COVID-2019–2020–2021: Systematic review and meta-analysis

Introduction: The world has faced the pandemic of COVID-19 in March 2020 and still it continues to affect in 2021. There is a great variation about the course of the disease and its features. Hence, in the present systemic review, we intend to determine the pooled estimations in the clinical feature...
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Autor*in:	S Ganesh Kumar Reddy [verfasserIn] Maanini Mantena [verfasserIn] Sameer Krishna Prasad Garlapati [verfasserIn] B Prasanth Manohar [verfasserIn] Harpreet Singh [verfasserIn] Karan Singh Bajwa [verfasserIn] Heena Tiwari [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	clinical features covid-19 meta-analysis outcomes systemic review

Übergeordnetes Werk:	In: Journal of Pharmacy and Bioallied Sciences - Wolters Kluwer Medknow Publications, 2009, 13(2021), 6, Seite 921-926
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:6 ; pages:921-926

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/jpbs.jpbs_371_21

Katalog-ID:	DOAJ076009165

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520			\|a Introduction: The world has faced the pandemic of COVID-19 in March 2020 and still it continues to affect in 2021. There is a great variation about the course of the disease and its features. Hence, in the present systemic review, we intend to determine the pooled estimations in the clinical features and prognosis along with the subgroups based on the severity of the disease in various regions of the world. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were COVID 19, CORONA, SARS-CoV-2, clinical features, Wuhan, etc. The study articles were collected that from January 2020 to February 2021. Based on the PRISMA guidelines, a meta-analysis was performed. Results: A total of 5067 articles were selected, of which 176 were finalized for the study. There were a total of 11 countries that were included, with a total of 2½ lakh participants. Mean age was 47.5 years. Around 22.5% had comorbidities. The mortality was 5.5%. We observed a strong association between the medical condition of the patient and the severity of the infection. In severe cases, the most common symptoms were respiratory and gastrointestinal. The mortality was registered in those with pneumonia and end-organ failure. Conclusion: It can be concluded from this meta-analysis that in a fourth of the positive patients, the disease was severe. In nearly 6% of the COVID-19 patients, mortality was seen. Patients with comorbidities and the severe form of the disease should be closely monitored.
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allfields	10.4103/jpbs.jpbs_371_21 doi (DE-627)DOAJ076009165 (DE-599)DOAJ68cd24b027aa42969e80fd2ba0b0b580 DE-627 ger DE-627 rakwb eng RS1-441 QD71-142 S Ganesh Kumar Reddy verfasserin aut COVID-2019–2020–2021: Systematic review and meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The world has faced the pandemic of COVID-19 in March 2020 and still it continues to affect in 2021. There is a great variation about the course of the disease and its features. Hence, in the present systemic review, we intend to determine the pooled estimations in the clinical features and prognosis along with the subgroups based on the severity of the disease in various regions of the world. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were COVID 19, CORONA, SARS-CoV-2, clinical features, Wuhan, etc. The study articles were collected that from January 2020 to February 2021. Based on the PRISMA guidelines, a meta-analysis was performed. Results: A total of 5067 articles were selected, of which 176 were finalized for the study. There were a total of 11 countries that were included, with a total of 2½ lakh participants. Mean age was 47.5 years. Around 22.5% had comorbidities. The mortality was 5.5%. We observed a strong association between the medical condition of the patient and the severity of the infection. In severe cases, the most common symptoms were respiratory and gastrointestinal. The mortality was registered in those with pneumonia and end-organ failure. Conclusion: It can be concluded from this meta-analysis that in a fourth of the positive patients, the disease was severe. In nearly 6% of the COVID-19 patients, mortality was seen. Patients with comorbidities and the severe form of the disease should be closely monitored. clinical features covid-19 meta-analysis outcomes systemic review Pharmacy and materia medica Analytical chemistry Maanini Mantena verfasserin aut Sameer Krishna Prasad Garlapati verfasserin aut B Prasanth Manohar verfasserin aut Harpreet Singh verfasserin aut Karan Singh Bajwa verfasserin aut Heena Tiwari verfasserin aut In Journal of Pharmacy and Bioallied Sciences Wolters Kluwer Medknow Publications, 2009 13(2021), 6, Seite 921-926 (DE-627)635603888 (DE-600)2573569-X 09757406 nnns volume:13 year:2021 number:6 pages:921-926 https://doi.org/10.4103/jpbs.jpbs_371_21 kostenfrei https://doaj.org/article/68cd24b027aa42969e80fd2ba0b0b580 kostenfrei http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=921;epage=926;aulast=Reddy kostenfrei https://doaj.org/toc/0975-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6 921-926
spelling	10.4103/jpbs.jpbs_371_21 doi (DE-627)DOAJ076009165 (DE-599)DOAJ68cd24b027aa42969e80fd2ba0b0b580 DE-627 ger DE-627 rakwb eng RS1-441 QD71-142 S Ganesh Kumar Reddy verfasserin aut COVID-2019–2020–2021: Systematic review and meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The world has faced the pandemic of COVID-19 in March 2020 and still it continues to affect in 2021. There is a great variation about the course of the disease and its features. Hence, in the present systemic review, we intend to determine the pooled estimations in the clinical features and prognosis along with the subgroups based on the severity of the disease in various regions of the world. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were COVID 19, CORONA, SARS-CoV-2, clinical features, Wuhan, etc. The study articles were collected that from January 2020 to February 2021. Based on the PRISMA guidelines, a meta-analysis was performed. Results: A total of 5067 articles were selected, of which 176 were finalized for the study. There were a total of 11 countries that were included, with a total of 2½ lakh participants. Mean age was 47.5 years. Around 22.5% had comorbidities. The mortality was 5.5%. We observed a strong association between the medical condition of the patient and the severity of the infection. In severe cases, the most common symptoms were respiratory and gastrointestinal. The mortality was registered in those with pneumonia and end-organ failure. Conclusion: It can be concluded from this meta-analysis that in a fourth of the positive patients, the disease was severe. In nearly 6% of the COVID-19 patients, mortality was seen. Patients with comorbidities and the severe form of the disease should be closely monitored. clinical features covid-19 meta-analysis outcomes systemic review Pharmacy and materia medica Analytical chemistry Maanini Mantena verfasserin aut Sameer Krishna Prasad Garlapati verfasserin aut B Prasanth Manohar verfasserin aut Harpreet Singh verfasserin aut Karan Singh Bajwa verfasserin aut Heena Tiwari verfasserin aut In Journal of Pharmacy and Bioallied Sciences Wolters Kluwer Medknow Publications, 2009 13(2021), 6, Seite 921-926 (DE-627)635603888 (DE-600)2573569-X 09757406 nnns volume:13 year:2021 number:6 pages:921-926 https://doi.org/10.4103/jpbs.jpbs_371_21 kostenfrei https://doaj.org/article/68cd24b027aa42969e80fd2ba0b0b580 kostenfrei http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=921;epage=926;aulast=Reddy kostenfrei https://doaj.org/toc/0975-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6 921-926
allfields_unstemmed	10.4103/jpbs.jpbs_371_21 doi (DE-627)DOAJ076009165 (DE-599)DOAJ68cd24b027aa42969e80fd2ba0b0b580 DE-627 ger DE-627 rakwb eng RS1-441 QD71-142 S Ganesh Kumar Reddy verfasserin aut COVID-2019–2020–2021: Systematic review and meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The world has faced the pandemic of COVID-19 in March 2020 and still it continues to affect in 2021. There is a great variation about the course of the disease and its features. Hence, in the present systemic review, we intend to determine the pooled estimations in the clinical features and prognosis along with the subgroups based on the severity of the disease in various regions of the world. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were COVID 19, CORONA, SARS-CoV-2, clinical features, Wuhan, etc. The study articles were collected that from January 2020 to February 2021. Based on the PRISMA guidelines, a meta-analysis was performed. Results: A total of 5067 articles were selected, of which 176 were finalized for the study. There were a total of 11 countries that were included, with a total of 2½ lakh participants. Mean age was 47.5 years. Around 22.5% had comorbidities. The mortality was 5.5%. We observed a strong association between the medical condition of the patient and the severity of the infection. In severe cases, the most common symptoms were respiratory and gastrointestinal. The mortality was registered in those with pneumonia and end-organ failure. Conclusion: It can be concluded from this meta-analysis that in a fourth of the positive patients, the disease was severe. In nearly 6% of the COVID-19 patients, mortality was seen. Patients with comorbidities and the severe form of the disease should be closely monitored. clinical features covid-19 meta-analysis outcomes systemic review Pharmacy and materia medica Analytical chemistry Maanini Mantena verfasserin aut Sameer Krishna Prasad Garlapati verfasserin aut B Prasanth Manohar verfasserin aut Harpreet Singh verfasserin aut Karan Singh Bajwa verfasserin aut Heena Tiwari verfasserin aut In Journal of Pharmacy and Bioallied Sciences Wolters Kluwer Medknow Publications, 2009 13(2021), 6, Seite 921-926 (DE-627)635603888 (DE-600)2573569-X 09757406 nnns volume:13 year:2021 number:6 pages:921-926 https://doi.org/10.4103/jpbs.jpbs_371_21 kostenfrei https://doaj.org/article/68cd24b027aa42969e80fd2ba0b0b580 kostenfrei http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=921;epage=926;aulast=Reddy kostenfrei https://doaj.org/toc/0975-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6 921-926
allfieldsGer	10.4103/jpbs.jpbs_371_21 doi (DE-627)DOAJ076009165 (DE-599)DOAJ68cd24b027aa42969e80fd2ba0b0b580 DE-627 ger DE-627 rakwb eng RS1-441 QD71-142 S Ganesh Kumar Reddy verfasserin aut COVID-2019–2020–2021: Systematic review and meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The world has faced the pandemic of COVID-19 in March 2020 and still it continues to affect in 2021. There is a great variation about the course of the disease and its features. Hence, in the present systemic review, we intend to determine the pooled estimations in the clinical features and prognosis along with the subgroups based on the severity of the disease in various regions of the world. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were COVID 19, CORONA, SARS-CoV-2, clinical features, Wuhan, etc. The study articles were collected that from January 2020 to February 2021. Based on the PRISMA guidelines, a meta-analysis was performed. Results: A total of 5067 articles were selected, of which 176 were finalized for the study. There were a total of 11 countries that were included, with a total of 2½ lakh participants. Mean age was 47.5 years. Around 22.5% had comorbidities. The mortality was 5.5%. We observed a strong association between the medical condition of the patient and the severity of the infection. In severe cases, the most common symptoms were respiratory and gastrointestinal. The mortality was registered in those with pneumonia and end-organ failure. Conclusion: It can be concluded from this meta-analysis that in a fourth of the positive patients, the disease was severe. In nearly 6% of the COVID-19 patients, mortality was seen. Patients with comorbidities and the severe form of the disease should be closely monitored. clinical features covid-19 meta-analysis outcomes systemic review Pharmacy and materia medica Analytical chemistry Maanini Mantena verfasserin aut Sameer Krishna Prasad Garlapati verfasserin aut B Prasanth Manohar verfasserin aut Harpreet Singh verfasserin aut Karan Singh Bajwa verfasserin aut Heena Tiwari verfasserin aut In Journal of Pharmacy and Bioallied Sciences Wolters Kluwer Medknow Publications, 2009 13(2021), 6, Seite 921-926 (DE-627)635603888 (DE-600)2573569-X 09757406 nnns volume:13 year:2021 number:6 pages:921-926 https://doi.org/10.4103/jpbs.jpbs_371_21 kostenfrei https://doaj.org/article/68cd24b027aa42969e80fd2ba0b0b580 kostenfrei http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=921;epage=926;aulast=Reddy kostenfrei https://doaj.org/toc/0975-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6 921-926
allfieldsSound	10.4103/jpbs.jpbs_371_21 doi (DE-627)DOAJ076009165 (DE-599)DOAJ68cd24b027aa42969e80fd2ba0b0b580 DE-627 ger DE-627 rakwb eng RS1-441 QD71-142 S Ganesh Kumar Reddy verfasserin aut COVID-2019–2020–2021: Systematic review and meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The world has faced the pandemic of COVID-19 in March 2020 and still it continues to affect in 2021. There is a great variation about the course of the disease and its features. Hence, in the present systemic review, we intend to determine the pooled estimations in the clinical features and prognosis along with the subgroups based on the severity of the disease in various regions of the world. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were COVID 19, CORONA, SARS-CoV-2, clinical features, Wuhan, etc. The study articles were collected that from January 2020 to February 2021. Based on the PRISMA guidelines, a meta-analysis was performed. Results: A total of 5067 articles were selected, of which 176 were finalized for the study. There were a total of 11 countries that were included, with a total of 2½ lakh participants. Mean age was 47.5 years. Around 22.5% had comorbidities. The mortality was 5.5%. We observed a strong association between the medical condition of the patient and the severity of the infection. In severe cases, the most common symptoms were respiratory and gastrointestinal. The mortality was registered in those with pneumonia and end-organ failure. Conclusion: It can be concluded from this meta-analysis that in a fourth of the positive patients, the disease was severe. In nearly 6% of the COVID-19 patients, mortality was seen. Patients with comorbidities and the severe form of the disease should be closely monitored. clinical features covid-19 meta-analysis outcomes systemic review Pharmacy and materia medica Analytical chemistry Maanini Mantena verfasserin aut Sameer Krishna Prasad Garlapati verfasserin aut B Prasanth Manohar verfasserin aut Harpreet Singh verfasserin aut Karan Singh Bajwa verfasserin aut Heena Tiwari verfasserin aut In Journal of Pharmacy and Bioallied Sciences Wolters Kluwer Medknow Publications, 2009 13(2021), 6, Seite 921-926 (DE-627)635603888 (DE-600)2573569-X 09757406 nnns volume:13 year:2021 number:6 pages:921-926 https://doi.org/10.4103/jpbs.jpbs_371_21 kostenfrei https://doaj.org/article/68cd24b027aa42969e80fd2ba0b0b580 kostenfrei http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=921;epage=926;aulast=Reddy kostenfrei https://doaj.org/toc/0975-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6 921-926
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topic_title	RS1-441 QD71-142 COVID-2019–2020–2021: Systematic review and meta-analysis clinical features covid-19 meta-analysis outcomes systemic review
topic	misc RS1-441 misc QD71-142 misc clinical features misc covid-19 misc meta-analysis misc outcomes misc systemic review misc Pharmacy and materia medica misc Analytical chemistry
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title	COVID-2019–2020–2021: Systematic review and meta-analysis
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title_full	COVID-2019–2020–2021: Systematic review and meta-analysis
author_sort	S Ganesh Kumar Reddy
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author_browse	S Ganesh Kumar Reddy Maanini Mantena Sameer Krishna Prasad Garlapati B Prasanth Manohar Harpreet Singh Karan Singh Bajwa Heena Tiwari
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doi_str_mv	10.4103/jpbs.jpbs_371_21
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title_sort	covid-2019–2020–2021: systematic review and meta-analysis
callnumber	RS1-441
title_auth	COVID-2019–2020–2021: Systematic review and meta-analysis
abstract	Introduction: The world has faced the pandemic of COVID-19 in March 2020 and still it continues to affect in 2021. There is a great variation about the course of the disease and its features. Hence, in the present systemic review, we intend to determine the pooled estimations in the clinical features and prognosis along with the subgroups based on the severity of the disease in various regions of the world. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were COVID 19, CORONA, SARS-CoV-2, clinical features, Wuhan, etc. The study articles were collected that from January 2020 to February 2021. Based on the PRISMA guidelines, a meta-analysis was performed. Results: A total of 5067 articles were selected, of which 176 were finalized for the study. There were a total of 11 countries that were included, with a total of 2½ lakh participants. Mean age was 47.5 years. Around 22.5% had comorbidities. The mortality was 5.5%. We observed a strong association between the medical condition of the patient and the severity of the infection. In severe cases, the most common symptoms were respiratory and gastrointestinal. The mortality was registered in those with pneumonia and end-organ failure. Conclusion: It can be concluded from this meta-analysis that in a fourth of the positive patients, the disease was severe. In nearly 6% of the COVID-19 patients, mortality was seen. Patients with comorbidities and the severe form of the disease should be closely monitored.
abstractGer	Introduction: The world has faced the pandemic of COVID-19 in March 2020 and still it continues to affect in 2021. There is a great variation about the course of the disease and its features. Hence, in the present systemic review, we intend to determine the pooled estimations in the clinical features and prognosis along with the subgroups based on the severity of the disease in various regions of the world. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were COVID 19, CORONA, SARS-CoV-2, clinical features, Wuhan, etc. The study articles were collected that from January 2020 to February 2021. Based on the PRISMA guidelines, a meta-analysis was performed. Results: A total of 5067 articles were selected, of which 176 were finalized for the study. There were a total of 11 countries that were included, with a total of 2½ lakh participants. Mean age was 47.5 years. Around 22.5% had comorbidities. The mortality was 5.5%. We observed a strong association between the medical condition of the patient and the severity of the infection. In severe cases, the most common symptoms were respiratory and gastrointestinal. The mortality was registered in those with pneumonia and end-organ failure. Conclusion: It can be concluded from this meta-analysis that in a fourth of the positive patients, the disease was severe. In nearly 6% of the COVID-19 patients, mortality was seen. Patients with comorbidities and the severe form of the disease should be closely monitored.
abstract_unstemmed	Introduction: The world has faced the pandemic of COVID-19 in March 2020 and still it continues to affect in 2021. There is a great variation about the course of the disease and its features. Hence, in the present systemic review, we intend to determine the pooled estimations in the clinical features and prognosis along with the subgroups based on the severity of the disease in various regions of the world. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were COVID 19, CORONA, SARS-CoV-2, clinical features, Wuhan, etc. The study articles were collected that from January 2020 to February 2021. Based on the PRISMA guidelines, a meta-analysis was performed. Results: A total of 5067 articles were selected, of which 176 were finalized for the study. There were a total of 11 countries that were included, with a total of 2½ lakh participants. Mean age was 47.5 years. Around 22.5% had comorbidities. The mortality was 5.5%. We observed a strong association between the medical condition of the patient and the severity of the infection. In severe cases, the most common symptoms were respiratory and gastrointestinal. The mortality was registered in those with pneumonia and end-organ failure. Conclusion: It can be concluded from this meta-analysis that in a fourth of the positive patients, the disease was severe. In nearly 6% of the COVID-19 patients, mortality was seen. Patients with comorbidities and the severe form of the disease should be closely monitored.
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container_issue	6
title_short	COVID-2019–2020–2021: Systematic review and meta-analysis
url	https://doi.org/10.4103/jpbs.jpbs_371_21 https://doaj.org/article/68cd24b027aa42969e80fd2ba0b0b580 http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=921;epage=926;aulast=Reddy https://doaj.org/toc/0975-7406
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author2	Maanini Mantena Sameer Krishna Prasad Garlapati B Prasanth Manohar Harpreet Singh Karan Singh Bajwa Heena Tiwari
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