Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?

Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Material...
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Autor*in:	Rocio Porcel-Chacón [verfasserIn] Cristina Antúnez-Fernández [verfasserIn] Maria Mora Loro [verfasserIn] Ana-Belen Ariza-Jimenez [verfasserIn] Leopoldo Tapia Ceballos [verfasserIn] Jose Manuel Jimenez Hinojosa [verfasserIn] Juan Pedro Lopez-Siguero [verfasserIn] Isabel Leiva Gea [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	type 1 diabetes mellitus pediatric diabetes continuous glucose monitoring time in 28 range HbA1c capillary blood glucose test

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 21, p 4913
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:21, p 4913

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm10214913

Katalog-ID:	DOAJ075809478

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520			\|a Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Materials and methods: A cohort prospective study with 191 pediatric patients with T1D was conducted. Time in range (TIR), time below range (TBR), coefficient of variation (CV), number of capillary blood glucose tests, and HbA1c before sensor insertion and at one year of use were collected. Results: Patients were classified into five groups according to HbA1c at one year of using CGM. They performed fewer capillary blood glucose test at one year using CGM (−6 +/− 2, <i<p</i< < 0.0001). We found statistically significant differences in TIR between categories. Although groups with HbA1c < 6.5% and HbA1c 6.5–7% had the highest TIR (62.214 and 50.462%), their values were highly below optimal control according to CGM consensus. Groups with TBR < 5% were those with HbA1c between 6.5% and 8%. Conclusions: In our study, groups classified as well-controlled by guidelines were not consistent with good control according to the CGM consensus criteria. HbA1c should not be considered as the only parameter for metabolic control. CGM parameters allow individualized targets.
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spelling	10.3390/jcm10214913 doi (DE-627)DOAJ075809478 (DE-599)DOAJ99165e44ffba4a0bbba31374711f9c16 DE-627 ger DE-627 rakwb eng Rocio Porcel-Chacón verfasserin aut Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Materials and methods: A cohort prospective study with 191 pediatric patients with T1D was conducted. Time in range (TIR), time below range (TBR), coefficient of variation (CV), number of capillary blood glucose tests, and HbA1c before sensor insertion and at one year of use were collected. Results: Patients were classified into five groups according to HbA1c at one year of using CGM. They performed fewer capillary blood glucose test at one year using CGM (−6 +/− 2, <i<p</i< < 0.0001). We found statistically significant differences in TIR between categories. Although groups with HbA1c < 6.5% and HbA1c 6.5–7% had the highest TIR (62.214 and 50.462%), their values were highly below optimal control according to CGM consensus. Groups with TBR < 5% were those with HbA1c between 6.5% and 8%. Conclusions: In our study, groups classified as well-controlled by guidelines were not consistent with good control according to the CGM consensus criteria. HbA1c should not be considered as the only parameter for metabolic control. CGM parameters allow individualized targets. type 1 diabetes mellitus pediatric diabetes continuous glucose monitoring time in 28 range HbA1c capillary blood glucose test Medicine R Cristina Antúnez-Fernández verfasserin aut Maria Mora Loro verfasserin aut Ana-Belen Ariza-Jimenez verfasserin aut Leopoldo Tapia Ceballos verfasserin aut Jose Manuel Jimenez Hinojosa verfasserin aut Juan Pedro Lopez-Siguero verfasserin aut Isabel Leiva Gea verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 21, p 4913 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:21, p 4913 https://doi.org/10.3390/jcm10214913 kostenfrei https://doaj.org/article/99165e44ffba4a0bbba31374711f9c16 kostenfrei https://www.mdpi.com/2077-0383/10/21/4913 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 21, p 4913
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allfieldsSound	10.3390/jcm10214913 doi (DE-627)DOAJ075809478 (DE-599)DOAJ99165e44ffba4a0bbba31374711f9c16 DE-627 ger DE-627 rakwb eng Rocio Porcel-Chacón verfasserin aut Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Materials and methods: A cohort prospective study with 191 pediatric patients with T1D was conducted. Time in range (TIR), time below range (TBR), coefficient of variation (CV), number of capillary blood glucose tests, and HbA1c before sensor insertion and at one year of use were collected. Results: Patients were classified into five groups according to HbA1c at one year of using CGM. They performed fewer capillary blood glucose test at one year using CGM (−6 +/− 2, <i<p</i< < 0.0001). We found statistically significant differences in TIR between categories. Although groups with HbA1c < 6.5% and HbA1c 6.5–7% had the highest TIR (62.214 and 50.462%), their values were highly below optimal control according to CGM consensus. Groups with TBR < 5% were those with HbA1c between 6.5% and 8%. Conclusions: In our study, groups classified as well-controlled by guidelines were not consistent with good control according to the CGM consensus criteria. HbA1c should not be considered as the only parameter for metabolic control. CGM parameters allow individualized targets. type 1 diabetes mellitus pediatric diabetes continuous glucose monitoring time in 28 range HbA1c capillary blood glucose test Medicine R Cristina Antúnez-Fernández verfasserin aut Maria Mora Loro verfasserin aut Ana-Belen Ariza-Jimenez verfasserin aut Leopoldo Tapia Ceballos verfasserin aut Jose Manuel Jimenez Hinojosa verfasserin aut Juan Pedro Lopez-Siguero verfasserin aut Isabel Leiva Gea verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 21, p 4913 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:21, p 4913 https://doi.org/10.3390/jcm10214913 kostenfrei https://doaj.org/article/99165e44ffba4a0bbba31374711f9c16 kostenfrei https://www.mdpi.com/2077-0383/10/21/4913 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 21, p 4913
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author	Rocio Porcel-Chacón
spellingShingle	Rocio Porcel-Chacón misc type 1 diabetes mellitus misc pediatric diabetes misc continuous glucose monitoring misc time in 28 range misc HbA1c misc capillary blood glucose test misc Medicine misc R Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
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topic_title	Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre? type 1 diabetes mellitus pediatric diabetes continuous glucose monitoring time in 28 range HbA1c capillary blood glucose test
topic	misc type 1 diabetes mellitus misc pediatric diabetes misc continuous glucose monitoring misc time in 28 range misc HbA1c misc capillary blood glucose test misc Medicine misc R
topic_unstemmed	misc type 1 diabetes mellitus misc pediatric diabetes misc continuous glucose monitoring misc time in 28 range misc HbA1c misc capillary blood glucose test misc Medicine misc R
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title	Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
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title_full	Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
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author_browse	Rocio Porcel-Chacón Cristina Antúnez-Fernández Maria Mora Loro Ana-Belen Ariza-Jimenez Leopoldo Tapia Ceballos Jose Manuel Jimenez Hinojosa Juan Pedro Lopez-Siguero Isabel Leiva Gea
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title_sort	good metabolic control in children with type 1 diabetes mellitus: does glycated hemoglobin correlate with interstitial glucose monitoring using freestyle libre?
title_auth	Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
abstract	Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Materials and methods: A cohort prospective study with 191 pediatric patients with T1D was conducted. Time in range (TIR), time below range (TBR), coefficient of variation (CV), number of capillary blood glucose tests, and HbA1c before sensor insertion and at one year of use were collected. Results: Patients were classified into five groups according to HbA1c at one year of using CGM. They performed fewer capillary blood glucose test at one year using CGM (−6 +/− 2, <i<p</i< < 0.0001). We found statistically significant differences in TIR between categories. Although groups with HbA1c < 6.5% and HbA1c 6.5–7% had the highest TIR (62.214 and 50.462%), their values were highly below optimal control according to CGM consensus. Groups with TBR < 5% were those with HbA1c between 6.5% and 8%. Conclusions: In our study, groups classified as well-controlled by guidelines were not consistent with good control according to the CGM consensus criteria. HbA1c should not be considered as the only parameter for metabolic control. CGM parameters allow individualized targets.
abstractGer	Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Materials and methods: A cohort prospective study with 191 pediatric patients with T1D was conducted. Time in range (TIR), time below range (TBR), coefficient of variation (CV), number of capillary blood glucose tests, and HbA1c before sensor insertion and at one year of use were collected. Results: Patients were classified into five groups according to HbA1c at one year of using CGM. They performed fewer capillary blood glucose test at one year using CGM (−6 +/− 2, <i<p</i< < 0.0001). We found statistically significant differences in TIR between categories. Although groups with HbA1c < 6.5% and HbA1c 6.5–7% had the highest TIR (62.214 and 50.462%), their values were highly below optimal control according to CGM consensus. Groups with TBR < 5% were those with HbA1c between 6.5% and 8%. Conclusions: In our study, groups classified as well-controlled by guidelines were not consistent with good control according to the CGM consensus criteria. HbA1c should not be considered as the only parameter for metabolic control. CGM parameters allow individualized targets.
abstract_unstemmed	Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Materials and methods: A cohort prospective study with 191 pediatric patients with T1D was conducted. Time in range (TIR), time below range (TBR), coefficient of variation (CV), number of capillary blood glucose tests, and HbA1c before sensor insertion and at one year of use were collected. Results: Patients were classified into five groups according to HbA1c at one year of using CGM. They performed fewer capillary blood glucose test at one year using CGM (−6 +/− 2, <i<p</i< < 0.0001). We found statistically significant differences in TIR between categories. Although groups with HbA1c < 6.5% and HbA1c 6.5–7% had the highest TIR (62.214 and 50.462%), their values were highly below optimal control according to CGM consensus. Groups with TBR < 5% were those with HbA1c between 6.5% and 8%. Conclusions: In our study, groups classified as well-controlled by guidelines were not consistent with good control according to the CGM consensus criteria. HbA1c should not be considered as the only parameter for metabolic control. CGM parameters allow individualized targets.
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title_short	Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
url	https://doi.org/10.3390/jcm10214913 https://doaj.org/article/99165e44ffba4a0bbba31374711f9c16 https://www.mdpi.com/2077-0383/10/21/4913 https://doaj.org/toc/2077-0383
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author2	Cristina Antúnez-Fernández Maria Mora Loro Ana-Belen Ariza-Jimenez Leopoldo Tapia Ceballos Jose Manuel Jimenez Hinojosa Juan Pedro Lopez-Siguero Isabel Leiva Gea
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up_date	2024-07-03T16:57:03.760Z
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