RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma

Background/Aims: RNF43 is a member of transmembrane E3 ubiquitin ligases and plays important roles in tumor formation progression. In current study, we aimed to explore RNF43 expression and analyze its role in gastric carcinoma. Methods and Results: The level of RNF43 was detected in 77 cases of gas...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Lei Niu [verfasserIn] Hong-Zhen Qin [verfasserIn] Hong-Qing Xi [verfasserIn] Bo Wei [verfasserIn] Shao-You Xia [verfasserIn] Lin Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	RNF43 E3 ubiquitin ligases Gastric carcinoma Tumor suppressor Wnt signaling

Übergeordnetes Werk:	In: Cellular Physiology and Biochemistry - Cell Physiol Biochem Press GmbH & Co KG, 2002, 36(2015), 5, Seite 1835-1846
Übergeordnetes Werk:	volume:36 ; year:2015 ; number:5 ; pages:1835-1846

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1159/000430154

Katalog-ID:	DOAJ075590581

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spelling	10.1159/000430154 doi (DE-627)DOAJ075590581 (DE-599)DOAJd5b38b9236374306a07a7a0fabebd8ac DE-627 ger DE-627 rakwb eng QP1-981 QD415-436 Lei Niu verfasserin aut RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims: RNF43 is a member of transmembrane E3 ubiquitin ligases and plays important roles in tumor formation progression. In current study, we aimed to explore RNF43 expression and analyze its role in gastric carcinoma. Methods and Results: The level of RNF43 was detected in 77 cases of gastric carcinoma and matched normal tissues by real-time PCR, western blotting and immunohistochemistry. We found that the expression of RNF43 was significantly down-regulated in the gastric carcinoma tissues compared to the normal mucosae (all PConcolusion: In conclusion, RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis RNF43 E3 ubiquitin ligases Gastric carcinoma Tumor suppressor Wnt signaling Physiology Biochemistry Hong-Zhen Qin verfasserin aut Hong-Qing Xi verfasserin aut Bo Wei verfasserin aut Shao-You Xia verfasserin aut Lin Chen verfasserin aut In Cellular Physiology and Biochemistry Cell Physiol Biochem Press GmbH & Co KG, 2002 36(2015), 5, Seite 1835-1846 (DE-627)300189702 (DE-600)1482056-0 14219778 nnns volume:36 year:2015 number:5 pages:1835-1846 https://doi.org/10.1159/000430154 kostenfrei https://doaj.org/article/d5b38b9236374306a07a7a0fabebd8ac kostenfrei http://www.karger.com/Article/FullText/430154 kostenfrei https://doaj.org/toc/1015-8987 Journal toc kostenfrei https://doaj.org/toc/1421-9778 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2153 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2015 5 1835-1846
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allfieldsSound	10.1159/000430154 doi (DE-627)DOAJ075590581 (DE-599)DOAJd5b38b9236374306a07a7a0fabebd8ac DE-627 ger DE-627 rakwb eng QP1-981 QD415-436 Lei Niu verfasserin aut RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims: RNF43 is a member of transmembrane E3 ubiquitin ligases and plays important roles in tumor formation progression. In current study, we aimed to explore RNF43 expression and analyze its role in gastric carcinoma. Methods and Results: The level of RNF43 was detected in 77 cases of gastric carcinoma and matched normal tissues by real-time PCR, western blotting and immunohistochemistry. We found that the expression of RNF43 was significantly down-regulated in the gastric carcinoma tissues compared to the normal mucosae (all PConcolusion: In conclusion, RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis RNF43 E3 ubiquitin ligases Gastric carcinoma Tumor suppressor Wnt signaling Physiology Biochemistry Hong-Zhen Qin verfasserin aut Hong-Qing Xi verfasserin aut Bo Wei verfasserin aut Shao-You Xia verfasserin aut Lin Chen verfasserin aut In Cellular Physiology and Biochemistry Cell Physiol Biochem Press GmbH & Co KG, 2002 36(2015), 5, Seite 1835-1846 (DE-627)300189702 (DE-600)1482056-0 14219778 nnns volume:36 year:2015 number:5 pages:1835-1846 https://doi.org/10.1159/000430154 kostenfrei https://doaj.org/article/d5b38b9236374306a07a7a0fabebd8ac kostenfrei http://www.karger.com/Article/FullText/430154 kostenfrei https://doaj.org/toc/1015-8987 Journal toc kostenfrei https://doaj.org/toc/1421-9778 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2153 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2015 5 1835-1846
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source	In Cellular Physiology and Biochemistry 36(2015), 5, Seite 1835-1846 volume:36 year:2015 number:5 pages:1835-1846
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topic_facet	RNF43 E3 ubiquitin ligases Gastric carcinoma Tumor suppressor Wnt signaling Physiology Biochemistry
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container_title	Cellular Physiology and Biochemistry
authorswithroles_txt_mv	Lei Niu @@aut@@ Hong-Zhen Qin @@aut@@ Hong-Qing Xi @@aut@@ Bo Wei @@aut@@ Shao-You Xia @@aut@@ Lin Chen @@aut@@
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callnumber-first	Q - Science
author	Lei Niu
spellingShingle	Lei Niu misc QP1-981 misc QD415-436 misc RNF43 misc E3 ubiquitin ligases misc Gastric carcinoma misc Tumor suppressor misc Wnt signaling misc Physiology misc Biochemistry RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma
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topic_title	QP1-981 QD415-436 RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma RNF43 E3 ubiquitin ligases Gastric carcinoma Tumor suppressor Wnt signaling
topic	misc QP1-981 misc QD415-436 misc RNF43 misc E3 ubiquitin ligases misc Gastric carcinoma misc Tumor suppressor misc Wnt signaling misc Physiology misc Biochemistry
topic_unstemmed	misc QP1-981 misc QD415-436 misc RNF43 misc E3 ubiquitin ligases misc Gastric carcinoma misc Tumor suppressor misc Wnt signaling misc Physiology misc Biochemistry
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title	RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma
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title_full	RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma
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title_sort	rnf43 inhibits cancer cell proliferation and could be a potential prognostic factor for human gastric carcinoma
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title_auth	RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma
abstract	Background/Aims: RNF43 is a member of transmembrane E3 ubiquitin ligases and plays important roles in tumor formation progression. In current study, we aimed to explore RNF43 expression and analyze its role in gastric carcinoma. Methods and Results: The level of RNF43 was detected in 77 cases of gastric carcinoma and matched normal tissues by real-time PCR, western blotting and immunohistochemistry. We found that the expression of RNF43 was significantly down-regulated in the gastric carcinoma tissues compared to the normal mucosae (all PConcolusion: In conclusion, RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis
abstractGer	Background/Aims: RNF43 is a member of transmembrane E3 ubiquitin ligases and plays important roles in tumor formation progression. In current study, we aimed to explore RNF43 expression and analyze its role in gastric carcinoma. Methods and Results: The level of RNF43 was detected in 77 cases of gastric carcinoma and matched normal tissues by real-time PCR, western blotting and immunohistochemistry. We found that the expression of RNF43 was significantly down-regulated in the gastric carcinoma tissues compared to the normal mucosae (all PConcolusion: In conclusion, RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis
abstract_unstemmed	Background/Aims: RNF43 is a member of transmembrane E3 ubiquitin ligases and plays important roles in tumor formation progression. In current study, we aimed to explore RNF43 expression and analyze its role in gastric carcinoma. Methods and Results: The level of RNF43 was detected in 77 cases of gastric carcinoma and matched normal tissues by real-time PCR, western blotting and immunohistochemistry. We found that the expression of RNF43 was significantly down-regulated in the gastric carcinoma tissues compared to the normal mucosae (all PConcolusion: In conclusion, RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis
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title_short	RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma
url	https://doi.org/10.1159/000430154 https://doaj.org/article/d5b38b9236374306a07a7a0fabebd8ac http://www.karger.com/Article/FullText/430154 https://doaj.org/toc/1015-8987 https://doaj.org/toc/1421-9778
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