Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions

Sabrina E Dass,1 Taryn Huizenga,2 Mehdi Farshchian,2 Darius R Mehregan2 1Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Dermatology, Wayne State University, Detroit, MI, USACorrespondence: Mehdi FarshchianDepartment of Dermatology, Wayne State University, 18100 Oakwood B...
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Autor*in:	Dass SE [verfasserIn] Huizenga T [verfasserIn] Farshchian M [verfasserIn] Mehregan DR [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	immunohistochemical stains melanocytes benign melanocytic lesion lentigo atypical junctional melanocytic hyperplasia

Übergeordnetes Werk:	In: Clinical, Cosmetic and Investigational Dermatology - Dove Medical Press, 2009, (2021), Seite 1419-1425
Übergeordnetes Werk:	year:2021 ; pages:1419-1425

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Katalog-ID:	DOAJ075216329

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520			\|a Sabrina E Dass,1 Taryn Huizenga,2 Mehdi Farshchian,2 Darius R Mehregan2 1Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Dermatology, Wayne State University, Detroit, MI, USACorrespondence: Mehdi FarshchianDepartment of Dermatology, Wayne State University, 18100 Oakwood Blvd., Suite 300, Detroit, MI, 48124, USAEmail mfarshchmed.wayne.eduPurpose: Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.Methods: SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.Results: Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).Conclusion: SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.Keywords: immunohistochemical stains, melanocytes, benign melanocytic lesion, lentigo, atypical junctional melanocytic hyperplasia
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allfields	(DE-627)DOAJ075216329 (DE-599)DOAJ71f9a53523bc4a67ac970a19ebad5d2e DE-627 ger DE-627 rakwb eng RL1-803 Dass SE verfasserin aut Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sabrina E Dass,1 Taryn Huizenga,2 Mehdi Farshchian,2 Darius R Mehregan2 1Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Dermatology, Wayne State University, Detroit, MI, USACorrespondence: Mehdi FarshchianDepartment of Dermatology, Wayne State University, 18100 Oakwood Blvd., Suite 300, Detroit, MI, 48124, USAEmail mfarshchmed.wayne.eduPurpose: Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.Methods: SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.Results: Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).Conclusion: SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.Keywords: immunohistochemical stains, melanocytes, benign melanocytic lesion, lentigo, atypical junctional melanocytic hyperplasia immunohistochemical stains melanocytes benign melanocytic lesion lentigo atypical junctional melanocytic hyperplasia Dermatology Huizenga T verfasserin aut Farshchian M verfasserin aut Mehregan DR verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2021), Seite 1419-1425 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2021 pages:1419-1425 https://doaj.org/article/71f9a53523bc4a67ac970a19ebad5d2e kostenfrei https://www.dovepress.com/comparison-of-sox-10-hmb-45-and-melan-a-in-benign-melanocytic-lesions-peer-reviewed-fulltext-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 1419-1425
spelling	(DE-627)DOAJ075216329 (DE-599)DOAJ71f9a53523bc4a67ac970a19ebad5d2e DE-627 ger DE-627 rakwb eng RL1-803 Dass SE verfasserin aut Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sabrina E Dass,1 Taryn Huizenga,2 Mehdi Farshchian,2 Darius R Mehregan2 1Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Dermatology, Wayne State University, Detroit, MI, USACorrespondence: Mehdi FarshchianDepartment of Dermatology, Wayne State University, 18100 Oakwood Blvd., Suite 300, Detroit, MI, 48124, USAEmail mfarshchmed.wayne.eduPurpose: Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.Methods: SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.Results: Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).Conclusion: SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.Keywords: immunohistochemical stains, melanocytes, benign melanocytic lesion, lentigo, atypical junctional melanocytic hyperplasia immunohistochemical stains melanocytes benign melanocytic lesion lentigo atypical junctional melanocytic hyperplasia Dermatology Huizenga T verfasserin aut Farshchian M verfasserin aut Mehregan DR verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2021), Seite 1419-1425 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2021 pages:1419-1425 https://doaj.org/article/71f9a53523bc4a67ac970a19ebad5d2e kostenfrei https://www.dovepress.com/comparison-of-sox-10-hmb-45-and-melan-a-in-benign-melanocytic-lesions-peer-reviewed-fulltext-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 1419-1425
allfields_unstemmed	(DE-627)DOAJ075216329 (DE-599)DOAJ71f9a53523bc4a67ac970a19ebad5d2e DE-627 ger DE-627 rakwb eng RL1-803 Dass SE verfasserin aut Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sabrina E Dass,1 Taryn Huizenga,2 Mehdi Farshchian,2 Darius R Mehregan2 1Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Dermatology, Wayne State University, Detroit, MI, USACorrespondence: Mehdi FarshchianDepartment of Dermatology, Wayne State University, 18100 Oakwood Blvd., Suite 300, Detroit, MI, 48124, USAEmail mfarshchmed.wayne.eduPurpose: Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.Methods: SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.Results: Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).Conclusion: SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.Keywords: immunohistochemical stains, melanocytes, benign melanocytic lesion, lentigo, atypical junctional melanocytic hyperplasia immunohistochemical stains melanocytes benign melanocytic lesion lentigo atypical junctional melanocytic hyperplasia Dermatology Huizenga T verfasserin aut Farshchian M verfasserin aut Mehregan DR verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2021), Seite 1419-1425 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2021 pages:1419-1425 https://doaj.org/article/71f9a53523bc4a67ac970a19ebad5d2e kostenfrei https://www.dovepress.com/comparison-of-sox-10-hmb-45-and-melan-a-in-benign-melanocytic-lesions-peer-reviewed-fulltext-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 1419-1425
allfieldsGer	(DE-627)DOAJ075216329 (DE-599)DOAJ71f9a53523bc4a67ac970a19ebad5d2e DE-627 ger DE-627 rakwb eng RL1-803 Dass SE verfasserin aut Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sabrina E Dass,1 Taryn Huizenga,2 Mehdi Farshchian,2 Darius R Mehregan2 1Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Dermatology, Wayne State University, Detroit, MI, USACorrespondence: Mehdi FarshchianDepartment of Dermatology, Wayne State University, 18100 Oakwood Blvd., Suite 300, Detroit, MI, 48124, USAEmail mfarshchmed.wayne.eduPurpose: Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.Methods: SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.Results: Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).Conclusion: SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.Keywords: immunohistochemical stains, melanocytes, benign melanocytic lesion, lentigo, atypical junctional melanocytic hyperplasia immunohistochemical stains melanocytes benign melanocytic lesion lentigo atypical junctional melanocytic hyperplasia Dermatology Huizenga T verfasserin aut Farshchian M verfasserin aut Mehregan DR verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2021), Seite 1419-1425 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2021 pages:1419-1425 https://doaj.org/article/71f9a53523bc4a67ac970a19ebad5d2e kostenfrei https://www.dovepress.com/comparison-of-sox-10-hmb-45-and-melan-a-in-benign-melanocytic-lesions-peer-reviewed-fulltext-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 1419-1425
allfieldsSound	(DE-627)DOAJ075216329 (DE-599)DOAJ71f9a53523bc4a67ac970a19ebad5d2e DE-627 ger DE-627 rakwb eng RL1-803 Dass SE verfasserin aut Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sabrina E Dass,1 Taryn Huizenga,2 Mehdi Farshchian,2 Darius R Mehregan2 1Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Dermatology, Wayne State University, Detroit, MI, USACorrespondence: Mehdi FarshchianDepartment of Dermatology, Wayne State University, 18100 Oakwood Blvd., Suite 300, Detroit, MI, 48124, USAEmail mfarshchmed.wayne.eduPurpose: Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.Methods: SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.Results: Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).Conclusion: SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.Keywords: immunohistochemical stains, melanocytes, benign melanocytic lesion, lentigo, atypical junctional melanocytic hyperplasia immunohistochemical stains melanocytes benign melanocytic lesion lentigo atypical junctional melanocytic hyperplasia Dermatology Huizenga T verfasserin aut Farshchian M verfasserin aut Mehregan DR verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2021), Seite 1419-1425 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2021 pages:1419-1425 https://doaj.org/article/71f9a53523bc4a67ac970a19ebad5d2e kostenfrei https://www.dovepress.com/comparison-of-sox-10-hmb-45-and-melan-a-in-benign-melanocytic-lesions-peer-reviewed-fulltext-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 1419-1425
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callnumber-first	R - Medicine
author	Dass SE
spellingShingle	Dass SE misc RL1-803 misc immunohistochemical stains misc melanocytes misc benign melanocytic lesion misc lentigo misc atypical junctional melanocytic hyperplasia misc Dermatology Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions
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topic_title	RL1-803 Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions immunohistochemical stains melanocytes benign melanocytic lesion lentigo atypical junctional melanocytic hyperplasia
topic	misc RL1-803 misc immunohistochemical stains misc melanocytes misc benign melanocytic lesion misc lentigo misc atypical junctional melanocytic hyperplasia misc Dermatology
topic_unstemmed	misc RL1-803 misc immunohistochemical stains misc melanocytes misc benign melanocytic lesion misc lentigo misc atypical junctional melanocytic hyperplasia misc Dermatology
topic_browse	misc RL1-803 misc immunohistochemical stains misc melanocytes misc benign melanocytic lesion misc lentigo misc atypical junctional melanocytic hyperplasia misc Dermatology
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title	Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions
ctrlnum	(DE-627)DOAJ075216329 (DE-599)DOAJ71f9a53523bc4a67ac970a19ebad5d2e
title_full	Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions
author_sort	Dass SE
journal	Clinical, Cosmetic and Investigational Dermatology
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author_browse	Dass SE Huizenga T Farshchian M Mehregan DR
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author-letter	Dass SE
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title_sort	comparison of sox-10, hmb-45, and melan-a in benign melanocytic lesions
callnumber	RL1-803
title_auth	Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions
abstract	Sabrina E Dass,1 Taryn Huizenga,2 Mehdi Farshchian,2 Darius R Mehregan2 1Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Dermatology, Wayne State University, Detroit, MI, USACorrespondence: Mehdi FarshchianDepartment of Dermatology, Wayne State University, 18100 Oakwood Blvd., Suite 300, Detroit, MI, 48124, USAEmail mfarshchmed.wayne.eduPurpose: Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.Methods: SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.Results: Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).Conclusion: SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.Keywords: immunohistochemical stains, melanocytes, benign melanocytic lesion, lentigo, atypical junctional melanocytic hyperplasia
abstractGer	Sabrina E Dass,1 Taryn Huizenga,2 Mehdi Farshchian,2 Darius R Mehregan2 1Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Dermatology, Wayne State University, Detroit, MI, USACorrespondence: Mehdi FarshchianDepartment of Dermatology, Wayne State University, 18100 Oakwood Blvd., Suite 300, Detroit, MI, 48124, USAEmail mfarshchmed.wayne.eduPurpose: Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.Methods: SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.Results: Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).Conclusion: SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.Keywords: immunohistochemical stains, melanocytes, benign melanocytic lesion, lentigo, atypical junctional melanocytic hyperplasia
abstract_unstemmed	Sabrina E Dass,1 Taryn Huizenga,2 Mehdi Farshchian,2 Darius R Mehregan2 1Wayne State University School of Medicine, Detroit, MI, USA; 2Department of Dermatology, Wayne State University, Detroit, MI, USACorrespondence: Mehdi FarshchianDepartment of Dermatology, Wayne State University, 18100 Oakwood Blvd., Suite 300, Detroit, MI, 48124, USAEmail mfarshchmed.wayne.eduPurpose: Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions.Methods: SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.Results: Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).Conclusion: SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.Keywords: immunohistochemical stains, melanocytes, benign melanocytic lesion, lentigo, atypical junctional melanocytic hyperplasia
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title_short	Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions
url	https://doaj.org/article/71f9a53523bc4a67ac970a19ebad5d2e https://www.dovepress.com/comparison-of-sox-10-hmb-45-and-melan-a-in-benign-melanocytic-lesions-peer-reviewed-fulltext-article-CCID https://doaj.org/toc/1178-7015
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up_date	2024-07-03T13:39:43.491Z
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The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings.Results: Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810).Conclusion: SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. 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Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions

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