Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells

Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A,...
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Autor*in:	Suthat Chottanapund [verfasserIn] M.B.M. Van Duursen [verfasserIn] Anne Zwartsen [verfasserIn] Supatchaya Timtavorn [verfasserIn] Panida Navasumrit [verfasserIn] Prasat Kittakoop [verfasserIn] Sanya Sureram [verfasserIn] Mathuros Ruchirawat [verfasserIn] Martin Van den Berg [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Toxicology Reports - Elsevier, 2016, 4(2017), Seite 165-171
Übergeordnetes Werk:	volume:4 ; year:2017 ; pages:165-171

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.toxrep.2017.03.004

Katalog-ID:	DOAJ077078985

Internformat


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520			\|a Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this in vitro model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC50 values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC50 values of respectively, 0.19 and 0.14Â Î¼M, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3Â Î¼M. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance. Keywords: Depsidones, Aromatase, Breast cancer, Co-culture
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700	0		\|a Anne Zwartsen \|e verfasserin \|4 aut
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700	0		\|a Panida Navasumrit \|e verfasserin \|4 aut
700	0		\|a Prasat Kittakoop \|e verfasserin \|4 aut
700	0		\|a Sanya Sureram \|e verfasserin \|4 aut
700	0		\|a Mathuros Ruchirawat \|e verfasserin \|4 aut
700	0		\|a Martin Van den Berg \|e verfasserin \|4 aut
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publishDate	2017
allfields	10.1016/j.toxrep.2017.03.004 doi (DE-627)DOAJ077078985 (DE-599)DOAJa4ced36dec1b44e1bbd2946be3563b22 DE-627 ger DE-627 rakwb eng RA1190-1270 Suthat Chottanapund verfasserin aut Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this in vitro model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC50 values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC50 values of respectively, 0.19 and 0.14Â Î¼M, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3Â Î¼M. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance. Keywords: Depsidones, Aromatase, Breast cancer, Co-culture Toxicology. Poisons M.B.M. Van Duursen verfasserin aut Anne Zwartsen verfasserin aut Supatchaya Timtavorn verfasserin aut Panida Navasumrit verfasserin aut Prasat Kittakoop verfasserin aut Sanya Sureram verfasserin aut Mathuros Ruchirawat verfasserin aut Martin Van den Berg verfasserin aut In Toxicology Reports Elsevier, 2016 4(2017), Seite 165-171 (DE-627)815397534 (DE-600)2805786-7 22147500 nnns volume:4 year:2017 pages:165-171 https://doi.org/10.1016/j.toxrep.2017.03.004 kostenfrei https://doaj.org/article/a4ced36dec1b44e1bbd2946be3563b22 kostenfrei http://www.sciencedirect.com/science/article/pii/S2214750017300148 kostenfrei https://doaj.org/toc/2214-7500 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2017 165-171
spelling	10.1016/j.toxrep.2017.03.004 doi (DE-627)DOAJ077078985 (DE-599)DOAJa4ced36dec1b44e1bbd2946be3563b22 DE-627 ger DE-627 rakwb eng RA1190-1270 Suthat Chottanapund verfasserin aut Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this in vitro model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC50 values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC50 values of respectively, 0.19 and 0.14Â Î¼M, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3Â Î¼M. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance. Keywords: Depsidones, Aromatase, Breast cancer, Co-culture Toxicology. Poisons M.B.M. Van Duursen verfasserin aut Anne Zwartsen verfasserin aut Supatchaya Timtavorn verfasserin aut Panida Navasumrit verfasserin aut Prasat Kittakoop verfasserin aut Sanya Sureram verfasserin aut Mathuros Ruchirawat verfasserin aut Martin Van den Berg verfasserin aut In Toxicology Reports Elsevier, 2016 4(2017), Seite 165-171 (DE-627)815397534 (DE-600)2805786-7 22147500 nnns volume:4 year:2017 pages:165-171 https://doi.org/10.1016/j.toxrep.2017.03.004 kostenfrei https://doaj.org/article/a4ced36dec1b44e1bbd2946be3563b22 kostenfrei http://www.sciencedirect.com/science/article/pii/S2214750017300148 kostenfrei https://doaj.org/toc/2214-7500 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2017 165-171
allfields_unstemmed	10.1016/j.toxrep.2017.03.004 doi (DE-627)DOAJ077078985 (DE-599)DOAJa4ced36dec1b44e1bbd2946be3563b22 DE-627 ger DE-627 rakwb eng RA1190-1270 Suthat Chottanapund verfasserin aut Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this in vitro model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC50 values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC50 values of respectively, 0.19 and 0.14Â Î¼M, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3Â Î¼M. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance. Keywords: Depsidones, Aromatase, Breast cancer, Co-culture Toxicology. Poisons M.B.M. Van Duursen verfasserin aut Anne Zwartsen verfasserin aut Supatchaya Timtavorn verfasserin aut Panida Navasumrit verfasserin aut Prasat Kittakoop verfasserin aut Sanya Sureram verfasserin aut Mathuros Ruchirawat verfasserin aut Martin Van den Berg verfasserin aut In Toxicology Reports Elsevier, 2016 4(2017), Seite 165-171 (DE-627)815397534 (DE-600)2805786-7 22147500 nnns volume:4 year:2017 pages:165-171 https://doi.org/10.1016/j.toxrep.2017.03.004 kostenfrei https://doaj.org/article/a4ced36dec1b44e1bbd2946be3563b22 kostenfrei http://www.sciencedirect.com/science/article/pii/S2214750017300148 kostenfrei https://doaj.org/toc/2214-7500 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2017 165-171
allfieldsGer	10.1016/j.toxrep.2017.03.004 doi (DE-627)DOAJ077078985 (DE-599)DOAJa4ced36dec1b44e1bbd2946be3563b22 DE-627 ger DE-627 rakwb eng RA1190-1270 Suthat Chottanapund verfasserin aut Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this in vitro model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC50 values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC50 values of respectively, 0.19 and 0.14Â Î¼M, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3Â Î¼M. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance. Keywords: Depsidones, Aromatase, Breast cancer, Co-culture Toxicology. Poisons M.B.M. Van Duursen verfasserin aut Anne Zwartsen verfasserin aut Supatchaya Timtavorn verfasserin aut Panida Navasumrit verfasserin aut Prasat Kittakoop verfasserin aut Sanya Sureram verfasserin aut Mathuros Ruchirawat verfasserin aut Martin Van den Berg verfasserin aut In Toxicology Reports Elsevier, 2016 4(2017), Seite 165-171 (DE-627)815397534 (DE-600)2805786-7 22147500 nnns volume:4 year:2017 pages:165-171 https://doi.org/10.1016/j.toxrep.2017.03.004 kostenfrei https://doaj.org/article/a4ced36dec1b44e1bbd2946be3563b22 kostenfrei http://www.sciencedirect.com/science/article/pii/S2214750017300148 kostenfrei https://doaj.org/toc/2214-7500 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2017 165-171
allfieldsSound	10.1016/j.toxrep.2017.03.004 doi (DE-627)DOAJ077078985 (DE-599)DOAJa4ced36dec1b44e1bbd2946be3563b22 DE-627 ger DE-627 rakwb eng RA1190-1270 Suthat Chottanapund verfasserin aut Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this in vitro model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC50 values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC50 values of respectively, 0.19 and 0.14Â Î¼M, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3Â Î¼M. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance. Keywords: Depsidones, Aromatase, Breast cancer, Co-culture Toxicology. Poisons M.B.M. Van Duursen verfasserin aut Anne Zwartsen verfasserin aut Supatchaya Timtavorn verfasserin aut Panida Navasumrit verfasserin aut Prasat Kittakoop verfasserin aut Sanya Sureram verfasserin aut Mathuros Ruchirawat verfasserin aut Martin Van den Berg verfasserin aut In Toxicology Reports Elsevier, 2016 4(2017), Seite 165-171 (DE-627)815397534 (DE-600)2805786-7 22147500 nnns volume:4 year:2017 pages:165-171 https://doi.org/10.1016/j.toxrep.2017.03.004 kostenfrei https://doaj.org/article/a4ced36dec1b44e1bbd2946be3563b22 kostenfrei http://www.sciencedirect.com/science/article/pii/S2214750017300148 kostenfrei https://doaj.org/toc/2214-7500 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2017 165-171
language	English
source	In Toxicology Reports 4(2017), Seite 165-171 volume:4 year:2017 pages:165-171
sourceStr	In Toxicology Reports 4(2017), Seite 165-171 volume:4 year:2017 pages:165-171
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Toxicology. Poisons
isfreeaccess_bool	true
container_title	Toxicology Reports
authorswithroles_txt_mv	Suthat Chottanapund @@aut@@ M.B.M. Van Duursen @@aut@@ Anne Zwartsen @@aut@@ Supatchaya Timtavorn @@aut@@ Panida Navasumrit @@aut@@ Prasat Kittakoop @@aut@@ Sanya Sureram @@aut@@ Mathuros Ruchirawat @@aut@@ Martin Van den Berg @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	815397534
id	DOAJ077078985
language_de	englisch
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callnumber-first	R - Medicine
author	Suthat Chottanapund
spellingShingle	Suthat Chottanapund misc RA1190-1270 misc Toxicology. Poisons Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells
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topic_title	RA1190-1270 Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells
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title	Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells
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title_full	Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells
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author_browse	Suthat Chottanapund M.B.M. Van Duursen Anne Zwartsen Supatchaya Timtavorn Panida Navasumrit Prasat Kittakoop Sanya Sureram Mathuros Ruchirawat Martin Van den Berg
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title_sort	depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and t47d breast tumor cells
callnumber	RA1190-1270
title_auth	Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells
abstract	Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this in vitro model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC50 values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC50 values of respectively, 0.19 and 0.14Â Î¼M, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3Â Î¼M. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance. Keywords: Depsidones, Aromatase, Breast cancer, Co-culture
abstractGer	Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this in vitro model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC50 values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC50 values of respectively, 0.19 and 0.14Â Î¼M, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3Â Î¼M. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance. Keywords: Depsidones, Aromatase, Breast cancer, Co-culture
abstract_unstemmed	Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this in vitro model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC50 values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC50 values of respectively, 0.19 and 0.14Â Î¼M, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3Â Î¼M. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance. Keywords: Depsidones, Aromatase, Breast cancer, Co-culture
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title_short	Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells
url	https://doi.org/10.1016/j.toxrep.2017.03.004 https://doaj.org/article/a4ced36dec1b44e1bbd2946be3563b22 http://www.sciencedirect.com/science/article/pii/S2214750017300148 https://doaj.org/toc/2214-7500
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author2	M.B.M. Van Duursen Anne Zwartsen Supatchaya Timtavorn Panida Navasumrit Prasat Kittakoop Sanya Sureram Mathuros Ruchirawat Martin Van den Berg
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up_date	2024-07-03T23:48:21.301Z
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The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this in vitro model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC50 values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC50 values of respectively, 0.19 and 0.14Â Î¼M, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3Â Î¼M. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance. Keywords: Depsidones, Aromatase, Breast cancer, Co-culture</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Toxicology. 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Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells

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