The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel
Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents.
Autor*in: |
Gabriele Stephan [verfasserIn] Lumei Huang [verfasserIn] Yong Tang [verfasserIn] Sandra Vilotti [verfasserIn] Elsa Fabbretti [verfasserIn] Ye Yu [verfasserIn] Wolfgang Nörenberg [verfasserIn] Heike Franke [verfasserIn] Flóra Gölöncsér [verfasserIn] Beáta Sperlágh [verfasserIn] Anke Dopychai [verfasserIn] Ralf Hausmann [verfasserIn] Günther Schmalzing [verfasserIn] Patrizia Rubini [verfasserIn] Peter Illes [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018 |
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Übergeordnetes Werk: |
In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 18 |
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Übergeordnetes Werk: |
volume:9 ; year:2018 ; number:1 ; pages:18 |
Links: |
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DOI / URN: |
10.1038/s41467-018-03728-5 |
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Katalog-ID: |
DOAJ075277875 |
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10.1038/s41467-018-03728-5 doi (DE-627)DOAJ075277875 (DE-599)DOAJa74b5c103f5b4b358a8a947c36ebe64a DE-627 ger DE-627 rakwb eng Gabriele Stephan verfasserin aut The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents. Science Q Lumei Huang verfasserin aut Yong Tang verfasserin aut Sandra Vilotti verfasserin aut Elsa Fabbretti verfasserin aut Ye Yu verfasserin aut Wolfgang Nörenberg verfasserin aut Heike Franke verfasserin aut Flóra Gölöncsér verfasserin aut Beáta Sperlágh verfasserin aut Anke Dopychai verfasserin aut Ralf Hausmann verfasserin aut Günther Schmalzing verfasserin aut Patrizia Rubini verfasserin aut Peter Illes verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 18 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:18 https://doi.org/10.1038/s41467-018-03728-5 kostenfrei https://doaj.org/article/a74b5c103f5b4b358a8a947c36ebe64a kostenfrei https://doi.org/10.1038/s41467-018-03728-5 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 18 |
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10.1038/s41467-018-03728-5 doi (DE-627)DOAJ075277875 (DE-599)DOAJa74b5c103f5b4b358a8a947c36ebe64a DE-627 ger DE-627 rakwb eng Gabriele Stephan verfasserin aut The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents. Science Q Lumei Huang verfasserin aut Yong Tang verfasserin aut Sandra Vilotti verfasserin aut Elsa Fabbretti verfasserin aut Ye Yu verfasserin aut Wolfgang Nörenberg verfasserin aut Heike Franke verfasserin aut Flóra Gölöncsér verfasserin aut Beáta Sperlágh verfasserin aut Anke Dopychai verfasserin aut Ralf Hausmann verfasserin aut Günther Schmalzing verfasserin aut Patrizia Rubini verfasserin aut Peter Illes verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 18 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:18 https://doi.org/10.1038/s41467-018-03728-5 kostenfrei https://doaj.org/article/a74b5c103f5b4b358a8a947c36ebe64a kostenfrei https://doi.org/10.1038/s41467-018-03728-5 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 18 |
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10.1038/s41467-018-03728-5 doi (DE-627)DOAJ075277875 (DE-599)DOAJa74b5c103f5b4b358a8a947c36ebe64a DE-627 ger DE-627 rakwb eng Gabriele Stephan verfasserin aut The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents. Science Q Lumei Huang verfasserin aut Yong Tang verfasserin aut Sandra Vilotti verfasserin aut Elsa Fabbretti verfasserin aut Ye Yu verfasserin aut Wolfgang Nörenberg verfasserin aut Heike Franke verfasserin aut Flóra Gölöncsér verfasserin aut Beáta Sperlágh verfasserin aut Anke Dopychai verfasserin aut Ralf Hausmann verfasserin aut Günther Schmalzing verfasserin aut Patrizia Rubini verfasserin aut Peter Illes verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 18 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:18 https://doi.org/10.1038/s41467-018-03728-5 kostenfrei https://doaj.org/article/a74b5c103f5b4b358a8a947c36ebe64a kostenfrei https://doi.org/10.1038/s41467-018-03728-5 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 18 |
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10.1038/s41467-018-03728-5 doi (DE-627)DOAJ075277875 (DE-599)DOAJa74b5c103f5b4b358a8a947c36ebe64a DE-627 ger DE-627 rakwb eng Gabriele Stephan verfasserin aut The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents. Science Q Lumei Huang verfasserin aut Yong Tang verfasserin aut Sandra Vilotti verfasserin aut Elsa Fabbretti verfasserin aut Ye Yu verfasserin aut Wolfgang Nörenberg verfasserin aut Heike Franke verfasserin aut Flóra Gölöncsér verfasserin aut Beáta Sperlágh verfasserin aut Anke Dopychai verfasserin aut Ralf Hausmann verfasserin aut Günther Schmalzing verfasserin aut Patrizia Rubini verfasserin aut Peter Illes verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 18 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:18 https://doi.org/10.1038/s41467-018-03728-5 kostenfrei https://doaj.org/article/a74b5c103f5b4b358a8a947c36ebe64a kostenfrei https://doi.org/10.1038/s41467-018-03728-5 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 18 |
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The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
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The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
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Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents. |
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Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents. |
abstract_unstemmed |
Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents. |
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The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
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