Fusobacterium nucleatum and oral cancer: a critical review

Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal can...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Emily McIlvanna [verfasserIn] Gerard J. Linden [verfasserIn] Stephanie G. Craig [verfasserIn] Fionnuala T. Lundy [verfasserIn] Jacqueline A. James [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Fusobacteria F. nucleatum Carcinogenesis Oral cancer OSCC

Übergeordnetes Werk:	In: BMC Cancer - BMC, 2003, 21(2021), 1, Seite 11
Übergeordnetes Werk:	volume:21 ; year:2021 ; number:1 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12885-021-08903-4

Katalog-ID:	DOAJ075860147

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allfields	10.1186/s12885-021-08903-4 doi (DE-627)DOAJ075860147 (DE-599)DOAJ4fe7821000194282b227188231027b4b DE-627 ger DE-627 rakwb eng RC254-282 Emily McIlvanna verfasserin aut Fusobacterium nucleatum and oral cancer: a critical review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it. Fusobacteria F. nucleatum Carcinogenesis Oral cancer OSCC Neoplasms. Tumors. Oncology. Including cancer and carcinogens Gerard J. Linden verfasserin aut Stephanie G. Craig verfasserin aut Fionnuala T. Lundy verfasserin aut Jacqueline A. James verfasserin aut In BMC Cancer BMC, 2003 21(2021), 1, Seite 11 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:21 year:2021 number:1 pages:11 https://doi.org/10.1186/s12885-021-08903-4 kostenfrei https://doaj.org/article/4fe7821000194282b227188231027b4b kostenfrei https://doi.org/10.1186/s12885-021-08903-4 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 11
spelling	10.1186/s12885-021-08903-4 doi (DE-627)DOAJ075860147 (DE-599)DOAJ4fe7821000194282b227188231027b4b DE-627 ger DE-627 rakwb eng RC254-282 Emily McIlvanna verfasserin aut Fusobacterium nucleatum and oral cancer: a critical review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it. Fusobacteria F. nucleatum Carcinogenesis Oral cancer OSCC Neoplasms. Tumors. Oncology. Including cancer and carcinogens Gerard J. Linden verfasserin aut Stephanie G. Craig verfasserin aut Fionnuala T. Lundy verfasserin aut Jacqueline A. James verfasserin aut In BMC Cancer BMC, 2003 21(2021), 1, Seite 11 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:21 year:2021 number:1 pages:11 https://doi.org/10.1186/s12885-021-08903-4 kostenfrei https://doaj.org/article/4fe7821000194282b227188231027b4b kostenfrei https://doi.org/10.1186/s12885-021-08903-4 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 11
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allfieldsGer	10.1186/s12885-021-08903-4 doi (DE-627)DOAJ075860147 (DE-599)DOAJ4fe7821000194282b227188231027b4b DE-627 ger DE-627 rakwb eng RC254-282 Emily McIlvanna verfasserin aut Fusobacterium nucleatum and oral cancer: a critical review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it. Fusobacteria F. nucleatum Carcinogenesis Oral cancer OSCC Neoplasms. Tumors. Oncology. Including cancer and carcinogens Gerard J. Linden verfasserin aut Stephanie G. Craig verfasserin aut Fionnuala T. Lundy verfasserin aut Jacqueline A. James verfasserin aut In BMC Cancer BMC, 2003 21(2021), 1, Seite 11 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:21 year:2021 number:1 pages:11 https://doi.org/10.1186/s12885-021-08903-4 kostenfrei https://doaj.org/article/4fe7821000194282b227188231027b4b kostenfrei https://doi.org/10.1186/s12885-021-08903-4 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 11
allfieldsSound	10.1186/s12885-021-08903-4 doi (DE-627)DOAJ075860147 (DE-599)DOAJ4fe7821000194282b227188231027b4b DE-627 ger DE-627 rakwb eng RC254-282 Emily McIlvanna verfasserin aut Fusobacterium nucleatum and oral cancer: a critical review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it. Fusobacteria F. nucleatum Carcinogenesis Oral cancer OSCC Neoplasms. Tumors. Oncology. Including cancer and carcinogens Gerard J. Linden verfasserin aut Stephanie G. Craig verfasserin aut Fionnuala T. Lundy verfasserin aut Jacqueline A. James verfasserin aut In BMC Cancer BMC, 2003 21(2021), 1, Seite 11 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:21 year:2021 number:1 pages:11 https://doi.org/10.1186/s12885-021-08903-4 kostenfrei https://doaj.org/article/4fe7821000194282b227188231027b4b kostenfrei https://doi.org/10.1186/s12885-021-08903-4 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 11
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authorswithroles_txt_mv	Emily McIlvanna @@aut@@ Gerard J. Linden @@aut@@ Stephanie G. Craig @@aut@@ Fionnuala T. Lundy @@aut@@ Jacqueline A. James @@aut@@
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callnumber-first	R - Medicine
author	Emily McIlvanna
spellingShingle	Emily McIlvanna misc RC254-282 misc Fusobacteria misc F. nucleatum misc Carcinogenesis misc Oral cancer misc OSCC misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fusobacterium nucleatum and oral cancer: a critical review
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topic_title	RC254-282 Fusobacterium nucleatum and oral cancer: a critical review Fusobacteria F. nucleatum Carcinogenesis Oral cancer OSCC
topic	misc RC254-282 misc Fusobacteria misc F. nucleatum misc Carcinogenesis misc Oral cancer misc OSCC misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Fusobacteria misc F. nucleatum misc Carcinogenesis misc Oral cancer misc OSCC misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Fusobacterium nucleatum and oral cancer: a critical review
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title_full	Fusobacterium nucleatum and oral cancer: a critical review
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title_sort	fusobacterium nucleatum and oral cancer: a critical review
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title_auth	Fusobacterium nucleatum and oral cancer: a critical review
abstract	Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it.
abstractGer	Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it.
abstract_unstemmed	Abstract There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it.
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title_short	Fusobacterium nucleatum and oral cancer: a critical review
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Fusobacterium nucleatum and oral cancer: a critical review

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