G-Quadruplexes as Sensing Probes

Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Int...
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Autor*in:	Branislav Ruttkay-Nedecky [verfasserIn] Jiri Kudr [verfasserIn] Lukas Nejdl [verfasserIn] Darina Maskova [verfasserIn] Rene Kizek [verfasserIn] Vojtech Adam [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	G-quadruplex DNAzyme hemin

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 18(2013), 12, Seite 14760-14779
Übergeordnetes Werk:	volume:18 ; year:2013 ; number:12 ; pages:14760-14779

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules181214760

Katalog-ID:	DOAJ07557425X

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520			\|a Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplexes form a complex with anionic porphyrin hemin and exhibit peroxidase-like activity. This review focuses on overview of sensing techniques based on G-quadruplex complexes with anionic porphyrins for detection of various analytes, including metal ions such as K+, Ca2+, Ag+, Hg2+, Cu2+, Pb2+, Sr2+, organic molecules, nucleic acids, and proteins. Principles of G-quadruplex-based detection methods involve DNA conformational change caused by the presence of analyte which leads to a decrease or an increase in peroxidase activity, fluorescence, or electrochemical signal of the used probe. The advantages of various detection techniques are also discussed.
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spelling	10.3390/molecules181214760 doi (DE-627)DOAJ07557425X (DE-599)DOAJ8bb654612ecf4396bdf996f0f2172191 DE-627 ger DE-627 rakwb eng QD241-441 Branislav Ruttkay-Nedecky verfasserin aut G-Quadruplexes as Sensing Probes 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplexes form a complex with anionic porphyrin hemin and exhibit peroxidase-like activity. This review focuses on overview of sensing techniques based on G-quadruplex complexes with anionic porphyrins for detection of various analytes, including metal ions such as K+, Ca2+, Ag+, Hg2+, Cu2+, Pb2+, Sr2+, organic molecules, nucleic acids, and proteins. Principles of G-quadruplex-based detection methods involve DNA conformational change caused by the presence of analyte which leads to a decrease or an increase in peroxidase activity, fluorescence, or electrochemical signal of the used probe. The advantages of various detection techniques are also discussed. G-quadruplex DNAzyme hemin Organic chemistry Jiri Kudr verfasserin aut Lukas Nejdl verfasserin aut Darina Maskova verfasserin aut Rene Kizek verfasserin aut Vojtech Adam verfasserin aut In Molecules MDPI AG, 2003 18(2013), 12, Seite 14760-14779 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:18 year:2013 number:12 pages:14760-14779 https://doi.org/10.3390/molecules181214760 kostenfrei https://doaj.org/article/8bb654612ecf4396bdf996f0f2172191 kostenfrei http://www.mdpi.com/1420-3049/18/12/14760 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2013 12 14760-14779
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allfieldsSound	10.3390/molecules181214760 doi (DE-627)DOAJ07557425X (DE-599)DOAJ8bb654612ecf4396bdf996f0f2172191 DE-627 ger DE-627 rakwb eng QD241-441 Branislav Ruttkay-Nedecky verfasserin aut G-Quadruplexes as Sensing Probes 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplexes form a complex with anionic porphyrin hemin and exhibit peroxidase-like activity. This review focuses on overview of sensing techniques based on G-quadruplex complexes with anionic porphyrins for detection of various analytes, including metal ions such as K+, Ca2+, Ag+, Hg2+, Cu2+, Pb2+, Sr2+, organic molecules, nucleic acids, and proteins. Principles of G-quadruplex-based detection methods involve DNA conformational change caused by the presence of analyte which leads to a decrease or an increase in peroxidase activity, fluorescence, or electrochemical signal of the used probe. The advantages of various detection techniques are also discussed. G-quadruplex DNAzyme hemin Organic chemistry Jiri Kudr verfasserin aut Lukas Nejdl verfasserin aut Darina Maskova verfasserin aut Rene Kizek verfasserin aut Vojtech Adam verfasserin aut In Molecules MDPI AG, 2003 18(2013), 12, Seite 14760-14779 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:18 year:2013 number:12 pages:14760-14779 https://doi.org/10.3390/molecules181214760 kostenfrei https://doaj.org/article/8bb654612ecf4396bdf996f0f2172191 kostenfrei http://www.mdpi.com/1420-3049/18/12/14760 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2013 12 14760-14779
language	English
source	In Molecules 18(2013), 12, Seite 14760-14779 volume:18 year:2013 number:12 pages:14760-14779
sourceStr	In Molecules 18(2013), 12, Seite 14760-14779 volume:18 year:2013 number:12 pages:14760-14779
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authorswithroles_txt_mv	Branislav Ruttkay-Nedecky @@aut@@ Jiri Kudr @@aut@@ Lukas Nejdl @@aut@@ Darina Maskova @@aut@@ Rene Kizek @@aut@@ Vojtech Adam @@aut@@
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callnumber-first	Q - Science
author	Branislav Ruttkay-Nedecky
spellingShingle	Branislav Ruttkay-Nedecky misc QD241-441 misc G-quadruplex misc DNAzyme misc hemin misc Organic chemistry G-Quadruplexes as Sensing Probes
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topic_title	QD241-441 G-Quadruplexes as Sensing Probes G-quadruplex DNAzyme hemin
topic	misc QD241-441 misc G-quadruplex misc DNAzyme misc hemin misc Organic chemistry
topic_unstemmed	misc QD241-441 misc G-quadruplex misc DNAzyme misc hemin misc Organic chemistry
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title	G-Quadruplexes as Sensing Probes
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title_full	G-Quadruplexes as Sensing Probes
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title_sort	g-quadruplexes as sensing probes
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title_auth	G-Quadruplexes as Sensing Probes
abstract	Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplexes form a complex with anionic porphyrin hemin and exhibit peroxidase-like activity. This review focuses on overview of sensing techniques based on G-quadruplex complexes with anionic porphyrins for detection of various analytes, including metal ions such as K+, Ca2+, Ag+, Hg2+, Cu2+, Pb2+, Sr2+, organic molecules, nucleic acids, and proteins. Principles of G-quadruplex-based detection methods involve DNA conformational change caused by the presence of analyte which leads to a decrease or an increase in peroxidase activity, fluorescence, or electrochemical signal of the used probe. The advantages of various detection techniques are also discussed.
abstractGer	Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplexes form a complex with anionic porphyrin hemin and exhibit peroxidase-like activity. This review focuses on overview of sensing techniques based on G-quadruplex complexes with anionic porphyrins for detection of various analytes, including metal ions such as K+, Ca2+, Ag+, Hg2+, Cu2+, Pb2+, Sr2+, organic molecules, nucleic acids, and proteins. Principles of G-quadruplex-based detection methods involve DNA conformational change caused by the presence of analyte which leads to a decrease or an increase in peroxidase activity, fluorescence, or electrochemical signal of the used probe. The advantages of various detection techniques are also discussed.
abstract_unstemmed	Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplexes form a complex with anionic porphyrin hemin and exhibit peroxidase-like activity. This review focuses on overview of sensing techniques based on G-quadruplex complexes with anionic porphyrins for detection of various analytes, including metal ions such as K+, Ca2+, Ag+, Hg2+, Cu2+, Pb2+, Sr2+, organic molecules, nucleic acids, and proteins. Principles of G-quadruplex-based detection methods involve DNA conformational change caused by the presence of analyte which leads to a decrease or an increase in peroxidase activity, fluorescence, or electrochemical signal of the used probe. The advantages of various detection techniques are also discussed.
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title_short	G-Quadruplexes as Sensing Probes
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