Forced expiration measurements in mouse models of obstructive and restrictive lung diseases

Abstract Background Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most common...
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Autor*in:	Fien C. Devos [verfasserIn] André Maaske [verfasserIn] Annette Robichaud [verfasserIn] Lore Pollaris [verfasserIn] Sven Seys [verfasserIn] Carolina Aznar Lopez [verfasserIn] Erik Verbeken [verfasserIn] Matthias Tenbusch [verfasserIn] Rik Lories [verfasserIn] Benoit Nemery [verfasserIn] Peter HM Hoet [verfasserIn] Jeroen AJ Vanoirbeek [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Fibrosis Emphysema Asthma Acute lung injury Mice Forced oscillations technique

Übergeordnetes Werk:	In: Respiratory Research - BMC, 2003, 18(2017), 1, Seite 14
Übergeordnetes Werk:	volume:18 ; year:2017 ; number:1 ; pages:14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12931-017-0610-1

Katalog-ID:	DOAJ075520451

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520			\|a Abstract Background Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. Method Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis, elastase-induced emphysema, LPS-induced acute lung injury and house dust mite-induced asthma. Results Respiratory mechanics parameters (airway resistance, tissue damping and tissue elastance) confirmed disease-specific phenotypes either at baseline or following methacholine challenge. Similarly, lung function defects could be detected in each disease model by at least one FE-related parameter (FEV0.1, FEF0.1, FVC, FEV0.1/FVC ratio and PEF) at baseline or during the methacholine provocation assay. Conclusions FE-derived outcomes in four mouse disease models behaved similarly to changes found in human spirometry. Routine combined lung function assessments could increase the translational utility of mouse models.
650		4	\|a Fibrosis
650		4	\|a Emphysema
650		4	\|a Asthma
650		4	\|a Acute lung injury
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650		4	\|a Forced oscillations technique
653		0	\|a Diseases of the respiratory system
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allfields	10.1186/s12931-017-0610-1 doi (DE-627)DOAJ075520451 (DE-599)DOAJ332e4e5749134564b11fd2d0f727e766 DE-627 ger DE-627 rakwb eng RC705-779 Fien C. Devos verfasserin aut Forced expiration measurements in mouse models of obstructive and restrictive lung diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. Method Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis, elastase-induced emphysema, LPS-induced acute lung injury and house dust mite-induced asthma. Results Respiratory mechanics parameters (airway resistance, tissue damping and tissue elastance) confirmed disease-specific phenotypes either at baseline or following methacholine challenge. Similarly, lung function defects could be detected in each disease model by at least one FE-related parameter (FEV0.1, FEF0.1, FVC, FEV0.1/FVC ratio and PEF) at baseline or during the methacholine provocation assay. Conclusions FE-derived outcomes in four mouse disease models behaved similarly to changes found in human spirometry. Routine combined lung function assessments could increase the translational utility of mouse models. Fibrosis Emphysema Asthma Acute lung injury Mice Forced oscillations technique Diseases of the respiratory system André Maaske verfasserin aut Annette Robichaud verfasserin aut Lore Pollaris verfasserin aut Sven Seys verfasserin aut Carolina Aznar Lopez verfasserin aut Erik Verbeken verfasserin aut Matthias Tenbusch verfasserin aut Rik Lories verfasserin aut Benoit Nemery verfasserin aut Peter HM Hoet verfasserin aut Jeroen AJ Vanoirbeek verfasserin aut In Respiratory Research BMC, 2003 18(2017), 1, Seite 14 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:18 year:2017 number:1 pages:14 https://doi.org/10.1186/s12931-017-0610-1 kostenfrei https://doaj.org/article/332e4e5749134564b11fd2d0f727e766 kostenfrei http://link.springer.com/article/10.1186/s12931-017-0610-1 kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 14
spelling	10.1186/s12931-017-0610-1 doi (DE-627)DOAJ075520451 (DE-599)DOAJ332e4e5749134564b11fd2d0f727e766 DE-627 ger DE-627 rakwb eng RC705-779 Fien C. Devos verfasserin aut Forced expiration measurements in mouse models of obstructive and restrictive lung diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. Method Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis, elastase-induced emphysema, LPS-induced acute lung injury and house dust mite-induced asthma. Results Respiratory mechanics parameters (airway resistance, tissue damping and tissue elastance) confirmed disease-specific phenotypes either at baseline or following methacholine challenge. Similarly, lung function defects could be detected in each disease model by at least one FE-related parameter (FEV0.1, FEF0.1, FVC, FEV0.1/FVC ratio and PEF) at baseline or during the methacholine provocation assay. Conclusions FE-derived outcomes in four mouse disease models behaved similarly to changes found in human spirometry. Routine combined lung function assessments could increase the translational utility of mouse models. Fibrosis Emphysema Asthma Acute lung injury Mice Forced oscillations technique Diseases of the respiratory system André Maaske verfasserin aut Annette Robichaud verfasserin aut Lore Pollaris verfasserin aut Sven Seys verfasserin aut Carolina Aznar Lopez verfasserin aut Erik Verbeken verfasserin aut Matthias Tenbusch verfasserin aut Rik Lories verfasserin aut Benoit Nemery verfasserin aut Peter HM Hoet verfasserin aut Jeroen AJ Vanoirbeek verfasserin aut In Respiratory Research BMC, 2003 18(2017), 1, Seite 14 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:18 year:2017 number:1 pages:14 https://doi.org/10.1186/s12931-017-0610-1 kostenfrei https://doaj.org/article/332e4e5749134564b11fd2d0f727e766 kostenfrei http://link.springer.com/article/10.1186/s12931-017-0610-1 kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 14
allfields_unstemmed	10.1186/s12931-017-0610-1 doi (DE-627)DOAJ075520451 (DE-599)DOAJ332e4e5749134564b11fd2d0f727e766 DE-627 ger DE-627 rakwb eng RC705-779 Fien C. Devos verfasserin aut Forced expiration measurements in mouse models of obstructive and restrictive lung diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. Method Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis, elastase-induced emphysema, LPS-induced acute lung injury and house dust mite-induced asthma. Results Respiratory mechanics parameters (airway resistance, tissue damping and tissue elastance) confirmed disease-specific phenotypes either at baseline or following methacholine challenge. Similarly, lung function defects could be detected in each disease model by at least one FE-related parameter (FEV0.1, FEF0.1, FVC, FEV0.1/FVC ratio and PEF) at baseline or during the methacholine provocation assay. Conclusions FE-derived outcomes in four mouse disease models behaved similarly to changes found in human spirometry. Routine combined lung function assessments could increase the translational utility of mouse models. Fibrosis Emphysema Asthma Acute lung injury Mice Forced oscillations technique Diseases of the respiratory system André Maaske verfasserin aut Annette Robichaud verfasserin aut Lore Pollaris verfasserin aut Sven Seys verfasserin aut Carolina Aznar Lopez verfasserin aut Erik Verbeken verfasserin aut Matthias Tenbusch verfasserin aut Rik Lories verfasserin aut Benoit Nemery verfasserin aut Peter HM Hoet verfasserin aut Jeroen AJ Vanoirbeek verfasserin aut In Respiratory Research BMC, 2003 18(2017), 1, Seite 14 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:18 year:2017 number:1 pages:14 https://doi.org/10.1186/s12931-017-0610-1 kostenfrei https://doaj.org/article/332e4e5749134564b11fd2d0f727e766 kostenfrei http://link.springer.com/article/10.1186/s12931-017-0610-1 kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 14
allfieldsGer	10.1186/s12931-017-0610-1 doi (DE-627)DOAJ075520451 (DE-599)DOAJ332e4e5749134564b11fd2d0f727e766 DE-627 ger DE-627 rakwb eng RC705-779 Fien C. Devos verfasserin aut Forced expiration measurements in mouse models of obstructive and restrictive lung diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. Method Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis, elastase-induced emphysema, LPS-induced acute lung injury and house dust mite-induced asthma. Results Respiratory mechanics parameters (airway resistance, tissue damping and tissue elastance) confirmed disease-specific phenotypes either at baseline or following methacholine challenge. Similarly, lung function defects could be detected in each disease model by at least one FE-related parameter (FEV0.1, FEF0.1, FVC, FEV0.1/FVC ratio and PEF) at baseline or during the methacholine provocation assay. Conclusions FE-derived outcomes in four mouse disease models behaved similarly to changes found in human spirometry. Routine combined lung function assessments could increase the translational utility of mouse models. Fibrosis Emphysema Asthma Acute lung injury Mice Forced oscillations technique Diseases of the respiratory system André Maaske verfasserin aut Annette Robichaud verfasserin aut Lore Pollaris verfasserin aut Sven Seys verfasserin aut Carolina Aznar Lopez verfasserin aut Erik Verbeken verfasserin aut Matthias Tenbusch verfasserin aut Rik Lories verfasserin aut Benoit Nemery verfasserin aut Peter HM Hoet verfasserin aut Jeroen AJ Vanoirbeek verfasserin aut In Respiratory Research BMC, 2003 18(2017), 1, Seite 14 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:18 year:2017 number:1 pages:14 https://doi.org/10.1186/s12931-017-0610-1 kostenfrei https://doaj.org/article/332e4e5749134564b11fd2d0f727e766 kostenfrei http://link.springer.com/article/10.1186/s12931-017-0610-1 kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 14
allfieldsSound	10.1186/s12931-017-0610-1 doi (DE-627)DOAJ075520451 (DE-599)DOAJ332e4e5749134564b11fd2d0f727e766 DE-627 ger DE-627 rakwb eng RC705-779 Fien C. Devos verfasserin aut Forced expiration measurements in mouse models of obstructive and restrictive lung diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. Method Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis, elastase-induced emphysema, LPS-induced acute lung injury and house dust mite-induced asthma. Results Respiratory mechanics parameters (airway resistance, tissue damping and tissue elastance) confirmed disease-specific phenotypes either at baseline or following methacholine challenge. Similarly, lung function defects could be detected in each disease model by at least one FE-related parameter (FEV0.1, FEF0.1, FVC, FEV0.1/FVC ratio and PEF) at baseline or during the methacholine provocation assay. Conclusions FE-derived outcomes in four mouse disease models behaved similarly to changes found in human spirometry. Routine combined lung function assessments could increase the translational utility of mouse models. Fibrosis Emphysema Asthma Acute lung injury Mice Forced oscillations technique Diseases of the respiratory system André Maaske verfasserin aut Annette Robichaud verfasserin aut Lore Pollaris verfasserin aut Sven Seys verfasserin aut Carolina Aznar Lopez verfasserin aut Erik Verbeken verfasserin aut Matthias Tenbusch verfasserin aut Rik Lories verfasserin aut Benoit Nemery verfasserin aut Peter HM Hoet verfasserin aut Jeroen AJ Vanoirbeek verfasserin aut In Respiratory Research BMC, 2003 18(2017), 1, Seite 14 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:18 year:2017 number:1 pages:14 https://doi.org/10.1186/s12931-017-0610-1 kostenfrei https://doaj.org/article/332e4e5749134564b11fd2d0f727e766 kostenfrei http://link.springer.com/article/10.1186/s12931-017-0610-1 kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 14
language	English
source	In Respiratory Research 18(2017), 1, Seite 14 volume:18 year:2017 number:1 pages:14
sourceStr	In Respiratory Research 18(2017), 1, Seite 14 volume:18 year:2017 number:1 pages:14
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Fibrosis Emphysema Asthma Acute lung injury Mice Forced oscillations technique Diseases of the respiratory system
isfreeaccess_bool	true
container_title	Respiratory Research
authorswithroles_txt_mv	Fien C. Devos @@aut@@ André Maaske @@aut@@ Annette Robichaud @@aut@@ Lore Pollaris @@aut@@ Sven Seys @@aut@@ Carolina Aznar Lopez @@aut@@ Erik Verbeken @@aut@@ Matthias Tenbusch @@aut@@ Rik Lories @@aut@@ Benoit Nemery @@aut@@ Peter HM Hoet @@aut@@ Jeroen AJ Vanoirbeek @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	326646485
id	DOAJ075520451
language_de	englisch
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Devos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Forced expiration measurements in mouse models of obstructive and restrictive lung diseases</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Pulmonary function measurements are important when studying respiratory disease models. 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callnumber-first	R - Medicine
author	Fien C. Devos
spellingShingle	Fien C. Devos misc RC705-779 misc Fibrosis misc Emphysema misc Asthma misc Acute lung injury misc Mice misc Forced oscillations technique misc Diseases of the respiratory system Forced expiration measurements in mouse models of obstructive and restrictive lung diseases
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topic_title	RC705-779 Forced expiration measurements in mouse models of obstructive and restrictive lung diseases Fibrosis Emphysema Asthma Acute lung injury Mice Forced oscillations technique
topic	misc RC705-779 misc Fibrosis misc Emphysema misc Asthma misc Acute lung injury misc Mice misc Forced oscillations technique misc Diseases of the respiratory system
topic_unstemmed	misc RC705-779 misc Fibrosis misc Emphysema misc Asthma misc Acute lung injury misc Mice misc Forced oscillations technique misc Diseases of the respiratory system
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title	Forced expiration measurements in mouse models of obstructive and restrictive lung diseases
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title_full	Forced expiration measurements in mouse models of obstructive and restrictive lung diseases
author_sort	Fien C. Devos
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author_browse	Fien C. Devos André Maaske Annette Robichaud Lore Pollaris Sven Seys Carolina Aznar Lopez Erik Verbeken Matthias Tenbusch Rik Lories Benoit Nemery Peter HM Hoet Jeroen AJ Vanoirbeek
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title_sort	forced expiration measurements in mouse models of obstructive and restrictive lung diseases
callnumber	RC705-779
title_auth	Forced expiration measurements in mouse models of obstructive and restrictive lung diseases
abstract	Abstract Background Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. Method Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis, elastase-induced emphysema, LPS-induced acute lung injury and house dust mite-induced asthma. Results Respiratory mechanics parameters (airway resistance, tissue damping and tissue elastance) confirmed disease-specific phenotypes either at baseline or following methacholine challenge. Similarly, lung function defects could be detected in each disease model by at least one FE-related parameter (FEV0.1, FEF0.1, FVC, FEV0.1/FVC ratio and PEF) at baseline or during the methacholine provocation assay. Conclusions FE-derived outcomes in four mouse disease models behaved similarly to changes found in human spirometry. Routine combined lung function assessments could increase the translational utility of mouse models.
abstractGer	Abstract Background Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. Method Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis, elastase-induced emphysema, LPS-induced acute lung injury and house dust mite-induced asthma. Results Respiratory mechanics parameters (airway resistance, tissue damping and tissue elastance) confirmed disease-specific phenotypes either at baseline or following methacholine challenge. Similarly, lung function defects could be detected in each disease model by at least one FE-related parameter (FEV0.1, FEF0.1, FVC, FEV0.1/FVC ratio and PEF) at baseline or during the methacholine provocation assay. Conclusions FE-derived outcomes in four mouse disease models behaved similarly to changes found in human spirometry. Routine combined lung function assessments could increase the translational utility of mouse models.
abstract_unstemmed	Abstract Background Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. Method Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis, elastase-induced emphysema, LPS-induced acute lung injury and house dust mite-induced asthma. Results Respiratory mechanics parameters (airway resistance, tissue damping and tissue elastance) confirmed disease-specific phenotypes either at baseline or following methacholine challenge. Similarly, lung function defects could be detected in each disease model by at least one FE-related parameter (FEV0.1, FEF0.1, FVC, FEV0.1/FVC ratio and PEF) at baseline or during the methacholine provocation assay. Conclusions FE-derived outcomes in four mouse disease models behaved similarly to changes found in human spirometry. Routine combined lung function assessments could increase the translational utility of mouse models.
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title_short	Forced expiration measurements in mouse models of obstructive and restrictive lung diseases
url	https://doi.org/10.1186/s12931-017-0610-1 https://doaj.org/article/332e4e5749134564b11fd2d0f727e766 http://link.springer.com/article/10.1186/s12931-017-0610-1 https://doaj.org/toc/1465-993X
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Forced expiration measurements in mouse models of obstructive and restrictive lung diseases

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