Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review

Abstract Background The plant Olax subscorpioidea Oliv (Olacaceae) is a shrub that is widely available in Africa. It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. Graphical abstract Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Mubarak Hussaini Ahmad [verfasserIn] Abubakar Ibrahim Jatau [verfasserIn] Omar Yahya Alshargi [verfasserIn] Sa’adatu Muhammad Julde [verfasserIn] Mustapha Mohammed [verfasserIn] Surajuddeen Muhammad [verfasserIn] Sagir Mustapha [verfasserIn] Auwal Adam Bala [verfasserIn] Abubakar Sadiq Wada [verfasserIn] Musa Aminu [verfasserIn] Abba Musab Usman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Bioactive compounds Ethnomedicinal uses Medicinal plants Olax subscorpioidea Pharmacology Phytochemistry

Übergeordnetes Werk:	In: Future Journal of Pharmaceutical Sciences - SpringerOpen, 2016, 7(2021), 1, Seite 13
Übergeordnetes Werk:	volume:7 ; year:2021 ; number:1 ; pages:13

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s43094-021-00264-w

Katalog-ID:	DOAJ076402355

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520			\|a Abstract Background The plant Olax subscorpioidea Oliv (Olacaceae) is a shrub that is widely available in Africa. It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. Graphical abstract
650		4	\|a Bioactive compounds
650		4	\|a Ethnomedicinal uses
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700	0		\|a Abba Musab Usman \|e verfasserin \|4 aut
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allfields	10.1186/s43094-021-00264-w doi (DE-627)DOAJ076402355 (DE-599)DOAJe6937a1e56024d0497fa87381d3a1c14 DE-627 ger DE-627 rakwb eng RM1-950 RS1-441 Mubarak Hussaini Ahmad verfasserin aut Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The plant Olax subscorpioidea Oliv (Olacaceae) is a shrub that is widely available in Africa. It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. Graphical abstract Bioactive compounds Ethnomedicinal uses Medicinal plants Olax subscorpioidea Pharmacology Phytochemistry Therapeutics. Pharmacology Pharmacy and materia medica Abubakar Ibrahim Jatau verfasserin aut Omar Yahya Alshargi verfasserin aut Sa’adatu Muhammad Julde verfasserin aut Mustapha Mohammed verfasserin aut Surajuddeen Muhammad verfasserin aut Sagir Mustapha verfasserin aut Auwal Adam Bala verfasserin aut Abubakar Sadiq Wada verfasserin aut Musa Aminu verfasserin aut Abba Musab Usman verfasserin aut In Future Journal of Pharmaceutical Sciences SpringerOpen, 2016 7(2021), 1, Seite 13 (DE-627)835143171 (DE-600)2834845-X 23147253 nnns volume:7 year:2021 number:1 pages:13 https://doi.org/10.1186/s43094-021-00264-w kostenfrei https://doaj.org/article/e6937a1e56024d0497fa87381d3a1c14 kostenfrei https://doi.org/10.1186/s43094-021-00264-w kostenfrei https://doaj.org/toc/2314-7253 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1 13
spelling	10.1186/s43094-021-00264-w doi (DE-627)DOAJ076402355 (DE-599)DOAJe6937a1e56024d0497fa87381d3a1c14 DE-627 ger DE-627 rakwb eng RM1-950 RS1-441 Mubarak Hussaini Ahmad verfasserin aut Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The plant Olax subscorpioidea Oliv (Olacaceae) is a shrub that is widely available in Africa. It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. Graphical abstract Bioactive compounds Ethnomedicinal uses Medicinal plants Olax subscorpioidea Pharmacology Phytochemistry Therapeutics. Pharmacology Pharmacy and materia medica Abubakar Ibrahim Jatau verfasserin aut Omar Yahya Alshargi verfasserin aut Sa’adatu Muhammad Julde verfasserin aut Mustapha Mohammed verfasserin aut Surajuddeen Muhammad verfasserin aut Sagir Mustapha verfasserin aut Auwal Adam Bala verfasserin aut Abubakar Sadiq Wada verfasserin aut Musa Aminu verfasserin aut Abba Musab Usman verfasserin aut In Future Journal of Pharmaceutical Sciences SpringerOpen, 2016 7(2021), 1, Seite 13 (DE-627)835143171 (DE-600)2834845-X 23147253 nnns volume:7 year:2021 number:1 pages:13 https://doi.org/10.1186/s43094-021-00264-w kostenfrei https://doaj.org/article/e6937a1e56024d0497fa87381d3a1c14 kostenfrei https://doi.org/10.1186/s43094-021-00264-w kostenfrei https://doaj.org/toc/2314-7253 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1 13
allfields_unstemmed	10.1186/s43094-021-00264-w doi (DE-627)DOAJ076402355 (DE-599)DOAJe6937a1e56024d0497fa87381d3a1c14 DE-627 ger DE-627 rakwb eng RM1-950 RS1-441 Mubarak Hussaini Ahmad verfasserin aut Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The plant Olax subscorpioidea Oliv (Olacaceae) is a shrub that is widely available in Africa. It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. Graphical abstract Bioactive compounds Ethnomedicinal uses Medicinal plants Olax subscorpioidea Pharmacology Phytochemistry Therapeutics. Pharmacology Pharmacy and materia medica Abubakar Ibrahim Jatau verfasserin aut Omar Yahya Alshargi verfasserin aut Sa’adatu Muhammad Julde verfasserin aut Mustapha Mohammed verfasserin aut Surajuddeen Muhammad verfasserin aut Sagir Mustapha verfasserin aut Auwal Adam Bala verfasserin aut Abubakar Sadiq Wada verfasserin aut Musa Aminu verfasserin aut Abba Musab Usman verfasserin aut In Future Journal of Pharmaceutical Sciences SpringerOpen, 2016 7(2021), 1, Seite 13 (DE-627)835143171 (DE-600)2834845-X 23147253 nnns volume:7 year:2021 number:1 pages:13 https://doi.org/10.1186/s43094-021-00264-w kostenfrei https://doaj.org/article/e6937a1e56024d0497fa87381d3a1c14 kostenfrei https://doi.org/10.1186/s43094-021-00264-w kostenfrei https://doaj.org/toc/2314-7253 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1 13
allfieldsGer	10.1186/s43094-021-00264-w doi (DE-627)DOAJ076402355 (DE-599)DOAJe6937a1e56024d0497fa87381d3a1c14 DE-627 ger DE-627 rakwb eng RM1-950 RS1-441 Mubarak Hussaini Ahmad verfasserin aut Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The plant Olax subscorpioidea Oliv (Olacaceae) is a shrub that is widely available in Africa. It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. Graphical abstract Bioactive compounds Ethnomedicinal uses Medicinal plants Olax subscorpioidea Pharmacology Phytochemistry Therapeutics. Pharmacology Pharmacy and materia medica Abubakar Ibrahim Jatau verfasserin aut Omar Yahya Alshargi verfasserin aut Sa’adatu Muhammad Julde verfasserin aut Mustapha Mohammed verfasserin aut Surajuddeen Muhammad verfasserin aut Sagir Mustapha verfasserin aut Auwal Adam Bala verfasserin aut Abubakar Sadiq Wada verfasserin aut Musa Aminu verfasserin aut Abba Musab Usman verfasserin aut In Future Journal of Pharmaceutical Sciences SpringerOpen, 2016 7(2021), 1, Seite 13 (DE-627)835143171 (DE-600)2834845-X 23147253 nnns volume:7 year:2021 number:1 pages:13 https://doi.org/10.1186/s43094-021-00264-w kostenfrei https://doaj.org/article/e6937a1e56024d0497fa87381d3a1c14 kostenfrei https://doi.org/10.1186/s43094-021-00264-w kostenfrei https://doaj.org/toc/2314-7253 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1 13
allfieldsSound	10.1186/s43094-021-00264-w doi (DE-627)DOAJ076402355 (DE-599)DOAJe6937a1e56024d0497fa87381d3a1c14 DE-627 ger DE-627 rakwb eng RM1-950 RS1-441 Mubarak Hussaini Ahmad verfasserin aut Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The plant Olax subscorpioidea Oliv (Olacaceae) is a shrub that is widely available in Africa. It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. Graphical abstract Bioactive compounds Ethnomedicinal uses Medicinal plants Olax subscorpioidea Pharmacology Phytochemistry Therapeutics. Pharmacology Pharmacy and materia medica Abubakar Ibrahim Jatau verfasserin aut Omar Yahya Alshargi verfasserin aut Sa’adatu Muhammad Julde verfasserin aut Mustapha Mohammed verfasserin aut Surajuddeen Muhammad verfasserin aut Sagir Mustapha verfasserin aut Auwal Adam Bala verfasserin aut Abubakar Sadiq Wada verfasserin aut Musa Aminu verfasserin aut Abba Musab Usman verfasserin aut In Future Journal of Pharmaceutical Sciences SpringerOpen, 2016 7(2021), 1, Seite 13 (DE-627)835143171 (DE-600)2834845-X 23147253 nnns volume:7 year:2021 number:1 pages:13 https://doi.org/10.1186/s43094-021-00264-w kostenfrei https://doaj.org/article/e6937a1e56024d0497fa87381d3a1c14 kostenfrei https://doi.org/10.1186/s43094-021-00264-w kostenfrei https://doaj.org/toc/2314-7253 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1 13
language	English
source	In Future Journal of Pharmaceutical Sciences 7(2021), 1, Seite 13 volume:7 year:2021 number:1 pages:13
sourceStr	In Future Journal of Pharmaceutical Sciences 7(2021), 1, Seite 13 volume:7 year:2021 number:1 pages:13
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Bioactive compounds Ethnomedicinal uses Medicinal plants Olax subscorpioidea Pharmacology Phytochemistry Therapeutics. Pharmacology Pharmacy and materia medica
isfreeaccess_bool	true
container_title	Future Journal of Pharmaceutical Sciences
authorswithroles_txt_mv	Mubarak Hussaini Ahmad @@aut@@ Abubakar Ibrahim Jatau @@aut@@ Omar Yahya Alshargi @@aut@@ Sa’adatu Muhammad Julde @@aut@@ Mustapha Mohammed @@aut@@ Surajuddeen Muhammad @@aut@@ Sagir Mustapha @@aut@@ Auwal Adam Bala @@aut@@ Abubakar Sadiq Wada @@aut@@ Musa Aminu @@aut@@ Abba Musab Usman @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	835143171
id	DOAJ076402355
language_de	englisch
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It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. 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callnumber-first	R - Medicine
author	Mubarak Hussaini Ahmad
spellingShingle	Mubarak Hussaini Ahmad misc RM1-950 misc RS1-441 misc Bioactive compounds misc Ethnomedicinal uses misc Medicinal plants misc Olax subscorpioidea misc Pharmacology misc Phytochemistry misc Therapeutics. Pharmacology misc Pharmacy and materia medica Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review
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topic_title	RM1-950 RS1-441 Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review Bioactive compounds Ethnomedicinal uses Medicinal plants Olax subscorpioidea Pharmacology Phytochemistry
topic	misc RM1-950 misc RS1-441 misc Bioactive compounds misc Ethnomedicinal uses misc Medicinal plants misc Olax subscorpioidea misc Pharmacology misc Phytochemistry misc Therapeutics. Pharmacology misc Pharmacy and materia medica
topic_unstemmed	misc RM1-950 misc RS1-441 misc Bioactive compounds misc Ethnomedicinal uses misc Medicinal plants misc Olax subscorpioidea misc Pharmacology misc Phytochemistry misc Therapeutics. Pharmacology misc Pharmacy and materia medica
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title	Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review
ctrlnum	(DE-627)DOAJ076402355 (DE-599)DOAJe6937a1e56024d0497fa87381d3a1c14
title_full	Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review
author_sort	Mubarak Hussaini Ahmad
journal	Future Journal of Pharmaceutical Sciences
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author_browse	Mubarak Hussaini Ahmad Abubakar Ibrahim Jatau Omar Yahya Alshargi Sa’adatu Muhammad Julde Mustapha Mohammed Surajuddeen Muhammad Sagir Mustapha Auwal Adam Bala Abubakar Sadiq Wada Musa Aminu Abba Musab Usman
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title_sort	ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of olax subscorpioidea oliv (olacaceae): a review
callnumber	RM1-950
title_auth	Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review
abstract	Abstract Background The plant Olax subscorpioidea Oliv (Olacaceae) is a shrub that is widely available in Africa. It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. Graphical abstract
abstractGer	Abstract Background The plant Olax subscorpioidea Oliv (Olacaceae) is a shrub that is widely available in Africa. It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. Graphical abstract
abstract_unstemmed	Abstract Background The plant Olax subscorpioidea Oliv (Olacaceae) is a shrub that is widely available in Africa. It has been used in traditional medicine to treat various diseases including asthma, pain, inflammation, gastrointestinal and central nervous system (CNS) disorders, cough, diabetes mellitus, cancer, infectious diseases, hepatic diseases, and many other diseases. Several phytochemical and pharmacological investigations were conducted on this plant. However, comprehensive information on this medicinally important plant is not available in the literature. Therefore, in this review, we aimed to provide comprehensive and critical information on all the reported ethnomedicinal uses, phytochemistry, pharmacological activities, and potential toxicity of Olax subscorpioidea to highlight its therapeutic potentials based on traditional usage and identify research gaps as a basis for further investigations to develop novel therapeutic compounds. Main body The available information about the plant was retrieved from the online bibliographic databases (PubMed and Google Scholar) and published PhD dissertation using the search terms Olax subscorpioidea, traditional uses, ethnomedicinal uses, phytochemistry, pharmacology, toxicology, and safety. Phytochemical studies have shown that the plant contains several bioactive compounds such as rutin, morin, quercetin, caffeic acid, santalbic acid, n-hexadecanoic acid, squalene, nonacosane, hentriacontane, and many more compounds. Also, pharmacological investigations revealed that Olax subscorpioidea has antidepressant, antiepileptic, anti-Alzheimer’s, cytotoxic, antioxidant, antihyperlipidemic, analgesic, antiinflammatory, antiarthritic, antidiabetic, anticancer, antiulcer, antimicrobial, hepatoprotective, apoptotic, antiprotease, and other CNS effects. Conclusion Several pharmacological studies on Olax subscorpioidea have established its ethnopharmacological uses. However, there are limited phytochemical and pharmacological studies to validate other folkloric claims of the plant. Therefore, extensive phytochemical and further pre-clinical efficacy and safety evaluations to fully establish its therapeutic potentials and elucidate its mechanisms of pharmacological actions could be necessary. Graphical abstract
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title_short	Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review
url	https://doi.org/10.1186/s43094-021-00264-w https://doaj.org/article/e6937a1e56024d0497fa87381d3a1c14 https://doaj.org/toc/2314-7253
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author2	Abubakar Ibrahim Jatau Omar Yahya Alshargi Sa’adatu Muhammad Julde Mustapha Mohammed Surajuddeen Muhammad Sagir Mustapha Auwal Adam Bala Abubakar Sadiq Wada Musa Aminu Abba Musab Usman
author2Str	Abubakar Ibrahim Jatau Omar Yahya Alshargi Sa’adatu Muhammad Julde Mustapha Mohammed Surajuddeen Muhammad Sagir Mustapha Auwal Adam Bala Abubakar Sadiq Wada Musa Aminu Abba Musab Usman
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