Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo

Inhibition of bromo-and extra-terminal domain (BET) proteins, epigenetic regulators of genes involved in cell viability, has been efficiently tested in preclinical models of triple negative breast cancer (TNBC). However, the use of the selective BET-inhibitor JQ1 on humans is limited by its very sho...
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Gespeichert in:

Autor*in:	Valentina Maggisano [verfasserIn] Marilena Celano [verfasserIn] Rocco Malivindi [verfasserIn] Ines Barone [verfasserIn] Donato Cosco [verfasserIn] Catia Mio [verfasserIn] Chiara Mignogna [verfasserIn] Salvatore Panza [verfasserIn] Giuseppe Damante [verfasserIn] Massimo Fresta [verfasserIn] Sebastiano Andò [verfasserIn] Diego Russo [verfasserIn] Stefania Catalano [verfasserIn] Stefania Bulotta [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	triple negative breast cancer targeted therapy nanoparticles bet inhibitors jq1

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 12(2019), 1, p 91
Übergeordnetes Werk:	volume:12 ; year:2019 ; number:1, p 91

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers12010091

Katalog-ID:	DOAJ07679170X

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spelling	10.3390/cancers12010091 doi (DE-627)DOAJ07679170X (DE-599)DOAJa2a451c66d154d29b969af5a262aed68 DE-627 ger DE-627 rakwb eng RC254-282 Valentina Maggisano verfasserin aut Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inhibition of bromo-and extra-terminal domain (BET) proteins, epigenetic regulators of genes involved in cell viability, has been efficiently tested in preclinical models of triple negative breast cancer (TNBC). However, the use of the selective BET-inhibitor JQ1 on humans is limited by its very short half-life. Herein, we developed, characterized and tested a novel formulation of nanoparticles containing JQ1 (N-JQ1) against TNBC in vitro and in vivo. N-JQ1, prepared using the nanoprecipitation method of preformedpoly-lactid-co-glycolic acid in an aqueous solution containing JQ1 and poloxamer-188 as a stabilizer, presented a high physico-chemical stability. Treatment of MDA-MB 157 and MDA-MB 231 TNBC cells with N-JQ1 determined a significant decrease in cell viability, adhesion and migration. Intra-peritoneal administration (5 days/week for two weeks) of N-JQ1 in nude mice hosting a xenograft TNBC after flank injection of MDA-MB-231 cells determined a great reduction in the growth and vascularity of the neoplasm. Moreover, the treatment resulted in a minimal infiltration of nearby tissues. Finally, the encapsulation of JQ1 in nanoparticles improved the anticancer efficacy of this epigenetic compound against TNBC in vitro and in vivo, opening the way to test it in the treatment of TNBC. triple negative breast cancer targeted therapy nanoparticles bet inhibitors jq1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Marilena Celano verfasserin aut Rocco Malivindi verfasserin aut Ines Barone verfasserin aut Donato Cosco verfasserin aut Catia Mio verfasserin aut Chiara Mignogna verfasserin aut Salvatore Panza verfasserin aut Giuseppe Damante verfasserin aut Massimo Fresta verfasserin aut Sebastiano Andò verfasserin aut Diego Russo verfasserin aut Stefania Catalano verfasserin aut Stefania Bulotta verfasserin aut In Cancers MDPI AG, 2010 12(2019), 1, p 91 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2019 number:1, p 91 https://doi.org/10.3390/cancers12010091 kostenfrei https://doaj.org/article/a2a451c66d154d29b969af5a262aed68 kostenfrei https://www.mdpi.com/2072-6694/12/1/91 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1, p 91
allfields_unstemmed	10.3390/cancers12010091 doi (DE-627)DOAJ07679170X (DE-599)DOAJa2a451c66d154d29b969af5a262aed68 DE-627 ger DE-627 rakwb eng RC254-282 Valentina Maggisano verfasserin aut Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inhibition of bromo-and extra-terminal domain (BET) proteins, epigenetic regulators of genes involved in cell viability, has been efficiently tested in preclinical models of triple negative breast cancer (TNBC). However, the use of the selective BET-inhibitor JQ1 on humans is limited by its very short half-life. Herein, we developed, characterized and tested a novel formulation of nanoparticles containing JQ1 (N-JQ1) against TNBC in vitro and in vivo. N-JQ1, prepared using the nanoprecipitation method of preformedpoly-lactid-co-glycolic acid in an aqueous solution containing JQ1 and poloxamer-188 as a stabilizer, presented a high physico-chemical stability. Treatment of MDA-MB 157 and MDA-MB 231 TNBC cells with N-JQ1 determined a significant decrease in cell viability, adhesion and migration. Intra-peritoneal administration (5 days/week for two weeks) of N-JQ1 in nude mice hosting a xenograft TNBC after flank injection of MDA-MB-231 cells determined a great reduction in the growth and vascularity of the neoplasm. Moreover, the treatment resulted in a minimal infiltration of nearby tissues. Finally, the encapsulation of JQ1 in nanoparticles improved the anticancer efficacy of this epigenetic compound against TNBC in vitro and in vivo, opening the way to test it in the treatment of TNBC. triple negative breast cancer targeted therapy nanoparticles bet inhibitors jq1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Marilena Celano verfasserin aut Rocco Malivindi verfasserin aut Ines Barone verfasserin aut Donato Cosco verfasserin aut Catia Mio verfasserin aut Chiara Mignogna verfasserin aut Salvatore Panza verfasserin aut Giuseppe Damante verfasserin aut Massimo Fresta verfasserin aut Sebastiano Andò verfasserin aut Diego Russo verfasserin aut Stefania Catalano verfasserin aut Stefania Bulotta verfasserin aut In Cancers MDPI AG, 2010 12(2019), 1, p 91 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2019 number:1, p 91 https://doi.org/10.3390/cancers12010091 kostenfrei https://doaj.org/article/a2a451c66d154d29b969af5a262aed68 kostenfrei https://www.mdpi.com/2072-6694/12/1/91 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1, p 91
allfieldsGer	10.3390/cancers12010091 doi (DE-627)DOAJ07679170X (DE-599)DOAJa2a451c66d154d29b969af5a262aed68 DE-627 ger DE-627 rakwb eng RC254-282 Valentina Maggisano verfasserin aut Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inhibition of bromo-and extra-terminal domain (BET) proteins, epigenetic regulators of genes involved in cell viability, has been efficiently tested in preclinical models of triple negative breast cancer (TNBC). However, the use of the selective BET-inhibitor JQ1 on humans is limited by its very short half-life. Herein, we developed, characterized and tested a novel formulation of nanoparticles containing JQ1 (N-JQ1) against TNBC in vitro and in vivo. N-JQ1, prepared using the nanoprecipitation method of preformedpoly-lactid-co-glycolic acid in an aqueous solution containing JQ1 and poloxamer-188 as a stabilizer, presented a high physico-chemical stability. Treatment of MDA-MB 157 and MDA-MB 231 TNBC cells with N-JQ1 determined a significant decrease in cell viability, adhesion and migration. Intra-peritoneal administration (5 days/week for two weeks) of N-JQ1 in nude mice hosting a xenograft TNBC after flank injection of MDA-MB-231 cells determined a great reduction in the growth and vascularity of the neoplasm. Moreover, the treatment resulted in a minimal infiltration of nearby tissues. Finally, the encapsulation of JQ1 in nanoparticles improved the anticancer efficacy of this epigenetic compound against TNBC in vitro and in vivo, opening the way to test it in the treatment of TNBC. triple negative breast cancer targeted therapy nanoparticles bet inhibitors jq1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Marilena Celano verfasserin aut Rocco Malivindi verfasserin aut Ines Barone verfasserin aut Donato Cosco verfasserin aut Catia Mio verfasserin aut Chiara Mignogna verfasserin aut Salvatore Panza verfasserin aut Giuseppe Damante verfasserin aut Massimo Fresta verfasserin aut Sebastiano Andò verfasserin aut Diego Russo verfasserin aut Stefania Catalano verfasserin aut Stefania Bulotta verfasserin aut In Cancers MDPI AG, 2010 12(2019), 1, p 91 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2019 number:1, p 91 https://doi.org/10.3390/cancers12010091 kostenfrei https://doaj.org/article/a2a451c66d154d29b969af5a262aed68 kostenfrei https://www.mdpi.com/2072-6694/12/1/91 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1, p 91
allfieldsSound	10.3390/cancers12010091 doi (DE-627)DOAJ07679170X (DE-599)DOAJa2a451c66d154d29b969af5a262aed68 DE-627 ger DE-627 rakwb eng RC254-282 Valentina Maggisano verfasserin aut Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inhibition of bromo-and extra-terminal domain (BET) proteins, epigenetic regulators of genes involved in cell viability, has been efficiently tested in preclinical models of triple negative breast cancer (TNBC). However, the use of the selective BET-inhibitor JQ1 on humans is limited by its very short half-life. Herein, we developed, characterized and tested a novel formulation of nanoparticles containing JQ1 (N-JQ1) against TNBC in vitro and in vivo. N-JQ1, prepared using the nanoprecipitation method of preformedpoly-lactid-co-glycolic acid in an aqueous solution containing JQ1 and poloxamer-188 as a stabilizer, presented a high physico-chemical stability. Treatment of MDA-MB 157 and MDA-MB 231 TNBC cells with N-JQ1 determined a significant decrease in cell viability, adhesion and migration. Intra-peritoneal administration (5 days/week for two weeks) of N-JQ1 in nude mice hosting a xenograft TNBC after flank injection of MDA-MB-231 cells determined a great reduction in the growth and vascularity of the neoplasm. Moreover, the treatment resulted in a minimal infiltration of nearby tissues. Finally, the encapsulation of JQ1 in nanoparticles improved the anticancer efficacy of this epigenetic compound against TNBC in vitro and in vivo, opening the way to test it in the treatment of TNBC. triple negative breast cancer targeted therapy nanoparticles bet inhibitors jq1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Marilena Celano verfasserin aut Rocco Malivindi verfasserin aut Ines Barone verfasserin aut Donato Cosco verfasserin aut Catia Mio verfasserin aut Chiara Mignogna verfasserin aut Salvatore Panza verfasserin aut Giuseppe Damante verfasserin aut Massimo Fresta verfasserin aut Sebastiano Andò verfasserin aut Diego Russo verfasserin aut Stefania Catalano verfasserin aut Stefania Bulotta verfasserin aut In Cancers MDPI AG, 2010 12(2019), 1, p 91 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2019 number:1, p 91 https://doi.org/10.3390/cancers12010091 kostenfrei https://doaj.org/article/a2a451c66d154d29b969af5a262aed68 kostenfrei https://www.mdpi.com/2072-6694/12/1/91 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1, p 91
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topic_facet	triple negative breast cancer targeted therapy nanoparticles bet inhibitors jq1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
authorswithroles_txt_mv	Valentina Maggisano @@aut@@ Marilena Celano @@aut@@ Rocco Malivindi @@aut@@ Ines Barone @@aut@@ Donato Cosco @@aut@@ Catia Mio @@aut@@ Chiara Mignogna @@aut@@ Salvatore Panza @@aut@@ Giuseppe Damante @@aut@@ Massimo Fresta @@aut@@ Sebastiano Andò @@aut@@ Diego Russo @@aut@@ Stefania Catalano @@aut@@ Stefania Bulotta @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Valentina Maggisano
spellingShingle	Valentina Maggisano misc RC254-282 misc triple negative breast cancer misc targeted therapy misc nanoparticles misc bet inhibitors misc jq1 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo
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topic_title	RC254-282 Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo triple negative breast cancer targeted therapy nanoparticles bet inhibitors jq1
topic	misc RC254-282 misc triple negative breast cancer misc targeted therapy misc nanoparticles misc bet inhibitors misc jq1 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc triple negative breast cancer misc targeted therapy misc nanoparticles misc bet inhibitors misc jq1 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc triple negative breast cancer misc targeted therapy misc nanoparticles misc bet inhibitors misc jq1 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo
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title_full	Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo
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author_browse	Valentina Maggisano Marilena Celano Rocco Malivindi Ines Barone Donato Cosco Catia Mio Chiara Mignogna Salvatore Panza Giuseppe Damante Massimo Fresta Sebastiano Andò Diego Russo Stefania Catalano Stefania Bulotta
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title_sort	nanoparticles loaded with the bet inhibitor jq1 block the growth of triple negative breast cancer cells in vitro and in vivo
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title_auth	Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo
abstract	Inhibition of bromo-and extra-terminal domain (BET) proteins, epigenetic regulators of genes involved in cell viability, has been efficiently tested in preclinical models of triple negative breast cancer (TNBC). However, the use of the selective BET-inhibitor JQ1 on humans is limited by its very short half-life. Herein, we developed, characterized and tested a novel formulation of nanoparticles containing JQ1 (N-JQ1) against TNBC in vitro and in vivo. N-JQ1, prepared using the nanoprecipitation method of preformedpoly-lactid-co-glycolic acid in an aqueous solution containing JQ1 and poloxamer-188 as a stabilizer, presented a high physico-chemical stability. Treatment of MDA-MB 157 and MDA-MB 231 TNBC cells with N-JQ1 determined a significant decrease in cell viability, adhesion and migration. Intra-peritoneal administration (5 days/week for two weeks) of N-JQ1 in nude mice hosting a xenograft TNBC after flank injection of MDA-MB-231 cells determined a great reduction in the growth and vascularity of the neoplasm. Moreover, the treatment resulted in a minimal infiltration of nearby tissues. Finally, the encapsulation of JQ1 in nanoparticles improved the anticancer efficacy of this epigenetic compound against TNBC in vitro and in vivo, opening the way to test it in the treatment of TNBC.
abstractGer	Inhibition of bromo-and extra-terminal domain (BET) proteins, epigenetic regulators of genes involved in cell viability, has been efficiently tested in preclinical models of triple negative breast cancer (TNBC). However, the use of the selective BET-inhibitor JQ1 on humans is limited by its very short half-life. Herein, we developed, characterized and tested a novel formulation of nanoparticles containing JQ1 (N-JQ1) against TNBC in vitro and in vivo. N-JQ1, prepared using the nanoprecipitation method of preformedpoly-lactid-co-glycolic acid in an aqueous solution containing JQ1 and poloxamer-188 as a stabilizer, presented a high physico-chemical stability. Treatment of MDA-MB 157 and MDA-MB 231 TNBC cells with N-JQ1 determined a significant decrease in cell viability, adhesion and migration. Intra-peritoneal administration (5 days/week for two weeks) of N-JQ1 in nude mice hosting a xenograft TNBC after flank injection of MDA-MB-231 cells determined a great reduction in the growth and vascularity of the neoplasm. Moreover, the treatment resulted in a minimal infiltration of nearby tissues. Finally, the encapsulation of JQ1 in nanoparticles improved the anticancer efficacy of this epigenetic compound against TNBC in vitro and in vivo, opening the way to test it in the treatment of TNBC.
abstract_unstemmed	Inhibition of bromo-and extra-terminal domain (BET) proteins, epigenetic regulators of genes involved in cell viability, has been efficiently tested in preclinical models of triple negative breast cancer (TNBC). However, the use of the selective BET-inhibitor JQ1 on humans is limited by its very short half-life. Herein, we developed, characterized and tested a novel formulation of nanoparticles containing JQ1 (N-JQ1) against TNBC in vitro and in vivo. N-JQ1, prepared using the nanoprecipitation method of preformedpoly-lactid-co-glycolic acid in an aqueous solution containing JQ1 and poloxamer-188 as a stabilizer, presented a high physico-chemical stability. Treatment of MDA-MB 157 and MDA-MB 231 TNBC cells with N-JQ1 determined a significant decrease in cell viability, adhesion and migration. Intra-peritoneal administration (5 days/week for two weeks) of N-JQ1 in nude mice hosting a xenograft TNBC after flank injection of MDA-MB-231 cells determined a great reduction in the growth and vascularity of the neoplasm. Moreover, the treatment resulted in a minimal infiltration of nearby tissues. Finally, the encapsulation of JQ1 in nanoparticles improved the anticancer efficacy of this epigenetic compound against TNBC in vitro and in vivo, opening the way to test it in the treatment of TNBC.
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title_short	Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo
url	https://doi.org/10.3390/cancers12010091 https://doaj.org/article/a2a451c66d154d29b969af5a262aed68 https://www.mdpi.com/2072-6694/12/1/91 https://doaj.org/toc/2072-6694
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Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo

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