DNA sequence features in the establishing of H3K27ac [version 2; referees: 2 approved]

The presence of H3K27me3 has been demonstrated to correlate with the CpG content. In this work, we tested whether H3K27ac has similar sequence preferences. We performed a translocation of DNA sequences with various properties into a beta-globin locus to control for the local chromatin environment. O...
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Autor*in:	Anatoliy Zubritskiy [verfasserIn] Yulia A. Medvedeva [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Biomacromolecule-Ligand Interactions Genomics

Übergeordnetes Werk:	In: F1000Research - F1000 Research Ltd, 2013, 7(2018)
Übergeordnetes Werk:	volume:7 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.12688/f1000research.13441.2

Katalog-ID:	DOAJ076484963

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author	Anatoliy Zubritskiy
spellingShingle	Anatoliy Zubritskiy misc Biomacromolecule-Ligand Interactions misc Genomics misc Medicine misc R misc Science misc Q DNA sequence features in the establishing of H3K27ac [version 2; referees: 2 approved]
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topic_title	DNA sequence features in the establishing of H3K27ac [version 2; referees: 2 approved] Biomacromolecule-Ligand Interactions Genomics
topic	misc Biomacromolecule-Ligand Interactions misc Genomics misc Medicine misc R misc Science misc Q
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title	DNA sequence features in the establishing of H3K27ac [version 2; referees: 2 approved]
ctrlnum	(DE-627)DOAJ076484963 (DE-599)DOAJ22ec035c463b420f921d0363cba9c009
title_full	DNA sequence features in the establishing of H3K27ac [version 2; referees: 2 approved]
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author_browse	Anatoliy Zubritskiy Yulia A. Medvedeva
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title_sort	dna sequence features in the establishing of h3k27ac [version 2; referees: 2 approved]
title_auth	DNA sequence features in the establishing of H3K27ac [version 2; referees: 2 approved]
abstract	The presence of H3K27me3 has been demonstrated to correlate with the CpG content. In this work, we tested whether H3K27ac has similar sequence preferences. We performed a translocation of DNA sequences with various properties into a beta-globin locus to control for the local chromatin environment. Our results suggest that in contrast to H3K27me3, H3K27ac gain is unlikely affected by the CpG content of the underlying DNA sequence, while extremely high GC-content might contribute to the gain of the H3K27ac.
abstractGer	The presence of H3K27me3 has been demonstrated to correlate with the CpG content. In this work, we tested whether H3K27ac has similar sequence preferences. We performed a translocation of DNA sequences with various properties into a beta-globin locus to control for the local chromatin environment. Our results suggest that in contrast to H3K27me3, H3K27ac gain is unlikely affected by the CpG content of the underlying DNA sequence, while extremely high GC-content might contribute to the gain of the H3K27ac.
abstract_unstemmed	The presence of H3K27me3 has been demonstrated to correlate with the CpG content. In this work, we tested whether H3K27ac has similar sequence preferences. We performed a translocation of DNA sequences with various properties into a beta-globin locus to control for the local chromatin environment. Our results suggest that in contrast to H3K27me3, H3K27ac gain is unlikely affected by the CpG content of the underlying DNA sequence, while extremely high GC-content might contribute to the gain of the H3K27ac.
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title_short	DNA sequence features in the establishing of H3K27ac [version 2; referees: 2 approved]
url	https://doi.org/10.12688/f1000research.13441.2 https://doaj.org/article/22ec035c463b420f921d0363cba9c009 https://f1000research.com/articles/7-165/v2 https://doaj.org/toc/2046-1402
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up_date	2024-07-03T20:46:06.670Z
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