Atypical manifestation of parathyroid carcinoma with late-onset distant metastases

Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (...
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Autor*in:	MarinaTsoli [verfasserIn] Anna Angelousi [verfasserIn] Dimitra Rontogianni [verfasserIn] Constantine Stratakis [verfasserIn] Gregory Kaltsas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Endocrinology, Diabetes & Metabolism Case Reports - Bioscientifica, 2014, 1(2017), 1, Seite 5
Übergeordnetes Werk:	volume:1 ; year:2017 ; number:1 ; pages:5

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1530/EDM-17-0106

Katalog-ID:	DOAJ075191482

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520			\|a Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (PTH) levels and a 4.5 × 3 × 2.5 cm cystic lesion in the lower pole of the right thyroid lobe that was shown histologically to be a parathyroid carcinoma. Ten years later, the patient developed brain and pulmonary metastases and recurrence of PTH-related hypercalcemia. Treatment of hypercalcemia along with localized radiotherapy and various chemotherapy regimens failed to induce a biochemical or radiological response. In conclusion, parathyroid carcinoma is a rare neoplasia that may develop metastases even after prolonged follow-up, for which there is no evidence-based treatment besides surgery. Different chemotherapeutic schemes did not prove to be of any benefit in our case highlighting the need for registering such patients to better understand tumor biology and develop specific treatment.
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language	English
source	In Endocrinology, Diabetes & Metabolism Case Reports 1(2017), 1, Seite 5 volume:1 year:2017 number:1 pages:5
sourceStr	In Endocrinology, Diabetes & Metabolism Case Reports 1(2017), 1, Seite 5 volume:1 year:2017 number:1 pages:5
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Diseases of the endocrine glands. Clinical endocrinology
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container_title	Endocrinology, Diabetes & Metabolism Case Reports
authorswithroles_txt_mv	MarinaTsoli @@aut@@ Anna Angelousi @@aut@@ Dimitra Rontogianni @@aut@@ Constantine Stratakis @@aut@@ Gregory Kaltsas @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
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topic_title	RC648-665 Atypical manifestation of parathyroid carcinoma with late-onset distant metastases
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title	Atypical manifestation of parathyroid carcinoma with late-onset distant metastases
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title_full	Atypical manifestation of parathyroid carcinoma with late-onset distant metastases
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title_sort	atypical manifestation of parathyroid carcinoma with late-onset distant metastases
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title_auth	Atypical manifestation of parathyroid carcinoma with late-onset distant metastases
abstract	Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (PTH) levels and a 4.5 × 3 × 2.5 cm cystic lesion in the lower pole of the right thyroid lobe that was shown histologically to be a parathyroid carcinoma. Ten years later, the patient developed brain and pulmonary metastases and recurrence of PTH-related hypercalcemia. Treatment of hypercalcemia along with localized radiotherapy and various chemotherapy regimens failed to induce a biochemical or radiological response. In conclusion, parathyroid carcinoma is a rare neoplasia that may develop metastases even after prolonged follow-up, for which there is no evidence-based treatment besides surgery. Different chemotherapeutic schemes did not prove to be of any benefit in our case highlighting the need for registering such patients to better understand tumor biology and develop specific treatment.
abstractGer	Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (PTH) levels and a 4.5 × 3 × 2.5 cm cystic lesion in the lower pole of the right thyroid lobe that was shown histologically to be a parathyroid carcinoma. Ten years later, the patient developed brain and pulmonary metastases and recurrence of PTH-related hypercalcemia. Treatment of hypercalcemia along with localized radiotherapy and various chemotherapy regimens failed to induce a biochemical or radiological response. In conclusion, parathyroid carcinoma is a rare neoplasia that may develop metastases even after prolonged follow-up, for which there is no evidence-based treatment besides surgery. Different chemotherapeutic schemes did not prove to be of any benefit in our case highlighting the need for registering such patients to better understand tumor biology and develop specific treatment.
abstract_unstemmed	Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (PTH) levels and a 4.5 × 3 × 2.5 cm cystic lesion in the lower pole of the right thyroid lobe that was shown histologically to be a parathyroid carcinoma. Ten years later, the patient developed brain and pulmonary metastases and recurrence of PTH-related hypercalcemia. Treatment of hypercalcemia along with localized radiotherapy and various chemotherapy regimens failed to induce a biochemical or radiological response. In conclusion, parathyroid carcinoma is a rare neoplasia that may develop metastases even after prolonged follow-up, for which there is no evidence-based treatment besides surgery. Different chemotherapeutic schemes did not prove to be of any benefit in our case highlighting the need for registering such patients to better understand tumor biology and develop specific treatment.
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title_short	Atypical manifestation of parathyroid carcinoma with late-onset distant metastases
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Atypical manifestation of parathyroid carcinoma with late-onset distant metastases

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