Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate

Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer signaling to control cell behaviors. Here, we...
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Autor*in:	Liang Guo [verfasserIn] Kan Zhu [verfasserIn] Michael Pargett [verfasserIn] Adam Contreras [verfasserIn] Patrick Tsai [verfasserIn] Quan Qing [verfasserIn] Wolfgang Losert [verfasserIn] John Albeck [verfasserIn] Min Zhao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Biotechnology Cell biology Integrative aspects of cell biology Functional aspects of cell biology

Übergeordnetes Werk:	In: iScience - Elsevier, 2019, 24(2021), 11, Seite 103240-
Übergeordnetes Werk:	volume:24 ; year:2021 ; number:11 ; pages:103240-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.isci.2021.103240

Katalog-ID:	DOAJ075498103

Internformat


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allfields	10.1016/j.isci.2021.103240 doi (DE-627)DOAJ075498103 (DE-599)DOAJ1d7951c8fef84b53b75c23fe71a219f8 DE-627 ger DE-627 rakwb eng Liang Guo verfasserin aut Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer signaling to control cell behaviors. Here, we showed a practical approach to achieve precise amplitude modulation (AM), frequency modulation (FM), and duration modulation (DM) of MAP kinase activation. Alternating current (AC) electrical stimulation induced synchronized ERK activation. Amplitude and duration of ERK activation were controlled by varying stimulation strength and duration. ERK activation frequencies were arbitrarily modulated with trains of short AC applications with accurately defined intervals. Significantly, ERK dynamics coded by well-designed AC can rewire PC12 cell fate independent of growth factors. This technique can be used to synchronize and modulate ERK activation dynamics, thus would offer a practical way to control cell behaviors in vivo without the use of biochemical agents or genetic manipulation. Biotechnology Cell biology Integrative aspects of cell biology Functional aspects of cell biology Science Q Kan Zhu verfasserin aut Michael Pargett verfasserin aut Adam Contreras verfasserin aut Patrick Tsai verfasserin aut Quan Qing verfasserin aut Wolfgang Losert verfasserin aut John Albeck verfasserin aut Min Zhao verfasserin aut In iScience Elsevier, 2019 24(2021), 11, Seite 103240- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:11 pages:103240- https://doi.org/10.1016/j.isci.2021.103240 kostenfrei https://doaj.org/article/1d7951c8fef84b53b75c23fe71a219f8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221012086 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 11 103240-
spelling	10.1016/j.isci.2021.103240 doi (DE-627)DOAJ075498103 (DE-599)DOAJ1d7951c8fef84b53b75c23fe71a219f8 DE-627 ger DE-627 rakwb eng Liang Guo verfasserin aut Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer signaling to control cell behaviors. Here, we showed a practical approach to achieve precise amplitude modulation (AM), frequency modulation (FM), and duration modulation (DM) of MAP kinase activation. Alternating current (AC) electrical stimulation induced synchronized ERK activation. Amplitude and duration of ERK activation were controlled by varying stimulation strength and duration. ERK activation frequencies were arbitrarily modulated with trains of short AC applications with accurately defined intervals. Significantly, ERK dynamics coded by well-designed AC can rewire PC12 cell fate independent of growth factors. This technique can be used to synchronize and modulate ERK activation dynamics, thus would offer a practical way to control cell behaviors in vivo without the use of biochemical agents or genetic manipulation. Biotechnology Cell biology Integrative aspects of cell biology Functional aspects of cell biology Science Q Kan Zhu verfasserin aut Michael Pargett verfasserin aut Adam Contreras verfasserin aut Patrick Tsai verfasserin aut Quan Qing verfasserin aut Wolfgang Losert verfasserin aut John Albeck verfasserin aut Min Zhao verfasserin aut In iScience Elsevier, 2019 24(2021), 11, Seite 103240- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:11 pages:103240- https://doi.org/10.1016/j.isci.2021.103240 kostenfrei https://doaj.org/article/1d7951c8fef84b53b75c23fe71a219f8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221012086 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 11 103240-
allfields_unstemmed	10.1016/j.isci.2021.103240 doi (DE-627)DOAJ075498103 (DE-599)DOAJ1d7951c8fef84b53b75c23fe71a219f8 DE-627 ger DE-627 rakwb eng Liang Guo verfasserin aut Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer signaling to control cell behaviors. Here, we showed a practical approach to achieve precise amplitude modulation (AM), frequency modulation (FM), and duration modulation (DM) of MAP kinase activation. Alternating current (AC) electrical stimulation induced synchronized ERK activation. Amplitude and duration of ERK activation were controlled by varying stimulation strength and duration. ERK activation frequencies were arbitrarily modulated with trains of short AC applications with accurately defined intervals. Significantly, ERK dynamics coded by well-designed AC can rewire PC12 cell fate independent of growth factors. This technique can be used to synchronize and modulate ERK activation dynamics, thus would offer a practical way to control cell behaviors in vivo without the use of biochemical agents or genetic manipulation. Biotechnology Cell biology Integrative aspects of cell biology Functional aspects of cell biology Science Q Kan Zhu verfasserin aut Michael Pargett verfasserin aut Adam Contreras verfasserin aut Patrick Tsai verfasserin aut Quan Qing verfasserin aut Wolfgang Losert verfasserin aut John Albeck verfasserin aut Min Zhao verfasserin aut In iScience Elsevier, 2019 24(2021), 11, Seite 103240- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:11 pages:103240- https://doi.org/10.1016/j.isci.2021.103240 kostenfrei https://doaj.org/article/1d7951c8fef84b53b75c23fe71a219f8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221012086 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 11 103240-
allfieldsGer	10.1016/j.isci.2021.103240 doi (DE-627)DOAJ075498103 (DE-599)DOAJ1d7951c8fef84b53b75c23fe71a219f8 DE-627 ger DE-627 rakwb eng Liang Guo verfasserin aut Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer signaling to control cell behaviors. Here, we showed a practical approach to achieve precise amplitude modulation (AM), frequency modulation (FM), and duration modulation (DM) of MAP kinase activation. Alternating current (AC) electrical stimulation induced synchronized ERK activation. Amplitude and duration of ERK activation were controlled by varying stimulation strength and duration. ERK activation frequencies were arbitrarily modulated with trains of short AC applications with accurately defined intervals. Significantly, ERK dynamics coded by well-designed AC can rewire PC12 cell fate independent of growth factors. This technique can be used to synchronize and modulate ERK activation dynamics, thus would offer a practical way to control cell behaviors in vivo without the use of biochemical agents or genetic manipulation. Biotechnology Cell biology Integrative aspects of cell biology Functional aspects of cell biology Science Q Kan Zhu verfasserin aut Michael Pargett verfasserin aut Adam Contreras verfasserin aut Patrick Tsai verfasserin aut Quan Qing verfasserin aut Wolfgang Losert verfasserin aut John Albeck verfasserin aut Min Zhao verfasserin aut In iScience Elsevier, 2019 24(2021), 11, Seite 103240- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:11 pages:103240- https://doi.org/10.1016/j.isci.2021.103240 kostenfrei https://doaj.org/article/1d7951c8fef84b53b75c23fe71a219f8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221012086 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 11 103240-
allfieldsSound	10.1016/j.isci.2021.103240 doi (DE-627)DOAJ075498103 (DE-599)DOAJ1d7951c8fef84b53b75c23fe71a219f8 DE-627 ger DE-627 rakwb eng Liang Guo verfasserin aut Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer signaling to control cell behaviors. Here, we showed a practical approach to achieve precise amplitude modulation (AM), frequency modulation (FM), and duration modulation (DM) of MAP kinase activation. Alternating current (AC) electrical stimulation induced synchronized ERK activation. Amplitude and duration of ERK activation were controlled by varying stimulation strength and duration. ERK activation frequencies were arbitrarily modulated with trains of short AC applications with accurately defined intervals. Significantly, ERK dynamics coded by well-designed AC can rewire PC12 cell fate independent of growth factors. This technique can be used to synchronize and modulate ERK activation dynamics, thus would offer a practical way to control cell behaviors in vivo without the use of biochemical agents or genetic manipulation. Biotechnology Cell biology Integrative aspects of cell biology Functional aspects of cell biology Science Q Kan Zhu verfasserin aut Michael Pargett verfasserin aut Adam Contreras verfasserin aut Patrick Tsai verfasserin aut Quan Qing verfasserin aut Wolfgang Losert verfasserin aut John Albeck verfasserin aut Min Zhao verfasserin aut In iScience Elsevier, 2019 24(2021), 11, Seite 103240- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:11 pages:103240- https://doi.org/10.1016/j.isci.2021.103240 kostenfrei https://doaj.org/article/1d7951c8fef84b53b75c23fe71a219f8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221012086 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 11 103240-
language	English
source	In iScience 24(2021), 11, Seite 103240- volume:24 year:2021 number:11 pages:103240-
sourceStr	In iScience 24(2021), 11, Seite 103240- volume:24 year:2021 number:11 pages:103240-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biotechnology Cell biology Integrative aspects of cell biology Functional aspects of cell biology Science Q
isfreeaccess_bool	true
container_title	iScience
authorswithroles_txt_mv	Liang Guo @@aut@@ Kan Zhu @@aut@@ Michael Pargett @@aut@@ Adam Contreras @@aut@@ Patrick Tsai @@aut@@ Quan Qing @@aut@@ Wolfgang Losert @@aut@@ John Albeck @@aut@@ Min Zhao @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	1019532106
id	DOAJ075498103
language_de	englisch
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author	Liang Guo
spellingShingle	Liang Guo misc Biotechnology misc Cell biology misc Integrative aspects of cell biology misc Functional aspects of cell biology misc Science misc Q Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate
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topic_title	Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate Biotechnology Cell biology Integrative aspects of cell biology Functional aspects of cell biology
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title	Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate
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title_full	Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate
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author_browse	Liang Guo Kan Zhu Michael Pargett Adam Contreras Patrick Tsai Quan Qing Wolfgang Losert John Albeck Min Zhao
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title_sort	electrically synchronizing and modulating the dynamics of erk activation to regulate cell fate
title_auth	Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate
abstract	Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer signaling to control cell behaviors. Here, we showed a practical approach to achieve precise amplitude modulation (AM), frequency modulation (FM), and duration modulation (DM) of MAP kinase activation. Alternating current (AC) electrical stimulation induced synchronized ERK activation. Amplitude and duration of ERK activation were controlled by varying stimulation strength and duration. ERK activation frequencies were arbitrarily modulated with trains of short AC applications with accurately defined intervals. Significantly, ERK dynamics coded by well-designed AC can rewire PC12 cell fate independent of growth factors. This technique can be used to synchronize and modulate ERK activation dynamics, thus would offer a practical way to control cell behaviors in vivo without the use of biochemical agents or genetic manipulation.
abstractGer	Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer signaling to control cell behaviors. Here, we showed a practical approach to achieve precise amplitude modulation (AM), frequency modulation (FM), and duration modulation (DM) of MAP kinase activation. Alternating current (AC) electrical stimulation induced synchronized ERK activation. Amplitude and duration of ERK activation were controlled by varying stimulation strength and duration. ERK activation frequencies were arbitrarily modulated with trains of short AC applications with accurately defined intervals. Significantly, ERK dynamics coded by well-designed AC can rewire PC12 cell fate independent of growth factors. This technique can be used to synchronize and modulate ERK activation dynamics, thus would offer a practical way to control cell behaviors in vivo without the use of biochemical agents or genetic manipulation.
abstract_unstemmed	Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer signaling to control cell behaviors. Here, we showed a practical approach to achieve precise amplitude modulation (AM), frequency modulation (FM), and duration modulation (DM) of MAP kinase activation. Alternating current (AC) electrical stimulation induced synchronized ERK activation. Amplitude and duration of ERK activation were controlled by varying stimulation strength and duration. ERK activation frequencies were arbitrarily modulated with trains of short AC applications with accurately defined intervals. Significantly, ERK dynamics coded by well-designed AC can rewire PC12 cell fate independent of growth factors. This technique can be used to synchronize and modulate ERK activation dynamics, thus would offer a practical way to control cell behaviors in vivo without the use of biochemical agents or genetic manipulation.
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container_issue	11
title_short	Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate
url	https://doi.org/10.1016/j.isci.2021.103240 https://doaj.org/article/1d7951c8fef84b53b75c23fe71a219f8 http://www.sciencedirect.com/science/article/pii/S2589004221012086 https://doaj.org/toc/2589-0042
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Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate

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