Enhanced nanodrug delivery in tumors after near-infrared photoimmunotherapy
To date, the delivery of nanosized therapeutic agents to cancers largely relies on the enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. Whereas leaky vessels are often found in mouse xenografts, nanosized agents have demonstrated limited su...
Ausführliche Beschreibung
Autor*in: |
Inagaki Fuyuki F. [verfasserIn] Furusawa Aki [verfasserIn] Choyke Peter L. [verfasserIn] Kobayashi Hisataka [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Schlagwörter: |
near-infrared photoimmunotherapy |
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Übergeordnetes Werk: |
In: Nanophotonics - De Gruyter, 2016, 8(2019), 10, Seite 1673-1688 |
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Übergeordnetes Werk: |
volume:8 ; year:2019 ; number:10 ; pages:1673-1688 |
Links: |
Link aufrufen |
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DOI / URN: |
10.1515/nanoph-2019-0186 |
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Katalog-ID: |
DOAJ076986233 |
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10.1515/nanoph-2019-0186 doi (DE-627)DOAJ076986233 (DE-599)DOAJ3f8ece71aea14926a587bf5b03a978d1 DE-627 ger DE-627 rakwb eng QC1-999 Inagaki Fuyuki F. verfasserin aut Enhanced nanodrug delivery in tumors after near-infrared photoimmunotherapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To date, the delivery of nanosized therapeutic agents to cancers largely relies on the enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. Whereas leaky vessels are often found in mouse xenografts, nanosized agents have demonstrated limited success in humans due to the relatively small magnitude of the EPR effect in naturally occurring cancers. To achieve the superior delivery of nanosized agents, alternate methods of increasing permeability and retention are needed. Near-infrared photoimmunotherapy (NIR-PIT) is a recently reported therapy that relies on an antibody-photon absorber conjugate that binds to tumors and then is activated by light. NIR-PIT causes an increase in nanodrug delivery by up to 24-fold compared to untreated tumors in which only the EPR effect is present. This effect, termed super-EPR (SUPR), can enhance the delivery of a wide variety of nanosized agents, including nanoparticles, antibodies, and protein-binding small-molecular-weight agents into tumors. Therefore, taking advantage of the SUPR effect after NIR-PIT may be a promising avenue to use a wide variety of nanodrugs in a highly effective manner. cancer near-infrared photoimmunotherapy epr effects super-enhanced permeability and retention (supr) effects nanodrug delivery Physics Furusawa Aki verfasserin aut Choyke Peter L. verfasserin aut Kobayashi Hisataka verfasserin aut In Nanophotonics De Gruyter, 2016 8(2019), 10, Seite 1673-1688 (DE-627)720169909 (DE-600)2674162-3 21928614 nnns volume:8 year:2019 number:10 pages:1673-1688 https://doi.org/10.1515/nanoph-2019-0186 kostenfrei https://doaj.org/article/3f8ece71aea14926a587bf5b03a978d1 kostenfrei https://doi.org/10.1515/nanoph-2019-0186 kostenfrei https://doaj.org/toc/2192-8606 Journal toc kostenfrei https://doaj.org/toc/2192-8614 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 10 1673-1688 |
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10.1515/nanoph-2019-0186 doi (DE-627)DOAJ076986233 (DE-599)DOAJ3f8ece71aea14926a587bf5b03a978d1 DE-627 ger DE-627 rakwb eng QC1-999 Inagaki Fuyuki F. verfasserin aut Enhanced nanodrug delivery in tumors after near-infrared photoimmunotherapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To date, the delivery of nanosized therapeutic agents to cancers largely relies on the enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. Whereas leaky vessels are often found in mouse xenografts, nanosized agents have demonstrated limited success in humans due to the relatively small magnitude of the EPR effect in naturally occurring cancers. To achieve the superior delivery of nanosized agents, alternate methods of increasing permeability and retention are needed. Near-infrared photoimmunotherapy (NIR-PIT) is a recently reported therapy that relies on an antibody-photon absorber conjugate that binds to tumors and then is activated by light. NIR-PIT causes an increase in nanodrug delivery by up to 24-fold compared to untreated tumors in which only the EPR effect is present. This effect, termed super-EPR (SUPR), can enhance the delivery of a wide variety of nanosized agents, including nanoparticles, antibodies, and protein-binding small-molecular-weight agents into tumors. Therefore, taking advantage of the SUPR effect after NIR-PIT may be a promising avenue to use a wide variety of nanodrugs in a highly effective manner. cancer near-infrared photoimmunotherapy epr effects super-enhanced permeability and retention (supr) effects nanodrug delivery Physics Furusawa Aki verfasserin aut Choyke Peter L. verfasserin aut Kobayashi Hisataka verfasserin aut In Nanophotonics De Gruyter, 2016 8(2019), 10, Seite 1673-1688 (DE-627)720169909 (DE-600)2674162-3 21928614 nnns volume:8 year:2019 number:10 pages:1673-1688 https://doi.org/10.1515/nanoph-2019-0186 kostenfrei https://doaj.org/article/3f8ece71aea14926a587bf5b03a978d1 kostenfrei https://doi.org/10.1515/nanoph-2019-0186 kostenfrei https://doaj.org/toc/2192-8606 Journal toc kostenfrei https://doaj.org/toc/2192-8614 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 10 1673-1688 |
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10.1515/nanoph-2019-0186 doi (DE-627)DOAJ076986233 (DE-599)DOAJ3f8ece71aea14926a587bf5b03a978d1 DE-627 ger DE-627 rakwb eng QC1-999 Inagaki Fuyuki F. verfasserin aut Enhanced nanodrug delivery in tumors after near-infrared photoimmunotherapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To date, the delivery of nanosized therapeutic agents to cancers largely relies on the enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. Whereas leaky vessels are often found in mouse xenografts, nanosized agents have demonstrated limited success in humans due to the relatively small magnitude of the EPR effect in naturally occurring cancers. To achieve the superior delivery of nanosized agents, alternate methods of increasing permeability and retention are needed. Near-infrared photoimmunotherapy (NIR-PIT) is a recently reported therapy that relies on an antibody-photon absorber conjugate that binds to tumors and then is activated by light. NIR-PIT causes an increase in nanodrug delivery by up to 24-fold compared to untreated tumors in which only the EPR effect is present. This effect, termed super-EPR (SUPR), can enhance the delivery of a wide variety of nanosized agents, including nanoparticles, antibodies, and protein-binding small-molecular-weight agents into tumors. Therefore, taking advantage of the SUPR effect after NIR-PIT may be a promising avenue to use a wide variety of nanodrugs in a highly effective manner. cancer near-infrared photoimmunotherapy epr effects super-enhanced permeability and retention (supr) effects nanodrug delivery Physics Furusawa Aki verfasserin aut Choyke Peter L. verfasserin aut Kobayashi Hisataka verfasserin aut In Nanophotonics De Gruyter, 2016 8(2019), 10, Seite 1673-1688 (DE-627)720169909 (DE-600)2674162-3 21928614 nnns volume:8 year:2019 number:10 pages:1673-1688 https://doi.org/10.1515/nanoph-2019-0186 kostenfrei https://doaj.org/article/3f8ece71aea14926a587bf5b03a978d1 kostenfrei https://doi.org/10.1515/nanoph-2019-0186 kostenfrei https://doaj.org/toc/2192-8606 Journal toc kostenfrei https://doaj.org/toc/2192-8614 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 10 1673-1688 |
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To date, the delivery of nanosized therapeutic agents to cancers largely relies on the enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. Whereas leaky vessels are often found in mouse xenografts, nanosized agents have demonstrated limited success in humans due to the relatively small magnitude of the EPR effect in naturally occurring cancers. To achieve the superior delivery of nanosized agents, alternate methods of increasing permeability and retention are needed. Near-infrared photoimmunotherapy (NIR-PIT) is a recently reported therapy that relies on an antibody-photon absorber conjugate that binds to tumors and then is activated by light. NIR-PIT causes an increase in nanodrug delivery by up to 24-fold compared to untreated tumors in which only the EPR effect is present. This effect, termed super-EPR (SUPR), can enhance the delivery of a wide variety of nanosized agents, including nanoparticles, antibodies, and protein-binding small-molecular-weight agents into tumors. Therefore, taking advantage of the SUPR effect after NIR-PIT may be a promising avenue to use a wide variety of nanodrugs in a highly effective manner. |
abstractGer |
To date, the delivery of nanosized therapeutic agents to cancers largely relies on the enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. Whereas leaky vessels are often found in mouse xenografts, nanosized agents have demonstrated limited success in humans due to the relatively small magnitude of the EPR effect in naturally occurring cancers. To achieve the superior delivery of nanosized agents, alternate methods of increasing permeability and retention are needed. Near-infrared photoimmunotherapy (NIR-PIT) is a recently reported therapy that relies on an antibody-photon absorber conjugate that binds to tumors and then is activated by light. NIR-PIT causes an increase in nanodrug delivery by up to 24-fold compared to untreated tumors in which only the EPR effect is present. This effect, termed super-EPR (SUPR), can enhance the delivery of a wide variety of nanosized agents, including nanoparticles, antibodies, and protein-binding small-molecular-weight agents into tumors. Therefore, taking advantage of the SUPR effect after NIR-PIT may be a promising avenue to use a wide variety of nanodrugs in a highly effective manner. |
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To date, the delivery of nanosized therapeutic agents to cancers largely relies on the enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. Whereas leaky vessels are often found in mouse xenografts, nanosized agents have demonstrated limited success in humans due to the relatively small magnitude of the EPR effect in naturally occurring cancers. To achieve the superior delivery of nanosized agents, alternate methods of increasing permeability and retention are needed. Near-infrared photoimmunotherapy (NIR-PIT) is a recently reported therapy that relies on an antibody-photon absorber conjugate that binds to tumors and then is activated by light. NIR-PIT causes an increase in nanodrug delivery by up to 24-fold compared to untreated tumors in which only the EPR effect is present. This effect, termed super-EPR (SUPR), can enhance the delivery of a wide variety of nanosized agents, including nanoparticles, antibodies, and protein-binding small-molecular-weight agents into tumors. Therefore, taking advantage of the SUPR effect after NIR-PIT may be a promising avenue to use a wide variety of nanodrugs in a highly effective manner. |
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