IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology

The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense against pathogens. IL-10 and IL-22 are the best studied members of the IL-10 family and play essential roles in ma...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hua-Xing Wei [verfasserIn] Baolong Wang [verfasserIn] Bofeng Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	IL-10 IL-22 IBD colorectal cancer ILC inflammation

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2020.01315

Katalog-ID:	DOAJ075735776

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container_title	Frontiers in Immunology
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callnumber-first	R - Medicine
author	Hua-Xing Wei
spellingShingle	Hua-Xing Wei misc RC581-607 misc IL-10 misc IL-22 misc IBD misc colorectal cancer misc ILC misc inflammation misc Immunologic diseases. Allergy IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
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topic_title	RC581-607 IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology IL-10 IL-22 IBD colorectal cancer ILC inflammation
topic	misc RC581-607 misc IL-10 misc IL-22 misc IBD misc colorectal cancer misc ILC misc inflammation misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc IL-10 misc IL-22 misc IBD misc colorectal cancer misc ILC misc inflammation misc Immunologic diseases. Allergy
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title	IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
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title_sort	il-10 and il-22 in mucosal immunity: driving protection and pathology
callnumber	RC581-607
title_auth	IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
abstract	The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense against pathogens. IL-10 and IL-22 are the best studied members of the IL-10 family and play essential roles in maintaining mucosal homeostasis. IL-10 serves as an important regulator in preventing pro-inflammatory responses while IL-22 plays a protective role in tissue damage and contributes to pathology in certain settings. In this review, we focus on these two cytokines in the development of gastrointestinal diseases, including inflammatory bowel diseases (IBD) and colitis-associated cancer (CAC). We summarize the recent studies and try to gain a better understanding on how they regulate immune responses to maintain equilibrium under inflammatory conditions.
abstractGer	The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense against pathogens. IL-10 and IL-22 are the best studied members of the IL-10 family and play essential roles in maintaining mucosal homeostasis. IL-10 serves as an important regulator in preventing pro-inflammatory responses while IL-22 plays a protective role in tissue damage and contributes to pathology in certain settings. In this review, we focus on these two cytokines in the development of gastrointestinal diseases, including inflammatory bowel diseases (IBD) and colitis-associated cancer (CAC). We summarize the recent studies and try to gain a better understanding on how they regulate immune responses to maintain equilibrium under inflammatory conditions.
abstract_unstemmed	The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense against pathogens. IL-10 and IL-22 are the best studied members of the IL-10 family and play essential roles in maintaining mucosal homeostasis. IL-10 serves as an important regulator in preventing pro-inflammatory responses while IL-22 plays a protective role in tissue damage and contributes to pathology in certain settings. In this review, we focus on these two cytokines in the development of gastrointestinal diseases, including inflammatory bowel diseases (IBD) and colitis-associated cancer (CAC). We summarize the recent studies and try to gain a better understanding on how they regulate immune responses to maintain equilibrium under inflammatory conditions.
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title_short	IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
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