Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib

Cabozantinib (XL-184) is a multitarget tyrosine kinase inhibitor (TKI) targeting receptor tyrosine kinases (RTKs) involved in oncogenesis and angiogenesis. It is currently the standard therapy for medullary thyroid cancer (MTC), metastatic renal cell carcinoma (mRCC), and hepatocellular carcinoma (H...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Fabio Scirocchi [verfasserIn] Chiara Napoletano [verfasserIn] Angelica Pace [verfasserIn] Hassan Rahimi Koshkaki [verfasserIn] Alessandra Di Filippo [verfasserIn] Ilaria Grazia Zizzari [verfasserIn] Marianna Nuti [verfasserIn] Aurelia Rughetti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Cabozantinib immunogenic cell death (ICD) prostate cancer dendritic cell (DC) TKI (tyrosine kinase inhibitors) extracellular vesicle (EV)

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 11(2021)
Übergeordnetes Werk:	volume:11 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2021.755433

Katalog-ID:	DOAJ077139097

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520			\|a Cabozantinib (XL-184) is a multitarget tyrosine kinase inhibitor (TKI) targeting receptor tyrosine kinases (RTKs) involved in oncogenesis and angiogenesis. It is currently the standard therapy for medullary thyroid cancer (MTC), metastatic renal cell carcinoma (mRCC), and hepatocellular carcinoma (HCC). Combination of Cabozantinib with immunotherapy is now a standard treatment in metastatic renal cancer, and its efficacy is being tested in ongoing clinical trial in prostate cancer patients. Here, we report that Cabozantinib may exert an immunostimulatory role by inducing immunogenic stress of prostate cancer cells and directly modulating dendritic cells (DCs). Cabozantinib treatment arrested the cell cycle and triggered immunogenic cell death (ICD) in prostate cancer cells in vitro. Cabozantinib had a direct effect on DCs by the down-modulation of β-catenin and change in migratory and costimulatory phenotype of the DCs. These results may suggest possible immunomodulatory effects induced by Cabozantinib that could be exploited to optimize patient-tailored immunotherapeutic treatments.
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allfieldsSound	10.3389/fonc.2021.755433 doi (DE-627)DOAJ077139097 (DE-599)DOAJ5a02487f09014ddeb2567224fbef96c2 DE-627 ger DE-627 rakwb eng RC254-282 Fabio Scirocchi verfasserin aut Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cabozantinib (XL-184) is a multitarget tyrosine kinase inhibitor (TKI) targeting receptor tyrosine kinases (RTKs) involved in oncogenesis and angiogenesis. It is currently the standard therapy for medullary thyroid cancer (MTC), metastatic renal cell carcinoma (mRCC), and hepatocellular carcinoma (HCC). Combination of Cabozantinib with immunotherapy is now a standard treatment in metastatic renal cancer, and its efficacy is being tested in ongoing clinical trial in prostate cancer patients. Here, we report that Cabozantinib may exert an immunostimulatory role by inducing immunogenic stress of prostate cancer cells and directly modulating dendritic cells (DCs). Cabozantinib treatment arrested the cell cycle and triggered immunogenic cell death (ICD) in prostate cancer cells in vitro. Cabozantinib had a direct effect on DCs by the down-modulation of β-catenin and change in migratory and costimulatory phenotype of the DCs. These results may suggest possible immunomodulatory effects induced by Cabozantinib that could be exploited to optimize patient-tailored immunotherapeutic treatments. Cabozantinib immunogenic cell death (ICD) prostate cancer dendritic cell (DC) TKI (tyrosine kinase inhibitors) extracellular vesicle (EV) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chiara Napoletano verfasserin aut Angelica Pace verfasserin aut Hassan Rahimi Koshkaki verfasserin aut Alessandra Di Filippo verfasserin aut Ilaria Grazia Zizzari verfasserin aut Marianna Nuti verfasserin aut Aurelia Rughetti verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 11(2021) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:11 year:2021 https://doi.org/10.3389/fonc.2021.755433 kostenfrei https://doaj.org/article/5a02487f09014ddeb2567224fbef96c2 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2021.755433/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
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source	In Frontiers in Oncology 11(2021) volume:11 year:2021
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topic_facet	Cabozantinib immunogenic cell death (ICD) prostate cancer dendritic cell (DC) TKI (tyrosine kinase inhibitors) extracellular vesicle (EV) Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Frontiers in Oncology
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callnumber-first	R - Medicine
author	Fabio Scirocchi
spellingShingle	Fabio Scirocchi misc RC254-282 misc Cabozantinib misc immunogenic cell death (ICD) misc prostate cancer misc dendritic cell (DC) misc TKI (tyrosine kinase inhibitors) misc extracellular vesicle (EV) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib
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topic_title	RC254-282 Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib Cabozantinib immunogenic cell death (ICD) prostate cancer dendritic cell (DC) TKI (tyrosine kinase inhibitors) extracellular vesicle (EV)
topic	misc RC254-282 misc Cabozantinib misc immunogenic cell death (ICD) misc prostate cancer misc dendritic cell (DC) misc TKI (tyrosine kinase inhibitors) misc extracellular vesicle (EV) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Cabozantinib misc immunogenic cell death (ICD) misc prostate cancer misc dendritic cell (DC) misc TKI (tyrosine kinase inhibitors) misc extracellular vesicle (EV) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Cabozantinib misc immunogenic cell death (ICD) misc prostate cancer misc dendritic cell (DC) misc TKI (tyrosine kinase inhibitors) misc extracellular vesicle (EV) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib
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title_full	Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib
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author_browse	Fabio Scirocchi Chiara Napoletano Angelica Pace Hassan Rahimi Koshkaki Alessandra Di Filippo Ilaria Grazia Zizzari Marianna Nuti Aurelia Rughetti
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title_sort	immunogenic cell death and immunomodulatory effects of cabozantinib
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title_auth	Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib
abstract	Cabozantinib (XL-184) is a multitarget tyrosine kinase inhibitor (TKI) targeting receptor tyrosine kinases (RTKs) involved in oncogenesis and angiogenesis. It is currently the standard therapy for medullary thyroid cancer (MTC), metastatic renal cell carcinoma (mRCC), and hepatocellular carcinoma (HCC). Combination of Cabozantinib with immunotherapy is now a standard treatment in metastatic renal cancer, and its efficacy is being tested in ongoing clinical trial in prostate cancer patients. Here, we report that Cabozantinib may exert an immunostimulatory role by inducing immunogenic stress of prostate cancer cells and directly modulating dendritic cells (DCs). Cabozantinib treatment arrested the cell cycle and triggered immunogenic cell death (ICD) in prostate cancer cells in vitro. Cabozantinib had a direct effect on DCs by the down-modulation of β-catenin and change in migratory and costimulatory phenotype of the DCs. These results may suggest possible immunomodulatory effects induced by Cabozantinib that could be exploited to optimize patient-tailored immunotherapeutic treatments.
abstractGer	Cabozantinib (XL-184) is a multitarget tyrosine kinase inhibitor (TKI) targeting receptor tyrosine kinases (RTKs) involved in oncogenesis and angiogenesis. It is currently the standard therapy for medullary thyroid cancer (MTC), metastatic renal cell carcinoma (mRCC), and hepatocellular carcinoma (HCC). Combination of Cabozantinib with immunotherapy is now a standard treatment in metastatic renal cancer, and its efficacy is being tested in ongoing clinical trial in prostate cancer patients. Here, we report that Cabozantinib may exert an immunostimulatory role by inducing immunogenic stress of prostate cancer cells and directly modulating dendritic cells (DCs). Cabozantinib treatment arrested the cell cycle and triggered immunogenic cell death (ICD) in prostate cancer cells in vitro. Cabozantinib had a direct effect on DCs by the down-modulation of β-catenin and change in migratory and costimulatory phenotype of the DCs. These results may suggest possible immunomodulatory effects induced by Cabozantinib that could be exploited to optimize patient-tailored immunotherapeutic treatments.
abstract_unstemmed	Cabozantinib (XL-184) is a multitarget tyrosine kinase inhibitor (TKI) targeting receptor tyrosine kinases (RTKs) involved in oncogenesis and angiogenesis. It is currently the standard therapy for medullary thyroid cancer (MTC), metastatic renal cell carcinoma (mRCC), and hepatocellular carcinoma (HCC). Combination of Cabozantinib with immunotherapy is now a standard treatment in metastatic renal cancer, and its efficacy is being tested in ongoing clinical trial in prostate cancer patients. Here, we report that Cabozantinib may exert an immunostimulatory role by inducing immunogenic stress of prostate cancer cells and directly modulating dendritic cells (DCs). Cabozantinib treatment arrested the cell cycle and triggered immunogenic cell death (ICD) in prostate cancer cells in vitro. Cabozantinib had a direct effect on DCs by the down-modulation of β-catenin and change in migratory and costimulatory phenotype of the DCs. These results may suggest possible immunomodulatory effects induced by Cabozantinib that could be exploited to optimize patient-tailored immunotherapeutic treatments.
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title_short	Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib
url	https://doi.org/10.3389/fonc.2021.755433 https://doaj.org/article/5a02487f09014ddeb2567224fbef96c2 https://www.frontiersin.org/articles/10.3389/fonc.2021.755433/full https://doaj.org/toc/2234-943X
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up_date	2024-07-04T00:03:05.674Z
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