A Review of <i<FoxO1</i<-Regulated Metabolic Diseases and Related Drug Discoveries

<i<FoxO1</i< is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. <i<FoxO1</i< controls the transcription of downstream genes mediating metabolic reg...
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Autor*in:	Shiming Peng [verfasserIn] Wei Li [verfasserIn] Nannan Hou [verfasserIn] Niu Huang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	metabolic disease drug discovery

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 9(2020), 1, p 184
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:1, p 184

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells9010184

Katalog-ID:	DOAJ076061507

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callnumber-first	Q - Science
author	Shiming Peng
spellingShingle	Shiming Peng misc QH301-705.5 misc <i<foxo1</i< misc metabolic disease misc drug discovery misc Biology (General) A Review of <i<FoxO1</i<-Regulated Metabolic Diseases and Related Drug Discoveries
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topic_title	QH301-705.5 A Review of <i<FoxO1</i<-Regulated Metabolic Diseases and Related Drug Discoveries <i<foxo1</i< metabolic disease drug discovery
topic	misc QH301-705.5 misc <i<foxo1</i< misc metabolic disease misc drug discovery misc Biology (General)
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title	A Review of <i<FoxO1</i<-Regulated Metabolic Diseases and Related Drug Discoveries
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title_sort	review of <i<foxo1</i<-regulated metabolic diseases and related drug discoveries
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title_auth	A Review of <i<FoxO1</i<-Regulated Metabolic Diseases and Related Drug Discoveries
abstract	<i<FoxO1</i< is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. <i<FoxO1</i< controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of <i<FoxO1</i< pathways results in several metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis. Here, we summarize the mechanism of <i<FoxO1</i< regulation behind these diseases and <i<FoxO1</i<-related drug discoveries.
abstractGer	<i<FoxO1</i< is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. <i<FoxO1</i< controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of <i<FoxO1</i< pathways results in several metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis. Here, we summarize the mechanism of <i<FoxO1</i< regulation behind these diseases and <i<FoxO1</i<-related drug discoveries.
abstract_unstemmed	<i<FoxO1</i< is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. <i<FoxO1</i< controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of <i<FoxO1</i< pathways results in several metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis. Here, we summarize the mechanism of <i<FoxO1</i< regulation behind these diseases and <i<FoxO1</i<-related drug discoveries.
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title_short	A Review of <i<FoxO1</i<-Regulated Metabolic Diseases and Related Drug Discoveries
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