poll. The recommendations consist of several key issues from bone marrow sampling to final laboratory reporting to ensure quality and reproducibility of results. Furthermore, the experiences were tested by comparing two 8-color MRD panels in multiple laboratories. The results presented here underscore the feasibility and the utility of a harmonized theoretical and practical MFC-MRD assessment and are a next step toward further harmonization. Diseases of the blood and blood-forming organs Sylvie Freeman verfasserin aut Veit Buecklein verfasserin aut Adriano Venditti verfasserin aut Luca Maurillo verfasserin aut Wolfgang Kern verfasserin aut Roland B. Walter verfasserin aut Brent L. Wood verfasserin aut Christophe Roumier verfasserin aut Jan Philippé verfasserin aut Barbara Denys verfasserin aut Jeffrey L. Jorgensen verfasserin aut Marie C. Bene verfasserin aut Francis Lacombe verfasserin aut Adriana Plesa verfasserin aut Monica L. Guzman verfasserin aut Agnieszka Wierzbowska verfasserin aut Anna Czyz verfasserin aut Lok Lam Ngai verfasserin aut Adrian Schwarzer verfasserin aut Costa Bachas verfasserin aut Jacqueline Cloos verfasserin aut Marion Subklewe verfasserin aut Michaela Fuering-Buske verfasserin aut Francesco Buccisano verfasserin aut In HemaSphere Wiley, 2019 6(2022), 1, p e676 (DE-627)1015324924 (DE-600)2922183-3 25729241 nnns volume:6 year:2022 number:1, p e676 https://doi.org/10.1097/HS9.0000000000000676 kostenfrei https://doaj.org/article/58aecfe07be0436ea3d70c88f7d1c3d5 kostenfrei http://journals.lww.com/10.1097/HS9.0000000000000676 kostenfrei https://doaj.org/toc/2572-9241 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2022 1, p e676 |
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Jesse M. Tettero @@aut@@ Sylvie Freeman @@aut@@ Veit Buecklein @@aut@@ Adriano Venditti @@aut@@ Luca Maurillo @@aut@@ Wolfgang Kern @@aut@@ Roland B. Walter @@aut@@ Brent L. Wood @@aut@@ Christophe Roumier @@aut@@ Jan Philippé @@aut@@ Barbara Denys @@aut@@ Jeffrey L. Jorgensen @@aut@@ Marie C. Bene @@aut@@ Francis Lacombe @@aut@@ Adriana Plesa @@aut@@ Monica L. Guzman @@aut@@ Agnieszka Wierzbowska @@aut@@ Anna Czyz @@aut@@ Lok Lam Ngai @@aut@@ Adrian Schwarzer @@aut@@ Costa Bachas @@aut@@ Jacqueline Cloos @@aut@@ Marion Subklewe @@aut@@ Michaela Fuering-Buske @@aut@@ Francesco Buccisano @@aut@@ |
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RC633-647.5 Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party |
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technical aspects of flow cytometry-based measurable residual disease quantification in acute myeloid leukemia: experience of the european leukemianet mrd working party |
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Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party |
| abstract |
Measurable residual disease (MRD) quantified by multiparameter flow cytometry (MFC) is a strong and independent prognostic factor in acute myeloid leukemia (AML). However, several technical factors may affect the final read-out of the assay. Experts from the MRD Working Party of the European LeukemiaNet evaluated which aspects are crucial for accurate MFC-MRD measurement. Here, we report on the agreement, obtained via a combination of a cross-sectional questionnaire, live discussions, and a Delphi poll. The recommendations consist of several key issues from bone marrow sampling to final laboratory reporting to ensure quality and reproducibility of results. Furthermore, the experiences were tested by comparing two 8-color MRD panels in multiple laboratories. The results presented here underscore the feasibility and the utility of a harmonized theoretical and practical MFC-MRD assessment and are a next step toward further harmonization. |
| abstractGer |
Measurable residual disease (MRD) quantified by multiparameter flow cytometry (MFC) is a strong and independent prognostic factor in acute myeloid leukemia (AML). However, several technical factors may affect the final read-out of the assay. Experts from the MRD Working Party of the European LeukemiaNet evaluated which aspects are crucial for accurate MFC-MRD measurement. Here, we report on the agreement, obtained via a combination of a cross-sectional questionnaire, live discussions, and a Delphi poll. The recommendations consist of several key issues from bone marrow sampling to final laboratory reporting to ensure quality and reproducibility of results. Furthermore, the experiences were tested by comparing two 8-color MRD panels in multiple laboratories. The results presented here underscore the feasibility and the utility of a harmonized theoretical and practical MFC-MRD assessment and are a next step toward further harmonization. |
| abstract_unstemmed |
Measurable residual disease (MRD) quantified by multiparameter flow cytometry (MFC) is a strong and independent prognostic factor in acute myeloid leukemia (AML). However, several technical factors may affect the final read-out of the assay. Experts from the MRD Working Party of the European LeukemiaNet evaluated which aspects are crucial for accurate MFC-MRD measurement. Here, we report on the agreement, obtained via a combination of a cross-sectional questionnaire, live discussions, and a Delphi poll. The recommendations consist of several key issues from bone marrow sampling to final laboratory reporting to ensure quality and reproducibility of results. Furthermore, the experiences were tested by comparing two 8-color MRD panels in multiple laboratories. The results presented here underscore the feasibility and the utility of a harmonized theoretical and practical MFC-MRD assessment and are a next step toward further harmonization. |
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Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party |
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https://doi.org/10.1097/HS9.0000000000000676 https://doaj.org/article/58aecfe07be0436ea3d70c88f7d1c3d5 http://journals.lww.com/10.1097/HS9.0000000000000676 https://doaj.org/toc/2572-9241 |
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Sylvie Freeman Veit Buecklein Adriano Venditti Luca Maurillo Wolfgang Kern Roland B. Walter Brent L. Wood Christophe Roumier Jan Philippé Barbara Denys Jeffrey L. Jorgensen Marie C. Bene Francis Lacombe Adriana Plesa Monica L. Guzman Agnieszka Wierzbowska Anna Czyz Lok Lam Ngai Adrian Schwarzer Costa Bachas Jacqueline Cloos Marion Subklewe Michaela Fuering-Buske Francesco Buccisano |
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Sylvie Freeman Veit Buecklein Adriano Venditti Luca Maurillo Wolfgang Kern Roland B. Walter Brent L. Wood Christophe Roumier Jan Philippé Barbara Denys Jeffrey L. Jorgensen Marie C. Bene Francis Lacombe Adriana Plesa Monica L. Guzman Agnieszka Wierzbowska Anna Czyz Lok Lam Ngai Adrian Schwarzer Costa Bachas Jacqueline Cloos Marion Subklewe Michaela Fuering-Buske Francesco Buccisano |
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RC - Internal Medicine |
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10.1097/HS9.0000000000000676 |
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RC633-647.5 |
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2024-07-04T01:58:29.066Z |
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