Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations

Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations.

Gespeichert in:

Autor*in:	Yali Xue [verfasserIn] Massimo Mezzavilla [verfasserIn] Marc Haber [verfasserIn] Shane McCarthy [verfasserIn] Yuan Chen [verfasserIn] Vagheesh Narasimhan [verfasserIn] Arthur Gilly [verfasserIn] Qasim Ayub [verfasserIn] Vincenza Colonna [verfasserIn] Lorraine Southam [verfasserIn] Christopher Finan [verfasserIn] Andrea Massaia [verfasserIn] Himanshu Chheda [verfasserIn] Priit Palta [verfasserIn] Graham Ritchie [verfasserIn] Jennifer Asimit [verfasserIn] George Dedoussis [verfasserIn] Paolo Gasparini [verfasserIn] Aarno Palotie [verfasserIn] Samuli Ripatti [verfasserIn] Nicole Soranzo [verfasserIn] Daniela Toniolo [verfasserIn] James F. Wilson [verfasserIn] Richard Durbin [verfasserIn] Chris Tyler-Smith [verfasserIn] Eleftheria Zeggini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 8(2017), 1, Seite 7
Übergeordnetes Werk:	volume:8 ; year:2017 ; number:1 ; pages:7

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/ncomms15927

Katalog-ID:	DOAJ075270102

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allfields	10.1038/ncomms15927 doi (DE-627)DOAJ075270102 (DE-599)DOAJ09e63dea89244cb9bf890f07177b88d2 DE-627 ger DE-627 rakwb eng Yali Xue verfasserin aut Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations. Science Q Massimo Mezzavilla verfasserin aut Marc Haber verfasserin aut Shane McCarthy verfasserin aut Yuan Chen verfasserin aut Vagheesh Narasimhan verfasserin aut Arthur Gilly verfasserin aut Qasim Ayub verfasserin aut Vincenza Colonna verfasserin aut Lorraine Southam verfasserin aut Christopher Finan verfasserin aut Andrea Massaia verfasserin aut Himanshu Chheda verfasserin aut Priit Palta verfasserin aut Graham Ritchie verfasserin aut Jennifer Asimit verfasserin aut George Dedoussis verfasserin aut Paolo Gasparini verfasserin aut Aarno Palotie verfasserin aut Samuli Ripatti verfasserin aut Nicole Soranzo verfasserin aut Daniela Toniolo verfasserin aut James F. Wilson verfasserin aut Richard Durbin verfasserin aut Chris Tyler-Smith verfasserin aut Eleftheria Zeggini verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 7 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:7 https://doi.org/10.1038/ncomms15927 kostenfrei https://doaj.org/article/09e63dea89244cb9bf890f07177b88d2 kostenfrei https://doi.org/10.1038/ncomms15927 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 7
spelling	10.1038/ncomms15927 doi (DE-627)DOAJ075270102 (DE-599)DOAJ09e63dea89244cb9bf890f07177b88d2 DE-627 ger DE-627 rakwb eng Yali Xue verfasserin aut Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations. Science Q Massimo Mezzavilla verfasserin aut Marc Haber verfasserin aut Shane McCarthy verfasserin aut Yuan Chen verfasserin aut Vagheesh Narasimhan verfasserin aut Arthur Gilly verfasserin aut Qasim Ayub verfasserin aut Vincenza Colonna verfasserin aut Lorraine Southam verfasserin aut Christopher Finan verfasserin aut Andrea Massaia verfasserin aut Himanshu Chheda verfasserin aut Priit Palta verfasserin aut Graham Ritchie verfasserin aut Jennifer Asimit verfasserin aut George Dedoussis verfasserin aut Paolo Gasparini verfasserin aut Aarno Palotie verfasserin aut Samuli Ripatti verfasserin aut Nicole Soranzo verfasserin aut Daniela Toniolo verfasserin aut James F. Wilson verfasserin aut Richard Durbin verfasserin aut Chris Tyler-Smith verfasserin aut Eleftheria Zeggini verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 7 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:7 https://doi.org/10.1038/ncomms15927 kostenfrei https://doaj.org/article/09e63dea89244cb9bf890f07177b88d2 kostenfrei https://doi.org/10.1038/ncomms15927 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 7
allfields_unstemmed	10.1038/ncomms15927 doi (DE-627)DOAJ075270102 (DE-599)DOAJ09e63dea89244cb9bf890f07177b88d2 DE-627 ger DE-627 rakwb eng Yali Xue verfasserin aut Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations. Science Q Massimo Mezzavilla verfasserin aut Marc Haber verfasserin aut Shane McCarthy verfasserin aut Yuan Chen verfasserin aut Vagheesh Narasimhan verfasserin aut Arthur Gilly verfasserin aut Qasim Ayub verfasserin aut Vincenza Colonna verfasserin aut Lorraine Southam verfasserin aut Christopher Finan verfasserin aut Andrea Massaia verfasserin aut Himanshu Chheda verfasserin aut Priit Palta verfasserin aut Graham Ritchie verfasserin aut Jennifer Asimit verfasserin aut George Dedoussis verfasserin aut Paolo Gasparini verfasserin aut Aarno Palotie verfasserin aut Samuli Ripatti verfasserin aut Nicole Soranzo verfasserin aut Daniela Toniolo verfasserin aut James F. Wilson verfasserin aut Richard Durbin verfasserin aut Chris Tyler-Smith verfasserin aut Eleftheria Zeggini verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 7 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:7 https://doi.org/10.1038/ncomms15927 kostenfrei https://doaj.org/article/09e63dea89244cb9bf890f07177b88d2 kostenfrei https://doi.org/10.1038/ncomms15927 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 7
allfieldsGer	10.1038/ncomms15927 doi (DE-627)DOAJ075270102 (DE-599)DOAJ09e63dea89244cb9bf890f07177b88d2 DE-627 ger DE-627 rakwb eng Yali Xue verfasserin aut Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations. Science Q Massimo Mezzavilla verfasserin aut Marc Haber verfasserin aut Shane McCarthy verfasserin aut Yuan Chen verfasserin aut Vagheesh Narasimhan verfasserin aut Arthur Gilly verfasserin aut Qasim Ayub verfasserin aut Vincenza Colonna verfasserin aut Lorraine Southam verfasserin aut Christopher Finan verfasserin aut Andrea Massaia verfasserin aut Himanshu Chheda verfasserin aut Priit Palta verfasserin aut Graham Ritchie verfasserin aut Jennifer Asimit verfasserin aut George Dedoussis verfasserin aut Paolo Gasparini verfasserin aut Aarno Palotie verfasserin aut Samuli Ripatti verfasserin aut Nicole Soranzo verfasserin aut Daniela Toniolo verfasserin aut James F. Wilson verfasserin aut Richard Durbin verfasserin aut Chris Tyler-Smith verfasserin aut Eleftheria Zeggini verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 7 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:7 https://doi.org/10.1038/ncomms15927 kostenfrei https://doaj.org/article/09e63dea89244cb9bf890f07177b88d2 kostenfrei https://doi.org/10.1038/ncomms15927 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 7
allfieldsSound	10.1038/ncomms15927 doi (DE-627)DOAJ075270102 (DE-599)DOAJ09e63dea89244cb9bf890f07177b88d2 DE-627 ger DE-627 rakwb eng Yali Xue verfasserin aut Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations. Science Q Massimo Mezzavilla verfasserin aut Marc Haber verfasserin aut Shane McCarthy verfasserin aut Yuan Chen verfasserin aut Vagheesh Narasimhan verfasserin aut Arthur Gilly verfasserin aut Qasim Ayub verfasserin aut Vincenza Colonna verfasserin aut Lorraine Southam verfasserin aut Christopher Finan verfasserin aut Andrea Massaia verfasserin aut Himanshu Chheda verfasserin aut Priit Palta verfasserin aut Graham Ritchie verfasserin aut Jennifer Asimit verfasserin aut George Dedoussis verfasserin aut Paolo Gasparini verfasserin aut Aarno Palotie verfasserin aut Samuli Ripatti verfasserin aut Nicole Soranzo verfasserin aut Daniela Toniolo verfasserin aut James F. Wilson verfasserin aut Richard Durbin verfasserin aut Chris Tyler-Smith verfasserin aut Eleftheria Zeggini verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 7 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:7 https://doi.org/10.1038/ncomms15927 kostenfrei https://doaj.org/article/09e63dea89244cb9bf890f07177b88d2 kostenfrei https://doi.org/10.1038/ncomms15927 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 7
language	English
source	In Nature Communications 8(2017), 1, Seite 7 volume:8 year:2017 number:1 pages:7
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authorswithroles_txt_mv	Yali Xue @@aut@@ Massimo Mezzavilla @@aut@@ Marc Haber @@aut@@ Shane McCarthy @@aut@@ Yuan Chen @@aut@@ Vagheesh Narasimhan @@aut@@ Arthur Gilly @@aut@@ Qasim Ayub @@aut@@ Vincenza Colonna @@aut@@ Lorraine Southam @@aut@@ Christopher Finan @@aut@@ Andrea Massaia @@aut@@ Himanshu Chheda @@aut@@ Priit Palta @@aut@@ Graham Ritchie @@aut@@ Jennifer Asimit @@aut@@ George Dedoussis @@aut@@ Paolo Gasparini @@aut@@ Aarno Palotie @@aut@@ Samuli Ripatti @@aut@@ Nicole Soranzo @@aut@@ Daniela Toniolo @@aut@@ James F. Wilson @@aut@@ Richard Durbin @@aut@@ Chris Tyler-Smith @@aut@@ Eleftheria Zeggini @@aut@@
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author	Yali Xue
spellingShingle	Yali Xue misc Science misc Q Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
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topic_title	Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
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title	Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
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title_full	Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
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author_browse	Yali Xue Massimo Mezzavilla Marc Haber Shane McCarthy Yuan Chen Vagheesh Narasimhan Arthur Gilly Qasim Ayub Vincenza Colonna Lorraine Southam Christopher Finan Andrea Massaia Himanshu Chheda Priit Palta Graham Ritchie Jennifer Asimit George Dedoussis Paolo Gasparini Aarno Palotie Samuli Ripatti Nicole Soranzo Daniela Toniolo James F. Wilson Richard Durbin Chris Tyler-Smith Eleftheria Zeggini
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title_sort	enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated european populations
title_auth	Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
abstract	Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations.
abstractGer	Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations.
abstract_unstemmed	Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations.
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title_short	Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
url	https://doi.org/10.1038/ncomms15927 https://doaj.org/article/09e63dea89244cb9bf890f07177b88d2 https://doaj.org/toc/2041-1723
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author2	Massimo Mezzavilla Marc Haber Shane McCarthy Yuan Chen Vagheesh Narasimhan Arthur Gilly Qasim Ayub Vincenza Colonna Lorraine Southam Christopher Finan Andrea Massaia Himanshu Chheda Priit Palta Graham Ritchie Jennifer Asimit George Dedoussis Paolo Gasparini Aarno Palotie Samuli Ripatti Nicole Soranzo Daniela Toniolo James F. Wilson Richard Durbin Chris Tyler-Smith Eleftheria Zeggini
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up_date	2024-07-03T13:57:34.707Z
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Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations

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