HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.

Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia. Results of transplant in thalassemia and in sickle cell anemia have steadily improved over the last two decades due to improvements in pr...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Marco Marziali [verfasserIn] Antonella Isgrò [verfasserIn] Javid Gaziev [verfasserIn] Guido Lucarelli [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Hematopoietic Stem Cell Transplantation, Thalassemia , Sickle Cell Disease, Developping Countries

Übergeordnetes Werk:	In: Mediterranean Journal of Hematology and Infectious Diseases - Mattioli1885, 2010, 1(2009), 1, Seite e2009027-e2009027
Übergeordnetes Werk:	volume:1 ; year:2009 ; number:1 ; pages:e2009027-e2009027

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4084/mjhid.2009.027

Katalog-ID:	DOAJ075821710

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allfields	10.4084/mjhid.2009.027 doi (DE-627)DOAJ075821710 (DE-599)DOAJ3be26ac2a71a4fe784fee23b9b2249be DE-627 ger DE-627 rakwb eng RC633-647.5 Marco Marziali verfasserin aut HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia. Results of transplant in thalassemia and in sickle cell anemia have steadily improved over the last two decades due to improvements in preventive strategies, and effective control of transplant-related complications. From 2004 through 2009, 145 consecutive patients with thalassemia and sickle cell anemia, ethnically heterogeneous from Mediterranean and Middle East countries, were given HSCT in the International Center for Transplantation in Thalassemia and Sickle Cella Anemia in Rome. This experience is characterized by two peculiarities: patients were ethnically very heterogeneous and the vast majority of these patients were not regularly transfesed/chelated and therefore were highly sensitized due to RBC transfusions without leukodepletion filters. Consequently, they could have a high risk of graft rejection as a result of sensitization to HLA antigens. The Rome experience of SCT in patients with thalassemia and sickle cell anemia confirmed the results obtained in Pesaro, and most importantly showed the reproducibility of these results in other centers. Hematopoietic Stem Cell Transplantation, Thalassemia , Sickle Cell Disease, Developping Countries Diseases of the blood and blood-forming organs Antonella Isgrò verfasserin aut Javid Gaziev verfasserin aut Guido Lucarelli verfasserin aut In Mediterranean Journal of Hematology and Infectious Diseases Mattioli1885, 2010 1(2009), 1, Seite e2009027-e2009027 (DE-627)721581978 (DE-600)2674750-9 20353006 nnns volume:1 year:2009 number:1 pages:e2009027-e2009027 https://doi.org/10.4084/mjhid.2009.027 kostenfrei https://doaj.org/article/3be26ac2a71a4fe784fee23b9b2249be kostenfrei http://www.mjhid.org/index.php/mjhid/article/view/114 kostenfrei https://doaj.org/toc/2035-3006 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 e2009027-e2009027
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callnumber-first	R - Medicine
author	Marco Marziali
spellingShingle	Marco Marziali misc RC633-647.5 misc Hematopoietic Stem Cell Transplantation, Thalassemia , Sickle Cell Disease, Developping Countries misc Diseases of the blood and blood-forming organs HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.
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topic_title	RC633-647.5 HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION Hematopoietic Stem Cell Transplantation, Thalassemia , Sickle Cell Disease, Developping Countries
topic	misc RC633-647.5 misc Hematopoietic Stem Cell Transplantation, Thalassemia , Sickle Cell Disease, Developping Countries misc Diseases of the blood and blood-forming organs
topic_unstemmed	misc RC633-647.5 misc Hematopoietic Stem Cell Transplantation, Thalassemia , Sickle Cell Disease, Developping Countries misc Diseases of the blood and blood-forming organs
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title	HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.
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title_full	HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION
author_sort	Marco Marziali
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author_browse	Marco Marziali Antonella Isgrò Javid Gaziev Guido Lucarelli
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title_sort	hematopoietic stem cell transplantation in thalassemia and sickle cell disease: experience of mediterranean institute of hematology in a multi-ethnic population
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title_auth	HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.
abstract	Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia. Results of transplant in thalassemia and in sickle cell anemia have steadily improved over the last two decades due to improvements in preventive strategies, and effective control of transplant-related complications. From 2004 through 2009, 145 consecutive patients with thalassemia and sickle cell anemia, ethnically heterogeneous from Mediterranean and Middle East countries, were given HSCT in the International Center for Transplantation in Thalassemia and Sickle Cella Anemia in Rome. This experience is characterized by two peculiarities: patients were ethnically very heterogeneous and the vast majority of these patients were not regularly transfesed/chelated and therefore were highly sensitized due to RBC transfusions without leukodepletion filters. Consequently, they could have a high risk of graft rejection as a result of sensitization to HLA antigens. The Rome experience of SCT in patients with thalassemia and sickle cell anemia confirmed the results obtained in Pesaro, and most importantly showed the reproducibility of these results in other centers.
abstractGer	Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia. Results of transplant in thalassemia and in sickle cell anemia have steadily improved over the last two decades due to improvements in preventive strategies, and effective control of transplant-related complications. From 2004 through 2009, 145 consecutive patients with thalassemia and sickle cell anemia, ethnically heterogeneous from Mediterranean and Middle East countries, were given HSCT in the International Center for Transplantation in Thalassemia and Sickle Cella Anemia in Rome. This experience is characterized by two peculiarities: patients were ethnically very heterogeneous and the vast majority of these patients were not regularly transfesed/chelated and therefore were highly sensitized due to RBC transfusions without leukodepletion filters. Consequently, they could have a high risk of graft rejection as a result of sensitization to HLA antigens. The Rome experience of SCT in patients with thalassemia and sickle cell anemia confirmed the results obtained in Pesaro, and most importantly showed the reproducibility of these results in other centers.
abstract_unstemmed	Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia. Results of transplant in thalassemia and in sickle cell anemia have steadily improved over the last two decades due to improvements in preventive strategies, and effective control of transplant-related complications. From 2004 through 2009, 145 consecutive patients with thalassemia and sickle cell anemia, ethnically heterogeneous from Mediterranean and Middle East countries, were given HSCT in the International Center for Transplantation in Thalassemia and Sickle Cella Anemia in Rome. This experience is characterized by two peculiarities: patients were ethnically very heterogeneous and the vast majority of these patients were not regularly transfesed/chelated and therefore were highly sensitized due to RBC transfusions without leukodepletion filters. Consequently, they could have a high risk of graft rejection as a result of sensitization to HLA antigens. The Rome experience of SCT in patients with thalassemia and sickle cell anemia confirmed the results obtained in Pesaro, and most importantly showed the reproducibility of these results in other centers.
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title_short	HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.
url	https://doi.org/10.4084/mjhid.2009.027 https://doaj.org/article/3be26ac2a71a4fe784fee23b9b2249be http://www.mjhid.org/index.php/mjhid/article/view/114 https://doaj.org/toc/2035-3006
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up_date	2024-07-03T17:01:18.951Z
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HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.

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