Systematic analysis of transcriptomic profiles of COPD airway epithelium using next-generation sequencing and bioinformatics
Wei-An Chang,1,2 Ming-Ju Tsai,1–4 Shu-Fang Jian,1 Chau-Chyun Sheu,1–4 Po-Lin Kuo1,5 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical...
Ausführliche Beschreibung
Autor*in: |
Chang WA [verfasserIn] Tsai MJ [verfasserIn] Jian SF [verfasserIn] Sheu CC [verfasserIn] Kuo PL [verfasserIn] |
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Englisch |
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2018 |
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In: International Journal of COPD - Dove Medical Press, 2009, (2018), Seite 2387-2398 |
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year:2018 ; pages:2387-2398 |
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DOAJ077229991 |
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(DE-627)DOAJ077229991 (DE-599)DOAJ37c191504a3943b7b60848d7d28c1d12 DE-627 ger DE-627 rakwb eng RC705-779 Chang WA verfasserin aut Systematic analysis of transcriptomic profiles of COPD airway epithelium using next-generation sequencing and bioinformatics 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wei-An Chang,1,2 Ming-Ju Tsai,1–4 Shu-Fang Jian,1 Chau-Chyun Sheu,1–4 Po-Lin Kuo1,5 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 3Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 4Department of Respiratory Therapy, School of Medicine, College of Medicine, Kaohsiung Medical University, 5Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, TaiwanIntroduction: COPD is a chronic inflammatory disease of lung. The inflammatory response in COPD is associated with neutrophils, macrophages, T lymphocytes, and bronchial epithelial cells, and occurs mainly in the small airway, leading to irreversible airflow limitation.Methods: In order to investigate the microRNA–mRNA interaction in the microenvironment of the COPD airway, we used next-generation sequencing and bioinformatics in this study.Results: We identified four genes with microRNA–mRNA interactions involved in COPD small-airway bronchial epithelial cells: NT5E, SDK1, TNS1, and PCDH7. Furthermore, miR6511a-5p–NT5E interaction was found to be involved in small-airway bronchial epithelial cells, large-airway bronchial epithelial cells, and alveolar macrophages.Conclusion: Our results showed that miR6511a-5p–NT5E interaction plays an important role in COPD, which might be associated with cell–cell contact, activation of leukocytes, activation of T lymphocytes, and cellular homeostasis. These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD. Keywords: bioinformatics, COPD, epithelium, miR6511a-5p, next-generation sequencing, NT5E bioinformatics COPD epithelium miR-6511a-5p next-generation sequencing NT5E Diseases of the respiratory system Tsai MJ verfasserin aut Jian SF verfasserin aut Sheu CC verfasserin aut Kuo PL verfasserin aut In International Journal of COPD Dove Medical Press, 2009 (2018), Seite 2387-2398 (DE-627)504104357 (DE-600)2212419-6 11782005 nnns year:2018 pages:2387-2398 https://doaj.org/article/37c191504a3943b7b60848d7d28c1d12 kostenfrei https://www.dovepress.com/systematic-analysis-of-transcriptomic-profiles-of-copd-airway-epitheli-peer-reviewed-article-COPD kostenfrei https://doaj.org/toc/1178-2005 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 2387-2398 |
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(DE-627)DOAJ077229991 (DE-599)DOAJ37c191504a3943b7b60848d7d28c1d12 DE-627 ger DE-627 rakwb eng RC705-779 Chang WA verfasserin aut Systematic analysis of transcriptomic profiles of COPD airway epithelium using next-generation sequencing and bioinformatics 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wei-An Chang,1,2 Ming-Ju Tsai,1–4 Shu-Fang Jian,1 Chau-Chyun Sheu,1–4 Po-Lin Kuo1,5 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 3Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 4Department of Respiratory Therapy, School of Medicine, College of Medicine, Kaohsiung Medical University, 5Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, TaiwanIntroduction: COPD is a chronic inflammatory disease of lung. The inflammatory response in COPD is associated with neutrophils, macrophages, T lymphocytes, and bronchial epithelial cells, and occurs mainly in the small airway, leading to irreversible airflow limitation.Methods: In order to investigate the microRNA–mRNA interaction in the microenvironment of the COPD airway, we used next-generation sequencing and bioinformatics in this study.Results: We identified four genes with microRNA–mRNA interactions involved in COPD small-airway bronchial epithelial cells: NT5E, SDK1, TNS1, and PCDH7. Furthermore, miR6511a-5p–NT5E interaction was found to be involved in small-airway bronchial epithelial cells, large-airway bronchial epithelial cells, and alveolar macrophages.Conclusion: Our results showed that miR6511a-5p–NT5E interaction plays an important role in COPD, which might be associated with cell–cell contact, activation of leukocytes, activation of T lymphocytes, and cellular homeostasis. These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD. Keywords: bioinformatics, COPD, epithelium, miR6511a-5p, next-generation sequencing, NT5E bioinformatics COPD epithelium miR-6511a-5p next-generation sequencing NT5E Diseases of the respiratory system Tsai MJ verfasserin aut Jian SF verfasserin aut Sheu CC verfasserin aut Kuo PL verfasserin aut In International Journal of COPD Dove Medical Press, 2009 (2018), Seite 2387-2398 (DE-627)504104357 (DE-600)2212419-6 11782005 nnns year:2018 pages:2387-2398 https://doaj.org/article/37c191504a3943b7b60848d7d28c1d12 kostenfrei https://www.dovepress.com/systematic-analysis-of-transcriptomic-profiles-of-copd-airway-epitheli-peer-reviewed-article-COPD kostenfrei https://doaj.org/toc/1178-2005 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 2387-2398 |
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(DE-627)DOAJ077229991 (DE-599)DOAJ37c191504a3943b7b60848d7d28c1d12 DE-627 ger DE-627 rakwb eng RC705-779 Chang WA verfasserin aut Systematic analysis of transcriptomic profiles of COPD airway epithelium using next-generation sequencing and bioinformatics 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wei-An Chang,1,2 Ming-Ju Tsai,1–4 Shu-Fang Jian,1 Chau-Chyun Sheu,1–4 Po-Lin Kuo1,5 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 3Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 4Department of Respiratory Therapy, School of Medicine, College of Medicine, Kaohsiung Medical University, 5Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, TaiwanIntroduction: COPD is a chronic inflammatory disease of lung. The inflammatory response in COPD is associated with neutrophils, macrophages, T lymphocytes, and bronchial epithelial cells, and occurs mainly in the small airway, leading to irreversible airflow limitation.Methods: In order to investigate the microRNA–mRNA interaction in the microenvironment of the COPD airway, we used next-generation sequencing and bioinformatics in this study.Results: We identified four genes with microRNA–mRNA interactions involved in COPD small-airway bronchial epithelial cells: NT5E, SDK1, TNS1, and PCDH7. Furthermore, miR6511a-5p–NT5E interaction was found to be involved in small-airway bronchial epithelial cells, large-airway bronchial epithelial cells, and alveolar macrophages.Conclusion: Our results showed that miR6511a-5p–NT5E interaction plays an important role in COPD, which might be associated with cell–cell contact, activation of leukocytes, activation of T lymphocytes, and cellular homeostasis. These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD. Keywords: bioinformatics, COPD, epithelium, miR6511a-5p, next-generation sequencing, NT5E bioinformatics COPD epithelium miR-6511a-5p next-generation sequencing NT5E Diseases of the respiratory system Tsai MJ verfasserin aut Jian SF verfasserin aut Sheu CC verfasserin aut Kuo PL verfasserin aut In International Journal of COPD Dove Medical Press, 2009 (2018), Seite 2387-2398 (DE-627)504104357 (DE-600)2212419-6 11782005 nnns year:2018 pages:2387-2398 https://doaj.org/article/37c191504a3943b7b60848d7d28c1d12 kostenfrei https://www.dovepress.com/systematic-analysis-of-transcriptomic-profiles-of-copd-airway-epitheli-peer-reviewed-article-COPD kostenfrei https://doaj.org/toc/1178-2005 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 2387-2398 |
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(DE-627)DOAJ077229991 (DE-599)DOAJ37c191504a3943b7b60848d7d28c1d12 DE-627 ger DE-627 rakwb eng RC705-779 Chang WA verfasserin aut Systematic analysis of transcriptomic profiles of COPD airway epithelium using next-generation sequencing and bioinformatics 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wei-An Chang,1,2 Ming-Ju Tsai,1–4 Shu-Fang Jian,1 Chau-Chyun Sheu,1–4 Po-Lin Kuo1,5 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 3Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 4Department of Respiratory Therapy, School of Medicine, College of Medicine, Kaohsiung Medical University, 5Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, TaiwanIntroduction: COPD is a chronic inflammatory disease of lung. The inflammatory response in COPD is associated with neutrophils, macrophages, T lymphocytes, and bronchial epithelial cells, and occurs mainly in the small airway, leading to irreversible airflow limitation.Methods: In order to investigate the microRNA–mRNA interaction in the microenvironment of the COPD airway, we used next-generation sequencing and bioinformatics in this study.Results: We identified four genes with microRNA–mRNA interactions involved in COPD small-airway bronchial epithelial cells: NT5E, SDK1, TNS1, and PCDH7. Furthermore, miR6511a-5p–NT5E interaction was found to be involved in small-airway bronchial epithelial cells, large-airway bronchial epithelial cells, and alveolar macrophages.Conclusion: Our results showed that miR6511a-5p–NT5E interaction plays an important role in COPD, which might be associated with cell–cell contact, activation of leukocytes, activation of T lymphocytes, and cellular homeostasis. These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD. Keywords: bioinformatics, COPD, epithelium, miR6511a-5p, next-generation sequencing, NT5E bioinformatics COPD epithelium miR-6511a-5p next-generation sequencing NT5E Diseases of the respiratory system Tsai MJ verfasserin aut Jian SF verfasserin aut Sheu CC verfasserin aut Kuo PL verfasserin aut In International Journal of COPD Dove Medical Press, 2009 (2018), Seite 2387-2398 (DE-627)504104357 (DE-600)2212419-6 11782005 nnns year:2018 pages:2387-2398 https://doaj.org/article/37c191504a3943b7b60848d7d28c1d12 kostenfrei https://www.dovepress.com/systematic-analysis-of-transcriptomic-profiles-of-copd-airway-epitheli-peer-reviewed-article-COPD kostenfrei https://doaj.org/toc/1178-2005 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 2387-2398 |
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(DE-627)DOAJ077229991 (DE-599)DOAJ37c191504a3943b7b60848d7d28c1d12 DE-627 ger DE-627 rakwb eng RC705-779 Chang WA verfasserin aut Systematic analysis of transcriptomic profiles of COPD airway epithelium using next-generation sequencing and bioinformatics 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wei-An Chang,1,2 Ming-Ju Tsai,1–4 Shu-Fang Jian,1 Chau-Chyun Sheu,1–4 Po-Lin Kuo1,5 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 3Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 4Department of Respiratory Therapy, School of Medicine, College of Medicine, Kaohsiung Medical University, 5Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, TaiwanIntroduction: COPD is a chronic inflammatory disease of lung. The inflammatory response in COPD is associated with neutrophils, macrophages, T lymphocytes, and bronchial epithelial cells, and occurs mainly in the small airway, leading to irreversible airflow limitation.Methods: In order to investigate the microRNA–mRNA interaction in the microenvironment of the COPD airway, we used next-generation sequencing and bioinformatics in this study.Results: We identified four genes with microRNA–mRNA interactions involved in COPD small-airway bronchial epithelial cells: NT5E, SDK1, TNS1, and PCDH7. Furthermore, miR6511a-5p–NT5E interaction was found to be involved in small-airway bronchial epithelial cells, large-airway bronchial epithelial cells, and alveolar macrophages.Conclusion: Our results showed that miR6511a-5p–NT5E interaction plays an important role in COPD, which might be associated with cell–cell contact, activation of leukocytes, activation of T lymphocytes, and cellular homeostasis. These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD. Keywords: bioinformatics, COPD, epithelium, miR6511a-5p, next-generation sequencing, NT5E bioinformatics COPD epithelium miR-6511a-5p next-generation sequencing NT5E Diseases of the respiratory system Tsai MJ verfasserin aut Jian SF verfasserin aut Sheu CC verfasserin aut Kuo PL verfasserin aut In International Journal of COPD Dove Medical Press, 2009 (2018), Seite 2387-2398 (DE-627)504104357 (DE-600)2212419-6 11782005 nnns year:2018 pages:2387-2398 https://doaj.org/article/37c191504a3943b7b60848d7d28c1d12 kostenfrei https://www.dovepress.com/systematic-analysis-of-transcriptomic-profiles-of-copd-airway-epitheli-peer-reviewed-article-COPD kostenfrei https://doaj.org/toc/1178-2005 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 2387-2398 |
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These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD. 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Systematic analysis of transcriptomic profiles of COPD airway epithelium using next-generation sequencing and bioinformatics |
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Wei-An Chang,1,2 Ming-Ju Tsai,1–4 Shu-Fang Jian,1 Chau-Chyun Sheu,1–4 Po-Lin Kuo1,5 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 3Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 4Department of Respiratory Therapy, School of Medicine, College of Medicine, Kaohsiung Medical University, 5Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, TaiwanIntroduction: COPD is a chronic inflammatory disease of lung. The inflammatory response in COPD is associated with neutrophils, macrophages, T lymphocytes, and bronchial epithelial cells, and occurs mainly in the small airway, leading to irreversible airflow limitation.Methods: In order to investigate the microRNA–mRNA interaction in the microenvironment of the COPD airway, we used next-generation sequencing and bioinformatics in this study.Results: We identified four genes with microRNA–mRNA interactions involved in COPD small-airway bronchial epithelial cells: NT5E, SDK1, TNS1, and PCDH7. Furthermore, miR6511a-5p–NT5E interaction was found to be involved in small-airway bronchial epithelial cells, large-airway bronchial epithelial cells, and alveolar macrophages.Conclusion: Our results showed that miR6511a-5p–NT5E interaction plays an important role in COPD, which might be associated with cell–cell contact, activation of leukocytes, activation of T lymphocytes, and cellular homeostasis. These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD. Keywords: bioinformatics, COPD, epithelium, miR6511a-5p, next-generation sequencing, NT5E |
abstractGer |
Wei-An Chang,1,2 Ming-Ju Tsai,1–4 Shu-Fang Jian,1 Chau-Chyun Sheu,1–4 Po-Lin Kuo1,5 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 3Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 4Department of Respiratory Therapy, School of Medicine, College of Medicine, Kaohsiung Medical University, 5Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, TaiwanIntroduction: COPD is a chronic inflammatory disease of lung. The inflammatory response in COPD is associated with neutrophils, macrophages, T lymphocytes, and bronchial epithelial cells, and occurs mainly in the small airway, leading to irreversible airflow limitation.Methods: In order to investigate the microRNA–mRNA interaction in the microenvironment of the COPD airway, we used next-generation sequencing and bioinformatics in this study.Results: We identified four genes with microRNA–mRNA interactions involved in COPD small-airway bronchial epithelial cells: NT5E, SDK1, TNS1, and PCDH7. Furthermore, miR6511a-5p–NT5E interaction was found to be involved in small-airway bronchial epithelial cells, large-airway bronchial epithelial cells, and alveolar macrophages.Conclusion: Our results showed that miR6511a-5p–NT5E interaction plays an important role in COPD, which might be associated with cell–cell contact, activation of leukocytes, activation of T lymphocytes, and cellular homeostasis. These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD. Keywords: bioinformatics, COPD, epithelium, miR6511a-5p, next-generation sequencing, NT5E |
abstract_unstemmed |
Wei-An Chang,1,2 Ming-Ju Tsai,1–4 Shu-Fang Jian,1 Chau-Chyun Sheu,1–4 Po-Lin Kuo1,5 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 3Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 4Department of Respiratory Therapy, School of Medicine, College of Medicine, Kaohsiung Medical University, 5Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, TaiwanIntroduction: COPD is a chronic inflammatory disease of lung. The inflammatory response in COPD is associated with neutrophils, macrophages, T lymphocytes, and bronchial epithelial cells, and occurs mainly in the small airway, leading to irreversible airflow limitation.Methods: In order to investigate the microRNA–mRNA interaction in the microenvironment of the COPD airway, we used next-generation sequencing and bioinformatics in this study.Results: We identified four genes with microRNA–mRNA interactions involved in COPD small-airway bronchial epithelial cells: NT5E, SDK1, TNS1, and PCDH7. Furthermore, miR6511a-5p–NT5E interaction was found to be involved in small-airway bronchial epithelial cells, large-airway bronchial epithelial cells, and alveolar macrophages.Conclusion: Our results showed that miR6511a-5p–NT5E interaction plays an important role in COPD, which might be associated with cell–cell contact, activation of leukocytes, activation of T lymphocytes, and cellular homeostasis. These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD. Keywords: bioinformatics, COPD, epithelium, miR6511a-5p, next-generation sequencing, NT5E |
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Systematic analysis of transcriptomic profiles of COPD airway epithelium using next-generation sequencing and bioinformatics |
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The inflammatory response in COPD is associated with neutrophils, macrophages, T lymphocytes, and bronchial epithelial cells, and occurs mainly in the small airway, leading to irreversible airflow limitation.Methods: In order to investigate the microRNA&ndash;mRNA interaction in the microenvironment of the COPD airway, we used next-generation sequencing and bioinformatics in this study.Results: We identified four genes with microRNA&ndash;mRNA interactions involved in COPD small-airway bronchial epithelial cells: NT5E, SDK1, TNS1, and PCDH7. Furthermore, miR6511a-5p&ndash;NT5E interaction was found to be involved in small-airway bronchial epithelial cells, large-airway bronchial epithelial cells, and alveolar macrophages.Conclusion: Our results showed that miR6511a-5p&ndash;NT5E interaction plays an important role in COPD, which might be associated with cell&ndash;cell contact, activation of leukocytes, activation of T lymphocytes, and cellular homeostasis. These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD. 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