Investigation of Apoptotic Effect of Sinapic Acid in Hep3B and HepG2 Human Hepatocellular Carcinoma Cells

Hepatocellular carcinoma is one of the most common malignancies in worldwide. Sinapic acid (SA) is a phytochemical found in various fruits and vegetables. The aim of the study was to investigate the effect of SA on apoptosis in Hep3B and HepG2 hepatocellular carcinoma cells. XTT assay was used to de...
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Autor*in:	Canan Eroğlu [verfasserIn] Ercan Kurar [verfasserIn] Ebru Avcı [verfasserIn] Hasibe Vural [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	apoptosis Hep3B cells HepG2 cells sinapic acid

Übergeordnetes Werk:	In: Proceedings - MDPI AG, 2018, 1(2017), 10, p 1000
Übergeordnetes Werk:	volume:1 ; year:2017 ; number:10, p 1000

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/proceedings1101000

Katalog-ID:	DOAJ075258005

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520			\|a Hepatocellular carcinoma is one of the most common malignancies in worldwide. Sinapic acid (SA) is a phytochemical found in various fruits and vegetables. The aim of the study was to investigate the effect of SA on apoptosis in Hep3B and HepG2 hepatocellular carcinoma cells. XTT assay was used to determine the cytotoxic effect of SA. Total RNA isolation was conducted using TRIzol Reagent. Relative mRNA expression levels of important genes in apoptosis including CASP3, CASP7, CASP8, CASP9, BAX, BCL2, FAS and CYCS were quantified using qPCR in control and dose groups. The IC50 dose of SA in Hep3B and HepG2 cells were found to be 1000 µM and 1150 µM for 72 h, respectively. According to qPCR results, significant increases in the expressions of CASP3 and FAS were determined as 23.37 and 27.47 folds in treated Hep3B cells. On the other hand, SA in HepG2 cells caused a significant increase in the expressions of CASP3, CASP8, CASP9, BAX and FAS as 1.53, 1.77, 1.21, 1.47 and 1.39 folds respectively, compared with the control group. It is considered that SA may cause apoptosis in Hep3B and HepG2 cells. Further studies with SA should be conducted to can be therapeutic agent on hepatocellular carcinoma.
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spelling	10.3390/proceedings1101000 doi (DE-627)DOAJ075258005 (DE-599)DOAJ81fe2f5c234e4bf4855c1279f9f12b51 DE-627 ger DE-627 rakwb eng Canan Eroğlu verfasserin aut Investigation of Apoptotic Effect of Sinapic Acid in Hep3B and HepG2 Human Hepatocellular Carcinoma Cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatocellular carcinoma is one of the most common malignancies in worldwide. Sinapic acid (SA) is a phytochemical found in various fruits and vegetables. The aim of the study was to investigate the effect of SA on apoptosis in Hep3B and HepG2 hepatocellular carcinoma cells. XTT assay was used to determine the cytotoxic effect of SA. Total RNA isolation was conducted using TRIzol Reagent. Relative mRNA expression levels of important genes in apoptosis including CASP3, CASP7, CASP8, CASP9, BAX, BCL2, FAS and CYCS were quantified using qPCR in control and dose groups. The IC50 dose of SA in Hep3B and HepG2 cells were found to be 1000 µM and 1150 µM for 72 h, respectively. According to qPCR results, significant increases in the expressions of CASP3 and FAS were determined as 23.37 and 27.47 folds in treated Hep3B cells. On the other hand, SA in HepG2 cells caused a significant increase in the expressions of CASP3, CASP8, CASP9, BAX and FAS as 1.53, 1.77, 1.21, 1.47 and 1.39 folds respectively, compared with the control group. It is considered that SA may cause apoptosis in Hep3B and HepG2 cells. Further studies with SA should be conducted to can be therapeutic agent on hepatocellular carcinoma. apoptosis Hep3B cells HepG2 cells sinapic acid General Works A Ercan Kurar verfasserin aut Ebru Avcı verfasserin aut Hasibe Vural verfasserin aut In Proceedings MDPI AG, 2018 1(2017), 10, p 1000 (DE-627)896671828 (DE-600)2904077-2 25043900 nnns volume:1 year:2017 number:10, p 1000 https://doi.org/10.3390/proceedings1101000 kostenfrei https://doaj.org/article/81fe2f5c234e4bf4855c1279f9f12b51 kostenfrei https://www.mdpi.com/2504-3900/1/10/1000 kostenfrei https://doaj.org/toc/2504-3900 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2017 10, p 1000
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allfieldsGer	10.3390/proceedings1101000 doi (DE-627)DOAJ075258005 (DE-599)DOAJ81fe2f5c234e4bf4855c1279f9f12b51 DE-627 ger DE-627 rakwb eng Canan Eroğlu verfasserin aut Investigation of Apoptotic Effect of Sinapic Acid in Hep3B and HepG2 Human Hepatocellular Carcinoma Cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatocellular carcinoma is one of the most common malignancies in worldwide. Sinapic acid (SA) is a phytochemical found in various fruits and vegetables. The aim of the study was to investigate the effect of SA on apoptosis in Hep3B and HepG2 hepatocellular carcinoma cells. XTT assay was used to determine the cytotoxic effect of SA. Total RNA isolation was conducted using TRIzol Reagent. Relative mRNA expression levels of important genes in apoptosis including CASP3, CASP7, CASP8, CASP9, BAX, BCL2, FAS and CYCS were quantified using qPCR in control and dose groups. The IC50 dose of SA in Hep3B and HepG2 cells were found to be 1000 µM and 1150 µM for 72 h, respectively. According to qPCR results, significant increases in the expressions of CASP3 and FAS were determined as 23.37 and 27.47 folds in treated Hep3B cells. On the other hand, SA in HepG2 cells caused a significant increase in the expressions of CASP3, CASP8, CASP9, BAX and FAS as 1.53, 1.77, 1.21, 1.47 and 1.39 folds respectively, compared with the control group. It is considered that SA may cause apoptosis in Hep3B and HepG2 cells. Further studies with SA should be conducted to can be therapeutic agent on hepatocellular carcinoma. apoptosis Hep3B cells HepG2 cells sinapic acid General Works A Ercan Kurar verfasserin aut Ebru Avcı verfasserin aut Hasibe Vural verfasserin aut In Proceedings MDPI AG, 2018 1(2017), 10, p 1000 (DE-627)896671828 (DE-600)2904077-2 25043900 nnns volume:1 year:2017 number:10, p 1000 https://doi.org/10.3390/proceedings1101000 kostenfrei https://doaj.org/article/81fe2f5c234e4bf4855c1279f9f12b51 kostenfrei https://www.mdpi.com/2504-3900/1/10/1000 kostenfrei https://doaj.org/toc/2504-3900 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2017 10, p 1000
allfieldsSound	10.3390/proceedings1101000 doi (DE-627)DOAJ075258005 (DE-599)DOAJ81fe2f5c234e4bf4855c1279f9f12b51 DE-627 ger DE-627 rakwb eng Canan Eroğlu verfasserin aut Investigation of Apoptotic Effect of Sinapic Acid in Hep3B and HepG2 Human Hepatocellular Carcinoma Cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatocellular carcinoma is one of the most common malignancies in worldwide. Sinapic acid (SA) is a phytochemical found in various fruits and vegetables. The aim of the study was to investigate the effect of SA on apoptosis in Hep3B and HepG2 hepatocellular carcinoma cells. XTT assay was used to determine the cytotoxic effect of SA. Total RNA isolation was conducted using TRIzol Reagent. Relative mRNA expression levels of important genes in apoptosis including CASP3, CASP7, CASP8, CASP9, BAX, BCL2, FAS and CYCS were quantified using qPCR in control and dose groups. The IC50 dose of SA in Hep3B and HepG2 cells were found to be 1000 µM and 1150 µM for 72 h, respectively. According to qPCR results, significant increases in the expressions of CASP3 and FAS were determined as 23.37 and 27.47 folds in treated Hep3B cells. On the other hand, SA in HepG2 cells caused a significant increase in the expressions of CASP3, CASP8, CASP9, BAX and FAS as 1.53, 1.77, 1.21, 1.47 and 1.39 folds respectively, compared with the control group. It is considered that SA may cause apoptosis in Hep3B and HepG2 cells. Further studies with SA should be conducted to can be therapeutic agent on hepatocellular carcinoma. apoptosis Hep3B cells HepG2 cells sinapic acid General Works A Ercan Kurar verfasserin aut Ebru Avcı verfasserin aut Hasibe Vural verfasserin aut In Proceedings MDPI AG, 2018 1(2017), 10, p 1000 (DE-627)896671828 (DE-600)2904077-2 25043900 nnns volume:1 year:2017 number:10, p 1000 https://doi.org/10.3390/proceedings1101000 kostenfrei https://doaj.org/article/81fe2f5c234e4bf4855c1279f9f12b51 kostenfrei https://www.mdpi.com/2504-3900/1/10/1000 kostenfrei https://doaj.org/toc/2504-3900 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2017 10, p 1000
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author	Canan Eroğlu
spellingShingle	Canan Eroğlu misc apoptosis misc Hep3B cells misc HepG2 cells misc sinapic acid misc General Works misc A Investigation of Apoptotic Effect of Sinapic Acid in Hep3B and HepG2 Human Hepatocellular Carcinoma Cells
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topic_title	Investigation of Apoptotic Effect of Sinapic Acid in Hep3B and HepG2 Human Hepatocellular Carcinoma Cells apoptosis Hep3B cells HepG2 cells sinapic acid
topic	misc apoptosis misc Hep3B cells misc HepG2 cells misc sinapic acid misc General Works misc A
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title	Investigation of Apoptotic Effect of Sinapic Acid in Hep3B and HepG2 Human Hepatocellular Carcinoma Cells
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title_full	Investigation of Apoptotic Effect of Sinapic Acid in Hep3B and HepG2 Human Hepatocellular Carcinoma Cells
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title_sort	investigation of apoptotic effect of sinapic acid in hep3b and hepg2 human hepatocellular carcinoma cells
title_auth	Investigation of Apoptotic Effect of Sinapic Acid in Hep3B and HepG2 Human Hepatocellular Carcinoma Cells
abstract	Hepatocellular carcinoma is one of the most common malignancies in worldwide. Sinapic acid (SA) is a phytochemical found in various fruits and vegetables. The aim of the study was to investigate the effect of SA on apoptosis in Hep3B and HepG2 hepatocellular carcinoma cells. XTT assay was used to determine the cytotoxic effect of SA. Total RNA isolation was conducted using TRIzol Reagent. Relative mRNA expression levels of important genes in apoptosis including CASP3, CASP7, CASP8, CASP9, BAX, BCL2, FAS and CYCS were quantified using qPCR in control and dose groups. The IC50 dose of SA in Hep3B and HepG2 cells were found to be 1000 µM and 1150 µM for 72 h, respectively. According to qPCR results, significant increases in the expressions of CASP3 and FAS were determined as 23.37 and 27.47 folds in treated Hep3B cells. On the other hand, SA in HepG2 cells caused a significant increase in the expressions of CASP3, CASP8, CASP9, BAX and FAS as 1.53, 1.77, 1.21, 1.47 and 1.39 folds respectively, compared with the control group. It is considered that SA may cause apoptosis in Hep3B and HepG2 cells. Further studies with SA should be conducted to can be therapeutic agent on hepatocellular carcinoma.
abstractGer	Hepatocellular carcinoma is one of the most common malignancies in worldwide. Sinapic acid (SA) is a phytochemical found in various fruits and vegetables. The aim of the study was to investigate the effect of SA on apoptosis in Hep3B and HepG2 hepatocellular carcinoma cells. XTT assay was used to determine the cytotoxic effect of SA. Total RNA isolation was conducted using TRIzol Reagent. Relative mRNA expression levels of important genes in apoptosis including CASP3, CASP7, CASP8, CASP9, BAX, BCL2, FAS and CYCS were quantified using qPCR in control and dose groups. The IC50 dose of SA in Hep3B and HepG2 cells were found to be 1000 µM and 1150 µM for 72 h, respectively. According to qPCR results, significant increases in the expressions of CASP3 and FAS were determined as 23.37 and 27.47 folds in treated Hep3B cells. On the other hand, SA in HepG2 cells caused a significant increase in the expressions of CASP3, CASP8, CASP9, BAX and FAS as 1.53, 1.77, 1.21, 1.47 and 1.39 folds respectively, compared with the control group. It is considered that SA may cause apoptosis in Hep3B and HepG2 cells. Further studies with SA should be conducted to can be therapeutic agent on hepatocellular carcinoma.
abstract_unstemmed	Hepatocellular carcinoma is one of the most common malignancies in worldwide. Sinapic acid (SA) is a phytochemical found in various fruits and vegetables. The aim of the study was to investigate the effect of SA on apoptosis in Hep3B and HepG2 hepatocellular carcinoma cells. XTT assay was used to determine the cytotoxic effect of SA. Total RNA isolation was conducted using TRIzol Reagent. Relative mRNA expression levels of important genes in apoptosis including CASP3, CASP7, CASP8, CASP9, BAX, BCL2, FAS and CYCS were quantified using qPCR in control and dose groups. The IC50 dose of SA in Hep3B and HepG2 cells were found to be 1000 µM and 1150 µM for 72 h, respectively. According to qPCR results, significant increases in the expressions of CASP3 and FAS were determined as 23.37 and 27.47 folds in treated Hep3B cells. On the other hand, SA in HepG2 cells caused a significant increase in the expressions of CASP3, CASP8, CASP9, BAX and FAS as 1.53, 1.77, 1.21, 1.47 and 1.39 folds respectively, compared with the control group. It is considered that SA may cause apoptosis in Hep3B and HepG2 cells. Further studies with SA should be conducted to can be therapeutic agent on hepatocellular carcinoma.
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title_short	Investigation of Apoptotic Effect of Sinapic Acid in Hep3B and HepG2 Human Hepatocellular Carcinoma Cells
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up_date	2024-07-03T13:53:38.482Z
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