The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review

In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between humans and common...
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Autor*in:	Benjamin Zimmerman [verfasserIn] Payel Kundu [verfasserIn] William D. Rooney [verfasserIn] Jacob Raber [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	high-fat diet species differences cardiovascular health metabolism cerebrovasculature cognition

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 26(2021), 11, p 3406
Übergeordnetes Werk:	volume:26 ; year:2021 ; number:11, p 3406

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules26113406

Katalog-ID:	DOAJ075806142

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allfieldsSound	10.3390/molecules26113406 doi (DE-627)DOAJ075806142 (DE-599)DOAJ37916513bc844d0abf447fec7d6d2866 DE-627 ger DE-627 rakwb eng QD241-441 Benjamin Zimmerman verfasserin aut The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between humans and common animal models in terms of how they react metabolically to high-fat diets need to be considered. Here, we review the factors that may affect the translatability of mechanistic research in animal models, paying special attention to the effects of a high-fat diet on vascular outcomes. We draw attention to the dissociation between metabolic syndrome and dyslipidemia in rodents, unlike the state in humans, where the two commonly occur. We also discuss the differential vulnerability between species to the metabolic and vascular effects of macronutrients in the diet. Findings from animal studies are better interpreted as modeling specific aspects of dysfunction. We conclude that the differences between species provide an opportunity to explore why some species are protected from the detrimental aspects of high-fat-diet-induced dysfunction, and to translate these findings into benefits for human health. high-fat diet species differences cardiovascular health metabolism cerebrovasculature cognition Organic chemistry Payel Kundu verfasserin aut William D. Rooney verfasserin aut Jacob Raber verfasserin aut In Molecules MDPI AG, 2003 26(2021), 11, p 3406 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:11, p 3406 https://doi.org/10.3390/molecules26113406 kostenfrei https://doaj.org/article/37916513bc844d0abf447fec7d6d2866 kostenfrei https://www.mdpi.com/1420-3049/26/11/3406 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 11, p 3406
language	English
source	In Molecules 26(2021), 11, p 3406 volume:26 year:2021 number:11, p 3406
sourceStr	In Molecules 26(2021), 11, p 3406 volume:26 year:2021 number:11, p 3406
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	high-fat diet species differences cardiovascular health metabolism cerebrovasculature cognition Organic chemistry
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container_title	Molecules
authorswithroles_txt_mv	Benjamin Zimmerman @@aut@@ Payel Kundu @@aut@@ William D. Rooney @@aut@@ Jacob Raber @@aut@@
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callnumber-first	Q - Science
author	Benjamin Zimmerman
spellingShingle	Benjamin Zimmerman misc QD241-441 misc high-fat diet misc species differences misc cardiovascular health misc metabolism misc cerebrovasculature misc cognition misc Organic chemistry The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review
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topic_title	QD241-441 The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review high-fat diet species differences cardiovascular health metabolism cerebrovasculature cognition
topic	misc QD241-441 misc high-fat diet misc species differences misc cardiovascular health misc metabolism misc cerebrovasculature misc cognition misc Organic chemistry
topic_unstemmed	misc QD241-441 misc high-fat diet misc species differences misc cardiovascular health misc metabolism misc cerebrovasculature misc cognition misc Organic chemistry
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title_auth	The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review
abstract	In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between humans and common animal models in terms of how they react metabolically to high-fat diets need to be considered. Here, we review the factors that may affect the translatability of mechanistic research in animal models, paying special attention to the effects of a high-fat diet on vascular outcomes. We draw attention to the dissociation between metabolic syndrome and dyslipidemia in rodents, unlike the state in humans, where the two commonly occur. We also discuss the differential vulnerability between species to the metabolic and vascular effects of macronutrients in the diet. Findings from animal studies are better interpreted as modeling specific aspects of dysfunction. We conclude that the differences between species provide an opportunity to explore why some species are protected from the detrimental aspects of high-fat-diet-induced dysfunction, and to translate these findings into benefits for human health.
abstractGer	In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between humans and common animal models in terms of how they react metabolically to high-fat diets need to be considered. Here, we review the factors that may affect the translatability of mechanistic research in animal models, paying special attention to the effects of a high-fat diet on vascular outcomes. We draw attention to the dissociation between metabolic syndrome and dyslipidemia in rodents, unlike the state in humans, where the two commonly occur. We also discuss the differential vulnerability between species to the metabolic and vascular effects of macronutrients in the diet. Findings from animal studies are better interpreted as modeling specific aspects of dysfunction. We conclude that the differences between species provide an opportunity to explore why some species are protected from the detrimental aspects of high-fat-diet-induced dysfunction, and to translate these findings into benefits for human health.
abstract_unstemmed	In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between humans and common animal models in terms of how they react metabolically to high-fat diets need to be considered. Here, we review the factors that may affect the translatability of mechanistic research in animal models, paying special attention to the effects of a high-fat diet on vascular outcomes. We draw attention to the dissociation between metabolic syndrome and dyslipidemia in rodents, unlike the state in humans, where the two commonly occur. We also discuss the differential vulnerability between species to the metabolic and vascular effects of macronutrients in the diet. Findings from animal studies are better interpreted as modeling specific aspects of dysfunction. We conclude that the differences between species provide an opportunity to explore why some species are protected from the detrimental aspects of high-fat-diet-induced dysfunction, and to translate these findings into benefits for human health.
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title_short	The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review
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