Direct quality control of glycoengineered erythropoietin variants

Several therapeutics are glycosylated proteins, yet the analysis of their specific glycosylation patterns remains challenging. Here the authors demonstrate an approach for the detailed characterization of glycosylated biopharmaceuticals applied to the determination of the glycoproteoform profile of...
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Gespeichert in:

Autor*in:	Tomislav Čaval [verfasserIn] Weihua Tian [verfasserIn] Zhang Yang [verfasserIn] Henrik Clausen [verfasserIn] Albert J. R. Heck [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 8
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-018-05536-3

Katalog-ID:	DOAJ075278456

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author	Tomislav Čaval
spellingShingle	Tomislav Čaval misc Science misc Q Direct quality control of glycoengineered erythropoietin variants
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topic_title	Direct quality control of glycoengineered erythropoietin variants
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title	Direct quality control of glycoengineered erythropoietin variants
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title_full	Direct quality control of glycoengineered erythropoietin variants
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title_sort	direct quality control of glycoengineered erythropoietin variants
title_auth	Direct quality control of glycoengineered erythropoietin variants
abstract	Several therapeutics are glycosylated proteins, yet the analysis of their specific glycosylation patterns remains challenging. Here the authors demonstrate an approach for the detailed characterization of glycosylated biopharmaceuticals applied to the determination of the glycoproteoform profile of glycoengineered variants of erythropoietin.
abstractGer	Several therapeutics are glycosylated proteins, yet the analysis of their specific glycosylation patterns remains challenging. Here the authors demonstrate an approach for the detailed characterization of glycosylated biopharmaceuticals applied to the determination of the glycoproteoform profile of glycoengineered variants of erythropoietin.
abstract_unstemmed	Several therapeutics are glycosylated proteins, yet the analysis of their specific glycosylation patterns remains challenging. Here the authors demonstrate an approach for the detailed characterization of glycosylated biopharmaceuticals applied to the determination of the glycoproteoform profile of glycoengineered variants of erythropoietin.
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title_short	Direct quality control of glycoengineered erythropoietin variants
url	https://doi.org/10.1038/s41467-018-05536-3 https://doaj.org/article/6d591091bbd4425594268aada88a4112 https://doaj.org/toc/2041-1723
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