High-pressure intrapleural chemotherapy: feasibility in the pig model

<p<Abstract</p< <p<Background</p< <p<The usual treatments for pleural malignancies are mostly palliative. In contrast, peritoneal malignancies are often treated with a curative intent by cytoreductive surgery and intraperitoneal chemotherapy. As pressure has been shown...
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Gespeichert in:

Autor*in:	Facy Olivier [verfasserIn] Pages Pierre-Benoit [verfasserIn] Ortega-Deballon Pablo [verfasserIn] Magnin Guy [verfasserIn] Ladoire Sylvain [verfasserIn] Royer Bernard [verfasserIn] Chauffert Bruno [verfasserIn] Bernard Alain [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	intrapleural intracavitary chemotherapy pressure pig model

Übergeordnetes Werk:	In: World Journal of Surgical Oncology - BMC, 2003, 10(2012), 1, p 29
Übergeordnetes Werk:	volume:10 ; year:2012 ; number:1, p 29

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1477-7819-10-29

Katalog-ID:	DOAJ076897389

Internformat


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allfieldsSound	10.1186/1477-7819-10-29 doi (DE-627)DOAJ076897389 (DE-599)DOAJ61679b4e32e448cc95dac4d223f58871 DE-627 ger DE-627 rakwb eng RD1-811 RC254-282 Facy Olivier verfasserin aut High-pressure intrapleural chemotherapy: feasibility in the pig model 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The usual treatments for pleural malignancies are mostly palliative. In contrast, peritoneal malignancies are often treated with a curative intent by cytoreductive surgery and intraperitoneal chemotherapy. As pressure has been shown to increase antitumor efficacy, we applied the concept of high-pressure intracavitary chemotherapy to the pleural space in a swine model.</p< <p<Methods</p< <p<Cisplatin and gemcitabine were selected because of their antineoplasic efficacy in vitro in a wide spectrum of cancer cell lines. The pleural cavity of 21 pigs was filled with saline solution; haemodynamic and respiratory parameters were monitored. The pressure was increased to 15-25 cm H<sub<2</sub<O. This treatment was associated with pneumonectomy in 6 pigs. Five pigs were treated with chemotherapy under pressure.</p< <p<Results</p< <p<The combination of gemcitabine (100 mg/l) and cisplatin (30 mg/l) was highly cytotoxic in vitro. The maximum tolerated pressure was 20 cm H<sub<2</sub<0, due to haemodynamic failure. Pneumonectomy was not tolerated, either before or after pleural infusion. Five pigs survived intrapleural chemotherapy associating gemcitabine and cisplatin with 20 cm H<sub<2</sub<O pressure for 60 min.</p< <p<Conclusions</p< <p<High-pressure intrapleural chemotherapy is feasible in pigs. Further experiments will establish the pharmacokinetics and determine whether the benefit already shown in the peritoneum is also obtained in the pleura.</p< intrapleural intracavitary chemotherapy pressure pig model Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Pages Pierre-Benoit verfasserin aut Ortega-Deballon Pablo verfasserin aut Magnin Guy verfasserin aut Ladoire Sylvain verfasserin aut Royer Bernard verfasserin aut Chauffert Bruno verfasserin aut Bernard Alain verfasserin aut In World Journal of Surgical Oncology BMC, 2003 10(2012), 1, p 29 (DE-627)369082907 (DE-600)2118383-1 14777819 nnns volume:10 year:2012 number:1, p 29 https://doi.org/10.1186/1477-7819-10-29 kostenfrei https://doaj.org/article/61679b4e32e448cc95dac4d223f58871 kostenfrei http://www.wjso.com/content/10/1/29 kostenfrei https://doaj.org/toc/1477-7819 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2012 1, p 29
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spellingShingle	Facy Olivier misc RD1-811 misc RC254-282 misc intrapleural intracavitary chemotherapy misc pressure misc pig model misc Surgery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens High-pressure intrapleural chemotherapy: feasibility in the pig model
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topic_title	RD1-811 RC254-282 High-pressure intrapleural chemotherapy: feasibility in the pig model intrapleural intracavitary chemotherapy pressure pig model
topic	misc RD1-811 misc RC254-282 misc intrapleural intracavitary chemotherapy misc pressure misc pig model misc Surgery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RD1-811 misc RC254-282 misc intrapleural intracavitary chemotherapy misc pressure misc pig model misc Surgery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RD1-811 misc RC254-282 misc intrapleural intracavitary chemotherapy misc pressure misc pig model misc Surgery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	High-pressure intrapleural chemotherapy: feasibility in the pig model
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title_full	High-pressure intrapleural chemotherapy: feasibility in the pig model
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author_browse	Facy Olivier Pages Pierre-Benoit Ortega-Deballon Pablo Magnin Guy Ladoire Sylvain Royer Bernard Chauffert Bruno Bernard Alain
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title_sort	high-pressure intrapleural chemotherapy: feasibility in the pig model
callnumber	RD1-811
title_auth	High-pressure intrapleural chemotherapy: feasibility in the pig model
abstract	<p<Abstract</p< <p<Background</p< <p<The usual treatments for pleural malignancies are mostly palliative. In contrast, peritoneal malignancies are often treated with a curative intent by cytoreductive surgery and intraperitoneal chemotherapy. As pressure has been shown to increase antitumor efficacy, we applied the concept of high-pressure intracavitary chemotherapy to the pleural space in a swine model.</p< <p<Methods</p< <p<Cisplatin and gemcitabine were selected because of their antineoplasic efficacy in vitro in a wide spectrum of cancer cell lines. The pleural cavity of 21 pigs was filled with saline solution; haemodynamic and respiratory parameters were monitored. The pressure was increased to 15-25 cm H<sub<2</sub<O. This treatment was associated with pneumonectomy in 6 pigs. Five pigs were treated with chemotherapy under pressure.</p< <p<Results</p< <p<The combination of gemcitabine (100 mg/l) and cisplatin (30 mg/l) was highly cytotoxic in vitro. The maximum tolerated pressure was 20 cm H<sub<2</sub<0, due to haemodynamic failure. Pneumonectomy was not tolerated, either before or after pleural infusion. Five pigs survived intrapleural chemotherapy associating gemcitabine and cisplatin with 20 cm H<sub<2</sub<O pressure for 60 min.</p< <p<Conclusions</p< <p<High-pressure intrapleural chemotherapy is feasible in pigs. Further experiments will establish the pharmacokinetics and determine whether the benefit already shown in the peritoneum is also obtained in the pleura.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The usual treatments for pleural malignancies are mostly palliative. In contrast, peritoneal malignancies are often treated with a curative intent by cytoreductive surgery and intraperitoneal chemotherapy. As pressure has been shown to increase antitumor efficacy, we applied the concept of high-pressure intracavitary chemotherapy to the pleural space in a swine model.</p< <p<Methods</p< <p<Cisplatin and gemcitabine were selected because of their antineoplasic efficacy in vitro in a wide spectrum of cancer cell lines. The pleural cavity of 21 pigs was filled with saline solution; haemodynamic and respiratory parameters were monitored. The pressure was increased to 15-25 cm H<sub<2</sub<O. This treatment was associated with pneumonectomy in 6 pigs. Five pigs were treated with chemotherapy under pressure.</p< <p<Results</p< <p<The combination of gemcitabine (100 mg/l) and cisplatin (30 mg/l) was highly cytotoxic in vitro. The maximum tolerated pressure was 20 cm H<sub<2</sub<0, due to haemodynamic failure. Pneumonectomy was not tolerated, either before or after pleural infusion. Five pigs survived intrapleural chemotherapy associating gemcitabine and cisplatin with 20 cm H<sub<2</sub<O pressure for 60 min.</p< <p<Conclusions</p< <p<High-pressure intrapleural chemotherapy is feasible in pigs. Further experiments will establish the pharmacokinetics and determine whether the benefit already shown in the peritoneum is also obtained in the pleura.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The usual treatments for pleural malignancies are mostly palliative. In contrast, peritoneal malignancies are often treated with a curative intent by cytoreductive surgery and intraperitoneal chemotherapy. As pressure has been shown to increase antitumor efficacy, we applied the concept of high-pressure intracavitary chemotherapy to the pleural space in a swine model.</p< <p<Methods</p< <p<Cisplatin and gemcitabine were selected because of their antineoplasic efficacy in vitro in a wide spectrum of cancer cell lines. The pleural cavity of 21 pigs was filled with saline solution; haemodynamic and respiratory parameters were monitored. The pressure was increased to 15-25 cm H<sub<2</sub<O. This treatment was associated with pneumonectomy in 6 pigs. Five pigs were treated with chemotherapy under pressure.</p< <p<Results</p< <p<The combination of gemcitabine (100 mg/l) and cisplatin (30 mg/l) was highly cytotoxic in vitro. The maximum tolerated pressure was 20 cm H<sub<2</sub<0, due to haemodynamic failure. Pneumonectomy was not tolerated, either before or after pleural infusion. Five pigs survived intrapleural chemotherapy associating gemcitabine and cisplatin with 20 cm H<sub<2</sub<O pressure for 60 min.</p< <p<Conclusions</p< <p<High-pressure intrapleural chemotherapy is feasible in pigs. Further experiments will establish the pharmacokinetics and determine whether the benefit already shown in the peritoneum is also obtained in the pleura.</p<
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title_short	High-pressure intrapleural chemotherapy: feasibility in the pig model
url	https://doi.org/10.1186/1477-7819-10-29 https://doaj.org/article/61679b4e32e448cc95dac4d223f58871 http://www.wjso.com/content/10/1/29 https://doaj.org/toc/1477-7819
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In contrast, peritoneal malignancies are often treated with a curative intent by cytoreductive surgery and intraperitoneal chemotherapy. As pressure has been shown to increase antitumor efficacy, we applied the concept of high-pressure intracavitary chemotherapy to the pleural space in a swine model.</p< <p<Methods</p< <p<Cisplatin and gemcitabine were selected because of their antineoplasic efficacy in vitro in a wide spectrum of cancer cell lines. The pleural cavity of 21 pigs was filled with saline solution; haemodynamic and respiratory parameters were monitored. The pressure was increased to 15-25 cm H<sub<2</sub<O. This treatment was associated with pneumonectomy in 6 pigs. Five pigs were treated with chemotherapy under pressure.</p< <p<Results</p< <p<The combination of gemcitabine (100 mg/l) and cisplatin (30 mg/l) was highly cytotoxic in vitro. The maximum tolerated pressure was 20 cm H<sub<2</sub<0, due to haemodynamic failure. 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High-pressure intrapleural chemotherapy: feasibility in the pig model

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