Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors

The successful development of the proteasome inhibitor bortezomib as an anticancer drug has improved survival in patients with multiple myeloma. With the emergence of the newly US Food and Drug Administration-approved proteasome inhibitor carfilzomib, ongoing trials are investigating this compound a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Angel Chao [verfasserIn] Tzu-Hao Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	apoptosis autophagy bortezomib proteasome inhibitors solid tumors

Übergeordnetes Werk:	In: Taiwanese Journal of Obstetrics & Gynecology - Elsevier, 2017, 55(2016), 1, Seite 3-8
Übergeordnetes Werk:	volume:55 ; year:2016 ; number:1 ; pages:3-8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.tjog.2015.12.004

Katalog-ID:	DOAJ075434571

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spelling	10.1016/j.tjog.2015.12.004 doi (DE-627)DOAJ075434571 (DE-599)DOAJf96066956f8b48dab2a1a39aa265c5ae DE-627 ger DE-627 rakwb eng RG1-991 Angel Chao verfasserin aut Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The successful development of the proteasome inhibitor bortezomib as an anticancer drug has improved survival in patients with multiple myeloma. With the emergence of the newly US Food and Drug Administration-approved proteasome inhibitor carfilzomib, ongoing trials are investigating this compound and other proteasome inhibitors either alone or in combination with other chemotherapy drugs. However, in solid tumors, the efficacy of proteasome inhibitors has not lived up to expectations. Results regarding the potential clinical efficacy of bortezomib combined with other agents in the treatment of solid tumors are eagerly awaited. Recent identification of the molecular mechanisms (involving apoptosis and autophagy) by which bortezomib and cisplatin can overcome chemotherapy resistance and sensitize tumor cells to anticancer therapy can provide insights into the development of novel therapeutic strategies for patients with solid malignancies. apoptosis autophagy bortezomib proteasome inhibitors solid tumors Gynecology and obstetrics Tzu-Hao Wang verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 55(2016), 1, Seite 3-8 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:55 year:2016 number:1 pages:3-8 https://doi.org/10.1016/j.tjog.2015.12.004 kostenfrei https://doaj.org/article/f96066956f8b48dab2a1a39aa265c5ae kostenfrei http://www.sciencedirect.com/science/article/pii/S1028455915002879 kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2016 1 3-8
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allfieldsGer	10.1016/j.tjog.2015.12.004 doi (DE-627)DOAJ075434571 (DE-599)DOAJf96066956f8b48dab2a1a39aa265c5ae DE-627 ger DE-627 rakwb eng RG1-991 Angel Chao verfasserin aut Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The successful development of the proteasome inhibitor bortezomib as an anticancer drug has improved survival in patients with multiple myeloma. With the emergence of the newly US Food and Drug Administration-approved proteasome inhibitor carfilzomib, ongoing trials are investigating this compound and other proteasome inhibitors either alone or in combination with other chemotherapy drugs. However, in solid tumors, the efficacy of proteasome inhibitors has not lived up to expectations. Results regarding the potential clinical efficacy of bortezomib combined with other agents in the treatment of solid tumors are eagerly awaited. Recent identification of the molecular mechanisms (involving apoptosis and autophagy) by which bortezomib and cisplatin can overcome chemotherapy resistance and sensitize tumor cells to anticancer therapy can provide insights into the development of novel therapeutic strategies for patients with solid malignancies. apoptosis autophagy bortezomib proteasome inhibitors solid tumors Gynecology and obstetrics Tzu-Hao Wang verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 55(2016), 1, Seite 3-8 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:55 year:2016 number:1 pages:3-8 https://doi.org/10.1016/j.tjog.2015.12.004 kostenfrei https://doaj.org/article/f96066956f8b48dab2a1a39aa265c5ae kostenfrei http://www.sciencedirect.com/science/article/pii/S1028455915002879 kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2016 1 3-8
allfieldsSound	10.1016/j.tjog.2015.12.004 doi (DE-627)DOAJ075434571 (DE-599)DOAJf96066956f8b48dab2a1a39aa265c5ae DE-627 ger DE-627 rakwb eng RG1-991 Angel Chao verfasserin aut Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The successful development of the proteasome inhibitor bortezomib as an anticancer drug has improved survival in patients with multiple myeloma. With the emergence of the newly US Food and Drug Administration-approved proteasome inhibitor carfilzomib, ongoing trials are investigating this compound and other proteasome inhibitors either alone or in combination with other chemotherapy drugs. However, in solid tumors, the efficacy of proteasome inhibitors has not lived up to expectations. Results regarding the potential clinical efficacy of bortezomib combined with other agents in the treatment of solid tumors are eagerly awaited. Recent identification of the molecular mechanisms (involving apoptosis and autophagy) by which bortezomib and cisplatin can overcome chemotherapy resistance and sensitize tumor cells to anticancer therapy can provide insights into the development of novel therapeutic strategies for patients with solid malignancies. apoptosis autophagy bortezomib proteasome inhibitors solid tumors Gynecology and obstetrics Tzu-Hao Wang verfasserin aut In Taiwanese Journal of Obstetrics & Gynecology Elsevier, 2017 55(2016), 1, Seite 3-8 (DE-627)500021422 (DE-600)2202946-1 10284559 nnns volume:55 year:2016 number:1 pages:3-8 https://doi.org/10.1016/j.tjog.2015.12.004 kostenfrei https://doaj.org/article/f96066956f8b48dab2a1a39aa265c5ae kostenfrei http://www.sciencedirect.com/science/article/pii/S1028455915002879 kostenfrei https://doaj.org/toc/1028-4559 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2016 1 3-8
language	English
source	In Taiwanese Journal of Obstetrics & Gynecology 55(2016), 1, Seite 3-8 volume:55 year:2016 number:1 pages:3-8
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container_title	Taiwanese Journal of Obstetrics & Gynecology
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author	Angel Chao
spellingShingle	Angel Chao misc RG1-991 misc apoptosis misc autophagy misc bortezomib misc proteasome inhibitors misc solid tumors misc Gynecology and obstetrics Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors
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topic_title	RG1-991 Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors apoptosis autophagy bortezomib proteasome inhibitors solid tumors
topic	misc RG1-991 misc apoptosis misc autophagy misc bortezomib misc proteasome inhibitors misc solid tumors misc Gynecology and obstetrics
topic_unstemmed	misc RG1-991 misc apoptosis misc autophagy misc bortezomib misc proteasome inhibitors misc solid tumors misc Gynecology and obstetrics
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title	Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors
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title_full	Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors
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title_sort	molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors
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title_auth	Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors
abstract	The successful development of the proteasome inhibitor bortezomib as an anticancer drug has improved survival in patients with multiple myeloma. With the emergence of the newly US Food and Drug Administration-approved proteasome inhibitor carfilzomib, ongoing trials are investigating this compound and other proteasome inhibitors either alone or in combination with other chemotherapy drugs. However, in solid tumors, the efficacy of proteasome inhibitors has not lived up to expectations. Results regarding the potential clinical efficacy of bortezomib combined with other agents in the treatment of solid tumors are eagerly awaited. Recent identification of the molecular mechanisms (involving apoptosis and autophagy) by which bortezomib and cisplatin can overcome chemotherapy resistance and sensitize tumor cells to anticancer therapy can provide insights into the development of novel therapeutic strategies for patients with solid malignancies.
abstractGer	The successful development of the proteasome inhibitor bortezomib as an anticancer drug has improved survival in patients with multiple myeloma. With the emergence of the newly US Food and Drug Administration-approved proteasome inhibitor carfilzomib, ongoing trials are investigating this compound and other proteasome inhibitors either alone or in combination with other chemotherapy drugs. However, in solid tumors, the efficacy of proteasome inhibitors has not lived up to expectations. Results regarding the potential clinical efficacy of bortezomib combined with other agents in the treatment of solid tumors are eagerly awaited. Recent identification of the molecular mechanisms (involving apoptosis and autophagy) by which bortezomib and cisplatin can overcome chemotherapy resistance and sensitize tumor cells to anticancer therapy can provide insights into the development of novel therapeutic strategies for patients with solid malignancies.
abstract_unstemmed	The successful development of the proteasome inhibitor bortezomib as an anticancer drug has improved survival in patients with multiple myeloma. With the emergence of the newly US Food and Drug Administration-approved proteasome inhibitor carfilzomib, ongoing trials are investigating this compound and other proteasome inhibitors either alone or in combination with other chemotherapy drugs. However, in solid tumors, the efficacy of proteasome inhibitors has not lived up to expectations. Results regarding the potential clinical efficacy of bortezomib combined with other agents in the treatment of solid tumors are eagerly awaited. Recent identification of the molecular mechanisms (involving apoptosis and autophagy) by which bortezomib and cisplatin can overcome chemotherapy resistance and sensitize tumor cells to anticancer therapy can provide insights into the development of novel therapeutic strategies for patients with solid malignancies.
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title_short	Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors
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Molecular mechanisms for synergistic effect of proteasome inhibitors with platinum-based therapy in solid tumors

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