Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative

Six months after the publication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequence, a record number of vaccine candidates were listed, and quite a number of them have since been approved for emergency use against the novel coronavirus disease 2019 (COVID-19). This unpreced...
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Gespeichert in:

Autor*in:	Isaac Kyei-Barffour [verfasserIn] Samuel Akwetey Addo [verfasserIn] Enoch Aninagyei [verfasserIn] George Ghartey-Kwansah [verfasserIn] Desmond Omane Acheampong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Sterilizing immunity Adaptive immune response COVID-19 SARS-CoV-2 Antigen Reverse vaccinology

Übergeordnetes Werk:	In: Biomedicine & Pharmacotherapy - Elsevier, 2021, 144(2021), Seite 112282-
Übergeordnetes Werk:	volume:144 ; year:2021 ; pages:112282-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.biopha.2021.112282

Katalog-ID:	DOAJ075187744

Internformat


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author_variant	i k b ikb s a a saa e a ea g g k ggk d o a doa
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allfields	10.1016/j.biopha.2021.112282 doi (DE-627)DOAJ075187744 (DE-599)DOAJbf7b697a21b34619b8042c67ff89a092 DE-627 ger DE-627 rakwb eng RM1-950 Isaac Kyei-Barffour verfasserin aut Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Six months after the publication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequence, a record number of vaccine candidates were listed, and quite a number of them have since been approved for emergency use against the novel coronavirus disease 2019 (COVID-19). This unprecedented pharmaceutical feat did not only show commitment, creativity and collaboration of the scientific community, but also provided a swift solution that prevented global healthcare system breakdown. Notwithstanding, the available data show that most of the approved COVID-19 vaccines protect only a proportion of recipients against severe disease but do not prevent clinical manifestation of COVID-19. There is therefore the need to probe further to establish whether these vaccines can induce sterilizing immunity, otherwise, COVID-19 vaccination would have to become a regular phenomenon. The emergence of SARS-CoV-2 variants could further affect the capability of the available COVID-19 vaccines to prevent infection and protect recipients from a severe form of the disease. These notwithstanding, data about which vaccine(s), if any, can confer sterilizing immunity are unavailable. Here, we discuss the immune responses to viral infection with emphasis on COVID-19, and the specific adaptive immune response to SARS-CoV-2 and how it can be harnessed to develop COVID-19 vaccines capable of conferring sterilizing immunity. We further propose factors that could be considered in the development of COVID-19 vaccines capable of stimulating sterilizing immunity. Also, an old, but effective vaccine development technology that can be applied in the development of COVID-19 vaccines with sterilizing immunity potential is reviewed. Sterilizing immunity Adaptive immune response COVID-19 SARS-CoV-2 Antigen Reverse vaccinology Therapeutics. Pharmacology Samuel Akwetey Addo verfasserin aut Enoch Aninagyei verfasserin aut George Ghartey-Kwansah verfasserin aut Desmond Omane Acheampong verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 144(2021), Seite 112282- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:144 year:2021 pages:112282- https://doi.org/10.1016/j.biopha.2021.112282 kostenfrei https://doaj.org/article/bf7b697a21b34619b8042c67ff89a092 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332221010660 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 144 2021 112282-
spelling	10.1016/j.biopha.2021.112282 doi (DE-627)DOAJ075187744 (DE-599)DOAJbf7b697a21b34619b8042c67ff89a092 DE-627 ger DE-627 rakwb eng RM1-950 Isaac Kyei-Barffour verfasserin aut Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Six months after the publication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequence, a record number of vaccine candidates were listed, and quite a number of them have since been approved for emergency use against the novel coronavirus disease 2019 (COVID-19). This unprecedented pharmaceutical feat did not only show commitment, creativity and collaboration of the scientific community, but also provided a swift solution that prevented global healthcare system breakdown. Notwithstanding, the available data show that most of the approved COVID-19 vaccines protect only a proportion of recipients against severe disease but do not prevent clinical manifestation of COVID-19. There is therefore the need to probe further to establish whether these vaccines can induce sterilizing immunity, otherwise, COVID-19 vaccination would have to become a regular phenomenon. The emergence of SARS-CoV-2 variants could further affect the capability of the available COVID-19 vaccines to prevent infection and protect recipients from a severe form of the disease. These notwithstanding, data about which vaccine(s), if any, can confer sterilizing immunity are unavailable. Here, we discuss the immune responses to viral infection with emphasis on COVID-19, and the specific adaptive immune response to SARS-CoV-2 and how it can be harnessed to develop COVID-19 vaccines capable of conferring sterilizing immunity. We further propose factors that could be considered in the development of COVID-19 vaccines capable of stimulating sterilizing immunity. Also, an old, but effective vaccine development technology that can be applied in the development of COVID-19 vaccines with sterilizing immunity potential is reviewed. Sterilizing immunity Adaptive immune response COVID-19 SARS-CoV-2 Antigen Reverse vaccinology Therapeutics. Pharmacology Samuel Akwetey Addo verfasserin aut Enoch Aninagyei verfasserin aut George Ghartey-Kwansah verfasserin aut Desmond Omane Acheampong verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 144(2021), Seite 112282- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:144 year:2021 pages:112282- https://doi.org/10.1016/j.biopha.2021.112282 kostenfrei https://doaj.org/article/bf7b697a21b34619b8042c67ff89a092 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332221010660 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 144 2021 112282-
allfields_unstemmed	10.1016/j.biopha.2021.112282 doi (DE-627)DOAJ075187744 (DE-599)DOAJbf7b697a21b34619b8042c67ff89a092 DE-627 ger DE-627 rakwb eng RM1-950 Isaac Kyei-Barffour verfasserin aut Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Six months after the publication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequence, a record number of vaccine candidates were listed, and quite a number of them have since been approved for emergency use against the novel coronavirus disease 2019 (COVID-19). This unprecedented pharmaceutical feat did not only show commitment, creativity and collaboration of the scientific community, but also provided a swift solution that prevented global healthcare system breakdown. Notwithstanding, the available data show that most of the approved COVID-19 vaccines protect only a proportion of recipients against severe disease but do not prevent clinical manifestation of COVID-19. There is therefore the need to probe further to establish whether these vaccines can induce sterilizing immunity, otherwise, COVID-19 vaccination would have to become a regular phenomenon. The emergence of SARS-CoV-2 variants could further affect the capability of the available COVID-19 vaccines to prevent infection and protect recipients from a severe form of the disease. These notwithstanding, data about which vaccine(s), if any, can confer sterilizing immunity are unavailable. Here, we discuss the immune responses to viral infection with emphasis on COVID-19, and the specific adaptive immune response to SARS-CoV-2 and how it can be harnessed to develop COVID-19 vaccines capable of conferring sterilizing immunity. We further propose factors that could be considered in the development of COVID-19 vaccines capable of stimulating sterilizing immunity. Also, an old, but effective vaccine development technology that can be applied in the development of COVID-19 vaccines with sterilizing immunity potential is reviewed. Sterilizing immunity Adaptive immune response COVID-19 SARS-CoV-2 Antigen Reverse vaccinology Therapeutics. Pharmacology Samuel Akwetey Addo verfasserin aut Enoch Aninagyei verfasserin aut George Ghartey-Kwansah verfasserin aut Desmond Omane Acheampong verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 144(2021), Seite 112282- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:144 year:2021 pages:112282- https://doi.org/10.1016/j.biopha.2021.112282 kostenfrei https://doaj.org/article/bf7b697a21b34619b8042c67ff89a092 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332221010660 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 144 2021 112282-
allfieldsGer	10.1016/j.biopha.2021.112282 doi (DE-627)DOAJ075187744 (DE-599)DOAJbf7b697a21b34619b8042c67ff89a092 DE-627 ger DE-627 rakwb eng RM1-950 Isaac Kyei-Barffour verfasserin aut Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Six months after the publication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequence, a record number of vaccine candidates were listed, and quite a number of them have since been approved for emergency use against the novel coronavirus disease 2019 (COVID-19). This unprecedented pharmaceutical feat did not only show commitment, creativity and collaboration of the scientific community, but also provided a swift solution that prevented global healthcare system breakdown. Notwithstanding, the available data show that most of the approved COVID-19 vaccines protect only a proportion of recipients against severe disease but do not prevent clinical manifestation of COVID-19. There is therefore the need to probe further to establish whether these vaccines can induce sterilizing immunity, otherwise, COVID-19 vaccination would have to become a regular phenomenon. The emergence of SARS-CoV-2 variants could further affect the capability of the available COVID-19 vaccines to prevent infection and protect recipients from a severe form of the disease. These notwithstanding, data about which vaccine(s), if any, can confer sterilizing immunity are unavailable. Here, we discuss the immune responses to viral infection with emphasis on COVID-19, and the specific adaptive immune response to SARS-CoV-2 and how it can be harnessed to develop COVID-19 vaccines capable of conferring sterilizing immunity. We further propose factors that could be considered in the development of COVID-19 vaccines capable of stimulating sterilizing immunity. Also, an old, but effective vaccine development technology that can be applied in the development of COVID-19 vaccines with sterilizing immunity potential is reviewed. Sterilizing immunity Adaptive immune response COVID-19 SARS-CoV-2 Antigen Reverse vaccinology Therapeutics. Pharmacology Samuel Akwetey Addo verfasserin aut Enoch Aninagyei verfasserin aut George Ghartey-Kwansah verfasserin aut Desmond Omane Acheampong verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 144(2021), Seite 112282- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:144 year:2021 pages:112282- https://doi.org/10.1016/j.biopha.2021.112282 kostenfrei https://doaj.org/article/bf7b697a21b34619b8042c67ff89a092 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332221010660 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 144 2021 112282-
allfieldsSound	10.1016/j.biopha.2021.112282 doi (DE-627)DOAJ075187744 (DE-599)DOAJbf7b697a21b34619b8042c67ff89a092 DE-627 ger DE-627 rakwb eng RM1-950 Isaac Kyei-Barffour verfasserin aut Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Six months after the publication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequence, a record number of vaccine candidates were listed, and quite a number of them have since been approved for emergency use against the novel coronavirus disease 2019 (COVID-19). This unprecedented pharmaceutical feat did not only show commitment, creativity and collaboration of the scientific community, but also provided a swift solution that prevented global healthcare system breakdown. Notwithstanding, the available data show that most of the approved COVID-19 vaccines protect only a proportion of recipients against severe disease but do not prevent clinical manifestation of COVID-19. There is therefore the need to probe further to establish whether these vaccines can induce sterilizing immunity, otherwise, COVID-19 vaccination would have to become a regular phenomenon. The emergence of SARS-CoV-2 variants could further affect the capability of the available COVID-19 vaccines to prevent infection and protect recipients from a severe form of the disease. These notwithstanding, data about which vaccine(s), if any, can confer sterilizing immunity are unavailable. Here, we discuss the immune responses to viral infection with emphasis on COVID-19, and the specific adaptive immune response to SARS-CoV-2 and how it can be harnessed to develop COVID-19 vaccines capable of conferring sterilizing immunity. We further propose factors that could be considered in the development of COVID-19 vaccines capable of stimulating sterilizing immunity. Also, an old, but effective vaccine development technology that can be applied in the development of COVID-19 vaccines with sterilizing immunity potential is reviewed. Sterilizing immunity Adaptive immune response COVID-19 SARS-CoV-2 Antigen Reverse vaccinology Therapeutics. Pharmacology Samuel Akwetey Addo verfasserin aut Enoch Aninagyei verfasserin aut George Ghartey-Kwansah verfasserin aut Desmond Omane Acheampong verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 144(2021), Seite 112282- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:144 year:2021 pages:112282- https://doi.org/10.1016/j.biopha.2021.112282 kostenfrei https://doaj.org/article/bf7b697a21b34619b8042c67ff89a092 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332221010660 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 144 2021 112282-
language	English
source	In Biomedicine & Pharmacotherapy 144(2021), Seite 112282- volume:144 year:2021 pages:112282-
sourceStr	In Biomedicine & Pharmacotherapy 144(2021), Seite 112282- volume:144 year:2021 pages:112282-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Sterilizing immunity Adaptive immune response COVID-19 SARS-CoV-2 Antigen Reverse vaccinology Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Biomedicine & Pharmacotherapy
authorswithroles_txt_mv	Isaac Kyei-Barffour @@aut@@ Samuel Akwetey Addo @@aut@@ Enoch Aninagyei @@aut@@ George Ghartey-Kwansah @@aut@@ Desmond Omane Acheampong @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	306717565
id	DOAJ075187744
language_de	englisch
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callnumber-first	R - Medicine
author	Isaac Kyei-Barffour
spellingShingle	Isaac Kyei-Barffour misc RM1-950 misc Sterilizing immunity misc Adaptive immune response misc COVID-19 misc SARS-CoV-2 misc Antigen misc Reverse vaccinology misc Therapeutics. Pharmacology Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative
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topic_title	RM1-950 Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative Sterilizing immunity Adaptive immune response COVID-19 SARS-CoV-2 Antigen Reverse vaccinology
topic	misc RM1-950 misc Sterilizing immunity misc Adaptive immune response misc COVID-19 misc SARS-CoV-2 misc Antigen misc Reverse vaccinology misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc Sterilizing immunity misc Adaptive immune response misc COVID-19 misc SARS-CoV-2 misc Antigen misc Reverse vaccinology misc Therapeutics. Pharmacology
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title	Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative
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title_full	Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative
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title_sort	sterilizing immunity against covid-19: developing helper t cells i and ii activating vaccines is imperative
callnumber	RM1-950
title_auth	Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative
abstract	Six months after the publication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequence, a record number of vaccine candidates were listed, and quite a number of them have since been approved for emergency use against the novel coronavirus disease 2019 (COVID-19). This unprecedented pharmaceutical feat did not only show commitment, creativity and collaboration of the scientific community, but also provided a swift solution that prevented global healthcare system breakdown. Notwithstanding, the available data show that most of the approved COVID-19 vaccines protect only a proportion of recipients against severe disease but do not prevent clinical manifestation of COVID-19. There is therefore the need to probe further to establish whether these vaccines can induce sterilizing immunity, otherwise, COVID-19 vaccination would have to become a regular phenomenon. The emergence of SARS-CoV-2 variants could further affect the capability of the available COVID-19 vaccines to prevent infection and protect recipients from a severe form of the disease. These notwithstanding, data about which vaccine(s), if any, can confer sterilizing immunity are unavailable. Here, we discuss the immune responses to viral infection with emphasis on COVID-19, and the specific adaptive immune response to SARS-CoV-2 and how it can be harnessed to develop COVID-19 vaccines capable of conferring sterilizing immunity. We further propose factors that could be considered in the development of COVID-19 vaccines capable of stimulating sterilizing immunity. Also, an old, but effective vaccine development technology that can be applied in the development of COVID-19 vaccines with sterilizing immunity potential is reviewed.
abstractGer	Six months after the publication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequence, a record number of vaccine candidates were listed, and quite a number of them have since been approved for emergency use against the novel coronavirus disease 2019 (COVID-19). This unprecedented pharmaceutical feat did not only show commitment, creativity and collaboration of the scientific community, but also provided a swift solution that prevented global healthcare system breakdown. Notwithstanding, the available data show that most of the approved COVID-19 vaccines protect only a proportion of recipients against severe disease but do not prevent clinical manifestation of COVID-19. There is therefore the need to probe further to establish whether these vaccines can induce sterilizing immunity, otherwise, COVID-19 vaccination would have to become a regular phenomenon. The emergence of SARS-CoV-2 variants could further affect the capability of the available COVID-19 vaccines to prevent infection and protect recipients from a severe form of the disease. These notwithstanding, data about which vaccine(s), if any, can confer sterilizing immunity are unavailable. Here, we discuss the immune responses to viral infection with emphasis on COVID-19, and the specific adaptive immune response to SARS-CoV-2 and how it can be harnessed to develop COVID-19 vaccines capable of conferring sterilizing immunity. We further propose factors that could be considered in the development of COVID-19 vaccines capable of stimulating sterilizing immunity. Also, an old, but effective vaccine development technology that can be applied in the development of COVID-19 vaccines with sterilizing immunity potential is reviewed.
abstract_unstemmed	Six months after the publication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequence, a record number of vaccine candidates were listed, and quite a number of them have since been approved for emergency use against the novel coronavirus disease 2019 (COVID-19). This unprecedented pharmaceutical feat did not only show commitment, creativity and collaboration of the scientific community, but also provided a swift solution that prevented global healthcare system breakdown. Notwithstanding, the available data show that most of the approved COVID-19 vaccines protect only a proportion of recipients against severe disease but do not prevent clinical manifestation of COVID-19. There is therefore the need to probe further to establish whether these vaccines can induce sterilizing immunity, otherwise, COVID-19 vaccination would have to become a regular phenomenon. The emergence of SARS-CoV-2 variants could further affect the capability of the available COVID-19 vaccines to prevent infection and protect recipients from a severe form of the disease. These notwithstanding, data about which vaccine(s), if any, can confer sterilizing immunity are unavailable. Here, we discuss the immune responses to viral infection with emphasis on COVID-19, and the specific adaptive immune response to SARS-CoV-2 and how it can be harnessed to develop COVID-19 vaccines capable of conferring sterilizing immunity. We further propose factors that could be considered in the development of COVID-19 vaccines capable of stimulating sterilizing immunity. Also, an old, but effective vaccine development technology that can be applied in the development of COVID-19 vaccines with sterilizing immunity potential is reviewed.
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title_short	Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative
url	https://doi.org/10.1016/j.biopha.2021.112282 https://doaj.org/article/bf7b697a21b34619b8042c67ff89a092 http://www.sciencedirect.com/science/article/pii/S0753332221010660 https://doaj.org/toc/0753-3322
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