Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division

Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experime...
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Autor*in:	Andrea Vecchiola [verfasserIn] Cristóbal A. Fuentes [verfasserIn] Isidora Solar [verfasserIn] Carlos F. Lagos [verfasserIn] Maria Cecilia Opazo [verfasserIn] Natalia Muñoz-Durango [verfasserIn] Claudia A. Riedel [verfasserIn] Gareth I. Owen [verfasserIn] Alexis M. Kalergis [verfasserIn] Carlos E. Fardella [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	obesity aldosterone mineralocorticoid receptor MR antagonists eplerenone high-fat diet animal model

Übergeordnetes Werk:	In: Frontiers in Endocrinology - Frontiers Media S.A., 2011, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fendo.2020.00223

Katalog-ID:	DOAJ07548739X

Internformat


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520			\|a Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experimental approach: A group of mice with implanted placebo pellets were fed using two types of diet, a normal (ND) or a high fat (HFD) diet. Additionally, a group of mice fed HFD were implanted with an eplerenone pellet. Metabolic and biochemical parameters were assessed in each animal group. Adipocyte size and lipid accumulation were investigated in the liver and adipose tissue. We evaluated the components of renin-angiotensin-aldosterone system (RAAS) locally in adipose tissue.Key results: Eplerenone reduced HFD-induced body weight gain, fasting glucose levels, fat accumulation, HFD-induced adipocyte size and liver lipid accumulation and improved glucose tolerance. In the adipose tissue, HFD significantly increased the mRNA levels of the RAAS molecules relative to the ND group. Eplerenone lowered RAAS mRNA levels, components of lipid metabolism and markers of inflammation in HFD-fed animals.Conclusion: MR antagonism with eplerenone diminishes insulin resistance that is related to obesity partly via a reduction of RAAS activation, inflammatory progression and cytokines induction. This suggests that eplerenone should be further studied as a therapeutic option for obesity and overweight.
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allfields	10.3389/fendo.2020.00223 doi (DE-627)DOAJ07548739X (DE-599)DOAJff0efca0491648a4a82847b55c577659 DE-627 ger DE-627 rakwb eng RC648-665 Andrea Vecchiola verfasserin aut Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experimental approach: A group of mice with implanted placebo pellets were fed using two types of diet, a normal (ND) or a high fat (HFD) diet. Additionally, a group of mice fed HFD were implanted with an eplerenone pellet. Metabolic and biochemical parameters were assessed in each animal group. Adipocyte size and lipid accumulation were investigated in the liver and adipose tissue. We evaluated the components of renin-angiotensin-aldosterone system (RAAS) locally in adipose tissue.Key results: Eplerenone reduced HFD-induced body weight gain, fasting glucose levels, fat accumulation, HFD-induced adipocyte size and liver lipid accumulation and improved glucose tolerance. In the adipose tissue, HFD significantly increased the mRNA levels of the RAAS molecules relative to the ND group. Eplerenone lowered RAAS mRNA levels, components of lipid metabolism and markers of inflammation in HFD-fed animals.Conclusion: MR antagonism with eplerenone diminishes insulin resistance that is related to obesity partly via a reduction of RAAS activation, inflammatory progression and cytokines induction. This suggests that eplerenone should be further studied as a therapeutic option for obesity and overweight. obesity aldosterone mineralocorticoid receptor MR antagonists eplerenone high-fat diet animal model Diseases of the endocrine glands. Clinical endocrinology Andrea Vecchiola verfasserin aut Cristóbal A. Fuentes verfasserin aut Isidora Solar verfasserin aut Carlos F. Lagos verfasserin aut Maria Cecilia Opazo verfasserin aut Maria Cecilia Opazo verfasserin aut Natalia Muñoz-Durango verfasserin aut Natalia Muñoz-Durango verfasserin aut Claudia A. Riedel verfasserin aut Claudia A. Riedel verfasserin aut Gareth I. Owen verfasserin aut Gareth I. Owen verfasserin aut Alexis M. Kalergis verfasserin aut Alexis M. Kalergis verfasserin aut Alexis M. Kalergis verfasserin aut Carlos E. Fardella verfasserin aut Carlos E. Fardella verfasserin aut Carlos E. Fardella verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 11(2020) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:11 year:2020 https://doi.org/10.3389/fendo.2020.00223 kostenfrei https://doaj.org/article/ff0efca0491648a4a82847b55c577659 kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2020.00223/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
spelling	10.3389/fendo.2020.00223 doi (DE-627)DOAJ07548739X (DE-599)DOAJff0efca0491648a4a82847b55c577659 DE-627 ger DE-627 rakwb eng RC648-665 Andrea Vecchiola verfasserin aut Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experimental approach: A group of mice with implanted placebo pellets were fed using two types of diet, a normal (ND) or a high fat (HFD) diet. Additionally, a group of mice fed HFD were implanted with an eplerenone pellet. Metabolic and biochemical parameters were assessed in each animal group. Adipocyte size and lipid accumulation were investigated in the liver and adipose tissue. We evaluated the components of renin-angiotensin-aldosterone system (RAAS) locally in adipose tissue.Key results: Eplerenone reduced HFD-induced body weight gain, fasting glucose levels, fat accumulation, HFD-induced adipocyte size and liver lipid accumulation and improved glucose tolerance. In the adipose tissue, HFD significantly increased the mRNA levels of the RAAS molecules relative to the ND group. Eplerenone lowered RAAS mRNA levels, components of lipid metabolism and markers of inflammation in HFD-fed animals.Conclusion: MR antagonism with eplerenone diminishes insulin resistance that is related to obesity partly via a reduction of RAAS activation, inflammatory progression and cytokines induction. This suggests that eplerenone should be further studied as a therapeutic option for obesity and overweight. obesity aldosterone mineralocorticoid receptor MR antagonists eplerenone high-fat diet animal model Diseases of the endocrine glands. Clinical endocrinology Andrea Vecchiola verfasserin aut Cristóbal A. Fuentes verfasserin aut Isidora Solar verfasserin aut Carlos F. Lagos verfasserin aut Maria Cecilia Opazo verfasserin aut Maria Cecilia Opazo verfasserin aut Natalia Muñoz-Durango verfasserin aut Natalia Muñoz-Durango verfasserin aut Claudia A. Riedel verfasserin aut Claudia A. Riedel verfasserin aut Gareth I. Owen verfasserin aut Gareth I. Owen verfasserin aut Alexis M. Kalergis verfasserin aut Alexis M. Kalergis verfasserin aut Alexis M. Kalergis verfasserin aut Carlos E. Fardella verfasserin aut Carlos E. Fardella verfasserin aut Carlos E. Fardella verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 11(2020) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:11 year:2020 https://doi.org/10.3389/fendo.2020.00223 kostenfrei https://doaj.org/article/ff0efca0491648a4a82847b55c577659 kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2020.00223/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
allfields_unstemmed	10.3389/fendo.2020.00223 doi (DE-627)DOAJ07548739X (DE-599)DOAJff0efca0491648a4a82847b55c577659 DE-627 ger DE-627 rakwb eng RC648-665 Andrea Vecchiola verfasserin aut Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experimental approach: A group of mice with implanted placebo pellets were fed using two types of diet, a normal (ND) or a high fat (HFD) diet. Additionally, a group of mice fed HFD were implanted with an eplerenone pellet. Metabolic and biochemical parameters were assessed in each animal group. Adipocyte size and lipid accumulation were investigated in the liver and adipose tissue. We evaluated the components of renin-angiotensin-aldosterone system (RAAS) locally in adipose tissue.Key results: Eplerenone reduced HFD-induced body weight gain, fasting glucose levels, fat accumulation, HFD-induced adipocyte size and liver lipid accumulation and improved glucose tolerance. In the adipose tissue, HFD significantly increased the mRNA levels of the RAAS molecules relative to the ND group. Eplerenone lowered RAAS mRNA levels, components of lipid metabolism and markers of inflammation in HFD-fed animals.Conclusion: MR antagonism with eplerenone diminishes insulin resistance that is related to obesity partly via a reduction of RAAS activation, inflammatory progression and cytokines induction. This suggests that eplerenone should be further studied as a therapeutic option for obesity and overweight. obesity aldosterone mineralocorticoid receptor MR antagonists eplerenone high-fat diet animal model Diseases of the endocrine glands. Clinical endocrinology Andrea Vecchiola verfasserin aut Cristóbal A. Fuentes verfasserin aut Isidora Solar verfasserin aut Carlos F. Lagos verfasserin aut Maria Cecilia Opazo verfasserin aut Maria Cecilia Opazo verfasserin aut Natalia Muñoz-Durango verfasserin aut Natalia Muñoz-Durango verfasserin aut Claudia A. Riedel verfasserin aut Claudia A. Riedel verfasserin aut Gareth I. Owen verfasserin aut Gareth I. Owen verfasserin aut Alexis M. Kalergis verfasserin aut Alexis M. Kalergis verfasserin aut Alexis M. Kalergis verfasserin aut Carlos E. Fardella verfasserin aut Carlos E. Fardella verfasserin aut Carlos E. Fardella verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 11(2020) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:11 year:2020 https://doi.org/10.3389/fendo.2020.00223 kostenfrei https://doaj.org/article/ff0efca0491648a4a82847b55c577659 kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2020.00223/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
allfieldsGer	10.3389/fendo.2020.00223 doi (DE-627)DOAJ07548739X (DE-599)DOAJff0efca0491648a4a82847b55c577659 DE-627 ger DE-627 rakwb eng RC648-665 Andrea Vecchiola verfasserin aut Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experimental approach: A group of mice with implanted placebo pellets were fed using two types of diet, a normal (ND) or a high fat (HFD) diet. Additionally, a group of mice fed HFD were implanted with an eplerenone pellet. Metabolic and biochemical parameters were assessed in each animal group. Adipocyte size and lipid accumulation were investigated in the liver and adipose tissue. We evaluated the components of renin-angiotensin-aldosterone system (RAAS) locally in adipose tissue.Key results: Eplerenone reduced HFD-induced body weight gain, fasting glucose levels, fat accumulation, HFD-induced adipocyte size and liver lipid accumulation and improved glucose tolerance. In the adipose tissue, HFD significantly increased the mRNA levels of the RAAS molecules relative to the ND group. Eplerenone lowered RAAS mRNA levels, components of lipid metabolism and markers of inflammation in HFD-fed animals.Conclusion: MR antagonism with eplerenone diminishes insulin resistance that is related to obesity partly via a reduction of RAAS activation, inflammatory progression and cytokines induction. This suggests that eplerenone should be further studied as a therapeutic option for obesity and overweight. obesity aldosterone mineralocorticoid receptor MR antagonists eplerenone high-fat diet animal model Diseases of the endocrine glands. Clinical endocrinology Andrea Vecchiola verfasserin aut Cristóbal A. Fuentes verfasserin aut Isidora Solar verfasserin aut Carlos F. Lagos verfasserin aut Maria Cecilia Opazo verfasserin aut Maria Cecilia Opazo verfasserin aut Natalia Muñoz-Durango verfasserin aut Natalia Muñoz-Durango verfasserin aut Claudia A. Riedel verfasserin aut Claudia A. Riedel verfasserin aut Gareth I. Owen verfasserin aut Gareth I. Owen verfasserin aut Alexis M. Kalergis verfasserin aut Alexis M. Kalergis verfasserin aut Alexis M. Kalergis verfasserin aut Carlos E. Fardella verfasserin aut Carlos E. Fardella verfasserin aut Carlos E. Fardella verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 11(2020) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:11 year:2020 https://doi.org/10.3389/fendo.2020.00223 kostenfrei https://doaj.org/article/ff0efca0491648a4a82847b55c577659 kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2020.00223/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
allfieldsSound	10.3389/fendo.2020.00223 doi (DE-627)DOAJ07548739X (DE-599)DOAJff0efca0491648a4a82847b55c577659 DE-627 ger DE-627 rakwb eng RC648-665 Andrea Vecchiola verfasserin aut Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experimental approach: A group of mice with implanted placebo pellets were fed using two types of diet, a normal (ND) or a high fat (HFD) diet. Additionally, a group of mice fed HFD were implanted with an eplerenone pellet. Metabolic and biochemical parameters were assessed in each animal group. Adipocyte size and lipid accumulation were investigated in the liver and adipose tissue. We evaluated the components of renin-angiotensin-aldosterone system (RAAS) locally in adipose tissue.Key results: Eplerenone reduced HFD-induced body weight gain, fasting glucose levels, fat accumulation, HFD-induced adipocyte size and liver lipid accumulation and improved glucose tolerance. In the adipose tissue, HFD significantly increased the mRNA levels of the RAAS molecules relative to the ND group. Eplerenone lowered RAAS mRNA levels, components of lipid metabolism and markers of inflammation in HFD-fed animals.Conclusion: MR antagonism with eplerenone diminishes insulin resistance that is related to obesity partly via a reduction of RAAS activation, inflammatory progression and cytokines induction. This suggests that eplerenone should be further studied as a therapeutic option for obesity and overweight. obesity aldosterone mineralocorticoid receptor MR antagonists eplerenone high-fat diet animal model Diseases of the endocrine glands. Clinical endocrinology Andrea Vecchiola verfasserin aut Cristóbal A. Fuentes verfasserin aut Isidora Solar verfasserin aut Carlos F. Lagos verfasserin aut Maria Cecilia Opazo verfasserin aut Maria Cecilia Opazo verfasserin aut Natalia Muñoz-Durango verfasserin aut Natalia Muñoz-Durango verfasserin aut Claudia A. Riedel verfasserin aut Claudia A. Riedel verfasserin aut Gareth I. Owen verfasserin aut Gareth I. Owen verfasserin aut Alexis M. Kalergis verfasserin aut Alexis M. Kalergis verfasserin aut Alexis M. Kalergis verfasserin aut Carlos E. Fardella verfasserin aut Carlos E. Fardella verfasserin aut Carlos E. Fardella verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 11(2020) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:11 year:2020 https://doi.org/10.3389/fendo.2020.00223 kostenfrei https://doaj.org/article/ff0efca0491648a4a82847b55c577659 kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2020.00223/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
language	English
source	In Frontiers in Endocrinology 11(2020) volume:11 year:2020
sourceStr	In Frontiers in Endocrinology 11(2020) volume:11 year:2020
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	obesity aldosterone mineralocorticoid receptor MR antagonists eplerenone high-fat diet animal model Diseases of the endocrine glands. Clinical endocrinology
isfreeaccess_bool	true
container_title	Frontiers in Endocrinology
authorswithroles_txt_mv	Andrea Vecchiola @@aut@@ Cristóbal A. Fuentes @@aut@@ Isidora Solar @@aut@@ Carlos F. Lagos @@aut@@ Maria Cecilia Opazo @@aut@@ Natalia Muñoz-Durango @@aut@@ Claudia A. Riedel @@aut@@ Gareth I. Owen @@aut@@ Alexis M. Kalergis @@aut@@ Carlos E. Fardella @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	645090948
id	DOAJ07548739X
language_de	englisch
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callnumber-first	R - Medicine
author	Andrea Vecchiola
spellingShingle	Andrea Vecchiola misc RC648-665 misc obesity misc aldosterone misc mineralocorticoid receptor misc MR antagonists misc eplerenone misc high-fat diet animal model misc Diseases of the endocrine glands. Clinical endocrinology Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division
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topic_title	RC648-665 Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division obesity aldosterone mineralocorticoid receptor MR antagonists eplerenone high-fat diet animal model
topic	misc RC648-665 misc obesity misc aldosterone misc mineralocorticoid receptor misc MR antagonists misc eplerenone misc high-fat diet animal model misc Diseases of the endocrine glands. Clinical endocrinology
topic_unstemmed	misc RC648-665 misc obesity misc aldosterone misc mineralocorticoid receptor misc MR antagonists misc eplerenone misc high-fat diet animal model misc Diseases of the endocrine glands. Clinical endocrinology
topic_browse	misc RC648-665 misc obesity misc aldosterone misc mineralocorticoid receptor misc MR antagonists misc eplerenone misc high-fat diet animal model misc Diseases of the endocrine glands. Clinical endocrinology
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title	Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division
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title_full	Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division
author_sort	Andrea Vecchiola
journal	Frontiers in Endocrinology
journalStr	Frontiers in Endocrinology
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author_browse	Andrea Vecchiola Cristóbal A. Fuentes Isidora Solar Carlos F. Lagos Maria Cecilia Opazo Natalia Muñoz-Durango Claudia A. Riedel Gareth I. Owen Alexis M. Kalergis Carlos E. Fardella
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doi_str_mv	10.3389/fendo.2020.00223
author2-role	verfasserin
title_sort	eplerenone implantation improved adipose dysfunction averting raas activation and cell division
callnumber	RC648-665
title_auth	Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division
abstract	Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experimental approach: A group of mice with implanted placebo pellets were fed using two types of diet, a normal (ND) or a high fat (HFD) diet. Additionally, a group of mice fed HFD were implanted with an eplerenone pellet. Metabolic and biochemical parameters were assessed in each animal group. Adipocyte size and lipid accumulation were investigated in the liver and adipose tissue. We evaluated the components of renin-angiotensin-aldosterone system (RAAS) locally in adipose tissue.Key results: Eplerenone reduced HFD-induced body weight gain, fasting glucose levels, fat accumulation, HFD-induced adipocyte size and liver lipid accumulation and improved glucose tolerance. In the adipose tissue, HFD significantly increased the mRNA levels of the RAAS molecules relative to the ND group. Eplerenone lowered RAAS mRNA levels, components of lipid metabolism and markers of inflammation in HFD-fed animals.Conclusion: MR antagonism with eplerenone diminishes insulin resistance that is related to obesity partly via a reduction of RAAS activation, inflammatory progression and cytokines induction. This suggests that eplerenone should be further studied as a therapeutic option for obesity and overweight.
abstractGer	Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experimental approach: A group of mice with implanted placebo pellets were fed using two types of diet, a normal (ND) or a high fat (HFD) diet. Additionally, a group of mice fed HFD were implanted with an eplerenone pellet. Metabolic and biochemical parameters were assessed in each animal group. Adipocyte size and lipid accumulation were investigated in the liver and adipose tissue. We evaluated the components of renin-angiotensin-aldosterone system (RAAS) locally in adipose tissue.Key results: Eplerenone reduced HFD-induced body weight gain, fasting glucose levels, fat accumulation, HFD-induced adipocyte size and liver lipid accumulation and improved glucose tolerance. In the adipose tissue, HFD significantly increased the mRNA levels of the RAAS molecules relative to the ND group. Eplerenone lowered RAAS mRNA levels, components of lipid metabolism and markers of inflammation in HFD-fed animals.Conclusion: MR antagonism with eplerenone diminishes insulin resistance that is related to obesity partly via a reduction of RAAS activation, inflammatory progression and cytokines induction. This suggests that eplerenone should be further studied as a therapeutic option for obesity and overweight.
abstract_unstemmed	Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impact of eplerenone implantation upon obesity.Experimental approach: A group of mice with implanted placebo pellets were fed using two types of diet, a normal (ND) or a high fat (HFD) diet. Additionally, a group of mice fed HFD were implanted with an eplerenone pellet. Metabolic and biochemical parameters were assessed in each animal group. Adipocyte size and lipid accumulation were investigated in the liver and adipose tissue. We evaluated the components of renin-angiotensin-aldosterone system (RAAS) locally in adipose tissue.Key results: Eplerenone reduced HFD-induced body weight gain, fasting glucose levels, fat accumulation, HFD-induced adipocyte size and liver lipid accumulation and improved glucose tolerance. In the adipose tissue, HFD significantly increased the mRNA levels of the RAAS molecules relative to the ND group. Eplerenone lowered RAAS mRNA levels, components of lipid metabolism and markers of inflammation in HFD-fed animals.Conclusion: MR antagonism with eplerenone diminishes insulin resistance that is related to obesity partly via a reduction of RAAS activation, inflammatory progression and cytokines induction. This suggests that eplerenone should be further studied as a therapeutic option for obesity and overweight.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
title_short	Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division
url	https://doi.org/10.3389/fendo.2020.00223 https://doaj.org/article/ff0efca0491648a4a82847b55c577659 https://www.frontiersin.org/article/10.3389/fendo.2020.00223/full https://doaj.org/toc/1664-2392
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author2	Andrea Vecchiola Cristóbal A. Fuentes Isidora Solar Carlos F. Lagos Maria Cecilia Opazo Natalia Muñoz-Durango Claudia A. Riedel Gareth I. Owen Alexis M. Kalergis Carlos E. Fardella
author2Str	Andrea Vecchiola Cristóbal A. Fuentes Isidora Solar Carlos F. Lagos Maria Cecilia Opazo Natalia Muñoz-Durango Claudia A. Riedel Gareth I. Owen Alexis M. Kalergis Carlos E. Fardella
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doi_str	10.3389/fendo.2020.00223
callnumber-a	RC648-665
up_date	2024-07-03T15:10:53.133Z
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Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division

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