Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila

Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant recept...
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Autor*in:	Gonzalo M. Sanchez [verfasserIn] Liza Alkhori [verfasserIn] Eduardo Hatano [verfasserIn] Sebastian W. Schultz [verfasserIn] Anujaianthi Kuzhandaivel [verfasserIn] Shadi Jafari [verfasserIn] Björn Granseth [verfasserIn] Mattias Alenius [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 14(2016), 3, Seite 464-470
Übergeordnetes Werk:	volume:14 ; year:2016 ; number:3 ; pages:464-470

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2015.12.059

Katalog-ID:	DOAJ076415384

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publishDate	2016
allfields	10.1016/j.celrep.2015.12.059 doi (DE-627)DOAJ076415384 (DE-599)DOAJe4e6bb1f785f4efcbd4deae39849de23 DE-627 ger DE-627 rakwb eng QH301-705.5 Gonzalo M. Sanchez verfasserin aut Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant receptor (OR) transport to and within the primary cilium in OSN neurons. Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo). We further demonstrate that the Hh- and Smo-dependent regulation of the kinesin-like protein Cos2 acts in parallel to the intraflagellar transport system (IFT) to localize ORs within the cilium compartment. These findings expand our knowledge of Hh signaling to encompass chemosensory modulation and receptor trafficking. Biology (General) Liza Alkhori verfasserin aut Eduardo Hatano verfasserin aut Sebastian W. Schultz verfasserin aut Anujaianthi Kuzhandaivel verfasserin aut Shadi Jafari verfasserin aut Björn Granseth verfasserin aut Mattias Alenius verfasserin aut In Cell Reports Elsevier, 2015 14(2016), 3, Seite 464-470 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:14 year:2016 number:3 pages:464-470 https://doi.org/10.1016/j.celrep.2015.12.059 kostenfrei https://doaj.org/article/e4e6bb1f785f4efcbd4deae39849de23 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124715015004 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2016 3 464-470
spelling	10.1016/j.celrep.2015.12.059 doi (DE-627)DOAJ076415384 (DE-599)DOAJe4e6bb1f785f4efcbd4deae39849de23 DE-627 ger DE-627 rakwb eng QH301-705.5 Gonzalo M. Sanchez verfasserin aut Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant receptor (OR) transport to and within the primary cilium in OSN neurons. Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo). We further demonstrate that the Hh- and Smo-dependent regulation of the kinesin-like protein Cos2 acts in parallel to the intraflagellar transport system (IFT) to localize ORs within the cilium compartment. These findings expand our knowledge of Hh signaling to encompass chemosensory modulation and receptor trafficking. Biology (General) Liza Alkhori verfasserin aut Eduardo Hatano verfasserin aut Sebastian W. Schultz verfasserin aut Anujaianthi Kuzhandaivel verfasserin aut Shadi Jafari verfasserin aut Björn Granseth verfasserin aut Mattias Alenius verfasserin aut In Cell Reports Elsevier, 2015 14(2016), 3, Seite 464-470 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:14 year:2016 number:3 pages:464-470 https://doi.org/10.1016/j.celrep.2015.12.059 kostenfrei https://doaj.org/article/e4e6bb1f785f4efcbd4deae39849de23 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124715015004 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2016 3 464-470
allfields_unstemmed	10.1016/j.celrep.2015.12.059 doi (DE-627)DOAJ076415384 (DE-599)DOAJe4e6bb1f785f4efcbd4deae39849de23 DE-627 ger DE-627 rakwb eng QH301-705.5 Gonzalo M. Sanchez verfasserin aut Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant receptor (OR) transport to and within the primary cilium in OSN neurons. Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo). We further demonstrate that the Hh- and Smo-dependent regulation of the kinesin-like protein Cos2 acts in parallel to the intraflagellar transport system (IFT) to localize ORs within the cilium compartment. These findings expand our knowledge of Hh signaling to encompass chemosensory modulation and receptor trafficking. Biology (General) Liza Alkhori verfasserin aut Eduardo Hatano verfasserin aut Sebastian W. Schultz verfasserin aut Anujaianthi Kuzhandaivel verfasserin aut Shadi Jafari verfasserin aut Björn Granseth verfasserin aut Mattias Alenius verfasserin aut In Cell Reports Elsevier, 2015 14(2016), 3, Seite 464-470 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:14 year:2016 number:3 pages:464-470 https://doi.org/10.1016/j.celrep.2015.12.059 kostenfrei https://doaj.org/article/e4e6bb1f785f4efcbd4deae39849de23 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124715015004 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2016 3 464-470
allfieldsGer	10.1016/j.celrep.2015.12.059 doi (DE-627)DOAJ076415384 (DE-599)DOAJe4e6bb1f785f4efcbd4deae39849de23 DE-627 ger DE-627 rakwb eng QH301-705.5 Gonzalo M. Sanchez verfasserin aut Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant receptor (OR) transport to and within the primary cilium in OSN neurons. Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo). We further demonstrate that the Hh- and Smo-dependent regulation of the kinesin-like protein Cos2 acts in parallel to the intraflagellar transport system (IFT) to localize ORs within the cilium compartment. These findings expand our knowledge of Hh signaling to encompass chemosensory modulation and receptor trafficking. Biology (General) Liza Alkhori verfasserin aut Eduardo Hatano verfasserin aut Sebastian W. Schultz verfasserin aut Anujaianthi Kuzhandaivel verfasserin aut Shadi Jafari verfasserin aut Björn Granseth verfasserin aut Mattias Alenius verfasserin aut In Cell Reports Elsevier, 2015 14(2016), 3, Seite 464-470 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:14 year:2016 number:3 pages:464-470 https://doi.org/10.1016/j.celrep.2015.12.059 kostenfrei https://doaj.org/article/e4e6bb1f785f4efcbd4deae39849de23 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124715015004 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2016 3 464-470
allfieldsSound	10.1016/j.celrep.2015.12.059 doi (DE-627)DOAJ076415384 (DE-599)DOAJe4e6bb1f785f4efcbd4deae39849de23 DE-627 ger DE-627 rakwb eng QH301-705.5 Gonzalo M. Sanchez verfasserin aut Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant receptor (OR) transport to and within the primary cilium in OSN neurons. Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo). We further demonstrate that the Hh- and Smo-dependent regulation of the kinesin-like protein Cos2 acts in parallel to the intraflagellar transport system (IFT) to localize ORs within the cilium compartment. These findings expand our knowledge of Hh signaling to encompass chemosensory modulation and receptor trafficking. Biology (General) Liza Alkhori verfasserin aut Eduardo Hatano verfasserin aut Sebastian W. Schultz verfasserin aut Anujaianthi Kuzhandaivel verfasserin aut Shadi Jafari verfasserin aut Björn Granseth verfasserin aut Mattias Alenius verfasserin aut In Cell Reports Elsevier, 2015 14(2016), 3, Seite 464-470 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:14 year:2016 number:3 pages:464-470 https://doi.org/10.1016/j.celrep.2015.12.059 kostenfrei https://doaj.org/article/e4e6bb1f785f4efcbd4deae39849de23 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124715015004 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2016 3 464-470
language	English
source	In Cell Reports 14(2016), 3, Seite 464-470 volume:14 year:2016 number:3 pages:464-470
sourceStr	In Cell Reports 14(2016), 3, Seite 464-470 volume:14 year:2016 number:3 pages:464-470
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Gonzalo M. Sanchez @@aut@@ Liza Alkhori @@aut@@ Eduardo Hatano @@aut@@ Sebastian W. Schultz @@aut@@ Anujaianthi Kuzhandaivel @@aut@@ Shadi Jafari @@aut@@ Björn Granseth @@aut@@ Mattias Alenius @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ076415384
language_de	englisch
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callnumber-first	Q - Science
author	Gonzalo M. Sanchez
spellingShingle	Gonzalo M. Sanchez misc QH301-705.5 misc Biology (General) Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila
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topic_title	QH301-705.5 Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila
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title	Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila
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title_full	Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila
author_sort	Gonzalo M. Sanchez
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author_browse	Gonzalo M. Sanchez Liza Alkhori Eduardo Hatano Sebastian W. Schultz Anujaianthi Kuzhandaivel Shadi Jafari Björn Granseth Mattias Alenius
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author-letter	Gonzalo M. Sanchez
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title_sort	hedgehog signaling regulates the ciliary transport of odorant receptors in drosophila
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title_auth	Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila
abstract	Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant receptor (OR) transport to and within the primary cilium in OSN neurons. Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo). We further demonstrate that the Hh- and Smo-dependent regulation of the kinesin-like protein Cos2 acts in parallel to the intraflagellar transport system (IFT) to localize ORs within the cilium compartment. These findings expand our knowledge of Hh signaling to encompass chemosensory modulation and receptor trafficking.
abstractGer	Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant receptor (OR) transport to and within the primary cilium in OSN neurons. Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo). We further demonstrate that the Hh- and Smo-dependent regulation of the kinesin-like protein Cos2 acts in parallel to the intraflagellar transport system (IFT) to localize ORs within the cilium compartment. These findings expand our knowledge of Hh signaling to encompass chemosensory modulation and receptor trafficking.
abstract_unstemmed	Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant receptor (OR) transport to and within the primary cilium in OSN neurons. Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo). We further demonstrate that the Hh- and Smo-dependent regulation of the kinesin-like protein Cos2 acts in parallel to the intraflagellar transport system (IFT) to localize ORs within the cilium compartment. These findings expand our knowledge of Hh signaling to encompass chemosensory modulation and receptor trafficking.
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title_short	Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila
url	https://doi.org/10.1016/j.celrep.2015.12.059 https://doaj.org/article/e4e6bb1f785f4efcbd4deae39849de23 http://www.sciencedirect.com/science/article/pii/S2211124715015004 https://doaj.org/toc/2211-1247
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Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila

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