Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis

Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fluidity, which mediates cellular function. Phosphol...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Robert M. Schilke [verfasserIn] Cassidy M. R. Blackburn [verfasserIn] Temitayo T. Bamgbose [verfasserIn] Matthew D. Woolard [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	atherosclerosis phospholipases macrophages T cells lipins

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 10(2020), 10, p 1449
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:10, p 1449

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom10101449

Katalog-ID:	DOAJ07695210X

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callnumber-first	Q - Science
author	Robert M. Schilke
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topic_title	QR1-502 Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis atherosclerosis phospholipases macrophages T cells lipins
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title_auth	Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis
abstract	Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fluidity, which mediates cellular function. Phospholipases and the bioactive lipids they produce are important regulators of immune cell activity, dictating both pro-inflammatory and pro-resolving activity. During atherosclerosis, pro-inflammatory and pro-resolving activities govern atherosclerosis progression and regression, respectively. This review will look at the interface of phospholipase activity, immune cell function, and atherosclerosis.
abstractGer	Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fluidity, which mediates cellular function. Phospholipases and the bioactive lipids they produce are important regulators of immune cell activity, dictating both pro-inflammatory and pro-resolving activity. During atherosclerosis, pro-inflammatory and pro-resolving activities govern atherosclerosis progression and regression, respectively. This review will look at the interface of phospholipase activity, immune cell function, and atherosclerosis.
abstract_unstemmed	Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fluidity, which mediates cellular function. Phospholipases and the bioactive lipids they produce are important regulators of immune cell activity, dictating both pro-inflammatory and pro-resolving activity. During atherosclerosis, pro-inflammatory and pro-resolving activities govern atherosclerosis progression and regression, respectively. This review will look at the interface of phospholipase activity, immune cell function, and atherosclerosis.
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title_short	Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis
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