Primary Extraskeletal Ewing Sarcoma of the Thoracic Spinal Epidural Space: A Case Report
Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yasuhiro Yamamoto [verfasserIn] Osuke Washimi [verfasserIn] Daisuke Ishimura [verfasserIn] Harumoto Yamada [verfasserIn] Makoto Kuroda [verfasserIn] Masatake Matsubara [verfasserIn] Masahiro Yonekawa [verfasserIn] Mitsutosi Uchibori [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Übergeordnetes Werk: |
In: Clinical Medicine Insights: Oncology - SAGE Publishing, 2012, 1(2007) |
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| Übergeordnetes Werk: |
volume:1 ; year:2007 |
| Links: |
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| DOI / URN: |
10.4137/CMO.S332 |
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| Katalog-ID: |
DOAJ076707814 |
|---|
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| 520 | |a Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8–9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confirmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the first report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Post-operatively, the patient received aggressive adjuvant chemotherapy and radiotherapy. At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival. | ||
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10.4137/CMO.S332 doi (DE-627)DOAJ076707814 (DE-599)DOAJ294c3184acd348d3abcf9aed66f4def9 DE-627 ger DE-627 rakwb eng RC254-282 Yasuhiro Yamamoto verfasserin aut Primary Extraskeletal Ewing Sarcoma of the Thoracic Spinal Epidural Space: A Case Report 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8–9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confirmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the first report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Post-operatively, the patient received aggressive adjuvant chemotherapy and radiotherapy. At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Osuke Washimi verfasserin aut Daisuke Ishimura verfasserin aut Harumoto Yamada verfasserin aut Makoto Kuroda verfasserin aut Masatake Matsubara verfasserin aut Masahiro Yonekawa verfasserin aut Mitsutosi Uchibori verfasserin aut In Clinical Medicine Insights: Oncology SAGE Publishing, 2012 1(2007) (DE-627)63742266X (DE-600)2577877-8 11795549 nnns volume:1 year:2007 https://doi.org/10.4137/CMO.S332 kostenfrei https://doaj.org/article/294c3184acd348d3abcf9aed66f4def9 kostenfrei https://doi.org/10.4137/CMO.S332 kostenfrei https://doaj.org/toc/1179-5549 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 AR 1 2007 |
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10.4137/CMO.S332 doi (DE-627)DOAJ076707814 (DE-599)DOAJ294c3184acd348d3abcf9aed66f4def9 DE-627 ger DE-627 rakwb eng RC254-282 Yasuhiro Yamamoto verfasserin aut Primary Extraskeletal Ewing Sarcoma of the Thoracic Spinal Epidural Space: A Case Report 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8–9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confirmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the first report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Post-operatively, the patient received aggressive adjuvant chemotherapy and radiotherapy. At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Osuke Washimi verfasserin aut Daisuke Ishimura verfasserin aut Harumoto Yamada verfasserin aut Makoto Kuroda verfasserin aut Masatake Matsubara verfasserin aut Masahiro Yonekawa verfasserin aut Mitsutosi Uchibori verfasserin aut In Clinical Medicine Insights: Oncology SAGE Publishing, 2012 1(2007) (DE-627)63742266X (DE-600)2577877-8 11795549 nnns volume:1 year:2007 https://doi.org/10.4137/CMO.S332 kostenfrei https://doaj.org/article/294c3184acd348d3abcf9aed66f4def9 kostenfrei https://doi.org/10.4137/CMO.S332 kostenfrei https://doaj.org/toc/1179-5549 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 AR 1 2007 |
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10.4137/CMO.S332 doi (DE-627)DOAJ076707814 (DE-599)DOAJ294c3184acd348d3abcf9aed66f4def9 DE-627 ger DE-627 rakwb eng RC254-282 Yasuhiro Yamamoto verfasserin aut Primary Extraskeletal Ewing Sarcoma of the Thoracic Spinal Epidural Space: A Case Report 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8–9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confirmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the first report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Post-operatively, the patient received aggressive adjuvant chemotherapy and radiotherapy. At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Osuke Washimi verfasserin aut Daisuke Ishimura verfasserin aut Harumoto Yamada verfasserin aut Makoto Kuroda verfasserin aut Masatake Matsubara verfasserin aut Masahiro Yonekawa verfasserin aut Mitsutosi Uchibori verfasserin aut In Clinical Medicine Insights: Oncology SAGE Publishing, 2012 1(2007) (DE-627)63742266X (DE-600)2577877-8 11795549 nnns volume:1 year:2007 https://doi.org/10.4137/CMO.S332 kostenfrei https://doaj.org/article/294c3184acd348d3abcf9aed66f4def9 kostenfrei https://doi.org/10.4137/CMO.S332 kostenfrei https://doaj.org/toc/1179-5549 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 AR 1 2007 |
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10.4137/CMO.S332 doi (DE-627)DOAJ076707814 (DE-599)DOAJ294c3184acd348d3abcf9aed66f4def9 DE-627 ger DE-627 rakwb eng RC254-282 Yasuhiro Yamamoto verfasserin aut Primary Extraskeletal Ewing Sarcoma of the Thoracic Spinal Epidural Space: A Case Report 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8–9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confirmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the first report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Post-operatively, the patient received aggressive adjuvant chemotherapy and radiotherapy. At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Osuke Washimi verfasserin aut Daisuke Ishimura verfasserin aut Harumoto Yamada verfasserin aut Makoto Kuroda verfasserin aut Masatake Matsubara verfasserin aut Masahiro Yonekawa verfasserin aut Mitsutosi Uchibori verfasserin aut In Clinical Medicine Insights: Oncology SAGE Publishing, 2012 1(2007) (DE-627)63742266X (DE-600)2577877-8 11795549 nnns volume:1 year:2007 https://doi.org/10.4137/CMO.S332 kostenfrei https://doaj.org/article/294c3184acd348d3abcf9aed66f4def9 kostenfrei https://doi.org/10.4137/CMO.S332 kostenfrei https://doaj.org/toc/1179-5549 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 AR 1 2007 |
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10.4137/CMO.S332 doi (DE-627)DOAJ076707814 (DE-599)DOAJ294c3184acd348d3abcf9aed66f4def9 DE-627 ger DE-627 rakwb eng RC254-282 Yasuhiro Yamamoto verfasserin aut Primary Extraskeletal Ewing Sarcoma of the Thoracic Spinal Epidural Space: A Case Report 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8–9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confirmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the first report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Post-operatively, the patient received aggressive adjuvant chemotherapy and radiotherapy. At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Osuke Washimi verfasserin aut Daisuke Ishimura verfasserin aut Harumoto Yamada verfasserin aut Makoto Kuroda verfasserin aut Masatake Matsubara verfasserin aut Masahiro Yonekawa verfasserin aut Mitsutosi Uchibori verfasserin aut In Clinical Medicine Insights: Oncology SAGE Publishing, 2012 1(2007) (DE-627)63742266X (DE-600)2577877-8 11795549 nnns volume:1 year:2007 https://doi.org/10.4137/CMO.S332 kostenfrei https://doaj.org/article/294c3184acd348d3abcf9aed66f4def9 kostenfrei https://doi.org/10.4137/CMO.S332 kostenfrei https://doaj.org/toc/1179-5549 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 AR 1 2007 |
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Yasuhiro Yamamoto @@aut@@ Osuke Washimi @@aut@@ Daisuke Ishimura @@aut@@ Harumoto Yamada @@aut@@ Makoto Kuroda @@aut@@ Masatake Matsubara @@aut@@ Masahiro Yonekawa @@aut@@ Mitsutosi Uchibori @@aut@@ |
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Primary Extraskeletal Ewing Sarcoma of the Thoracic Spinal Epidural Space: A Case Report |
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Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8–9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confirmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the first report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Post-operatively, the patient received aggressive adjuvant chemotherapy and radiotherapy. At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival. |
| abstractGer |
Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8–9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confirmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the first report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Post-operatively, the patient received aggressive adjuvant chemotherapy and radiotherapy. At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival. |
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Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8–9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confirmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the first report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Post-operatively, the patient received aggressive adjuvant chemotherapy and radiotherapy. At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival. |
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