Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China

This study explored the association between oral microbes and head and neck cancer (HNC) as well as symptoms related to patients with HNC before surgical treatment. Fifty-six patients with HNC and 64 matched healthy controls were recruited from West China hospital in Southwest China. The demographic...
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Autor*in:	Hao-Jiang Zuo [verfasserIn] Mei R. Fu [verfasserIn] Hui-Ling Zhao [verfasserIn] Xin-Wen Du [verfasserIn] Zi-Yi Hu [verfasserIn] Xun-Ying Zhao [verfasserIn] Xiao-Qin Ji [verfasserIn] Xian-Qiong Feng [verfasserIn] Wuerken Zhumajiang [verfasserIn] Ting-Hui Zhou [verfasserIn] Ya-Li Tian [verfasserIn] Xiao-Fang Pei [verfasserIn] Rong Yu [verfasserIn] Xiu-Ying Hu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	head and neck cancer (HNC) saliva microbiota 16S rRNA gene sequencing symptom geographical biomarkers

Übergeordnetes Werk:	In: Frontiers in Cellular and Infection Microbiology - Frontiers Media S.A., 2016, 10(2020)
Übergeordnetes Werk:	volume:10 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcimb.2020.514943

Katalog-ID:	DOAJ075977095

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callnumber-first	Q - Science
author	Hao-Jiang Zuo
spellingShingle	Hao-Jiang Zuo misc QR1-502 misc head and neck cancer (HNC) misc saliva microbiota misc 16S rRNA gene sequencing misc symptom misc geographical biomarkers misc Microbiology Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China
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topic_title	QR1-502 Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China head and neck cancer (HNC) saliva microbiota 16S rRNA gene sequencing symptom geographical biomarkers
topic	misc QR1-502 misc head and neck cancer (HNC) misc saliva microbiota misc 16S rRNA gene sequencing misc symptom misc geographical biomarkers misc Microbiology
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title	Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China
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title_full	Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China
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author_browse	Hao-Jiang Zuo Mei R. Fu Hui-Ling Zhao Xin-Wen Du Zi-Yi Hu Xun-Ying Zhao Xiao-Qin Ji Xian-Qiong Feng Wuerken Zhumajiang Ting-Hui Zhou Ya-Li Tian Xiao-Fang Pei Rong Yu Xiu-Ying Hu
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title_sort	study on the salivary microbial alteration of men with head and neck cancer and its relationship with symptoms in southwest china
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title_auth	Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China
abstract	This study explored the association between oral microbes and head and neck cancer (HNC) as well as symptoms related to patients with HNC before surgical treatment. Fifty-six patients with HNC and 64 matched healthy controls were recruited from West China hospital in Southwest China. The demographic, clinical, and symptom data were collected. Salivary samples were collected to determine the microbial characteristics using 16S rRNA gene sequencing. Patients with HNC presented increased Capnocytophaga abundances. The oral microbial markers as Capnocytophaga (area under the curve=0.81) achieved a high classification power between the HNC patients and healthy controls. Moreover, using Capnocytophaga in conjunction with symptom of voice/speech difficulty achieved an overall predicting accuracy of 92.5% comparing with using Capnocytophaga alone (79.2% accuracy) in distinguishing the HNC patients from healthy controls. Salivary microbial profiles and HNC symptoms may be potential biomarkers for HNC screening.
abstractGer	This study explored the association between oral microbes and head and neck cancer (HNC) as well as symptoms related to patients with HNC before surgical treatment. Fifty-six patients with HNC and 64 matched healthy controls were recruited from West China hospital in Southwest China. The demographic, clinical, and symptom data were collected. Salivary samples were collected to determine the microbial characteristics using 16S rRNA gene sequencing. Patients with HNC presented increased Capnocytophaga abundances. The oral microbial markers as Capnocytophaga (area under the curve=0.81) achieved a high classification power between the HNC patients and healthy controls. Moreover, using Capnocytophaga in conjunction with symptom of voice/speech difficulty achieved an overall predicting accuracy of 92.5% comparing with using Capnocytophaga alone (79.2% accuracy) in distinguishing the HNC patients from healthy controls. Salivary microbial profiles and HNC symptoms may be potential biomarkers for HNC screening.
abstract_unstemmed	This study explored the association between oral microbes and head and neck cancer (HNC) as well as symptoms related to patients with HNC before surgical treatment. Fifty-six patients with HNC and 64 matched healthy controls were recruited from West China hospital in Southwest China. The demographic, clinical, and symptom data were collected. Salivary samples were collected to determine the microbial characteristics using 16S rRNA gene sequencing. Patients with HNC presented increased Capnocytophaga abundances. The oral microbial markers as Capnocytophaga (area under the curve=0.81) achieved a high classification power between the HNC patients and healthy controls. Moreover, using Capnocytophaga in conjunction with symptom of voice/speech difficulty achieved an overall predicting accuracy of 92.5% comparing with using Capnocytophaga alone (79.2% accuracy) in distinguishing the HNC patients from healthy controls. Salivary microbial profiles and HNC symptoms may be potential biomarkers for HNC screening.
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title_short	Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China
url	https://doi.org/10.3389/fcimb.2020.514943 https://doaj.org/article/248f4a4cbe9847c9996d8121f538e5ef https://www.frontiersin.org/articles/10.3389/fcimb.2020.514943/full https://doaj.org/toc/2235-2988
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author2	Hao-Jiang Zuo Mei R. Fu Hui-Ling Zhao Xin-Wen Du Zi-Yi Hu Xun-Ying Zhao Xiao-Qin Ji Xian-Qiong Feng Wuerken Zhumajiang Ting-Hui Zhou Ya-Li Tian Xiao-Fang Pei Rong Yu Xiu-Ying Hu
author2Str	Hao-Jiang Zuo Mei R. Fu Hui-Ling Zhao Xin-Wen Du Zi-Yi Hu Xun-Ying Zhao Xiao-Qin Ji Xian-Qiong Feng Wuerken Zhumajiang Ting-Hui Zhou Ya-Li Tian Xiao-Fang Pei Rong Yu Xiu-Ying Hu
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up_date	2024-07-03T17:53:44.710Z
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Fifty-six patients with HNC and 64 matched healthy controls were recruited from West China hospital in Southwest China. The demographic, clinical, and symptom data were collected. Salivary samples were collected to determine the microbial characteristics using 16S rRNA gene sequencing. Patients with HNC presented increased Capnocytophaga abundances. The oral microbial markers as Capnocytophaga (area under the curve=0.81) achieved a high classification power between the HNC patients and healthy controls. Moreover, using Capnocytophaga in conjunction with symptom of voice/speech difficulty achieved an overall predicting accuracy of 92.5% comparing with using Capnocytophaga alone (79.2% accuracy) in distinguishing the HNC patients from healthy controls. 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Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China

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