ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES

Objective: To determine the diagnostic accuracy of Aspartate Aminotransferase Platelet Ratio Index (APRI) as a predictor for esophageal varices. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital Karachi, from Oct 2015 to Sep 2016. Patients and Methods: One hundred and thirty five patients were enrolled in this study. Patients included in thisstudy belonged to both genders, and were aged between 18 to 80 years. Cirrhosis was detected by Ultrasonography. Platelet count and Serum Aspartate Aminotransferase (AST) levels were performed in pathology laboratory. APRI ratio was calculated by using the formula AST (times above upper limit of normal)/ platelets x (109/L) x 100. For each patient APRI was determined with a cutoff value of 1.3. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of APRI were calculated by comparing it with upper gastrointestinal endoscopy as a gold-standard. Results: In this cross sectional validation study, 27.4% (n=37) were aged between 18-40 years, 52.6% (n=71) were aged between 41 to 60 years and 27% (n=20) were aged between 61 to 80 years of age respectively, and mean ± SD was calculated as 48.6 ± 14.3. Amongst the total, 63.7% (n=86) were males whereas 36.3% (n=49) were females. The diagnostic accuracy of APRI was determined, considering endoscopy as gold standard, 65 % (n=65) were true positive, 35% (n=35) were false positive, 51.4% (n=18) were false negative and 48.57% (n=17) were true negative. Sensitivity, specificity and accuracy of APRI were 78.3%, 32.7% and 60.7%, respectively. Positive predictive value, negative predictive and diagnostic accuracy of APRI was 65.0%, 48.5% and 60.7% respectively. Conclusion: Our study results signify that APRI is an unsuitable replacement for endoscopy and cannot help in the screening of esophageal varices among cirrhotics because of low specificity and negative predictive value hence proved that we need further evaluation/trials to use APRI as a screening test in our domestic population. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Syed Hassan Raza [verfasserIn] Imran Ahmad [verfasserIn] Aamir Habib [verfasserIn] Zill -e- Humayaun [verfasserIn] Muhammad Ali Yousaf [verfasserIn] Muhammad Javad Yousaf [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	aspartate aminotransferase aspartate aminotransferase platelet ratio index

Übergeordnetes Werk:	In: Pakistan Armed Forces Medical Journal - Army Medical College Rawalpindi, 2016, 69(2019), 2, Seite 296-301
Übergeordnetes Werk:	volume:69 ; year:2019 ; number:2 ; pages:296-301

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ076854655

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allfields	(DE-627)DOAJ076854655 (DE-599)DOAJb1382885e66441dcb18796cf59eb696e DE-627 ger DE-627 rakwb eng R5-920 Syed Hassan Raza verfasserin aut ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To determine the diagnostic accuracy of Aspartate Aminotransferase Platelet Ratio Index (APRI) as a predictor for esophageal varices. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital Karachi, from Oct 2015 to Sep 2016. Patients and Methods: One hundred and thirty five patients were enrolled in this study. Patients included in thisstudy belonged to both genders, and were aged between 18 to 80 years. Cirrhosis was detected by Ultrasonography. Platelet count and Serum Aspartate Aminotransferase (AST) levels were performed in pathology laboratory. APRI ratio was calculated by using the formula AST (times above upper limit of normal)/ platelets x (109/L) x 100. For each patient APRI was determined with a cutoff value of 1.3. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of APRI were calculated by comparing it with upper gastrointestinal endoscopy as a gold-standard. Results: In this cross sectional validation study, 27.4% (n=37) were aged between 18-40 years, 52.6% (n=71) were aged between 41 to 60 years and 27% (n=20) were aged between 61 to 80 years of age respectively, and mean ± SD was calculated as 48.6 ± 14.3. Amongst the total, 63.7% (n=86) were males whereas 36.3% (n=49) were females. The diagnostic accuracy of APRI was determined, considering endoscopy as gold standard, 65 % (n=65) were true positive, 35% (n=35) were false positive, 51.4% (n=18) were false negative and 48.57% (n=17) were true negative. Sensitivity, specificity and accuracy of APRI were 78.3%, 32.7% and 60.7%, respectively. Positive predictive value, negative predictive and diagnostic accuracy of APRI was 65.0%, 48.5% and 60.7% respectively. Conclusion: Our study results signify that APRI is an unsuitable replacement for endoscopy and cannot help in the screening of esophageal varices among cirrhotics because of low specificity and negative predictive value hence proved that we need further evaluation/trials to use APRI as a screening test in our domestic population. aspartate aminotransferase aspartate aminotransferase platelet ratio index Medicine R Medicine (General) Imran Ahmad verfasserin aut Aamir Habib verfasserin aut Zill -e- Humayaun verfasserin aut Muhammad Ali Yousaf verfasserin aut Muhammad Javad Yousaf verfasserin aut In Pakistan Armed Forces Medical Journal Army Medical College Rawalpindi, 2016 69(2019), 2, Seite 296-301 (DE-627)1016057962 24118842 nnns volume:69 year:2019 number:2 pages:296-301 https://doaj.org/article/b1382885e66441dcb18796cf59eb696e kostenfrei https://www.pafmj.org/index.php/PAFMJ/article/view/2740/2148 kostenfrei https://doaj.org/toc/0030-9648 Journal toc kostenfrei https://doaj.org/toc/2411-8842 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2019 2 296-301
spelling	(DE-627)DOAJ076854655 (DE-599)DOAJb1382885e66441dcb18796cf59eb696e DE-627 ger DE-627 rakwb eng R5-920 Syed Hassan Raza verfasserin aut ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To determine the diagnostic accuracy of Aspartate Aminotransferase Platelet Ratio Index (APRI) as a predictor for esophageal varices. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital Karachi, from Oct 2015 to Sep 2016. Patients and Methods: One hundred and thirty five patients were enrolled in this study. Patients included in thisstudy belonged to both genders, and were aged between 18 to 80 years. Cirrhosis was detected by Ultrasonography. Platelet count and Serum Aspartate Aminotransferase (AST) levels were performed in pathology laboratory. APRI ratio was calculated by using the formula AST (times above upper limit of normal)/ platelets x (109/L) x 100. For each patient APRI was determined with a cutoff value of 1.3. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of APRI were calculated by comparing it with upper gastrointestinal endoscopy as a gold-standard. Results: In this cross sectional validation study, 27.4% (n=37) were aged between 18-40 years, 52.6% (n=71) were aged between 41 to 60 years and 27% (n=20) were aged between 61 to 80 years of age respectively, and mean ± SD was calculated as 48.6 ± 14.3. Amongst the total, 63.7% (n=86) were males whereas 36.3% (n=49) were females. The diagnostic accuracy of APRI was determined, considering endoscopy as gold standard, 65 % (n=65) were true positive, 35% (n=35) were false positive, 51.4% (n=18) were false negative and 48.57% (n=17) were true negative. Sensitivity, specificity and accuracy of APRI were 78.3%, 32.7% and 60.7%, respectively. Positive predictive value, negative predictive and diagnostic accuracy of APRI was 65.0%, 48.5% and 60.7% respectively. Conclusion: Our study results signify that APRI is an unsuitable replacement for endoscopy and cannot help in the screening of esophageal varices among cirrhotics because of low specificity and negative predictive value hence proved that we need further evaluation/trials to use APRI as a screening test in our domestic population. aspartate aminotransferase aspartate aminotransferase platelet ratio index Medicine R Medicine (General) Imran Ahmad verfasserin aut Aamir Habib verfasserin aut Zill -e- Humayaun verfasserin aut Muhammad Ali Yousaf verfasserin aut Muhammad Javad Yousaf verfasserin aut In Pakistan Armed Forces Medical Journal Army Medical College Rawalpindi, 2016 69(2019), 2, Seite 296-301 (DE-627)1016057962 24118842 nnns volume:69 year:2019 number:2 pages:296-301 https://doaj.org/article/b1382885e66441dcb18796cf59eb696e kostenfrei https://www.pafmj.org/index.php/PAFMJ/article/view/2740/2148 kostenfrei https://doaj.org/toc/0030-9648 Journal toc kostenfrei https://doaj.org/toc/2411-8842 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2019 2 296-301
allfields_unstemmed	(DE-627)DOAJ076854655 (DE-599)DOAJb1382885e66441dcb18796cf59eb696e DE-627 ger DE-627 rakwb eng R5-920 Syed Hassan Raza verfasserin aut ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To determine the diagnostic accuracy of Aspartate Aminotransferase Platelet Ratio Index (APRI) as a predictor for esophageal varices. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital Karachi, from Oct 2015 to Sep 2016. Patients and Methods: One hundred and thirty five patients were enrolled in this study. Patients included in thisstudy belonged to both genders, and were aged between 18 to 80 years. Cirrhosis was detected by Ultrasonography. Platelet count and Serum Aspartate Aminotransferase (AST) levels were performed in pathology laboratory. APRI ratio was calculated by using the formula AST (times above upper limit of normal)/ platelets x (109/L) x 100. For each patient APRI was determined with a cutoff value of 1.3. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of APRI were calculated by comparing it with upper gastrointestinal endoscopy as a gold-standard. Results: In this cross sectional validation study, 27.4% (n=37) were aged between 18-40 years, 52.6% (n=71) were aged between 41 to 60 years and 27% (n=20) were aged between 61 to 80 years of age respectively, and mean ± SD was calculated as 48.6 ± 14.3. Amongst the total, 63.7% (n=86) were males whereas 36.3% (n=49) were females. The diagnostic accuracy of APRI was determined, considering endoscopy as gold standard, 65 % (n=65) were true positive, 35% (n=35) were false positive, 51.4% (n=18) were false negative and 48.57% (n=17) were true negative. Sensitivity, specificity and accuracy of APRI were 78.3%, 32.7% and 60.7%, respectively. Positive predictive value, negative predictive and diagnostic accuracy of APRI was 65.0%, 48.5% and 60.7% respectively. Conclusion: Our study results signify that APRI is an unsuitable replacement for endoscopy and cannot help in the screening of esophageal varices among cirrhotics because of low specificity and negative predictive value hence proved that we need further evaluation/trials to use APRI as a screening test in our domestic population. aspartate aminotransferase aspartate aminotransferase platelet ratio index Medicine R Medicine (General) Imran Ahmad verfasserin aut Aamir Habib verfasserin aut Zill -e- Humayaun verfasserin aut Muhammad Ali Yousaf verfasserin aut Muhammad Javad Yousaf verfasserin aut In Pakistan Armed Forces Medical Journal Army Medical College Rawalpindi, 2016 69(2019), 2, Seite 296-301 (DE-627)1016057962 24118842 nnns volume:69 year:2019 number:2 pages:296-301 https://doaj.org/article/b1382885e66441dcb18796cf59eb696e kostenfrei https://www.pafmj.org/index.php/PAFMJ/article/view/2740/2148 kostenfrei https://doaj.org/toc/0030-9648 Journal toc kostenfrei https://doaj.org/toc/2411-8842 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2019 2 296-301
allfieldsGer	(DE-627)DOAJ076854655 (DE-599)DOAJb1382885e66441dcb18796cf59eb696e DE-627 ger DE-627 rakwb eng R5-920 Syed Hassan Raza verfasserin aut ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To determine the diagnostic accuracy of Aspartate Aminotransferase Platelet Ratio Index (APRI) as a predictor for esophageal varices. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital Karachi, from Oct 2015 to Sep 2016. Patients and Methods: One hundred and thirty five patients were enrolled in this study. Patients included in thisstudy belonged to both genders, and were aged between 18 to 80 years. Cirrhosis was detected by Ultrasonography. Platelet count and Serum Aspartate Aminotransferase (AST) levels were performed in pathology laboratory. APRI ratio was calculated by using the formula AST (times above upper limit of normal)/ platelets x (109/L) x 100. For each patient APRI was determined with a cutoff value of 1.3. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of APRI were calculated by comparing it with upper gastrointestinal endoscopy as a gold-standard. Results: In this cross sectional validation study, 27.4% (n=37) were aged between 18-40 years, 52.6% (n=71) were aged between 41 to 60 years and 27% (n=20) were aged between 61 to 80 years of age respectively, and mean ± SD was calculated as 48.6 ± 14.3. Amongst the total, 63.7% (n=86) were males whereas 36.3% (n=49) were females. The diagnostic accuracy of APRI was determined, considering endoscopy as gold standard, 65 % (n=65) were true positive, 35% (n=35) were false positive, 51.4% (n=18) were false negative and 48.57% (n=17) were true negative. Sensitivity, specificity and accuracy of APRI were 78.3%, 32.7% and 60.7%, respectively. Positive predictive value, negative predictive and diagnostic accuracy of APRI was 65.0%, 48.5% and 60.7% respectively. Conclusion: Our study results signify that APRI is an unsuitable replacement for endoscopy and cannot help in the screening of esophageal varices among cirrhotics because of low specificity and negative predictive value hence proved that we need further evaluation/trials to use APRI as a screening test in our domestic population. aspartate aminotransferase aspartate aminotransferase platelet ratio index Medicine R Medicine (General) Imran Ahmad verfasserin aut Aamir Habib verfasserin aut Zill -e- Humayaun verfasserin aut Muhammad Ali Yousaf verfasserin aut Muhammad Javad Yousaf verfasserin aut In Pakistan Armed Forces Medical Journal Army Medical College Rawalpindi, 2016 69(2019), 2, Seite 296-301 (DE-627)1016057962 24118842 nnns volume:69 year:2019 number:2 pages:296-301 https://doaj.org/article/b1382885e66441dcb18796cf59eb696e kostenfrei https://www.pafmj.org/index.php/PAFMJ/article/view/2740/2148 kostenfrei https://doaj.org/toc/0030-9648 Journal toc kostenfrei https://doaj.org/toc/2411-8842 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2019 2 296-301
allfieldsSound	(DE-627)DOAJ076854655 (DE-599)DOAJb1382885e66441dcb18796cf59eb696e DE-627 ger DE-627 rakwb eng R5-920 Syed Hassan Raza verfasserin aut ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To determine the diagnostic accuracy of Aspartate Aminotransferase Platelet Ratio Index (APRI) as a predictor for esophageal varices. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital Karachi, from Oct 2015 to Sep 2016. Patients and Methods: One hundred and thirty five patients were enrolled in this study. Patients included in thisstudy belonged to both genders, and were aged between 18 to 80 years. Cirrhosis was detected by Ultrasonography. Platelet count and Serum Aspartate Aminotransferase (AST) levels were performed in pathology laboratory. APRI ratio was calculated by using the formula AST (times above upper limit of normal)/ platelets x (109/L) x 100. For each patient APRI was determined with a cutoff value of 1.3. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of APRI were calculated by comparing it with upper gastrointestinal endoscopy as a gold-standard. Results: In this cross sectional validation study, 27.4% (n=37) were aged between 18-40 years, 52.6% (n=71) were aged between 41 to 60 years and 27% (n=20) were aged between 61 to 80 years of age respectively, and mean ± SD was calculated as 48.6 ± 14.3. Amongst the total, 63.7% (n=86) were males whereas 36.3% (n=49) were females. The diagnostic accuracy of APRI was determined, considering endoscopy as gold standard, 65 % (n=65) were true positive, 35% (n=35) were false positive, 51.4% (n=18) were false negative and 48.57% (n=17) were true negative. Sensitivity, specificity and accuracy of APRI were 78.3%, 32.7% and 60.7%, respectively. Positive predictive value, negative predictive and diagnostic accuracy of APRI was 65.0%, 48.5% and 60.7% respectively. Conclusion: Our study results signify that APRI is an unsuitable replacement for endoscopy and cannot help in the screening of esophageal varices among cirrhotics because of low specificity and negative predictive value hence proved that we need further evaluation/trials to use APRI as a screening test in our domestic population. aspartate aminotransferase aspartate aminotransferase platelet ratio index Medicine R Medicine (General) Imran Ahmad verfasserin aut Aamir Habib verfasserin aut Zill -e- Humayaun verfasserin aut Muhammad Ali Yousaf verfasserin aut Muhammad Javad Yousaf verfasserin aut In Pakistan Armed Forces Medical Journal Army Medical College Rawalpindi, 2016 69(2019), 2, Seite 296-301 (DE-627)1016057962 24118842 nnns volume:69 year:2019 number:2 pages:296-301 https://doaj.org/article/b1382885e66441dcb18796cf59eb696e kostenfrei https://www.pafmj.org/index.php/PAFMJ/article/view/2740/2148 kostenfrei https://doaj.org/toc/0030-9648 Journal toc kostenfrei https://doaj.org/toc/2411-8842 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2019 2 296-301
language	English
source	In Pakistan Armed Forces Medical Journal 69(2019), 2, Seite 296-301 volume:69 year:2019 number:2 pages:296-301
sourceStr	In Pakistan Armed Forces Medical Journal 69(2019), 2, Seite 296-301 volume:69 year:2019 number:2 pages:296-301
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	aspartate aminotransferase aspartate aminotransferase platelet ratio index Medicine R Medicine (General)
isfreeaccess_bool	true
container_title	Pakistan Armed Forces Medical Journal
authorswithroles_txt_mv	Syed Hassan Raza @@aut@@ Imran Ahmad @@aut@@ Aamir Habib @@aut@@ Zill -e- Humayaun @@aut@@ Muhammad Ali Yousaf @@aut@@ Muhammad Javad Yousaf @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	1016057962
id	DOAJ076854655
language_de	englisch
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Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital Karachi, from Oct 2015 to Sep 2016. Patients and Methods: One hundred and thirty five patients were enrolled in this study. Patients included in thisstudy belonged to both genders, and were aged between 18 to 80 years. Cirrhosis was detected by Ultrasonography. Platelet count and Serum Aspartate Aminotransferase (AST) levels were performed in pathology laboratory. APRI ratio was calculated by using the formula AST (times above upper limit of normal)/ platelets x (109/L) x 100. For each patient APRI was determined with a cutoff value of 1.3. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of APRI were calculated by comparing it with upper gastrointestinal endoscopy as a gold-standard. Results: In this cross sectional validation study, 27.4% (n=37) were aged between 18-40 years, 52.6% (n=71) were aged between 41 to 60 years and 27% (n=20) were aged between 61 to 80 years of age respectively, and mean ± SD was calculated as 48.6 ± 14.3. Amongst the total, 63.7% (n=86) were males whereas 36.3% (n=49) were females. The diagnostic accuracy of APRI was determined, considering endoscopy as gold standard, 65 % (n=65) were true positive, 35% (n=35) were false positive, 51.4% (n=18) were false negative and 48.57% (n=17) were true negative. Sensitivity, specificity and accuracy of APRI were 78.3%, 32.7% and 60.7%, respectively. Positive predictive value, negative predictive and diagnostic accuracy of APRI was 65.0%, 48.5% and 60.7% respectively. 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callnumber-first	R - Medicine
author	Syed Hassan Raza
spellingShingle	Syed Hassan Raza misc R5-920 misc aspartate aminotransferase misc aspartate aminotransferase platelet ratio index misc Medicine misc R misc Medicine (General) ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES
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topic_title	R5-920 ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES aspartate aminotransferase aspartate aminotransferase platelet ratio index
topic	misc R5-920 misc aspartate aminotransferase misc aspartate aminotransferase platelet ratio index misc Medicine misc R misc Medicine (General)
topic_unstemmed	misc R5-920 misc aspartate aminotransferase misc aspartate aminotransferase platelet ratio index misc Medicine misc R misc Medicine (General)
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title	ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES
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title_full	ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES
author_sort	Syed Hassan Raza
journal	Pakistan Armed Forces Medical Journal
journalStr	Pakistan Armed Forces Medical Journal
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author_browse	Syed Hassan Raza Imran Ahmad Aamir Habib Zill -e- Humayaun Muhammad Ali Yousaf Muhammad Javad Yousaf
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format_se	Elektronische Aufsätze
author-letter	Syed Hassan Raza
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title_sort	aspartate aminotransferase platelet ratio index as a non-invasive predictor for esophageal varices
callnumber	R5-920
title_auth	ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES
abstract	Objective: To determine the diagnostic accuracy of Aspartate Aminotransferase Platelet Ratio Index (APRI) as a predictor for esophageal varices. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital Karachi, from Oct 2015 to Sep 2016. Patients and Methods: One hundred and thirty five patients were enrolled in this study. Patients included in thisstudy belonged to both genders, and were aged between 18 to 80 years. Cirrhosis was detected by Ultrasonography. Platelet count and Serum Aspartate Aminotransferase (AST) levels were performed in pathology laboratory. APRI ratio was calculated by using the formula AST (times above upper limit of normal)/ platelets x (109/L) x 100. For each patient APRI was determined with a cutoff value of 1.3. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of APRI were calculated by comparing it with upper gastrointestinal endoscopy as a gold-standard. Results: In this cross sectional validation study, 27.4% (n=37) were aged between 18-40 years, 52.6% (n=71) were aged between 41 to 60 years and 27% (n=20) were aged between 61 to 80 years of age respectively, and mean ± SD was calculated as 48.6 ± 14.3. Amongst the total, 63.7% (n=86) were males whereas 36.3% (n=49) were females. The diagnostic accuracy of APRI was determined, considering endoscopy as gold standard, 65 % (n=65) were true positive, 35% (n=35) were false positive, 51.4% (n=18) were false negative and 48.57% (n=17) were true negative. Sensitivity, specificity and accuracy of APRI were 78.3%, 32.7% and 60.7%, respectively. Positive predictive value, negative predictive and diagnostic accuracy of APRI was 65.0%, 48.5% and 60.7% respectively. Conclusion: Our study results signify that APRI is an unsuitable replacement for endoscopy and cannot help in the screening of esophageal varices among cirrhotics because of low specificity and negative predictive value hence proved that we need further evaluation/trials to use APRI as a screening test in our domestic population.
abstractGer	Objective: To determine the diagnostic accuracy of Aspartate Aminotransferase Platelet Ratio Index (APRI) as a predictor for esophageal varices. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital Karachi, from Oct 2015 to Sep 2016. Patients and Methods: One hundred and thirty five patients were enrolled in this study. Patients included in thisstudy belonged to both genders, and were aged between 18 to 80 years. Cirrhosis was detected by Ultrasonography. Platelet count and Serum Aspartate Aminotransferase (AST) levels were performed in pathology laboratory. APRI ratio was calculated by using the formula AST (times above upper limit of normal)/ platelets x (109/L) x 100. For each patient APRI was determined with a cutoff value of 1.3. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of APRI were calculated by comparing it with upper gastrointestinal endoscopy as a gold-standard. Results: In this cross sectional validation study, 27.4% (n=37) were aged between 18-40 years, 52.6% (n=71) were aged between 41 to 60 years and 27% (n=20) were aged between 61 to 80 years of age respectively, and mean ± SD was calculated as 48.6 ± 14.3. Amongst the total, 63.7% (n=86) were males whereas 36.3% (n=49) were females. The diagnostic accuracy of APRI was determined, considering endoscopy as gold standard, 65 % (n=65) were true positive, 35% (n=35) were false positive, 51.4% (n=18) were false negative and 48.57% (n=17) were true negative. Sensitivity, specificity and accuracy of APRI were 78.3%, 32.7% and 60.7%, respectively. Positive predictive value, negative predictive and diagnostic accuracy of APRI was 65.0%, 48.5% and 60.7% respectively. Conclusion: Our study results signify that APRI is an unsuitable replacement for endoscopy and cannot help in the screening of esophageal varices among cirrhotics because of low specificity and negative predictive value hence proved that we need further evaluation/trials to use APRI as a screening test in our domestic population.
abstract_unstemmed	Objective: To determine the diagnostic accuracy of Aspartate Aminotransferase Platelet Ratio Index (APRI) as a predictor for esophageal varices. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital Karachi, from Oct 2015 to Sep 2016. Patients and Methods: One hundred and thirty five patients were enrolled in this study. Patients included in thisstudy belonged to both genders, and were aged between 18 to 80 years. Cirrhosis was detected by Ultrasonography. Platelet count and Serum Aspartate Aminotransferase (AST) levels were performed in pathology laboratory. APRI ratio was calculated by using the formula AST (times above upper limit of normal)/ platelets x (109/L) x 100. For each patient APRI was determined with a cutoff value of 1.3. Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of APRI were calculated by comparing it with upper gastrointestinal endoscopy as a gold-standard. Results: In this cross sectional validation study, 27.4% (n=37) were aged between 18-40 years, 52.6% (n=71) were aged between 41 to 60 years and 27% (n=20) were aged between 61 to 80 years of age respectively, and mean ± SD was calculated as 48.6 ± 14.3. Amongst the total, 63.7% (n=86) were males whereas 36.3% (n=49) were females. The diagnostic accuracy of APRI was determined, considering endoscopy as gold standard, 65 % (n=65) were true positive, 35% (n=35) were false positive, 51.4% (n=18) were false negative and 48.57% (n=17) were true negative. Sensitivity, specificity and accuracy of APRI were 78.3%, 32.7% and 60.7%, respectively. Positive predictive value, negative predictive and diagnostic accuracy of APRI was 65.0%, 48.5% and 60.7% respectively. Conclusion: Our study results signify that APRI is an unsuitable replacement for endoscopy and cannot help in the screening of esophageal varices among cirrhotics because of low specificity and negative predictive value hence proved that we need further evaluation/trials to use APRI as a screening test in our domestic population.
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title_short	ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES
url	https://doaj.org/article/b1382885e66441dcb18796cf59eb696e https://www.pafmj.org/index.php/PAFMJ/article/view/2740/2148 https://doaj.org/toc/0030-9648 https://doaj.org/toc/2411-8842
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author2	Imran Ahmad Aamir Habib Zill -e- Humayaun Muhammad Ali Yousaf Muhammad Javad Yousaf
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score	7.399846

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ASPARTATE AMINOTRANSFERASE PLATELET RATIO INDEX AS A NON-INVASIVE PREDICTOR FOR ESOPHAGEAL VARICES

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