Penile alterations at early stage of type 1 diabetes in rats
ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and m...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mingfang Tao [verfasserIn] Cemal Tasdemir [verfasserIn] Seda Tasdemir [verfasserIn] Ali Shahabi [verfasserIn] Guiming Liu [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
In: International Brazilian Journal of Urology - Sociedade Brasileira de Urologia, 2004 |
|---|
| Links: |
|---|
| DOI / URN: |
10.1590/s1677-5538.ibju.2016.0454 |
|---|
| Katalog-ID: |
DOAJ076654990 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ076654990 | ||
| 003 | DE-627 | ||
| 005 | 20230309144214.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230228nuuuuuuuuxx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1590/s1677-5538.ibju.2016.0454 |2 doi | |
| 035 | |a (DE-627)DOAJ076654990 | ||
| 035 | |a (DE-599)DOAJb9c4d8d58b4f4a8bbce1ef66f140296e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a RC870-923 | |
| 100 | 0 | |a Mingfang Tao |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Penile alterations at early stage of type 1 diabetes in rats |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted. | ||
| 650 | 4 | |a Diabetes Mellitus | |
| 650 | 4 | |a Penis | |
| 650 | 4 | |a Erectile Dysfunction | |
| 653 | 0 | |a Diseases of the genitourinary system. Urology | |
| 700 | 0 | |a Cemal Tasdemir |e verfasserin |4 aut | |
| 700 | 0 | |a Seda Tasdemir |e verfasserin |4 aut | |
| 700 | 0 | |a Ali Shahabi |e verfasserin |4 aut | |
| 700 | 0 | |a Guiming Liu |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t International Brazilian Journal of Urology |d Sociedade Brasileira de Urologia, 2004 |w (DE-627)394567234 |w (DE-600)2160867-2 |x 16776119 |7 nnns |
| 856 | 4 | 0 | |u https://doi.org/10.1590/s1677-5538.ibju.2016.0454 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/b9c4d8d58b4f4a8bbce1ef66f140296e |z kostenfrei |
| 856 | 4 | 0 | |u http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000400753&lng=en&tlng=en |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1677-6119 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| author_variant |
m t mt c t ct s t st a s as g l gl |
|---|---|
| matchkey_str |
article:16776119:uuuuuuuu::eieleainaerytgotp1 |
| callnumber-subject-code |
RC |
| allfields |
10.1590/s1677-5538.ibju.2016.0454 doi (DE-627)DOAJ076654990 (DE-599)DOAJb9c4d8d58b4f4a8bbce1ef66f140296e DE-627 ger DE-627 rakwb eng RC870-923 Mingfang Tao verfasserin aut Penile alterations at early stage of type 1 diabetes in rats Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted. Diabetes Mellitus Penis Erectile Dysfunction Diseases of the genitourinary system. Urology Cemal Tasdemir verfasserin aut Seda Tasdemir verfasserin aut Ali Shahabi verfasserin aut Guiming Liu verfasserin aut In International Brazilian Journal of Urology Sociedade Brasileira de Urologia, 2004 (DE-627)394567234 (DE-600)2160867-2 16776119 nnns https://doi.org/10.1590/s1677-5538.ibju.2016.0454 kostenfrei https://doaj.org/article/b9c4d8d58b4f4a8bbce1ef66f140296e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000400753&lng=en&tlng=en kostenfrei https://doaj.org/toc/1677-6119 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
| spelling |
10.1590/s1677-5538.ibju.2016.0454 doi (DE-627)DOAJ076654990 (DE-599)DOAJb9c4d8d58b4f4a8bbce1ef66f140296e DE-627 ger DE-627 rakwb eng RC870-923 Mingfang Tao verfasserin aut Penile alterations at early stage of type 1 diabetes in rats Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted. Diabetes Mellitus Penis Erectile Dysfunction Diseases of the genitourinary system. Urology Cemal Tasdemir verfasserin aut Seda Tasdemir verfasserin aut Ali Shahabi verfasserin aut Guiming Liu verfasserin aut In International Brazilian Journal of Urology Sociedade Brasileira de Urologia, 2004 (DE-627)394567234 (DE-600)2160867-2 16776119 nnns https://doi.org/10.1590/s1677-5538.ibju.2016.0454 kostenfrei https://doaj.org/article/b9c4d8d58b4f4a8bbce1ef66f140296e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000400753&lng=en&tlng=en kostenfrei https://doaj.org/toc/1677-6119 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
| allfields_unstemmed |
10.1590/s1677-5538.ibju.2016.0454 doi (DE-627)DOAJ076654990 (DE-599)DOAJb9c4d8d58b4f4a8bbce1ef66f140296e DE-627 ger DE-627 rakwb eng RC870-923 Mingfang Tao verfasserin aut Penile alterations at early stage of type 1 diabetes in rats Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted. Diabetes Mellitus Penis Erectile Dysfunction Diseases of the genitourinary system. Urology Cemal Tasdemir verfasserin aut Seda Tasdemir verfasserin aut Ali Shahabi verfasserin aut Guiming Liu verfasserin aut In International Brazilian Journal of Urology Sociedade Brasileira de Urologia, 2004 (DE-627)394567234 (DE-600)2160867-2 16776119 nnns https://doi.org/10.1590/s1677-5538.ibju.2016.0454 kostenfrei https://doaj.org/article/b9c4d8d58b4f4a8bbce1ef66f140296e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000400753&lng=en&tlng=en kostenfrei https://doaj.org/toc/1677-6119 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
| allfieldsGer |
10.1590/s1677-5538.ibju.2016.0454 doi (DE-627)DOAJ076654990 (DE-599)DOAJb9c4d8d58b4f4a8bbce1ef66f140296e DE-627 ger DE-627 rakwb eng RC870-923 Mingfang Tao verfasserin aut Penile alterations at early stage of type 1 diabetes in rats Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted. Diabetes Mellitus Penis Erectile Dysfunction Diseases of the genitourinary system. Urology Cemal Tasdemir verfasserin aut Seda Tasdemir verfasserin aut Ali Shahabi verfasserin aut Guiming Liu verfasserin aut In International Brazilian Journal of Urology Sociedade Brasileira de Urologia, 2004 (DE-627)394567234 (DE-600)2160867-2 16776119 nnns https://doi.org/10.1590/s1677-5538.ibju.2016.0454 kostenfrei https://doaj.org/article/b9c4d8d58b4f4a8bbce1ef66f140296e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000400753&lng=en&tlng=en kostenfrei https://doaj.org/toc/1677-6119 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
| allfieldsSound |
10.1590/s1677-5538.ibju.2016.0454 doi (DE-627)DOAJ076654990 (DE-599)DOAJb9c4d8d58b4f4a8bbce1ef66f140296e DE-627 ger DE-627 rakwb eng RC870-923 Mingfang Tao verfasserin aut Penile alterations at early stage of type 1 diabetes in rats Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted. Diabetes Mellitus Penis Erectile Dysfunction Diseases of the genitourinary system. Urology Cemal Tasdemir verfasserin aut Seda Tasdemir verfasserin aut Ali Shahabi verfasserin aut Guiming Liu verfasserin aut In International Brazilian Journal of Urology Sociedade Brasileira de Urologia, 2004 (DE-627)394567234 (DE-600)2160867-2 16776119 nnns https://doi.org/10.1590/s1677-5538.ibju.2016.0454 kostenfrei https://doaj.org/article/b9c4d8d58b4f4a8bbce1ef66f140296e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000400753&lng=en&tlng=en kostenfrei https://doaj.org/toc/1677-6119 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
| language |
English |
| source |
In International Brazilian Journal of Urology |
| sourceStr |
In International Brazilian Journal of Urology |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Diabetes Mellitus Penis Erectile Dysfunction Diseases of the genitourinary system. Urology |
| isfreeaccess_bool |
true |
| container_title |
International Brazilian Journal of Urology |
| authorswithroles_txt_mv |
Mingfang Tao @@aut@@ Cemal Tasdemir @@aut@@ Seda Tasdemir @@aut@@ Ali Shahabi @@aut@@ Guiming Liu @@aut@@ |
| publishDateDaySort_date |
2024-01-01T00:00:00Z |
| hierarchy_top_id |
394567234 |
| id |
DOAJ076654990 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ076654990</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309144214.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228nuuuuuuuuxx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1590/s1677-5538.ibju.2016.0454</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ076654990</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJb9c4d8d58b4f4a8bbce1ef66f140296e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC870-923</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Mingfang Tao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Penile alterations at early stage of type 1 diabetes in rats</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Diabetes Mellitus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Penis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Erectile Dysfunction</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the genitourinary system. Urology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cemal Tasdemir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Seda Tasdemir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ali Shahabi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Guiming Liu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Brazilian Journal of Urology</subfield><subfield code="d">Sociedade Brasileira de Urologia, 2004</subfield><subfield code="w">(DE-627)394567234</subfield><subfield code="w">(DE-600)2160867-2</subfield><subfield code="x">16776119</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1590/s1677-5538.ibju.2016.0454</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/b9c4d8d58b4f4a8bbce1ef66f140296e</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000400753&lng=en&tlng=en</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1677-6119</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield></record></collection>
|
| callnumber-first |
R - Medicine |
| author |
Mingfang Tao |
| spellingShingle |
Mingfang Tao misc RC870-923 misc Diabetes Mellitus misc Penis misc Erectile Dysfunction misc Diseases of the genitourinary system. Urology Penile alterations at early stage of type 1 diabetes in rats |
| authorStr |
Mingfang Tao |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)394567234 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut |
| collection |
DOAJ |
| remote_str |
true |
| callnumber-label |
RC870-923 |
| illustrated |
Not Illustrated |
| issn |
16776119 |
| topic_title |
RC870-923 Penile alterations at early stage of type 1 diabetes in rats Diabetes Mellitus Penis Erectile Dysfunction |
| topic |
misc RC870-923 misc Diabetes Mellitus misc Penis misc Erectile Dysfunction misc Diseases of the genitourinary system. Urology |
| topic_unstemmed |
misc RC870-923 misc Diabetes Mellitus misc Penis misc Erectile Dysfunction misc Diseases of the genitourinary system. Urology |
| topic_browse |
misc RC870-923 misc Diabetes Mellitus misc Penis misc Erectile Dysfunction misc Diseases of the genitourinary system. Urology |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
International Brazilian Journal of Urology |
| hierarchy_parent_id |
394567234 |
| hierarchy_top_title |
International Brazilian Journal of Urology |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)394567234 (DE-600)2160867-2 |
| title |
Penile alterations at early stage of type 1 diabetes in rats |
| ctrlnum |
(DE-627)DOAJ076654990 (DE-599)DOAJb9c4d8d58b4f4a8bbce1ef66f140296e |
| title_full |
Penile alterations at early stage of type 1 diabetes in rats |
| author_sort |
Mingfang Tao |
| journal |
International Brazilian Journal of Urology |
| journalStr |
International Brazilian Journal of Urology |
| callnumber-first-code |
R |
| lang_code |
eng |
| isOA_bool |
true |
| recordtype |
marc |
| contenttype_str_mv |
txt |
| author_browse |
Mingfang Tao Cemal Tasdemir Seda Tasdemir Ali Shahabi Guiming Liu |
| class |
RC870-923 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Mingfang Tao |
| doi_str_mv |
10.1590/s1677-5538.ibju.2016.0454 |
| author2-role |
verfasserin |
| title_sort |
penile alterations at early stage of type 1 diabetes in rats |
| callnumber |
RC870-923 |
| title_auth |
Penile alterations at early stage of type 1 diabetes in rats |
| abstract |
ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted. |
| abstractGer |
ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted. |
| abstract_unstemmed |
ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ |
| title_short |
Penile alterations at early stage of type 1 diabetes in rats |
| url |
https://doi.org/10.1590/s1677-5538.ibju.2016.0454 https://doaj.org/article/b9c4d8d58b4f4a8bbce1ef66f140296e http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000400753&lng=en&tlng=en https://doaj.org/toc/1677-6119 |
| remote_bool |
true |
| author2 |
Cemal Tasdemir Seda Tasdemir Ali Shahabi Guiming Liu |
| author2Str |
Cemal Tasdemir Seda Tasdemir Ali Shahabi Guiming Liu |
| ppnlink |
394567234 |
| callnumber-subject |
RC - Internal Medicine |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.1590/s1677-5538.ibju.2016.0454 |
| callnumber-a |
RC870-923 |
| up_date |
2024-07-03T21:42:04.089Z |
| _version_ |
1803595729169547264 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ076654990</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309144214.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228nuuuuuuuuxx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1590/s1677-5538.ibju.2016.0454</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ076654990</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJb9c4d8d58b4f4a8bbce1ef66f140296e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC870-923</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Mingfang Tao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Penile alterations at early stage of type 1 diabetes in rats</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Diabetes Mellitus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Penis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Erectile Dysfunction</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the genitourinary system. Urology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cemal Tasdemir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Seda Tasdemir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ali Shahabi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Guiming Liu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Brazilian Journal of Urology</subfield><subfield code="d">Sociedade Brasileira de Urologia, 2004</subfield><subfield code="w">(DE-627)394567234</subfield><subfield code="w">(DE-600)2160867-2</subfield><subfield code="x">16776119</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1590/s1677-5538.ibju.2016.0454</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/b9c4d8d58b4f4a8bbce1ef66f140296e</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000400753&lng=en&tlng=en</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1677-6119</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield></record></collection>
|
| score |
7.3995714 |