Translational control of breast cancer plasticity

Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance.

Gespeichert in:

Autor*in:	Michael Jewer [verfasserIn] Laura Lee [verfasserIn] Matthew Leibovitch [verfasserIn] Guihua Zhang [verfasserIn] Jiahui Liu [verfasserIn] Scott D. Findlay [verfasserIn] Krista M. Vincent [verfasserIn] Kristofferson Tandoc [verfasserIn] Dylan Dieters-Castator [verfasserIn] Daniela F. Quail [verfasserIn] Indrani Dutta [verfasserIn] Mackenzie Coatham [verfasserIn] Zhihua Xu [verfasserIn] Aakshi Puri [verfasserIn] Bo-Jhih Guan [verfasserIn] Maria Hatzoglou [verfasserIn] Andrea Brumwell [verfasserIn] James Uniacke [verfasserIn] Christos Patsis [verfasserIn] Antonis Koromilas [verfasserIn] Julia Schueler [verfasserIn] Gabrielle M. Siegers [verfasserIn] Ivan Topisirovic [verfasserIn] Lynne-Marie Postovit [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 11(2020), 1, Seite 16
Übergeordnetes Werk:	volume:11 ; year:2020 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-020-16352-z

Katalog-ID:	DOAJ075614448

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allfields	10.1038/s41467-020-16352-z doi (DE-627)DOAJ075614448 (DE-599)DOAJ312a98522c974e78ae7065a78eaa0f90 DE-627 ger DE-627 rakwb eng Michael Jewer verfasserin aut Translational control of breast cancer plasticity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance. Science Q Laura Lee verfasserin aut Matthew Leibovitch verfasserin aut Guihua Zhang verfasserin aut Jiahui Liu verfasserin aut Scott D. Findlay verfasserin aut Krista M. Vincent verfasserin aut Kristofferson Tandoc verfasserin aut Dylan Dieters-Castator verfasserin aut Daniela F. Quail verfasserin aut Indrani Dutta verfasserin aut Mackenzie Coatham verfasserin aut Zhihua Xu verfasserin aut Aakshi Puri verfasserin aut Bo-Jhih Guan verfasserin aut Maria Hatzoglou verfasserin aut Andrea Brumwell verfasserin aut James Uniacke verfasserin aut Christos Patsis verfasserin aut Antonis Koromilas verfasserin aut Julia Schueler verfasserin aut Gabrielle M. Siegers verfasserin aut Ivan Topisirovic verfasserin aut Lynne-Marie Postovit verfasserin aut In Nature Communications Nature Portfolio, 2016 11(2020), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:11 year:2020 number:1 pages:16 https://doi.org/10.1038/s41467-020-16352-z kostenfrei https://doaj.org/article/312a98522c974e78ae7065a78eaa0f90 kostenfrei https://doi.org/10.1038/s41467-020-16352-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 16
spelling	10.1038/s41467-020-16352-z doi (DE-627)DOAJ075614448 (DE-599)DOAJ312a98522c974e78ae7065a78eaa0f90 DE-627 ger DE-627 rakwb eng Michael Jewer verfasserin aut Translational control of breast cancer plasticity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance. Science Q Laura Lee verfasserin aut Matthew Leibovitch verfasserin aut Guihua Zhang verfasserin aut Jiahui Liu verfasserin aut Scott D. Findlay verfasserin aut Krista M. Vincent verfasserin aut Kristofferson Tandoc verfasserin aut Dylan Dieters-Castator verfasserin aut Daniela F. Quail verfasserin aut Indrani Dutta verfasserin aut Mackenzie Coatham verfasserin aut Zhihua Xu verfasserin aut Aakshi Puri verfasserin aut Bo-Jhih Guan verfasserin aut Maria Hatzoglou verfasserin aut Andrea Brumwell verfasserin aut James Uniacke verfasserin aut Christos Patsis verfasserin aut Antonis Koromilas verfasserin aut Julia Schueler verfasserin aut Gabrielle M. Siegers verfasserin aut Ivan Topisirovic verfasserin aut Lynne-Marie Postovit verfasserin aut In Nature Communications Nature Portfolio, 2016 11(2020), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:11 year:2020 number:1 pages:16 https://doi.org/10.1038/s41467-020-16352-z kostenfrei https://doaj.org/article/312a98522c974e78ae7065a78eaa0f90 kostenfrei https://doi.org/10.1038/s41467-020-16352-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 16
allfields_unstemmed	10.1038/s41467-020-16352-z doi (DE-627)DOAJ075614448 (DE-599)DOAJ312a98522c974e78ae7065a78eaa0f90 DE-627 ger DE-627 rakwb eng Michael Jewer verfasserin aut Translational control of breast cancer plasticity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance. Science Q Laura Lee verfasserin aut Matthew Leibovitch verfasserin aut Guihua Zhang verfasserin aut Jiahui Liu verfasserin aut Scott D. Findlay verfasserin aut Krista M. Vincent verfasserin aut Kristofferson Tandoc verfasserin aut Dylan Dieters-Castator verfasserin aut Daniela F. Quail verfasserin aut Indrani Dutta verfasserin aut Mackenzie Coatham verfasserin aut Zhihua Xu verfasserin aut Aakshi Puri verfasserin aut Bo-Jhih Guan verfasserin aut Maria Hatzoglou verfasserin aut Andrea Brumwell verfasserin aut James Uniacke verfasserin aut Christos Patsis verfasserin aut Antonis Koromilas verfasserin aut Julia Schueler verfasserin aut Gabrielle M. Siegers verfasserin aut Ivan Topisirovic verfasserin aut Lynne-Marie Postovit verfasserin aut In Nature Communications Nature Portfolio, 2016 11(2020), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:11 year:2020 number:1 pages:16 https://doi.org/10.1038/s41467-020-16352-z kostenfrei https://doaj.org/article/312a98522c974e78ae7065a78eaa0f90 kostenfrei https://doi.org/10.1038/s41467-020-16352-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 16
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allfieldsSound	10.1038/s41467-020-16352-z doi (DE-627)DOAJ075614448 (DE-599)DOAJ312a98522c974e78ae7065a78eaa0f90 DE-627 ger DE-627 rakwb eng Michael Jewer verfasserin aut Translational control of breast cancer plasticity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance. Science Q Laura Lee verfasserin aut Matthew Leibovitch verfasserin aut Guihua Zhang verfasserin aut Jiahui Liu verfasserin aut Scott D. Findlay verfasserin aut Krista M. Vincent verfasserin aut Kristofferson Tandoc verfasserin aut Dylan Dieters-Castator verfasserin aut Daniela F. Quail verfasserin aut Indrani Dutta verfasserin aut Mackenzie Coatham verfasserin aut Zhihua Xu verfasserin aut Aakshi Puri verfasserin aut Bo-Jhih Guan verfasserin aut Maria Hatzoglou verfasserin aut Andrea Brumwell verfasserin aut James Uniacke verfasserin aut Christos Patsis verfasserin aut Antonis Koromilas verfasserin aut Julia Schueler verfasserin aut Gabrielle M. Siegers verfasserin aut Ivan Topisirovic verfasserin aut Lynne-Marie Postovit verfasserin aut In Nature Communications Nature Portfolio, 2016 11(2020), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:11 year:2020 number:1 pages:16 https://doi.org/10.1038/s41467-020-16352-z kostenfrei https://doaj.org/article/312a98522c974e78ae7065a78eaa0f90 kostenfrei https://doi.org/10.1038/s41467-020-16352-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 16
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authorswithroles_txt_mv	Michael Jewer @@aut@@ Laura Lee @@aut@@ Matthew Leibovitch @@aut@@ Guihua Zhang @@aut@@ Jiahui Liu @@aut@@ Scott D. Findlay @@aut@@ Krista M. Vincent @@aut@@ Kristofferson Tandoc @@aut@@ Dylan Dieters-Castator @@aut@@ Daniela F. Quail @@aut@@ Indrani Dutta @@aut@@ Mackenzie Coatham @@aut@@ Zhihua Xu @@aut@@ Aakshi Puri @@aut@@ Bo-Jhih Guan @@aut@@ Maria Hatzoglou @@aut@@ Andrea Brumwell @@aut@@ James Uniacke @@aut@@ Christos Patsis @@aut@@ Antonis Koromilas @@aut@@ Julia Schueler @@aut@@ Gabrielle M. Siegers @@aut@@ Ivan Topisirovic @@aut@@ Lynne-Marie Postovit @@aut@@
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author	Michael Jewer
spellingShingle	Michael Jewer misc Science misc Q Translational control of breast cancer plasticity
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title	Translational control of breast cancer plasticity
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title_full	Translational control of breast cancer plasticity
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author_browse	Michael Jewer Laura Lee Matthew Leibovitch Guihua Zhang Jiahui Liu Scott D. Findlay Krista M. Vincent Kristofferson Tandoc Dylan Dieters-Castator Daniela F. Quail Indrani Dutta Mackenzie Coatham Zhihua Xu Aakshi Puri Bo-Jhih Guan Maria Hatzoglou Andrea Brumwell James Uniacke Christos Patsis Antonis Koromilas Julia Schueler Gabrielle M. Siegers Ivan Topisirovic Lynne-Marie Postovit
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title_sort	translational control of breast cancer plasticity
title_auth	Translational control of breast cancer plasticity
abstract	Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance.
abstractGer	Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance.
abstract_unstemmed	Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance.
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title_short	Translational control of breast cancer plasticity
url	https://doi.org/10.1038/s41467-020-16352-z https://doaj.org/article/312a98522c974e78ae7065a78eaa0f90 https://doaj.org/toc/2041-1723
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up_date	2024-07-03T15:53:51.029Z
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