Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis

Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zhang CH [verfasserIn] Su XL [verfasserIn] Liu YY [verfasserIn] Lin L [verfasserIn] Wang YC [verfasserIn] Li XD [verfasserIn] Zhang JZ [verfasserIn] Wei W [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm

Übergeordnetes Werk:	In: Journal of Inflammation Research - Dove Medical Press, 2009, (2021), Seite 3023-3037
Übergeordnetes Werk:	year:2021 ; pages:3023-3037

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ075644592

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allfields	(DE-627)DOAJ075644592 (DE-599)DOAJ7ad0ea1b741846ce90d8a8697367ea0e DE-627 ger DE-627 rakwb eng RB1-214 RM1-950 Zhang CH verfasserin aut Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm Pathology Therapeutics. Pharmacology Su XL verfasserin aut Liu YY verfasserin aut Lin L verfasserin aut Wang YC verfasserin aut Li XD verfasserin aut Zhang JZ verfasserin aut Wei W verfasserin aut In Journal of Inflammation Research Dove Medical Press, 2009 (2021), Seite 3023-3037 (DE-627)600306178 (DE-600)2494878-0 11787031 nnns year:2021 pages:3023-3037 https://doaj.org/article/7ad0ea1b741846ce90d8a8697367ea0e kostenfrei https://www.dovepress.com/study-on-the-effect-of-antiplatelet-and-gastric-mucosal-protection-of--peer-reviewed-fulltext-article-JIR kostenfrei https://doaj.org/toc/1178-7031 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 3023-3037
spelling	(DE-627)DOAJ075644592 (DE-599)DOAJ7ad0ea1b741846ce90d8a8697367ea0e DE-627 ger DE-627 rakwb eng RB1-214 RM1-950 Zhang CH verfasserin aut Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm Pathology Therapeutics. Pharmacology Su XL verfasserin aut Liu YY verfasserin aut Lin L verfasserin aut Wang YC verfasserin aut Li XD verfasserin aut Zhang JZ verfasserin aut Wei W verfasserin aut In Journal of Inflammation Research Dove Medical Press, 2009 (2021), Seite 3023-3037 (DE-627)600306178 (DE-600)2494878-0 11787031 nnns year:2021 pages:3023-3037 https://doaj.org/article/7ad0ea1b741846ce90d8a8697367ea0e kostenfrei https://www.dovepress.com/study-on-the-effect-of-antiplatelet-and-gastric-mucosal-protection-of--peer-reviewed-fulltext-article-JIR kostenfrei https://doaj.org/toc/1178-7031 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 3023-3037
allfields_unstemmed	(DE-627)DOAJ075644592 (DE-599)DOAJ7ad0ea1b741846ce90d8a8697367ea0e DE-627 ger DE-627 rakwb eng RB1-214 RM1-950 Zhang CH verfasserin aut Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm Pathology Therapeutics. Pharmacology Su XL verfasserin aut Liu YY verfasserin aut Lin L verfasserin aut Wang YC verfasserin aut Li XD verfasserin aut Zhang JZ verfasserin aut Wei W verfasserin aut In Journal of Inflammation Research Dove Medical Press, 2009 (2021), Seite 3023-3037 (DE-627)600306178 (DE-600)2494878-0 11787031 nnns year:2021 pages:3023-3037 https://doaj.org/article/7ad0ea1b741846ce90d8a8697367ea0e kostenfrei https://www.dovepress.com/study-on-the-effect-of-antiplatelet-and-gastric-mucosal-protection-of--peer-reviewed-fulltext-article-JIR kostenfrei https://doaj.org/toc/1178-7031 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 3023-3037
allfieldsGer	(DE-627)DOAJ075644592 (DE-599)DOAJ7ad0ea1b741846ce90d8a8697367ea0e DE-627 ger DE-627 rakwb eng RB1-214 RM1-950 Zhang CH verfasserin aut Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm Pathology Therapeutics. Pharmacology Su XL verfasserin aut Liu YY verfasserin aut Lin L verfasserin aut Wang YC verfasserin aut Li XD verfasserin aut Zhang JZ verfasserin aut Wei W verfasserin aut In Journal of Inflammation Research Dove Medical Press, 2009 (2021), Seite 3023-3037 (DE-627)600306178 (DE-600)2494878-0 11787031 nnns year:2021 pages:3023-3037 https://doaj.org/article/7ad0ea1b741846ce90d8a8697367ea0e kostenfrei https://www.dovepress.com/study-on-the-effect-of-antiplatelet-and-gastric-mucosal-protection-of--peer-reviewed-fulltext-article-JIR kostenfrei https://doaj.org/toc/1178-7031 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 3023-3037
allfieldsSound	(DE-627)DOAJ075644592 (DE-599)DOAJ7ad0ea1b741846ce90d8a8697367ea0e DE-627 ger DE-627 rakwb eng RB1-214 RM1-950 Zhang CH verfasserin aut Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm Pathology Therapeutics. Pharmacology Su XL verfasserin aut Liu YY verfasserin aut Lin L verfasserin aut Wang YC verfasserin aut Li XD verfasserin aut Zhang JZ verfasserin aut Wei W verfasserin aut In Journal of Inflammation Research Dove Medical Press, 2009 (2021), Seite 3023-3037 (DE-627)600306178 (DE-600)2494878-0 11787031 nnns year:2021 pages:3023-3037 https://doaj.org/article/7ad0ea1b741846ce90d8a8697367ea0e kostenfrei https://www.dovepress.com/study-on-the-effect-of-antiplatelet-and-gastric-mucosal-protection-of--peer-reviewed-fulltext-article-JIR kostenfrei https://doaj.org/toc/1178-7031 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 3023-3037
language	English
source	In Journal of Inflammation Research (2021), Seite 3023-3037 year:2021 pages:3023-3037
sourceStr	In Journal of Inflammation Research (2021), Seite 3023-3037 year:2021 pages:3023-3037
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm Pathology Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Journal of Inflammation Research
authorswithroles_txt_mv	Zhang CH @@aut@@ Su XL @@aut@@ Liu YY @@aut@@ Lin L @@aut@@ Wang YC @@aut@@ Li XD @@aut@@ Zhang JZ @@aut@@ Wei W @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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id	DOAJ075644592
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ075644592</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309135017.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ075644592</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ7ad0ea1b741846ce90d8a8697367ea0e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RB1-214</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Zhang CH</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. 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callnumber-first	R - Medicine
author	Zhang CH
spellingShingle	Zhang CH misc RB1-214 misc RM1-950 misc supplementing qi and hemostasis herbs misc proton pump inhibition misc antiplatelet effect misc gastric mucosal protection misc traditional chinese medicine misc tcm misc Pathology misc Therapeutics. Pharmacology Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
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topic_title	RB1-214 RM1-950 Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm
topic	misc RB1-214 misc RM1-950 misc supplementing qi and hemostasis herbs misc proton pump inhibition misc antiplatelet effect misc gastric mucosal protection misc traditional chinese medicine misc tcm misc Pathology misc Therapeutics. Pharmacology
topic_unstemmed	misc RB1-214 misc RM1-950 misc supplementing qi and hemostasis herbs misc proton pump inhibition misc antiplatelet effect misc gastric mucosal protection misc traditional chinese medicine misc tcm misc Pathology misc Therapeutics. Pharmacology
topic_browse	misc RB1-214 misc RM1-950 misc supplementing qi and hemostasis herbs misc proton pump inhibition misc antiplatelet effect misc gastric mucosal protection misc traditional chinese medicine misc tcm misc Pathology misc Therapeutics. Pharmacology
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title	Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
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title_full	Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
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author_browse	Zhang CH Su XL Liu YY Lin L Wang YC Li XD Zhang JZ Wei W
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title_sort	study on the effect of antiplatelet and gastric mucosal protection of traditional chinese medicine invigorating qi and hemostasis
callnumber	RB1-214
title_auth	Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
abstract	Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine
abstractGer	Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine
abstract_unstemmed	Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine
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title_short	Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
url	https://doaj.org/article/7ad0ea1b741846ce90d8a8697367ea0e https://www.dovepress.com/study-on-the-effect-of-antiplatelet-and-gastric-mucosal-protection-of--peer-reviewed-fulltext-article-JIR https://doaj.org/toc/1178-7031
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Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">supplementing qi and hemostasis herbs</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">proton pump inhibition</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antiplatelet effect</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">gastric mucosal protection</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">traditional chinese medicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">tcm</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pathology</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. 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Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis

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