Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system

Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	DEREK ROSENFIELD [verfasserIn] Mario Ferraro [verfasserIn] Claudia Igayara [verfasserIn] Silvia Renata Gaigo Cortopassi [verfasserIn] Cristiane Schilbach Pizzutto [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	rdds, wildlife chemical restraint, atipamezole, capybara.

Übergeordnetes Werk:	In: Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro, 2018, 42(2020), 1, Seite e107220-e107220
Übergeordnetes Werk:	volume:42 ; year:2020 ; number:1 ; pages:e107220-e107220

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.29374/2527-2179.bjvm107220

Katalog-ID:	DOAJ076717313

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allfields	10.29374/2527-2179.bjvm107220 doi (DE-627)DOAJ076717313 (DE-599)DOAJbadb55065c494b2bad89f632a329ed8c DE-627 ger DE-627 rakwb eng SF600-1100 DEREK ROSENFIELD verfasserin aut Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions. rdds, wildlife chemical restraint, atipamezole, capybara. Veterinary medicine Mario Ferraro verfasserin aut Claudia Igayara verfasserin aut Silvia Renata Gaigo Cortopassi verfasserin aut Cristiane Schilbach Pizzutto verfasserin aut In Brazilian Journal of Veterinary Medicine Sociedade de Medicina Veterinária do Estado do Rio de Janeiro, 2018 42(2020), 1, Seite e107220-e107220 (DE-627)88157595X (DE-600)2886972-2 25272179 nnns volume:42 year:2020 number:1 pages:e107220-e107220 https://doi.org/10.29374/2527-2179.bjvm107220 kostenfrei https://doaj.org/article/badb55065c494b2bad89f632a329ed8c kostenfrei https://rbmv.org/BJVM/article/view/1072 kostenfrei https://doaj.org/toc/0100-2430 Journal toc kostenfrei https://doaj.org/toc/2527-2179 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2020 1 e107220-e107220
spelling	10.29374/2527-2179.bjvm107220 doi (DE-627)DOAJ076717313 (DE-599)DOAJbadb55065c494b2bad89f632a329ed8c DE-627 ger DE-627 rakwb eng SF600-1100 DEREK ROSENFIELD verfasserin aut Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions. rdds, wildlife chemical restraint, atipamezole, capybara. Veterinary medicine Mario Ferraro verfasserin aut Claudia Igayara verfasserin aut Silvia Renata Gaigo Cortopassi verfasserin aut Cristiane Schilbach Pizzutto verfasserin aut In Brazilian Journal of Veterinary Medicine Sociedade de Medicina Veterinária do Estado do Rio de Janeiro, 2018 42(2020), 1, Seite e107220-e107220 (DE-627)88157595X (DE-600)2886972-2 25272179 nnns volume:42 year:2020 number:1 pages:e107220-e107220 https://doi.org/10.29374/2527-2179.bjvm107220 kostenfrei https://doaj.org/article/badb55065c494b2bad89f632a329ed8c kostenfrei https://rbmv.org/BJVM/article/view/1072 kostenfrei https://doaj.org/toc/0100-2430 Journal toc kostenfrei https://doaj.org/toc/2527-2179 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2020 1 e107220-e107220
allfields_unstemmed	10.29374/2527-2179.bjvm107220 doi (DE-627)DOAJ076717313 (DE-599)DOAJbadb55065c494b2bad89f632a329ed8c DE-627 ger DE-627 rakwb eng SF600-1100 DEREK ROSENFIELD verfasserin aut Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions. rdds, wildlife chemical restraint, atipamezole, capybara. Veterinary medicine Mario Ferraro verfasserin aut Claudia Igayara verfasserin aut Silvia Renata Gaigo Cortopassi verfasserin aut Cristiane Schilbach Pizzutto verfasserin aut In Brazilian Journal of Veterinary Medicine Sociedade de Medicina Veterinária do Estado do Rio de Janeiro, 2018 42(2020), 1, Seite e107220-e107220 (DE-627)88157595X (DE-600)2886972-2 25272179 nnns volume:42 year:2020 number:1 pages:e107220-e107220 https://doi.org/10.29374/2527-2179.bjvm107220 kostenfrei https://doaj.org/article/badb55065c494b2bad89f632a329ed8c kostenfrei https://rbmv.org/BJVM/article/view/1072 kostenfrei https://doaj.org/toc/0100-2430 Journal toc kostenfrei https://doaj.org/toc/2527-2179 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2020 1 e107220-e107220
allfieldsGer	10.29374/2527-2179.bjvm107220 doi (DE-627)DOAJ076717313 (DE-599)DOAJbadb55065c494b2bad89f632a329ed8c DE-627 ger DE-627 rakwb eng SF600-1100 DEREK ROSENFIELD verfasserin aut Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions. rdds, wildlife chemical restraint, atipamezole, capybara. Veterinary medicine Mario Ferraro verfasserin aut Claudia Igayara verfasserin aut Silvia Renata Gaigo Cortopassi verfasserin aut Cristiane Schilbach Pizzutto verfasserin aut In Brazilian Journal of Veterinary Medicine Sociedade de Medicina Veterinária do Estado do Rio de Janeiro, 2018 42(2020), 1, Seite e107220-e107220 (DE-627)88157595X (DE-600)2886972-2 25272179 nnns volume:42 year:2020 number:1 pages:e107220-e107220 https://doi.org/10.29374/2527-2179.bjvm107220 kostenfrei https://doaj.org/article/badb55065c494b2bad89f632a329ed8c kostenfrei https://rbmv.org/BJVM/article/view/1072 kostenfrei https://doaj.org/toc/0100-2430 Journal toc kostenfrei https://doaj.org/toc/2527-2179 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2020 1 e107220-e107220
allfieldsSound	10.29374/2527-2179.bjvm107220 doi (DE-627)DOAJ076717313 (DE-599)DOAJbadb55065c494b2bad89f632a329ed8c DE-627 ger DE-627 rakwb eng SF600-1100 DEREK ROSENFIELD verfasserin aut Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions. rdds, wildlife chemical restraint, atipamezole, capybara. Veterinary medicine Mario Ferraro verfasserin aut Claudia Igayara verfasserin aut Silvia Renata Gaigo Cortopassi verfasserin aut Cristiane Schilbach Pizzutto verfasserin aut In Brazilian Journal of Veterinary Medicine Sociedade de Medicina Veterinária do Estado do Rio de Janeiro, 2018 42(2020), 1, Seite e107220-e107220 (DE-627)88157595X (DE-600)2886972-2 25272179 nnns volume:42 year:2020 number:1 pages:e107220-e107220 https://doi.org/10.29374/2527-2179.bjvm107220 kostenfrei https://doaj.org/article/badb55065c494b2bad89f632a329ed8c kostenfrei https://rbmv.org/BJVM/article/view/1072 kostenfrei https://doaj.org/toc/0100-2430 Journal toc kostenfrei https://doaj.org/toc/2527-2179 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2020 1 e107220-e107220
language	English
source	In Brazilian Journal of Veterinary Medicine 42(2020), 1, Seite e107220-e107220 volume:42 year:2020 number:1 pages:e107220-e107220
sourceStr	In Brazilian Journal of Veterinary Medicine 42(2020), 1, Seite e107220-e107220 volume:42 year:2020 number:1 pages:e107220-e107220
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topic_facet	rdds, wildlife chemical restraint, atipamezole, capybara. Veterinary medicine
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authorswithroles_txt_mv	DEREK ROSENFIELD @@aut@@ Mario Ferraro @@aut@@ Claudia Igayara @@aut@@ Silvia Renata Gaigo Cortopassi @@aut@@ Cristiane Schilbach Pizzutto @@aut@@
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author	DEREK ROSENFIELD
spellingShingle	DEREK ROSENFIELD misc SF600-1100 misc rdds, wildlife chemical restraint, atipamezole, capybara. misc Veterinary medicine Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system
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topic_title	SF600-1100 Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system rdds, wildlife chemical restraint, atipamezole, capybara
topic	misc SF600-1100 misc rdds, wildlife chemical restraint, atipamezole, capybara. misc Veterinary medicine
topic_unstemmed	misc SF600-1100 misc rdds, wildlife chemical restraint, atipamezole, capybara. misc Veterinary medicine
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title	Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system
ctrlnum	(DE-627)DOAJ076717313 (DE-599)DOAJbadb55065c494b2bad89f632a329ed8c
title_full	Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system
author_sort	DEREK ROSENFIELD
journal	Brazilian Journal of Veterinary Medicine
journalStr	Brazilian Journal of Veterinary Medicine
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lang_code	eng
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author_browse	DEREK ROSENFIELD Mario Ferraro Claudia Igayara Silvia Renata Gaigo Cortopassi Cristiane Schilbach Pizzutto
container_volume	42
class	SF600-1100
format_se	Elektronische Aufsätze
author-letter	DEREK ROSENFIELD
doi_str_mv	10.29374/2527-2179.bjvm107220
author2-role	verfasserin
title_sort	chemical immobilization of free-living capybaras (hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system
callnumber	SF600-1100
title_auth	Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system
abstract	Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions.
abstractGer	Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions.
abstract_unstemmed	Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions.
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title_short	Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system
url	https://doi.org/10.29374/2527-2179.bjvm107220 https://doaj.org/article/badb55065c494b2bad89f632a329ed8c https://rbmv.org/BJVM/article/view/1072 https://doaj.org/toc/0100-2430 https://doaj.org/toc/2527-2179
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author2	Mario Ferraro Claudia Igayara Silvia Renata Gaigo Cortopassi Cristiane Schilbach Pizzutto
author2Str	Mario Ferraro Claudia Igayara Silvia Renata Gaigo Cortopassi Cristiane Schilbach Pizzutto
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up_date	2024-07-03T22:02:19.518Z
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Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system

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